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Aliases for FGF10 Gene

Aliases for FGF10 Gene

  • Fibroblast Growth Factor 10 2 3 5
  • Keratinocyte Growth Factor 2 3 4
  • FGF-10 3 4
  • Produced By Fibroblasts Of Urinary Bladder Lamina Propria 3

External Ids for FGF10 Gene

Previous GeneCards Identifiers for FGF10 Gene

  • GC05M044614
  • GC05M045481
  • GC05M044305
  • GC05M044350

Summaries for FGF10 Gene

Entrez Gene Summary for FGF10 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF10 Gene

FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include Lacrimoauriculodentodigital Syndrome and Aplasia Of Lacrimal And Salivary Glands. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF7.

UniProtKB/Swiss-Prot for FGF10 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Gene Wiki entry for FGF10 Gene

Additional gene information for FGF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF10 Gene

Genomics for FGF10 Gene

GeneHancer (GH) Regulatory Elements for FGF10 Gene

Promoters and enhancers for FGF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I044387 Promoter/Enhancer 2.1 VISTA EPDnew Ensembl ENCODE 550.8 +0.6 640 2.5 ZFHX2 SIN3A PRDM10 PRDM1 EZH2 EGR2 FGF10 FGF10-AS1
GH05I044603 Enhancer 0.2 ENCODE 10.7 -213.9 -213874 0.2 FGF10 FGF10-AS1 GC05P044546 LINC02224 GC05M044556
GH05I044392 Enhancer 0.5 UCNEbase 0.8 -2.3 -2349 0.2 MAFK FGF10 FGF10-AS1 GC05P044486
GH05I044405 Enhancer 0.2 FANTOM5 0.4 -16.2 -16161 0.1 FGF10 FGF10-AS1 GC05P044486
GH05I044483 Enhancer 0.2 FANTOM5 0.2 -93.4 -93439 0.3 ENSG00000272335 GC05P044486 FGF10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FGF10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGF10 gene promoter:

Genomic Locations for FGF10 Gene

Genomic Locations for FGF10 Gene
chr5:44,303,541-44,389,780
(GRCh38/hg38)
Size:
86,240 bases
Orientation:
Minus strand
chr5:44,303,646-44,389,808
(GRCh37/hg19)

Genomic View for FGF10 Gene

Genes around FGF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF10 Gene

Proteins for FGF10 Gene

  • Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15520-FGF10_HUMAN
    Recommended name:
    Fibroblast growth factor 10
    Protein Accession:
    O15520
    Secondary Accessions:
    • C7FDY0
    • Q6FHR3
    • Q6FHT6
    • Q96P59

    Protein attributes for FGF10 Gene

    Size:
    208 amino acids
    Molecular mass:
    23436 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

    Three dimensional structures from OCA and Proteopedia for FGF10 Gene

neXtProt entry for FGF10 Gene

Post-translational modifications for FGF10 Gene

  • Glycosylation at posLast=5151 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FGF10
  • Santa Cruz Biotechnology (SCBT) Antibodies for FGF10

No data available for DME Specific Peptides for FGF10 Gene

Domains & Families for FGF10 Gene

Gene Families for FGF10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

O15520

UniProtKB/Swiss-Prot:

FGF10_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF10: view

Function for FGF10 Gene

Molecular function for FGF10 Gene

GENATLAS Biochemistry:
fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

LifeMap Function Summary for FGF10 Gene

Phenotypes From GWAS Catalog for FGF10 Gene

Gene Ontology (GO) - Molecular Function for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IDA 11923311
GO:0005111 type 2 fibroblast growth factor receptor binding IPI 19224135
GO:0005515 protein binding IPI 12591959
genes like me logo Genes that share ontologies with FGF10: view
genes like me logo Genes that share phenotypes with FGF10: view

Human Phenotype Ontology for FGF10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF10 Gene

MGI Knock Outs for FGF10:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF10 Gene

Localization for FGF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 16597614
GO:0005634 nucleus IDA 11923311
GO:0005886 plasma membrane IDA 16597614
GO:0009986 cell surface NAS 11923311
genes like me logo Genes that share ontologies with FGF10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF10 Gene

Pathways & Interactions for FGF10 Gene

SuperPathways for FGF10 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 Downstream signaling of activated FGFR2
4 GPCR Pathway
5 PI3K/AKT activation
genes like me logo Genes that share pathways with FGF10: view

SIGNOR curated interactions for FGF10 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IDA 14975937
GO:0001525 angiogenesis IEA --
GO:0001656 metanephros development IEP 18437684
genes like me logo Genes that share ontologies with FGF10: view

