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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation s... See more...
Aliases for FGF2 Gene
Aliases for FGF2 Gene
External Ids for FGF2 Gene
- HGNC: 3676
- Entrez Gene: 2247
- Ensembl: ENSG00000138685
- OMIM: 134920
- UniProtKB: P09038
Previous HGNC Symbols for FGF2 Gene
- FGFB
Previous GeneCards Identifiers for FGF2 Gene
- GC04P124660
- GC04P124027
- GC04P124141
- GC04P124206
- GC04P124105
- GC04P123747
- GC04P119474
Summaries for FGF2 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF2 Gene
FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Chronic Ulcer Of Skin. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.
UniProtKB/Swiss-Prot Summary for FGF2 Gene
-
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).
Additional gene information for FGF2 Gene
- HGNC(3676)
- Entrez Gene(2247)
- Ensembl(ENSG00000138685)
- OMIM(134920)
- UniProtKB(P09038)
- Open Targets Platform(ENSG00000138685)
- Monarch Initiative
- Search for FGF2 at DataMed
- Search for FGF2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF2 Gene
Genomics for FGF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF2
- Top Transcription factor binding sites by QIAGEN in the FGF2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- LyF-1
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for FGF2 Gene
Genomic Locations for FGF2 Gene
- chr4:122,826,708-122,898,236
- (GRCh38/hg38)
- Size:
- 71,529 bases
- Orientation:
- Plus strand
- chr4:123,747,863-123,819,391
- (GRCh37/hg19)
- Size:
- 71,529 bases
- Orientation:
- Plus strand
Genomic View for FGF2 Gene
Genes around FGF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q28.1 by HGNC
- 4q28.1 by Entrez Gene
- 4q28.1 by Ensembl
FGF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF2 Gene
Proteins for FGF2 Gene
-
Protein details for FGF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09038-FGF2_HUMAN
- Recommended name:
- Fibroblast growth factor 2
- Protein Accession:
- P09038
- A4LBB8
- O00527
- P78443
- Q16443
- Q5PY50
- Q7KZ11
- Q7KZ72
- Q9UC54
- Q9UCS5
- Q9UCS6
Protein attributes for FGF2 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 30770 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).
- SequenceCaution:
-
- Sequence=AAA52448.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};
- Miscellaneous:
-
- This protein binds heparin more strongly than does aFGF.
- [Isoform 1]: Starts at an alternative CUG codon.
- [Isoform 2]: Starts at an alternative CUG codon.
- [Isoform 4]: Starts at an alternative CUG codon.
Three dimensional structures from OCA and Proteopedia for FGF2 Gene
Protein Expression for FGF2 Gene
Post-translational modifications for FGF2 Gene
- Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
- Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FGF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FGF2 Antibody
- NSJ Bioreagents FGF2 Antibody
- GeneTex Anti-FGF2 antibody [FB-8] and Anti-FGF2 antibody
-
Custom Antibody ServicesOriGene Antibodies for FGF2
- AM06116SU-N
- AM09155PU-N
- AM09157PU-N
- AM09159PU-N
- AM09160PU-N
- AM20811PU-L
- AM20811PU-N
- AM20811PU-S
- AP02009SU-N
- AP02009SU-S
- AP23263PU-N
- AP51656PU-N
- CF500012
- CF500013
- CF500269
- DP3506
- DP3506S
- PM1203P
- PP1007B1
- PP1007B2
- PP1007P1
- PP1007P2
- SM1286P
- TA319021
- TA321420
- TA321421
- TA328310
- TA328311
- TA346315
- TA500012
- TA500012S
- TA500013
- TA500013S
- TA500269
- TA500269S
- TA890058
- TA890058S
- Novus Biologicals Antibodies for FGF2
-
Abcam antibodies for FGF2
- Invitrogen Antibodies for FGF2 (AFLGC-FGF2)
