The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The... See more...

Aliases for FGF11 Gene

Aliases for FGF11 Gene

  • Fibroblast Growth Factor 11 2 3 4 5
  • Fibroblast Growth Factor Homologous Factor 3 2 3 4
  • FHF3 2 3 4
  • FGF-11 3 4
  • FHF-3 3 4
  • MGC102953 2
  • FLJ16061 2
  • MGC45269 2
  • FGF11 5

External Ids for FGF11 Gene

Previous GeneCards Identifiers for FGF11 Gene

  • GC17M007769
  • GC17P008072
  • GC17P007285
  • GC17P007544
  • GC17P007545
  • GC17P007283
  • GC17P007342
  • GC17P007343
  • GC17P007451
  • GC17P007462
  • GC17P007787
  • GC17P007824
  • GC17P007856
  • GC17P007930
  • GC17P007475
  • GC17P007510
  • GC17P007556
  • GC17P007611
  • GC17P007663
  • GC17P007692
  • GC17P007729
  • GC17P007766

Summaries for FGF11 Gene

Entrez Gene Summary for FGF11 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for FGF11 Gene

FGF11 (Fibroblast Growth Factor 11) is a Protein Coding gene. Diseases associated with FGF11 include Spinocerebellar Ataxia 27 and Lacrimoauriculodentodigital Syndrome. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is FGF12.

UniProtKB/Swiss-Prot Summary for FGF11 Gene

Additional gene information for FGF11 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF11 Gene

Genomics for FGF11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF11

Top Transcription factor binding sites by QIAGEN in the FGF11 gene promoter:
  • C/EBPalpha
  • CUTL1
  • GATA-1
  • GATA-2
  • ITF-2
  • Pax-5
  • POU3F2
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for FGF11 Gene

Genomic Locations for FGF11 Gene
chr17:7,438,273-7,444,937
(GRCh38/hg38)
Size:
6,665 bases
Orientation:
Plus strand
chr17:7,341,592-7,348,256
(GRCh37/hg19)
Size:
6,665 bases
Orientation:
Plus strand

Genomic View for FGF11 Gene

Genes around FGF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF11 Gene

Proteins for FGF11 Gene

  • Protein details for FGF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92914-FGF11_HUMAN
    Recommended name:
    Fibroblast growth factor 11
    Protein Accession:
    Q92914
    Secondary Accessions:
    • Q2YDX8

    Protein attributes for FGF11 Gene

    Size:
    225 amino acids
    Molecular mass:
    25005 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGF11 Gene

Post-translational modifications for FGF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF11 Gene

No data available for DME Specific Peptides for FGF11 Gene

Domains & Families for FGF11 Gene

Gene Families for FGF11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FGF11 Gene

InterPro:
Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature
ProtoNet:

Suggested Antigen Peptide Sequences for FGF11 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor homologous factor 3 (FGF11_HUMAN)
  • Fibroblast growth factor 11 (Q6LA99_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92914

UniProtKB/Swiss-Prot:

FGF11_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF11: view

Function for FGF11 Gene

Molecular function for FGF11 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in nervous system development and function.
GENATLAS Biochemistry:
fibroblast growth homologous factor 11,expressed principally in the nervous system

Phenotypes From GWAS Catalog for FGF11 Gene

Gene Ontology (GO) - Molecular Function for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with FGF11: view
genes like me logo Genes that share phenotypes with FGF11: view

Animal Models for FGF11 Gene

MGI Knock Outs for FGF11:
  • Fgf11 Fgf11<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF11 Gene

Localization for FGF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF11 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FGF11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FGF11 Gene

Pathways & Interactions for FGF11 Gene

PathCards logo

SuperPathways for FGF11 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
3 TGF-Beta Pathway
.60
.60
.57
.51
.43
.41
4 ERK Signaling
.61
.61
.58
.51
.49
5 Nanog in Mammalian ESC Pluripotency
.62
.62
.59
.48
genes like me logo Genes that share pathways with FGF11: view

Pathways by source for FGF11 Gene

1 BioSystems pathway for FGF11 Gene
59 Qiagen pathways for FGF11 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for FGF11 Gene

Gene Ontology (GO) - Biological Process for FGF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,TAS 8790420
GO:0007267 cell-cell signaling TAS 8790420
GO:0007399 nervous system development TAS 8790420
genes like me logo Genes that share ontologies with FGF11: view

Drugs & Compounds for FGF11 Gene

No Compound Related Data Available

Transcripts for FGF11 Gene

mRNA/cDNA for FGF11 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF11

Alternative Splicing Database (ASD) splice patterns (SP) for FGF11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: - -
SP8: -

Relevant External Links for FGF11 Gene

GeneLoc Exon Structure for
FGF11

Expression for FGF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF11 Gene

This gene is overexpressed in Adrenal Gland (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF11 Gene



Protein tissue co-expression partners for FGF11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF11

SOURCE GeneReport for Unigene cluster for FGF11 Gene:

Hs.655193

mRNA Expression by UniProt/SwissProt for FGF11 Gene:

Q92914-FGF11_HUMAN
Tissue specificity: Nervous system.

Evidence on tissue expression from TISSUES for FGF11 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Eye(4.4)
genes like me logo Genes that share expression patterns with FGF11: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF11 Gene

Orthologs for FGF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGF11 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF11 30 31
  • 95.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FGF11 30 31
  • 94.22 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgf11 30
  • 94.2 (n)
Mouse
(Mus musculus)
Mammalia Fgf11 30 17 31
  • 94.05 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGF11 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia FGF11 31
  • 79 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fgf11a 30 31
  • 68.04 (n)
OneToMany
fgf11b 31
  • 58 (a)
OneToMany
Species where no ortholog for FGF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF11 Gene

ENSEMBL:
Gene Tree for FGF11 (if available)
TreeFam:
Gene Tree for FGF11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF11: view image

Paralogs for FGF11 Gene

(16) SIMAP similar genes for FGF11 Gene using alignment to 3 proteins:

  • FGF11_HUMAN
  • I3L4N4_HUMAN
  • Q6LA99_HUMAN
genes like me logo Genes that share paralogs with FGF11: view

Variants for FGF11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF11 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
725927 Benign: not provided 7,442,722(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
771204 Benign: not provided 7,442,647(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
VAR_018886 - p.Arg163Gly

Additional dbSNP identifiers (rs#s) for FGF11 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGF11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for FGF11 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF11 Gene

Disorders for FGF11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGF11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia 27
  • sca27
lacrimoauriculodentodigital syndrome
  • ladd
- elite association - COSMIC cancer census association via MalaCards
Search FGF11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF11

genes like me logo Genes that share disorders with FGF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF11 Gene

Publications for FGF11 Gene

  1. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. (PMID: 8790420) Smallwood PM … Nathans J (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators. (PMID: 30984550) Lee KW … Yim HS (FEBS open bio 2019) 3
  5. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. (PMID: 29228324) Li Z … Dang Y (Nucleic acids research 2018) 3

Products for FGF11 Gene

  • Signalway ELISA kits for FGF11

Sources for FGF11 Gene