Aliases for FGF1 Gene
Aliases for FGF1 Gene
External Ids for FGF1 Gene
- HGNC: 3665
- Entrez Gene: 2246
- Ensembl: ENSG00000113578
- OMIM: 131220
- UniProtKB: P05230
Previous HGNC Symbols for FGF1 Gene
- FGFA
Previous GeneCards Identifiers for FGF1 Gene
- GC05M141873
- GC05M142001
- GC05M141953
- GC05M137120
Summaries for FGF1 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for FGF1 Gene
FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Overnutrition and Sclerosteosis. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.
UniProtKB/Swiss-Prot for FGF1 Gene
-
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Additional gene information for FGF1 Gene
- Monarch Initiative
- Search for FGF1 at DataMed
- Search for FGF1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF1 Gene
Genomics for FGF1 Gene
GeneHancer (GH) Regulatory Elements for FGF1 Gene
Promoters and enhancers for FGF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FGF1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FGF1 gene promoter:
Regulatory Element Products
Genomic Locations for FGF1 Gene
Genomic Locations for FGF1 Gene
- chr5:142,592,178-142,698,070
- (GRCh38/hg38)
- Size:
- 105,893 bases
- Orientation:
- Minus strand
- chr5:141,971,743-142,077,635
- (GRCh37/hg19)
Genomic View for FGF1 Gene
Genes around FGF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
FGF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF1 Gene
Proteins for FGF1 Gene
-
Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05230-FGF1_HUMAN
- Recommended name:
- Fibroblast growth factor 1
- Protein Accession:
- P05230
- B2R5T0
- D3DQF2
- P07502
- Q16588
Protein attributes for FGF1 Gene
- Size:
- 155 amino acids
- Molecular mass:
- 17460 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).
Three dimensional structures from OCA and Proteopedia for FGF1 Gene
Protein Expression for FGF1 Gene
Post-translational modifications for FGF1 Gene
- In the nucleus, phosphorylated by PKC/PRKCD.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FGF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_000791.1
- NP_001138364.1
- NP_001138406.1
- NP_001138407.1
- NP_001244134.1
- NP_001244135.1
- NP_001244136.1
- NP_001244137.1
- NP_001244138.1
- NP_001244139.1
- NP_001244140.1
- NP_001244141.1
- NP_001341880.1
- NP_001341881.1
- NP_001341882.1
- NP_001341883.1
- NP_001341884.1
- NP_001341885.1
- NP_001341886.1
- NP_001341887.1
- NP_001341888.1
- NP_001341890.1
- NP_001341891.1
- NP_001341892.1
- NP_001341893.1
- NP_149127.1
- NP_149128.1
- XP_005268447.1
- XP_011535909.1
Antibody Products
- R&D Systems Antibodies for FGF1 (FGF acidic)
-
Custom Antibody ServicesOriGene Antibodies for FGF1
- Novus Biologicals Antibodies for FGF1
-
Abcam antibodies for FGF1
-
Cloud-Clone Corp. Antibodies for FGF1
- Invitrogen Antibodies for FGF1
- antibodies-online: Search results for 225 available FGF1 Antibodies ranked by validation data
- Compare Top FGF1 Antibodies
-
Recommended
- 3 IHC Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 36 WB Antibodies (anti-mouse)
- 4 IP Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 111 WB Antibodies (anti-human)
- GeneTex FGF1 antibody for FGF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF1
- Sino Biological Antibodies for FGF1
Protein Products
- R&D Systems Proteins and Enzymes for FGF1 (FGF acidic)
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF1
- Origene Custom Protein Services for FGF1
- Sino Biological Recombinant Proteins for FGF1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FGF1
-
Cloud-Clone Corp. Proteins for FGF1
- GeneTex Proteins for FGF1
-
Abcam proteins for FGF1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for FGF1 (FGF acidic)
- antibodies-online: Search results for 119 available FGF1 Elisa Kits ranked by validation data
- Compare Top FGF1 Elisa Kits
-
Recommended
- 3 Wild boar (Sus scrofa) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 19 Rat (Rattus) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Pig (Porcine) ELISA Kits
- 21 Mouse (Murine) ELISA Kits
- 4 Monkey ELISA Kits
- 24 Human ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 3 Guinea Pig ELISA Kits
- 8 Goat ELISA Kits
