The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent lig... See more...

Aliases for FGF19 Gene

Aliases for FGF19 Gene

  • Fibroblast Growth Factor 19 2 3 4 5
  • FGF-19 3 4
  • FGF19 5

External Ids for FGF19 Gene

Previous GeneCards Identifiers for FGF19 Gene

  • GC11M072007
  • GC11M071199
  • GC11M069760
  • GC11M069285
  • GC11M069222
  • GC11M069513
  • GC11M065805

Summaries for FGF19 Gene

Entrez Gene Summary for FGF19 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

CIViC Summary for FGF19 Gene

GeneCards Summary for FGF19 Gene

FGF19 (Fibroblast Growth Factor 19) is a Protein Coding gene. Diseases associated with FGF19 include Functional Diarrhea and Extrahepatic Cholestasis. Among its related pathways are RET signaling and Farnesoid X Receptor Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF21.

UniProtKB/Swiss-Prot Summary for FGF19 Gene

  • Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Gene Wiki entry for FGF19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF19 Gene

Genomics for FGF19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J069700 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.2 1244 4.8 ZNF654 MYC NCOR1 ZNF600 ATF3 POLR2A ZIC2 NFIC YY1 REST FGF19 HSALNG0085374 LTO1
GH11J069840 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 26.3 -136.6 -136585 0.8 ZIC2 JUND GLIS1 ZBTB33 FGF3 FGF19 piR-57387-008 HSALNG0085389 ANO1
GH11J069705 Enhancer 0.9 Ensembl ENCODE 0.7 -2.7 -2728 2.9 ZIC2 FEZF1 KDM6A SMAD4 SAP130 RARA GABPB1 TEAD3 THRB ZNF843 ENSG00000246889 FGF19 HSALNG0085376 FGF4
GH11J069688 Enhancer 1 Ensembl ENCODE 0.4 +14.9 14949 2.5 SSRP1 ATF2 CEBPA FOXA1 MNT MAX EP300 TAF9B THAP11 FOXA2 LTO1 PPFIA1 HSALNG0085374 FGF19
GH11J069708 Enhancer 0.9 Ensembl ENCODE 0.4 -5.1 -5110 1.5 MXD4 HOMEZ THAP11 KDM6A SAP130 MIER3 RARA GABPB1 DMAP1 TEAD3 HSALNG0085376 FGF19 FGF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF19

Top Transcription factor binding sites by QIAGEN in the FGF19 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXF2
  • Sp1
  • Tal-1beta

Genomic Locations for FGF19 Gene

Latest Assembly
chr11:69,698,238-69,704,022
(GRCh38/hg38)
Size:
5,785 bases
Orientation:
Minus strand

Previous Assembly
chr11:69,513,006-69,518,790
(GRCh37/hg19 by Entrez Gene)
Size:
5,785 bases
Orientation:
Minus strand

chr11:69,513,000-69,519,410
(GRCh37/hg19 by Ensembl)
Size:
6,411 bases
Orientation:
Minus strand

Genomic View for FGF19 Gene

Genes around FGF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF19 Gene

Proteins for FGF19 Gene

  • Protein details for FGF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95750-FGF19_HUMAN
    Recommended name:
    Fibroblast growth factor 19
    Protein Accession:
    O95750

    Protein attributes for FGF19 Gene

    Size:
    216 amino acids
    Molecular mass:
    24003 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with KL; this interaction is direct. Interacts with KLB; this interaction is direct. Interacts with FGFR4 in the presence of heparin, KL or KLB. Interacts with MALRD1 (PubMed:23747249).
    Miscellaneous:
    • Contrarily to other members of the family that can bind several FGF receptors FGF19 is specific for FGFR4.

    Three dimensional structures from OCA and Proteopedia for FGF19 Gene

neXtProt entry for FGF19 Gene

Post-translational modifications for FGF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF19 Gene

Domains & Families for FGF19 Gene

Gene Families for FGF19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for FGF19 Gene

InterPro:
Blocks:
  • IL1/HBGF family signature

Suggested Antigen Peptide Sequences for FGF19 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor 19 (FGF19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95750

UniProtKB/Swiss-Prot:

FGF19_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF19: view

Function for FGF19 Gene

Molecular function for FGF19 Gene

UniProtKB/Swiss-Prot Function:
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
UniProtKB/Swiss-Prot Induction:
Induced by the bile acids receptor NR1H4 that binds and activates a NR1H4-responsive element within intron 2.
GENATLAS Biochemistry:
fibroblast growth factor 19,heparin dependent ligand for FGFR4,expressed in fetal brain,skin,cartilage and retina,gall bladder,potentially playing an important role in brain development,overexpressed in colon adenocarcinoma cell line

Phenotypes From GWAS Catalog for FGF19 Gene

Gene Ontology (GO) - Molecular Function for FGF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IBA,IPI 10525310
GO:0005515 protein binding IPI 18829467
GO:0008083 growth factor activity IBA 21873635
genes like me logo Genes that share ontologies with FGF19: view
genes like me logo Genes that share phenotypes with FGF19: view