- antibodies-online: Show 218 available FGF2 Antibodies ranked by validation data
- Compare Top FGF2 Antibodies
-
Recommended
- 236 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 5 IHC (fro) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (pfa) Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 Neut Antibodies (anti-mouse)
- 1 RIA Antibody (anti-mouse)
- 44 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 Neut Antibodies (anti-rat)
- 1 RIA Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF2
- Sino Biological Antibodies for FGF2
Protein Products
-
BioLegend
- Recombinant Human FGF-basic/145aa (carrier-free) (571504)
- Recombinant Human FGF-basic/145aa (carrier-free) (571508)
- Recombinant Human FGF-basic/145aa (carrier-free) (571502)
- Recombinant Human FGF-basic/145aa (carrier-free) (571506)
- Recombinant Human FGF-basic (146 aa) (Animal-Free)
- Recombinant Human FGF-basic (154 aa) (Animal-Free)
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF2
- Origene Custom Protein Services for FGF2
- Sino Biological Recombinant Proteins for FGF2
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FGF2
-
ProSci Proteins for FGF2
- fibroblast growth factor 2 [91-621]
- fibroblast growth factor 2 (basic) [40-160]
- fibroblast growth factor 2 (basic) [90-331]
- fibroblast growth factor 2 [92-617]
- fibroblast growth factor 2 [91-594]
- fibroblast growth factor 2 (basic) [96-063]
- fibroblast growth factor 2 [91-034]
- fibroblast growth factor 2 [91-036]
- fibroblast growth factor 2 (basic) [40-589]
- fibroblast growth factor 2 [40-480]
- fibroblast growth factor 2 [40-492]
- fibroblast growth factor 2 [40-616]
-
Abcam proteins for FGF2
Assay Products
- RayBiotech Human bFGF ELISA and Human bFGF ELISA (For Lysates)
- Novus Biologicals ELISA Kits for FGF2
- antibodies-online: Show 139 available FGF2 Elisa Kits ranked by validation data
- Compare Top FGF2 Elisa Kits
-
Quality Products:
- ABIN624947
- ABIN415057
- ABIN624948
- ABIN1559588
- ABIN365030
- ABIN3198428
- ABIN1379941
- ABIN5564670
- ABIN5520548
- ABIN2708206
- ABIN625113
- ABIN1113668
- ABIN365443
- ABIN1873360
- ABIN5520549
- ABIN5526796
- ABIN2684257
- ABIN5669788
- ABIN1569806
- ABIN5592047
- ABIN365551
- ABIN1113666
- ABIN416389
- ABIN5564669
- ABIN4993007
- ABIN2747985
- ABIN5520552
- ABIN454503
- ABIN5696342
- ABIN5670455
- ABIN414069
- ABIN833176
- ABIN2851143
- ABIN989382
- ABIN4881432
- ABIN6384509
- ABIN5654234
- ABIN4969107
- ABIN6199690
- ABIN6199691
No data available for DME Specific Peptides for FGF2 Gene
Domains & Families for FGF2 Gene
Gene Families for FGF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted secreted proteins
- Transporters
Protein Domains for FGF2 Gene
- InterPro:
- Blocks:
-
- Heparin binding growth factor family signature
- IL1/HBGF family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF2 Gene
- GenScript: Design optimal peptide antigens:
-
- Fibroblast growth factor 2 (Basic) (D9ZGF5_HUMAN)
- Basic fibroblast growth factor (FGF2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P09038- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF2 Gene
Molecular function for FGF2 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius. {ECO:0000269|PubMed:1721615}; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius. {ECO:0000269|PubMed:1721615};
- GENATLAS Biochemistry:
- fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in mouse. FGF2 expression is under the control of an antisense transcript (see NUDT6)
LifeMap Function Summary for FGF2 Gene
During embryonic development, FGF2 as signaling molecule is secreted from the following cells
- Limb
- Brain
- Hypoblast