Drugs & Compounds for FGF10 Gene

(4) Drugs for FGF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FGF10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF10: view

Transcripts for FGF10 Gene

mRNA/cDNA for FGF10 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF10 Gene

Fibroblast growth factor 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF10 Gene

No ASD Table

Relevant External Links for FGF10 Gene

GeneLoc Exon Structure for
FGF10
ECgene alternative splicing isoforms for
FGF10

Expression for FGF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF10 Gene

This gene is overexpressed in Cervix - Endocervix (x5.6), Cervix - Ectocervix (x5.2), Adipose - Visceral (Omentum) (x4.8), and Breast - Mammary Tissue (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FGF10 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGF10 Gene:

FGF10

SOURCE GeneReport for Unigene cluster for FGF10 Gene:

Hs.664499

Evidence on tissue expression from TISSUES for FGF10 Gene

  • Lung(4.5)
  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • middle ear
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tongue
  • tooth
Abdomen:
  • kidney
Pelvis:
  • penis
  • ureter
  • urethra
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • lower limb
  • radius
  • shin
  • tibia
  • toe
  • ulna
  • upper limb
General:
  • blood
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with FGF10: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FGF10 Gene

Orthologs for FGF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF10 33 34
  • 99.84 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF10 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGF10 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FGF10 33 34
  • 94.36 (n)
cow
(Bos Taurus)
Mammalia FGF10 33
  • 93.37 (n)
rat
(Rattus norvegicus)
Mammalia Fgf10 33
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Fgf10 33 16 34
  • 90.5 (n)
chicken
(Gallus gallus)
Aves FGF10 33 34
  • 83.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf10 33
  • 76.63 (n)
Str.15379 33
African clawed frog
(Xenopus laevis)
Amphibia fgf10-A 33
zebrafish
(Danio rerio)
Actinopterygii fgf10b 33 34
  • 62.83 (n)
fgf10a 34
  • 55 (a)
OneToMany
fgf10 33
sea squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 34
  • 19 (a)
OneToMany
Species where no ortholog for FGF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF10 Gene

ENSEMBL:
Gene Tree for FGF10 (if available)
TreeFam:
Gene Tree for FGF10 (if available)

Paralogs for FGF10 Gene

Paralogs for FGF10 Gene

genes like me logo Genes that share paralogs with FGF10: view

Variants for FGF10 Gene

Sequence variations from dbSNP and Humsavar for FGF10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs104893884 pathogenic, Congenital absence of salivary gland 44,305,045(-) G/A/C coding_sequence_variant, missense_variant, stop_gained
rs104893885 pathogenic, Levy-Hollister syndrome, Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730] 44,388,366(-) C/A coding_sequence_variant, missense_variant
rs104893886 pathogenic, Levy-Hollister syndrome, Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730] 44,305,155(-) A/C coding_sequence_variant, missense_variant
rs104893887 pathogenic, Congenital absence of salivary gland, Levy-Hollister syndrome 44,310,447(-) T/A coding_sequence_variant, stop_gained
rs104893888 pathogenic, Congenital absence of salivary gland 44,388,443(-) T/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FGF10 Gene

Variant ID Type Subtype PubMed ID
esv2677507 CNV deletion 23128226
esv3604923 CNV loss 21293372
nsv4816 CNV deletion 18451855
nsv830277 CNV gain 17160897

Variation tolerance for FGF10 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF10 Gene

Human Gene Mutation Database (HGMD)
FGF10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF10 Gene

Disorders for FGF10 Gene

MalaCards: The human disease database

(22) MalaCards diseases for FGF10 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lacrimoauriculodentodigital syndrome
  • ladd
aplasia of lacrimal and salivary glands
  • alsg
apert syndrome
  • acrocephalosyndactyly, type i; acs1
clear cell acanthoma
  • pale acanthoma
acanthoma
- elite association - COSMIC cancer census association via MalaCards
Search FGF10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF10_HUMAN
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for FGF10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGF10: view

No data available for Genatlas for FGF10 Gene

Publications for FGF10 Gene

  1. Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H … Itoh N (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PMID: 19727229) Wan WD … Lu ZH (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2009) 3 22 44 58
  3. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PMID: 18081024) Laurin N … Barr CL (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 44 58
  4. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PMID: 17264867) Beleza-Meireles A … Nordenskjöld A (European journal of human genetics : EJHG 2007) 3 22 44 58
  5. Mutations in different components of FGF signaling in LADD syndrome. (PMID: 16501574) Rohmann E … Wollnik B (Nature genetics 2006) 3 4 22 58

Products for FGF10 Gene

Sources for FGF10 Gene

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