- 3 Dog (Canine) ELISA Kits
- 10 Cow (Bovine) ELISA Kits
- 10 Chicken ELISA Kits
-
Abcam assays for FGF1
No data available for DME Specific Peptides for FGF1 Gene
Domains & Families for FGF1 Gene
Gene Families for FGF1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for FGF1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF1 Gene
Graphical View of Domain Structure for InterPro Entry
P05230- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF1 Gene
Molecular function for FGF1 Gene
- GENATLAS Biochemistry:
- fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Phenotypes From GWAS Catalog for FGF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005104 | fibroblast growth factor receptor binding | IPI | 10830168 |
| GO:0005178 | integrin binding | IDA | 18441324 |
| GO:0005515 | protein binding | IPI | 10618369 |
Phenotypes for FGF1 Gene
- MGI mutant phenotypes for FGF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FGF1:
Animal Models for FGF1 Gene
- MGI Knock Outs for FGF1:
-
- Fgf1 tm1Bas
Animal Model Products
-
Taconic Biosciences Mouse Models for FGF1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGF1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
- Search ViGene Biosciences for FGF1
CRISPR Products
-
OriGene CRISPR knockouts for FGF1
- genomics-online: gRNA clones - Search results for 188 available FGF1 gene related products
- Overview of 188 available FGF1 gene related products
- Applied Biological Materials CRISPR for FGF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF1
- GenScript: Design CRISPR guide RNA sequences for FGF1
miRNA for FGF1 Gene
- miRTarBase miRNAs that target FGF1
-
- hsa-mir-124-3p (MIRT022188)
- hsa-mir-7-5p (MIRT025666)
- hsa-mir-943 (MIRT446182)
- hsa-mir-4439 (MIRT446183)
- hsa-mir-3136-5p (MIRT446184)
- hsa-mir-526b-5p (MIRT446185)
- hsa-mir-6857-3p (MIRT446186)
- hsa-mir-6855-3p (MIRT446187)
- hsa-mir-4513 (MIRT446188)
- hsa-mir-6069 (MIRT710277)
- hsa-mir-6728-3p (MIRT710278)
- hsa-mir-186-3p (MIRT710279)
- hsa-mir-6877-3p (MIRT710280)
- hsa-mir-6819-3p (MIRT710281)
- hsa-mir-7109-3p (MIRT710282)
- hsa-mir-4753-3p (MIRT717728)
- hsa-mir-302d-5p (MIRT717729)
- hsa-mir-302b-5p (MIRT717730)
- hsa-mir-130b-5p (MIRT717731)
- hsa-mir-589-3p (MIRT717732)
- hsa-mir-500b-3p (MIRT717733)
- hsa-mir-4773 (MIRT717734)
- hsa-mir-1912 (MIRT717735)
- hsa-mir-1295b-5p (MIRT717736)
- hsa-mir-326 (MIRT731763)
miRNA Products
- Search ViGene Biosciences for FGF1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FGF1
- Browse OriGene Inhibitory RNA Products For FGF1
- genomics-online: shRNA clones - Search results for 188 available FGF1 gene related products
- Overview of 188 available FGF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
Clone Products
-
OriGene ORF clones in human for FGF1
- RC207434L2V
- RC227317L1V
- RC227317L2V
- RC227790L1V
- RC207434L1V
- RG214005
- RC214005L2
- RC214005L1
- RC214005
- RG219380
- RC219380L2
- RC219380L1
- RC219380
- RG231871
- RC231871
- RG231870
- RC231870
- RG231881
- RC231881
- RG231880
- RC231880
- RG231879
- RC231879
- RG231878
- RC231878
- RG231869
- RC231869
- RG231877
- RC231877
- RG227797
- RC227797L2
- RC227797L1
- RC227797
- RG227790
- RC227790L2
- RC227790L1
- RC227790
- RG227317
- RC227317L2
- RC227317L1
- RC227317
- RG207434
- RC207434L2
- RC207434L1
- RC207434
- RC214005L2V
- RC214005L1V
- RC219380L2V
- RC219380L1V
- RC227797L2V
- RC227797L1V
- RC227790L2V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF1
- VectorBuilder custom plasmid, inducible vectors for FGF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FGF1
- Applied Biological Materials Clones for FGF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FGF1
-
ViGene Biosciences adenoviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FGF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene
Localization for FGF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene
- Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IDA | 18400376 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF1 Gene
Pathways & Interactions for FGF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 4 | Negative regulation of FGFR3 signaling | ||
| 5 | GPCR Pathway |
.73