- Intermediate Mesoderm
- Primitive Streak
- Ovary
- Testis
It affects the following cells:
- Brain
-
Neural Tube
- d3 Neural Progenitor Cells (dP3 Neural Domain)
- d4 Neural Progenitor Cells (dP4 Neural Domain)
- d5 Neural Progenitor Cells (dP5 Neural Domain)
- Neocortical Radial Glia Cells (Cortical Sub Ventricular Zone)
- Oligodendrocyte Precursor Cells (Medial Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Caudal Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Lateral Ganglionic Eminence)
- Oligodendrocyte Precursor Cells (Anterior Entopeduncular Area)
- Gut Tube
-
Bone
- Immature Endochondral Osteoblasts (Autopod Periosteum)
- Immature Endochondral Osteoblasts (Zeugopod Periosteum)
- Immature Endochondral Osteoblasts (Vertebrae)
- Immature Endochondral Osteoblasts (Rib)
- Immature Endochondral Osteoblasts (Stylopod Periosteum)
- Intramembranous Osteoblasts (Rostral Skull Membranous Bones)
- Suture Cells (Rostral Sutures)
- Suture Cells (Facial Sutures)
- Lateral Plate Mesoderm
- Lymph
- Primitive Streak
- Kidney
- Ovary
- Testis
FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Gut Tube
-
Brain
- Anterior astrospheres
- Astrocyte-like cells
- B27-induced oligodendrocyte-like cells
- Brain microvascular endothelial cells
- Caudal astrospheres
- Dopamine-releasing cells
- Dopaminergic neuron-like cells
- Dopaminergic neurons
- Dorsal telencephalic astrospheres
- Endothelial cells
- Expanded oligodendrocyte progenitor cells
- GABA neuron-like cells
- Neuron-like cells
- Oligodendrocyte precursor cells
- Oligodendrocyte progenitor cells
- Pre-oligodendrocyte progenitor cells
- Ventral astrospheres
- Skeletal Muscle
- Glial Cells
- Endoderm
- Neurons
- Peripheral Nervous System
- Inner Cell Mass
- Neural Ectoderm
- Heart
- Endothelium
- Kidney
- Mesoderm
- Neural Crest
- Spinal Cord
- Pancreas
- Epiblast
- Intermediate Mesoderm
- Mesenchymal Stem Cells
- Eye
- Primitive Streak
- Neural Tube
- Smooth Muscle
- Ovary
- Gonad
- Blood
- Melanocytes
-
and also in
- Activin A-induced embryoid bodies
- B27-induced amniotic-derived mesenchymal stem cells
- Beating cells
- Blast colony cells
- BMP4-induced embryoid bodies
- Conditioned media-induced cells
- Culture-transduced Tau-GFP mouse embryonic fibroblasts
- Cystic structures
- Definitive endoderm-like cells
- Dopaminergic neuron precursor cells
- Early-stage aggregates
- EGF-induced cells
- Embryoid bodies
- Embryoid Bodies
- Embryonic germ cells
- Endoderm progenitor-like cells
- Endoderm-like cells
- Endothelial progenitor cells
- Expanded mesenchymal progenitor cells
- Expanded NGFR+ cells
- Expanded PAX7 cells
- Expanded purified spherical neural massess culture
- Fibroblast-induced cells
- Hepato-specified cells
- IGFII- induced cells
- Liquid-liquid interface cultured human embryonic stem cells
- Matrix-induced amniotic-derived mesenchymal stem cells
- Mesenchymal Progenitor Cells - Passage 2
- Mesenchyme-like progenitor cells
- Mesoderm-like cells
- N2-induced cells
- N2-induced embryoid bodies
- Neural precursor spheres
- Neural rosettes
- Neural stem cell-like spheres
- Neural stem cells
- Neurospheres
- Nkx2-1 induced endoderm
- Paraxial mesoderm cells
- Pre-oligodendrocyte progenitor cells - late stage
- Primary spheres
- Purified spherical neural massess
- PVA-expanded stem cells
- Retinoic acid-induced cells
- Retinoic acid-induced embryoid bodies
- Secondary spheres
- Spherical clumps
- Trophic factor-induced mesenchymal stem cells
- Vascular endothelial growth factor-induced cells
- Vascular endothelial growth factor-induced embryoid bodies
- VEGF/bFGF-induced embryoid bodies
