The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing ... See more...

Aliases for FGF10 Gene

Aliases for FGF10 Gene

  • Fibroblast Growth Factor 10 2 3 4 5
  • Keratinocyte Growth Factor 2 3 4
  • FGF-10 3 4
  • Produced By Fibroblasts Of Urinary Bladder Lamina Propria 3
  • FGF10 5

External Ids for FGF10 Gene

Previous GeneCards Identifiers for FGF10 Gene

  • GC05M044614
  • GC05M045481
  • GC05M044305
  • GC05M044350

Summaries for FGF10 Gene

Entrez Gene Summary for FGF10 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF10 Gene

FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include Lacrimoauriculodentodigital Syndrome and Aplasia Of Lacrimal And Salivary Glands. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF7.

UniProtKB/Swiss-Prot Summary for FGF10 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Gene Wiki entry for FGF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF10 Gene

Genomics for FGF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J044387 Promoter/Enhancer 1.8 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.4 1406 4.6 PRDM10 PRDM1 ZFHX2 SIN3A EZH2 EGR2 FGF10 FGF10-AS1 piR-32559-341 NNT
GH05J044331 Enhancer 0.5 Ensembl 11 +57.6 57605 1.4 CTCF RAD21 CEBPB SMC3 RFX5 ZNF654 TRIM22 FGF10 FGF10-AS1 piR-32559-341 NNT
GH05J044346 Enhancer 0.3 Ensembl 11.1 +43.6 43605 0.2 CTCF FGF10 FGF10-AS1 piR-32559-341 NNT
GH05J044329 Enhancer 0.2 Ensembl 11 +59.5 59505 1.2 FGF10 FGF10-AS1 piR-32559-341 NNT
GH05J044327 Enhancer 0.2 Ensembl 11 +61.8 61805 0.2 FGF10 FGF10-AS1 piR-32559-341 NNT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF10

Top Transcription factor binding sites by QIAGEN in the FGF10 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • STAT3

Genomic Locations for FGF10 Gene

Genomic Locations for FGF10 Gene
chr5:44,300,247-44,389,706
(GRCh38/hg38)
Size:
89,460 bases
Orientation:
Minus strand
chr5:44,303,646-44,389,808
(GRCh37/hg19)
Size:
86,163 bases
Orientation:
Minus strand

Genomic View for FGF10 Gene

Genes around FGF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF10 Gene

Proteins for FGF10 Gene

  • Protein details for FGF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15520-FGF10_HUMAN
    Recommended name:
    Fibroblast growth factor 10
    Protein Accession:
    O15520
    Secondary Accessions:
    • C7FDY0
    • Q6FHR3
    • Q6FHT6
    • Q96P59

    Protein attributes for FGF10 Gene

    Size:
    208 amino acids
    Molecular mass:
    23436 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

    Three dimensional structures from OCA and Proteopedia for FGF10 Gene

neXtProt entry for FGF10 Gene

Post-translational modifications for FGF10 Gene

  • Glycosylation at Asn51 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF10 Gene

Domains & Families for FGF10 Gene

Gene Families for FGF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for FGF10 Gene

InterPro:
Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature
ProtoNet:

Suggested Antigen Peptide Sequences for FGF10 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor 10 (C7FDY0_HUMAN)
  • Keratinocyte growth factor 2 (FGF10_HUMAN)
  • FGF10 protein (Q6FHR3_HUMAN)
  • Fibroblast growth factor 10 (Q8NFI9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15520

UniProtKB/Swiss-Prot:

FGF10_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF10: view

Function for FGF10 Gene

Molecular function for FGF10 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
GENATLAS Biochemistry:
fibroblast growth factor 10,19kDa,essential regulator of lung and limb formation,involved in the mesenchymal cells for the initiation and growth of the mouse limb bud,triggering FGF8 expression in ectoderm and SHH expression in mesoderm

LifeMap Function Summary for FGF10 Gene

Phenotypes From GWAS Catalog for FGF10 Gene

Gene Ontology (GO) - Molecular Function for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA,IDA 11923311
GO:0005111 type 2 fibroblast growth factor receptor binding IPI 19224135
GO:0005515 protein binding IPI 12591959
GO:0008083 growth factor activity IEA,IDA 11923311
GO:0008201 heparin binding IDA 11923311
genes like me logo Genes that share ontologies with FGF10: view
genes like me logo Genes that share phenotypes with FGF10: view

Human Phenotype Ontology for FGF10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGF10 Gene

MGI Knock Outs for FGF10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF10 Gene

Localization for FGF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 16597614
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 11923311
GO:0005886 plasma membrane IDA 16597614
genes like me logo Genes that share ontologies with FGF10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF10 Gene

Pathways & Interactions for FGF10 Gene

PathCards logo

SuperPathways for FGF10 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
3 Downstream signaling of activated FGFR2
4 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
5 GAB1 signalosome
genes like me logo Genes that share pathways with FGF10: view

Pathways by source for FGF10 Gene

1 GeneGo (Thomson Reuters) pathway for FGF10 Gene
  • Development FGF-family signaling
59 Qiagen pathways for FGF10 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for FGF10 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FGF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IDA 14975937
GO:0001525 angiogenesis IEA --
GO:0001656 metanephros development IEP 18437684
genes like me logo Genes that share ontologies with FGF10: view