.62
|
.55
|
Pathways by source for FGF1 Gene
3 Sino Biological pathways for FGF1 Gene
4 BioSystems pathways for FGF1 Gene
111 Reactome pathways for FGF1 Gene
1 PharmGKB pathway for FGF1 Gene
10 KEGG pathways for FGF1 Gene
1 GeneGo (Thomson Reuters) pathway for FGF1 Gene
59 Qiagen pathways for FGF1 Gene
2 Cell Signaling Technology pathways for FGF1 Gene
Interacting Proteins for FGF1 Gene
Selected Interacting proteins:
ENSP00000338548
P05230-FGF1_HUMAN
for FGF1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | IMP | 18441324 |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001759 | organ induction | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Drugs & Compounds for FGF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pentosan Polysulfate | Approved | Pharma | Target, antagonist, inhibitor | 0 | ||
| Amlexanox | Approved, Investigational | Pharma | Target, inhibitor | Inhibitor of TBK1 and IKKepsilon; antiallergic agent | 3 | |
| Heparin | Approved, Investigational | Pharma | Antagonist, Target | 905,282 | ||
| Formic acid | Approved, Experimental, Investigational | Pharma | Target | 0 | ||
| Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FGF1 Gene
mRNA/cDNA for FGF1 Gene
- (29) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (130) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FGF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGF1
- genomics-online: gRNA clones - Search results for 188 available FGF1 gene related products
- Overview of 188 available FGF1 gene related products
- Applied Biological Materials CRISPR for FGF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF1
- GenScript: Design CRISPR guide RNA sequences for FGF1
miRNA Products
- Search ViGene Biosciences for FGF1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FGF1
- Browse OriGene Inhibitory RNA Products For FGF1
- genomics-online: shRNA clones - Search results for 188 available FGF1 gene related products
- Overview of 188 available FGF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FGF1 gene
Clone Products
-
OriGene ORF clones in human for FGF1
- RC207434L2V
- RC227317L1V
- RC227317L2V
- RC227790L1V
- RC207434L1V
- RG214005
- RC214005L2
- RC214005L1
- RC214005
- RG219380
- RC219380L2
- RC219380L1
- RC219380
- RG231871
- RC231871
- RG231870
- RC231870
- RG231881
- RC231881
- RG231880
- RC231880
- RG231879
- RC231879
- RG231878
- RC231878
- RG231869
- RC231869
- RG231877
- RC231877
- RG227797
- RC227797L2
- RC227797L1
- RC227797
- RG227790
- RC227790L2
- RC227790L1
- RC227790
- RG227317
- RC227317L2
- RC227317L1
- RC227317
- RG207434
- RC207434L2
- RC207434L1
- RC207434
- RC214005L2V
- RC214005L1V
- RC219380L2V
- RC219380L1V
- RC227797L2V
- RC227797L1V
- RC227790L2V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGF1
- VectorBuilder custom plasmid, inducible vectors for FGF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FGF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FGF1
- Applied Biological Materials Clones for FGF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP14: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - |
| ExUns: | 10h | · | 10i | · | 10j |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: | |||||
| SP13: | |||||
| SP14: | |||||
| SP15: | |||||
| SP16: |
Expression for FGF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dentin
- Ameloblasts Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Inner Enamel Epithelial Cells Dental Enamel
-
Brain (Nervous System)
- Midbrain tegmentum
- Deep Cerebellar Nucleus
- Cerebellum
- Pituitary Gland
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Epithelial Cells
- Outer Enamel Epithelial Cells Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Dental Placode Cells Dental Placode
- Early Ameloblasts Dental Enamel
- Eye (Sensory Organs)
- Neural Tube (Nervous System)
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
-
Bone (Muscoskeletal System)
- Presumptive Suture Cells Rostral Sutures
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Endothelium (Cardiovascular System)
- Pericytes Microvessels
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for FGF1 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).