Animal Models for FGF19 Gene

MGI Knock Outs for FGF19:
  • Fgf15 Fgf15<tm1.1(KOMP)Vlcg>
  • Fgf15 Fgf15<tm1Sms>

miRNA for FGF19 Gene

miRTarBase miRNAs that target FGF19

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF19 Gene

Localization for FGF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF19 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF19 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with FGF19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF19 Gene

Pathways & Interactions for FGF19 Gene

PathCards logo

SuperPathways for FGF19 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
3 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
4 PI3K/AKT activation
5 Downstream signaling of activated FGFR2
genes like me logo Genes that share pathways with FGF19: view

Pathways by source for FGF19 Gene

1 GeneGo (Thomson Reuters) pathway for FGF19 Gene
  • Development FGF-family signaling
59 Qiagen pathways for FGF19 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for FGF19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FGF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IBA,IDA 17627937
GO:0007399 nervous system development TAS 9931477
GO:0008284 positive regulation of cell proliferation IGI 18187602
GO:0008543 fibroblast growth factor receptor signaling pathway IPI,TAS --
genes like me logo Genes that share ontologies with FGF19: view

Drugs & Compounds for FGF19 Gene

(12) Drugs for FGF19 Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chenodeoxycholic acid Approved Pharma 30
Heparin Approved, Investigational Pharma Target 1160
Tyrosine Approved, Investigational Nutra 1149
Antibodies Pharma 8474
Bile Acids and Salts Pharma 155

(1) Additional Compounds for FGF19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF19: view

Transcripts for FGF19 Gene

mRNA/cDNA for FGF19 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF19

Alternative Splicing Database (ASD) splice patterns (SP) for FGF19 Gene

No ASD Table

Relevant External Links for FGF19 Gene

GeneLoc Exon Structure for
FGF19

Expression for FGF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF19 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x23.5), Liver (x7.4), Pituitary (x4.6), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for FGF19 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF19 Gene



Protein tissue co-expression partners for FGF19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF19

SOURCE GeneReport for Unigene cluster for FGF19 Gene:

Hs.249200

mRNA Expression by UniProt/SwissProt for FGF19 Gene:

O95750-FGF19_HUMAN
Tissue specificity: Expressed in fetal brain, cartilage, retina, and adult gall bladder.

Evidence on tissue expression from TISSUES for FGF19 Gene

  • Intestine(4.5)
  • Nervous system(4.5)
  • Gall bladder(3.4)
  • Liver(2.4)
  • Kidney(2.4)
  • Pancreas(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with FGF19: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF19 Gene

Orthologs for FGF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGF19 29 30
  • 97.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FGF19 29 30
  • 82.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF19 29 30
  • 81.2 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FGF19 30
  • 75 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgf19 29
  • 67.63 (n)
Mouse
(Mus musculus)
Mammalia Fgf15 29 16 30
  • 67.31 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGF19 30
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGF19 29 30
  • 69.7 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FGF19 30
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgf19 29
  • 60.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii fgf19 29 30
  • 53.61 (n)
OneToOne
Species where no ortholog for FGF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF19 Gene

ENSEMBL:
Gene Tree for FGF19 (if available)
TreeFam:
Gene Tree for FGF19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF19: view image
Alliance of Genome Resources:
Additional Orthologs for FGF19

Paralogs for FGF19 Gene

(1) SIMAP similar genes for FGF19 Gene using alignment to 1 proteins:

  • FGF19_HUMAN
genes like me logo Genes that share paralogs with FGF19: view

Variants for FGF19 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGF19 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGF19 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
nsv825973 CNV gain 20364138
nsv825974 CNV gain 20364138

Variation tolerance for FGF19 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF19 Gene

Human Gene Mutation Database (HGMD)
FGF19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF19
Leiden Open Variation Database (LOVD)
FGF19

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF19 Gene

Disorders for FGF19 Gene

MalaCards: The human disease database

(15) MalaCards diseases for FGF19 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
functional diarrhea
  • functional diarrhoea
extrahepatic cholestasis
  • extrahepatic biliary stasis
outlet dysfunction constipation
constipation
non-alcoholic fatty liver disease
  • nafld
- elite association - COSMIC cancer census association via MalaCards
Search FGF19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF19

genes like me logo Genes that share disorders with FGF19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF19 Gene

Publications for FGF19 Gene

  1. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. (PMID: 10525310) Xie MH … Gurney AL (Cytokine 1999) 2 3 4 22
  2. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. (PMID: 19085950) Song KH … Chiang JY (Hepatology (Baltimore, Md.) 2009) 3 4 22
  3. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. (PMID: 17623664) Kurosu H … Kuro-O M (The Journal of biological chemistry 2007) 3 4 22
  4. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. (PMID: 17339340) Goetz R … Mohammadi M (Molecular and cellular biology 2007) 3 4 22
  5. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. (PMID: 14730967) Harmer NJ … Blundell TL (Biochemistry 2004) 3 4 22

Products for FGF19 Gene

Sources for FGF19 Gene