- VEGF-induced cells
Phenotypes From GWAS Catalog for FGF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005104 | fibroblast growth factor receptor binding | IPI | 2161540 |
| GO:0005125 | cytokine activity | IDA | 18059339 |
| GO:0005178 | integrin binding | IDA | 28302677 |
| GO:0005515 | protein binding | IPI | 9700203 |
| GO:0008083 | growth factor activity | IDA | 18059339 |
Phenotypes for FGF2 Gene
- MGI mutant phenotypes for FGF2:
-
inferred from 7 alleles
- nervous system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- neoplasm
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for FGF2:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased gamma-H2AX phosphorylation
- Decreased Hepatitis C virus replication
- Increased nuclear migration speed
Animal Models for FGF2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for FGF2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGF2 - Select products 50% OFF >
- * FGF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF2
miRNA for FGF2 Gene
- miRTarBase miRNAs that target FGF2
-
- hsa-miR-16-5p (MIRT001468)
- hsa-miR-140-5p (MIRT003962)
- hsa-miR-503-5p (MIRT007223)
- hsa-miR-155-5p (MIRT020683)
- hsa-miR-186-5p (MIRT021161)
- hsa-miR-215-5p (MIRT024732)
- hsa-miR-192-5p (MIRT026446)
- hsa-miR-103a-3p (MIRT027141)
- hsa-miR-32-5p (MIRT028310)
- hsa-miR-92a-3p (MIRT049684)
- hsa-miR-15b-5p (MIRT054815)
- hsa-miR-562 (MIRT211195)
- hsa-miR-4524a-5p (MIRT211196)
- hsa-miR-4524b-5p (MIRT211197)
- hsa-miR-5697 (MIRT211198)
- hsa-miR-15a-5p (MIRT211199)
- hsa-miR-195-5p (MIRT211200)
- hsa-miR-424-5p (MIRT211201)
- hsa-miR-450a-1-3p (MIRT211202)
- hsa-miR-497-5p (MIRT211203)
- hsa-miR-1276 (MIRT211204)
- hsa-miR-2278 (MIRT211205)
- hsa-miR-3148 (MIRT211206)
- hsa-miR-4668-5p (MIRT211207)
- hsa-miR-4670-3p (MIRT211208)
- hsa-miR-451b (MIRT211209)
- hsa-miR-6838-5p (MIRT211210)
- hsa-miR-181c-3p (MIRT211211)
- hsa-miR-25-3p (MIRT211223)
- hsa-miR-7-1-3p (MIRT211225)
- hsa-miR-7-2-3p (MIRT211226)
- hsa-miR-363-3p (MIRT211227)
- hsa-miR-367-3p (MIRT211228)
- hsa-miR-495-3p (MIRT211229)
- hsa-miR-92b-3p (MIRT211230)
- hsa-miR-548c-3p (MIRT211231)
- hsa-miR-5688 (MIRT211232)
- hsa-miR-101-3p (MIRT211237)
- hsa-miR-144-3p (MIRT211238)
- hsa-miR-600 (MIRT211239)
- hsa-miR-646 (MIRT211252)
- hsa-miR-545-3p (MIRT211257)
- hsa-miR-1468-3p (MIRT211258)
- hsa-miR-548p (MIRT211261)
- hsa-miR-6504-3p (MIRT211264)
- hsa-miR-107 (MIRT211265)
- hsa-miR-3686 (MIRT211270)
- hsa-miR-222-5p (MIRT309153)
- hsa-miR-506-5p (MIRT309156)
- hsa-miR-936 (MIRT309159)
- hsa-miR-5695 (MIRT309161)
- hsa-miR-892c-5p (MIRT309162)
- hsa-miR-152-3p (MIRT438378)
- mmu-miR-15a-5p (MIRT438765)
- mmu-miR-16-5p (MIRT438766)
- hsa-miR-5589-3p (MIRT476869)
- hsa-miR-759 (MIRT476870)
- hsa-miR-5003-3p (MIRT476871)
- hsa-miR-708-3p (MIRT507255)
- hsa-miR-4291 (MIRT507256)
- hsa-miR-3691-3p (MIRT507257)
- hsa-miR-7157-5p (MIRT507258)
- hsa-miR-4310 (MIRT507259)
- hsa-miR-376b-3p (MIRT537376)
- hsa-miR-376a-3p (MIRT537377)
- hsa-miR-6853-3p (MIRT537378)
- hsa-miR-1206 (MIRT537379)
- hsa-miR-582-5p (MIRT537380)
- hsa-miR-3529-3p (MIRT537381)
- hsa-miR-627-3p (MIRT537382)
- hsa-miR-302a-5p (MIRT537383)
- hsa-miR-466 (MIRT537384)
- hsa-miR-1284 (MIRT537385)
- hsa-miR-4729 (MIRT537386)
- hsa-miR-4643 (MIRT537387)
- hsa-miR-4789-3p (MIRT537389)
- hsa-miR-6074 (MIRT548232)
- hsa-miR-26b-3p (MIRT557864)
- hsa-miR-3129-5p (MIRT557865)
- hsa-miR-199a-3p (MIRT557866)
- hsa-miR-199b-3p (MIRT557867)
- hsa-miR-3935 (MIRT557868)
- hsa-miR-6831-5p (MIRT557869)
- hsa-miR-3927-3p (MIRT557870)
- hsa-miR-577 (MIRT557871)
- hsa-miR-7109-3p (MIRT557872)