Drugs & Compounds for FGF10 Gene

(4) Drugs for FGF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FGF10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF10: view

Transcripts for FGF10 Gene

mRNA/cDNA for FGF10 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF10

Alternative Splicing Database (ASD) splice patterns (SP) for FGF10 Gene

No ASD Table

Relevant External Links for FGF10 Gene

GeneLoc Exon Structure for
FGF10

Expression for FGF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF10 Gene

This gene is overexpressed in Cervix - Endocervix (x5.6), Cervix - Ectocervix (x5.2), Adipose - Visceral (Omentum) (x4.8), and Breast - Mammary Tissue (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF10

SOURCE GeneReport for Unigene cluster for FGF10 Gene:

Hs.664499

Evidence on tissue expression from TISSUES for FGF10 Gene

  • Lung(4.5)
  • Nervous system(4.5)
  • Skin(2.5)
  • Muscle(2.4)
  • Heart(2.4)
  • Pancreas(2.4)
  • Kidney(2.4)
  • Intestine(2.3)
  • Liver(2.3)
  • Stomach(2.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • middle ear
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tongue
  • tooth
Abdomen:
  • kidney
Pelvis:
  • penis
  • ureter
  • urethra
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • lower limb
  • radius
  • shin
  • tibia
  • toe
  • ulna
  • upper limb
General:
  • blood
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with FGF10: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FGF10 Gene

Orthologs for FGF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGF10 30 31
  • 99.84 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGF10 31
  • 99 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FGF10 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FGF10 30 31
  • 94.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF10 30
  • 93.37 (n)
Rat
(Rattus norvegicus)
Mammalia Fgf10 30
  • 92.11 (n)
Mouse
(Mus musculus)
Mammalia Fgf10 30 17 31
  • 90.5 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FGF10 30 31
  • 83.58 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgf10 30
  • 76.63 (n)
Str.15379 30
African clawed frog
(Xenopus laevis)
Amphibia fgf10-A 30
Zebrafish
(Danio rerio)
Actinopterygii fgf10b 30 31
  • 62.83 (n)
OneToMany
fgf10a 31
  • 55 (a)
OneToMany
fgf10 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 31
  • 19 (a)
OneToMany
Species where no ortholog for FGF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF10 Gene

ENSEMBL:
Gene Tree for FGF10 (if available)
TreeFam:
Gene Tree for FGF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF10: view image

Paralogs for FGF10 Gene

(19) SIMAP similar genes for FGF10 Gene using alignment to 5 proteins:

  • FGF10_HUMAN
  • C7FDY0_HUMAN
  • D6RG33_HUMAN
  • Q6FHR3_HUMAN
  • Q8NFI9_HUMAN
genes like me logo Genes that share paralogs with FGF10: view

Variants for FGF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF10 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
757093 Likely Benign: not provided 44,388,581(-) A/C SYNONYMOUS_VARIANT
907811 Benign: Congenital absence of salivary gland 44,305,012(-) T/C MISSENSE_VARIANT
907812 Uncertain Significance: Congenital absence of salivary gland 44,310,433(-) A/G SYNONYMOUS_VARIANT
rs104893884 Pathogenic: Congenital absence of salivary gland; not provided 44,305,045(-) G/A NONSENSE
rs104893885 Pathogenic: Levy-Hollister syndrome. Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730] 44,388,366(-) C/Ap.Cys106Phe MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FGF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGF10 Gene

Variant ID Type Subtype PubMed ID
esv2677507 CNV deletion 23128226
esv3604923 CNV loss 21293372
nsv4816 CNV deletion 18451855
nsv830277 CNV gain 17160897

Variation tolerance for FGF10 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF10 Gene

Human Gene Mutation Database (HGMD)
FGF10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF10 Gene

Disorders for FGF10 Gene

MalaCards: The human disease database

(45) MalaCards diseases for FGF10 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lacrimoauriculodentodigital syndrome
  • ladd
aplasia of lacrimal and salivary glands
  • alsg
apert syndrome
  • acrocephalosyndactyly, type i; acs1
clear cell acanthoma
  • pale acanthoma
craniosynostosis
  • craniostenosis
- elite association - COSMIC cancer census association via MalaCards
Search FGF10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGF10_HUMAN
  • Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. {ECO:0000269 PubMed:15654336}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. {ECO:0000269 PubMed:16501574, ECO:0000269 PubMed:16630169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for FGF10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FGF10: view

No data available for Genatlas for FGF10 Gene

Publications for FGF10 Gene

  1. Structure and expression of human fibroblast growth factor-10. (PMID: 9287324) Emoto H … Itoh N (The Journal of biological chemistry 1997) 2 3 4 23
  2. Correlation of the SNPs of FGFR1, FGF10, FGF18 with nonsyndromic cleft lip with or without palate in Chinese population. (PMID: 19727229) Wan WD … Lu ZH (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2009) 3 23 41
  3. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PMID: 18081024) Laurin N … Barr CL (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  4. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. (PMID: 17264867) Beleza-Meireles A … Nordenskjöld A (European journal of human genetics : EJHG 2007) 3 23 41
  5. Mutations in different components of FGF signaling in LADD syndrome. (PMID: 16501574) Rohmann E … Wollnik B (Nature genetics 2006) 3 4 23

Products for FGF10 Gene

Sources for FGF10 Gene