Aliases for FGF12 Gene
External Ids for FGF12 Gene
Previous HGNC Symbols for FGF12 Gene
Previous GeneCards Identifiers for FGF12 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019]
GeneCards Summary for FGF12 Gene
FGF12 (Fibroblast Growth Factor 12) is a Protein Coding gene. Diseases associated with FGF12 include Epileptic Encephalopathy, Early Infantile, 47 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor activity and ion channel binding. An important paralog of this gene is FGF14.
UniProtKB/Swiss-Prot Summary for FGF12 Gene
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.