The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to i... See more...

Aliases for FGF18 Gene

Aliases for FGF18 Gene

  • Fibroblast Growth Factor 18 2 3 4 5
  • FGF-18 2 3 4
  • ZFGF5 2 3 4
  • FGF18 5

External Ids for FGF18 Gene

Previous GeneCards Identifiers for FGF18 Gene

  • GC05P171049
  • GC05P171549
  • GC05P170782
  • GC05P170827
  • GC05P170779
  • GC05P170846
  • GC05P165944

Summaries for FGF18 Gene

Entrez Gene Summary for FGF18 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF18 Gene

FGF18 (Fibroblast Growth Factor 18) is a Protein Coding gene. Diseases associated with FGF18 include Dyslexia and Hyaline Fibromatosis Syndrome. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include growth factor activity and type 2 fibroblast growth factor receptor binding. An important paralog of this gene is FGF8.

UniProtKB/Swiss-Prot Summary for FGF18 Gene

  • Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.

Gene Wiki entry for FGF18 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF18 Gene

Genomics for FGF18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J171418 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.0 23 3.1 CREB1 CTCF PRDM10 REST TARDBP JUND ZNF143 ZIC2 PATZ1 RAD21 FGF18 NPM1 RF00017-5095 RF00017-5093 SMIM23
GH05J171422 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 +1.9 1854 0.2 EZH2 ZNF341 FGF18 RF00017-5095 RF00017-5093 SMIM23
GH05J171449 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.8 +30.9 30943 2.4 KDM1A JUND ZFX SMARCC1 KLF7 ESR1 FOS POLR2A FOSL1 BHLHE40 FGF18 SMIM23 RF00017-5095 RF00017-5093
GH05J171852 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 11.1 +434.7 434665 8.6 CTCF IKZF1 POLR2A DPF2 ZNF239 CBX3 SMARCA5 NFE2 ZNF444 ZNF316 lnc-SMIM23-2 ENSG00000253110 FGF18 SMIM23 LOC107986476 RF00017-5098 FBXW11
GH05J171908 Enhancer 0.8 Ensembl ENCODE 12 +486.8 486754 4 CTCF REST RAD21 IKZF2 TRIM22 GATAD2B ARID3A DPF2 RUNX3 ZSCAN5C FGF18 EFCAB9 RF00017-5098 RF00017-5101 FBXW11 SMIM23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF18

Top Transcription factor binding sites by QIAGEN in the FGF18 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT1

Genomic Locations for FGF18 Gene

Genomic Locations for FGF18 Gene
chr5:171,419,647-171,457,626
(GRCh38/hg38)
Size:
37,980 bases
Orientation:
Plus strand
chr5:170,846,660-170,884,630
(GRCh37/hg19)
Size:
37,971 bases
Orientation:
Plus strand

Genomic View for FGF18 Gene

Genes around FGF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF18 Gene

Proteins for FGF18 Gene

  • Protein details for FGF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76093-FGF18_HUMAN
    Recommended name:
    Fibroblast growth factor 18
    Protein Accession:
    O76093
    Secondary Accessions:
    • D3DQL7
    • Q6UWF1

    Protein attributes for FGF18 Gene

    Size:
    207 amino acids
    Molecular mass:
    23989 Da
    Quaternary structure:
    • Interacts with FGFR3 and FGFR4.

    Three dimensional structures from OCA and Proteopedia for FGF18 Gene

neXtProt entry for FGF18 Gene

Post-translational modifications for FGF18 Gene

  • Glycosylation at Asn39 and Asn137
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for FGF18
  • Abcam proteins for FGF18

No data available for DME Specific Peptides for FGF18 Gene

Domains & Families for FGF18 Gene

Gene Families for FGF18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for FGF18 Gene

InterPro:
Blocks:
  • IL1/HBGF family signature
ProtoNet:

Suggested Antigen Peptide Sequences for FGF18 Gene

GenScript: Design optimal peptide antigens:
  • zFGF5 (FGF18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76093

UniProtKB/Swiss-Prot:

FGF18_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF18: view

Function for FGF18 Gene

Molecular function for FGF18 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
GENATLAS Biochemistry:
fibroblast growth factor 18,secreted signaling molecule in adult liver,lung,small intestine and developing tissues

LifeMap Function Summary for FGF18 Gene

It affects the following cells:
FGF18 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for FGF18 Gene