- hsa-miR-4659b-3p (MIRT562330)
- hsa-miR-4659a-3p (MIRT562331)
- hsa-miR-3607-3p (MIRT562332)
- hsa-miR-6513-5p (MIRT574769)
- hsa-miR-887-5p (MIRT574770)
- hsa-miR-3913-5p (MIRT574771)
- hsa-miR-3122 (MIRT574772)
- hsa-miR-6739-5p (MIRT574773)
- hsa-miR-6733-5p (MIRT574774)
- hsa-miR-3153 (MIRT574775)
- hsa-miR-1305 (MIRT724418)
- hsa-miR-607 (MIRT724419)
- hsa-miR-3671 (MIRT724420)
- hsa-miR-1976 (MIRT724421)
- hsa-miR-3653-5p (MIRT724422)
- hsa-miR-196a-3p (MIRT731959)
- hsa-miR-132-3p (MIRT732595)
- hsa-miR-205-3p (MIRT733586)
- hsa-miR-152-5p (MIRT734136)
- hsa-miR-203a-3p (MIRT735202)
- hsa-miR-195-3p (MIRT735540)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF2
Clone Products
- Applied Biological Materials (abm): Clones for FGF2 - Select products 50% OFF >
- * FGF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGF2
- Addgene plasmids for FGF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF2
Cell Line Products
-
Horizon Cell Lines for FGF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF2 Gene
Localization for FGF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF2 Gene
- Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). {ECO:0000269 PubMed:20230531, ECO:0000269 PubMed:22321063}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| cytosol | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 2161540 |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for FGF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 4 | Negative regulation of FGFR3 signaling | ||
| 5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
Pathways by source for FGF2 Gene
14 BioSystems pathways for FGF2 Gene
117 Reactome pathways for FGF2 Gene
2 PharmGKB pathways for FGF2 Gene
13 KEGG pathways for FGF2 Gene
3 GeneGo (Thomson Reuters) pathways for FGF2 Gene
- Cell adhesion_Plasmin signaling
- Development FGF-family signaling
- Development FGFR signaling pathway
3 R&D Systems pathways for FGF2 Gene
61 Qiagen pathways for FGF2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
2 Cell Signaling Technology pathways for FGF2 Gene
Interacting Proteins for FGF2 Gene
Selected Interacting proteins:
P09038-FGF2_HUMAN
ENSP00000264498
for FGF2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FGF2
SIGNOR curated interactions for FGF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | 9712850 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IDA | 12631064 |
| GO:0001938 | positive regulation of endothelial cell proliferation | IDA,IMP | 18059339 |
Drugs & Compounds for FGF2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pentosan Polysulfate | Approved | Pharma | Target, antagonist, inhibitor | 0 | ||
| Sirolimus | Approved, Investigational | Pharma | Target, other/unknown, inhibitor | Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 1377 | |
| Heparin | Approved, Investigational | Pharma | Antagonist, Target | 1058 | ||
| Sucralfate | Approved | Pharma | Target, agonist, inducer | 15 | ||
| Thalidomide | Approved, Investigational, Withdrawn | Pharma | Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents | 429 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
-
BioLegend
- Recombinant Human FGF-basic/145aa (carrier-free) (571504)
- Recombinant Human FGF-basic/145aa (carrier-free) (571508)
- Recombinant Human FGF-basic/145aa (carrier-free) (571502)
- Recombinant Human FGF-basic/145aa (carrier-free) (571506)
- Recombinant Human FGF-basic (146 aa) (Animal-Free)
- Recombinant Human FGF-basic (154 aa) (Animal-Free)
Transcripts for FGF2 Gene
mRNA/cDNA for FGF2 Gene
- 2 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264498 6775 nts (view in UCSC)