This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGF1 Gene:
FGF1SOURCE GeneReport for Unigene cluster for FGF1 Gene:
Hs.483635mRNA Expression by UniProt/SwissProt for FGF1 Gene:
P05230-FGF1_HUMAN
Tissue specificity:
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for FGF1 Gene
- Nervous system(5)
- Liver(4.4)
- Heart(3.3)
- Muscle(3.1)
- Kidney(2.8)
- Eye(2.7)
Primer Products
-
OriGene qPCR primer pairs for FGF1
-
OriGene qPCR primer pairs and template standards for FGF1
- genomics-online: primer clones - Search results for 188 available FGF1 gene related products
- Overview of 188 available FGF1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF1 Gene
Orthologs for FGF1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGF1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FGF1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FGF1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgf1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGF1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fgf1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGF1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGF1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FGF1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgf1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgf1a 34 |
|
ManyToMany | |
| fgf1b 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | bnl 34 |
|
OneToMany |
- Species where no ortholog for FGF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FGF1 Gene
(19) SIMAP similar genes for FGF1 Gene using alignment to 6 proteins:
Variants for FGF1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000033172 | -- | 142,616,532(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000048145 | -- | 142,602,377(-) | A/C | intron_variant | |
| rs1000078835 | -- | 142,602,685(-) | G/A | intron_variant | |
| rs1000111556 | -- | 142,624,030(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000156285 | -- | 142,655,486(-) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1046e199 | CNV | deletion | 23128226 |
| esv2421733 | CNV | deletion | 20811451 |
| esv2665244 | CNV | deletion | 23128226 |
| esv2760957 | CNV | loss | 21179565 |
| esv27821 | CNV | loss | 19812545 |
| esv3570474 | CNV | loss | 25503493 |
| esv3606999 | CNV | gain | 21293372 |
| esv3607005 | CNV | gain | 21293372 |
| esv3607006 | CNV | loss | 21293372 |
| esv3607007 | CNV | loss | 21293372 |
| esv3607008 | CNV | loss | 21293372 |
| nsv1023306 | CNV | gain | 25217958 |
| nsv1031126 | CNV | gain | 25217958 |
| nsv1034911 | CNV | gain | 25217958 |
| nsv1123991 | CNV | deletion | 24896259 |
| nsv441966 | CNV | loss | 18776908 |
| nsv514325 | CNV | loss | 21397061 |
| nsv517346 | CNV | loss | 19592680 |
| nsv525272 | CNV | loss | 19592680 |
| nsv823281 | CNV | loss | 20364138 |
| nsv830510 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.69;
14.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene
Disorders for FGF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| overnutrition |
|
|
| sclerosteosis |
|
|
| 8p11 myeloproliferative syndrome |
|
|
| blount's disease |
|
|
| vitreoretinopathy, neovascular inflammatory |
|
Search FGF1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FGF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene
Publications for FGF1 Gene
- The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. (PMID: 18400376) Di Serio C … Tarantini F (Cancer letters 2008) 3 4 22 58
- Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. (PMID: 18441324) Mori S … Takada Y (The Journal of biological chemistry 2008) 3 4 22 58
- VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C … Rahman P (BMC musculoskeletal disorders 2007) 3 22 44 58
- Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 22 44 58
- Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PMID: 11069186) Pellegrini L … Blundell TL (Nature 2000) 3 4 22 58
Products for FGF1 Gene
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