Gene Ontology (GO) - Molecular Function for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0005105 type 1 fibroblast growth factor receptor binding IDA 16384934
GO:0005111 type 2 fibroblast growth factor receptor binding IDA 16384934
GO:0008083 growth factor activity TAS,IEA --
genes like me logo Genes that share ontologies with FGF18: view
genes like me logo Genes that share phenotypes with FGF18: view

Animal Models for FGF18 Gene

MGI Knock Outs for FGF18:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF18

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGF18 Gene

Localization for FGF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF18 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9742123
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with FGF18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF18 Gene

Pathways & Interactions for FGF18 Gene

PathCards logo

SuperPathways for FGF18 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
4 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
5 GAB1 signalosome
genes like me logo Genes that share pathways with FGF18: view

Pathways by source for FGF18 Gene

59 Qiagen pathways for FGF18 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for FGF18 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001503 ossification IEA --
GO:0001525 angiogenesis IEA --
GO:0001936 NOT regulation of endothelial cell proliferation IDA 16756958
GO:0001957 intramembranous ossification IEA --
genes like me logo Genes that share ontologies with FGF18: view

Drugs & Compounds for FGF18 Gene

(2) Drugs for FGF18 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitogens Pharma 2148
genes like me logo Genes that share compounds with FGF18: view

Transcripts for FGF18 Gene

mRNA/cDNA for FGF18 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF18

Alternative Splicing Database (ASD) splice patterns (SP) for FGF18 Gene

No ASD Table

Relevant External Links for FGF18 Gene

GeneLoc Exon Structure for
FGF18

Expression for FGF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF18 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF18 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF18

SOURCE GeneReport for Unigene cluster for FGF18 Gene:

Hs.87191

Evidence on tissue expression from TISSUES for FGF18 Gene

  • Lung(4.4)
  • Bone(2.2)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with FGF18: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF18 Gene

Orthologs for FGF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF18 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGF18 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FGF18 30 31
  • 95.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGF18 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF18 30 31
  • 94.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fgf18 30 17 31
  • 90.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgf18 30
  • 90.02 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FGF18 31
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGF18 30 31
  • 81.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FGF18 31
  • 89 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fgf18a 30 31
  • 72.69 (n)
OneToMany
fgf18b 31
  • 61 (a)
OneToMany
fgf24 31
  • 59 (a)
OneToMany
fgf18 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 14 (a)
OneToMany
Species where no ortholog for FGF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF18 Gene

ENSEMBL:
Gene Tree for FGF18 (if available)
TreeFam:
Gene Tree for FGF18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF18: view image

Paralogs for FGF18 Gene

(4) SIMAP similar genes for FGF18 Gene using alignment to 1 proteins:

  • FGF18_HUMAN
genes like me logo Genes that share paralogs with FGF18: view

Variants for FGF18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF18 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
731223 Benign: not provided 171,456,664(+) G/A SYNONYMOUS_VARIANT
rs1441510334 Likely Pathogenic: Short stature 171,436,234(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FGF18 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGF18 Gene

Variant ID Type Subtype PubMed ID
esv2412659 CNV deletion 18987734
esv3570552 CNV loss 25503493
nsv1074347 CNV deletion 25765185
nsv1133617 CNV deletion 24896259
nsv475015 CNV novel sequence insertion 20440878
nsv600278 CNV loss 21841781
nsv600279 CNV loss 21841781
nsv600280 CNV loss 21841781
nsv830551 CNV loss 17160897
nsv830552 CNV gain 17160897

Variation tolerance for FGF18 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF18

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF18 Gene

Disorders for FGF18 Gene

MalaCards: The human disease database

(9) MalaCards diseases for FGF18 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FGF18 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FGF18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF18 Gene

Publications for FGF18 Gene

  1. Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18. (PMID: 9660775) Ohbayashi N … Itoh N (The Journal of biological chemistry 1998) 2 3 4 23
  2. FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. (PMID: 9742123) Hu MC … Danilenko DM (Molecular and cellular biology 1998) 2 3 4
  3. Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes. (PMID: 19909293) Yamaoka H … Hoshi K (Cell proliferation 2010) 3 23
  4. Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PMID: 19727229) Wan WD … Lu ZH (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2009) 3 41
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 41

Products for FGF18 Gene

  • Signalway ELISA kits for FGF18
  • Signalway Proteins for FGF18

Sources for FGF18 Gene