- ENST00000608478 3880 nts (view in UCSC)
- ENST00000644866 6652 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGF2 - Select products 50% OFF >
- * FGF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF2
- Browse OriGene Inhibitory RNA Products For FGF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF2
Clone Products
- Applied Biological Materials (abm): Clones for FGF2 - Select products 50% OFF >
- * FGF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGF2
- Addgene plasmids for FGF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF2
Relevant External Links for FGF2 Gene
- GeneLoc Exon Structure for
- FGF2
Expression for FGF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Presumptive Suture Cells Rostral Sutures
- Intramembrenous Osteocytes Rostral Skull Membranous Bones
- Hypertrophic Chondrocytes Zeugopod Growth Plate
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Dental Papilla Cells Dental Papilla
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Hypertrophic Chondrocytes Zeugopod Growth Plate
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Zeugopod Epiphyseal End
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Choroid Plexus Progenitor Cells Choroid Plexus
- Pituitary Gland
- Cerebellum
- Neural stem cell line (CTX0E03)
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
-
Placenta (Extraembryonic Tissues)
- Villous Stromal Cells Chorionic Villus
- Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
- Syncytiotrophoblast Multinuclear Cells Chorionic Villus
- Villous Cytotrophoblast Cells Chorionic Villus
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Mature Choroid Plexus Cells Choroid Plexus
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Primary Oocyte Primordial Follicle
- Oviduct
- Mesenchymal Stem Cells
-
Primitive Streak (Early Embryonic Tissues)
- Mesoderm Progenitor Cells Anterior Primitive Streak
- Mesoderm Progenitor Cells Posterior Primitive Streak
-
Mesoderm (Gastrulation Derivatives)
- Mesoderm Progenitor Cells Anterior Primitive Streak
- Mesoderm Progenitor Cells Posterior Primitive Streak
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Integumentary System)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Chorion (Extraembryonic Tissues)
- Villous Stromal Cells Chorionic Villus
-
Hypoblast (Extraembryonic Tissues)
- Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Extraembryonic Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Gonad
- Primary Oocyte Primordial Follicle
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
-
Endothelium (Cardiovascular System)
- Lymphatic Endothelial Cells Lymphatic Vessels
-
Heart (Cardiovascular System)
- Cardiomyocytes Myocardium
- Gut Tube (Gastrointestinal Tract)
- Blood (Hematopoietic System)
- Umbilical Cord (Extraembryonic Tissues)
- Uncategorized
- Adipose (Muscoskeletal System)
-
Smooth Muscle (Muscoskeletal System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGF2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF2
SOURCE GeneReport for Unigene cluster for FGF2 Gene:
Hs.284244mRNA Expression by UniProt/SwissProt for FGF2 Gene:
P09038-FGF2_HUMAN
Tissue specificity:
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Evidence on tissue expression from TISSUES for FGF2 Gene
- Blood(4.7)
- Nervous system(3.9)
- Heart(3.8)
- Muscle(3.7)
- Eye(3.4)
- Bone marrow(3.4)
- Stomach(3.3)
- Skin(3.3)
- Bone(3.2)
- Kidney(3.1)
- Lung(3.1)
- Intestine(3)
- Thyroid gland(3)
- Liver(2.9)
- Pancreas(2.8)
- Adrenal gland(2.8)
- Lymph node(2.6)
- Spleen(2.4)
- Urine(2.2)
Primer Products
-
OriGene qPCR primer pairs for FGF2