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Aliases for FGF1 Gene

Aliases for FGF1 Gene

  • Fibroblast Growth Factor 1 2 3 5
  • Heparin-Binding Growth Factor 1 2 3 4
  • Endothelial Cell Growth Factor, Alpha 2 3
  • Endothelial Cell Growth Factor, Beta 2 3
  • Fibroblast Growth Factor 1 (Acidic) 2 3
  • HBGF-1 3 4
  • FGF-1 3 4
  • AFGF 3 4
  • FGFA 3 4
  • ECGF 3 4
  • Beta-Endothelial Cell Growth Factor 3
  • Acidic Fibroblast Growth Factor 4
  • Endothelial Cell Growth Factor 4
  • ECGF-Beta 3
  • FGF-Alpha 3
  • GLIO703 3
  • ECGFA 3
  • ECGFB 3
  • HBGF1 3

External Ids for FGF1 Gene

Previous HGNC Symbols for FGF1 Gene

  • FGFA

Previous GeneCards Identifiers for FGF1 Gene

  • GC05M141873
  • GC05M142001
  • GC05M141953
  • GC05M137120

Summaries for FGF1 Gene

Entrez Gene Summary for FGF1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for FGF1 Gene

FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Overnutrition and Sclerosteosis. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot for FGF1 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

Gene Wiki entry for FGF1 Gene

Additional gene information for FGF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF1 Gene

Genomics for FGF1 Gene

GeneHancer (GH) Regulatory Elements for FGF1 Gene

Promoters and enhancers for FGF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I142643 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.2 +53.2 53235 2.3 PKNOX1 INSM2 KLF17 GLIS2 ZNF366 FOS EGR2 ZNF362 YY2 CEBPB FGF1 GC05P142651 GC05M142626 SPRY4-AS1
GH05I142695 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 393 3.4 FOXA2 RB1 NFIB SIN3A ZNF2 ZNF48 RAD21 RFX5 ARID2 ZNF366 FGF1 GC05M142697 KIAA0141 GC05P142651
GH05I142684 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 587.4 +12.5 12542 3 FOXA2 RFX1 SAP130 ZSCAN4 ARID4B BACH1 ZIC2 ZFHX2 RFX3 PRDM10 FGF1 GC05M142697 GC05P142651
GH05I142620 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 565.9 +76.2 76232 2.1 JUND ZNF189 FOS FGF1 GC05M142626 RPS12P10 SPRY4-AS1
GH05I142680 Enhancer 1.2 Ensembl ENCODE dbSUPER 31.3 +17.0 16966 1.7 PKNOX1 FOXA2 NEUROD1 RARA ETS1 SCRT2 FOS RCOR1 KLF13 SMARCC1 FGF1 GC05M142697 GC05P142651
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FGF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGF1 gene promoter:

Genomic Locations for FGF1 Gene

Genomic Locations for FGF1 Gene
chr5:142,592,178-142,698,070
(GRCh38/hg38)
Size:
105,893 bases
Orientation:
Minus strand
chr5:141,971,743-142,077,635
(GRCh37/hg19)

Genomic View for FGF1 Gene

Genes around FGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF1 Gene

Proteins for FGF1 Gene

  • Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05230-FGF1_HUMAN
    Recommended name:
    Fibroblast growth factor 1
    Protein Accession:
    P05230
    Secondary Accessions:
    • B2R5T0
    • D3DQF2
    • P07502
    • Q16588

    Protein attributes for FGF1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17460 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).

    Three dimensional structures from OCA and Proteopedia for FGF1 Gene

    Alternative splice isoforms for FGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF1 Gene

Post-translational modifications for FGF1 Gene

No data available for DME Specific Peptides for FGF1 Gene

Domains & Families for FGF1 Gene

Gene Families for FGF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P05230

UniProtKB/Swiss-Prot:

FGF1_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF1: view

Function for FGF1 Gene

Molecular function for FGF1 Gene

GENATLAS Biochemistry:
fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)
UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

Phenotypes From GWAS Catalog for FGF1 Gene

Gene Ontology (GO) - Molecular Function for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IPI 10830168
GO:0005178 integrin binding IDA 18441324
GO:0005515 protein binding IPI 10618369
genes like me logo Genes that share ontologies with FGF1: view
genes like me logo Genes that share phenotypes with FGF1: view

Animal Models for FGF1 Gene

MGI Knock Outs for FGF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF1

Clone Products

  • Addgene plasmids for FGF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene

Localization for FGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 18400376
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FGF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF1 Gene

Pathways & Interactions for FGF1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 Negative regulation of FGFR3 signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF1: view

SIGNOR curated interactions for FGF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IMP 18441324
GO:0001525 angiogenesis IEA --
GO:0001759 organ induction IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with FGF1: view

Drugs & Compounds for FGF1 Gene

(52) Drugs for FGF1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma Target, antagonist, inhibitor 0
Amlexanox Approved, Investigational Pharma Target, inhibitor Inhibitor of TBK1 and IKKepsilon; antiallergic agent 3
Heparin Approved, Investigational Pharma Antagonist, Target 905,282
Formic acid Approved, Experimental, Investigational Pharma Target 0
Pazopanib Approved Pharma Target, inhibitor VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0

(49) Additional Compounds for FGF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF1: view

Transcripts for FGF1 Gene

Unigene Clusters for FGF1 Gene

Fibroblast growth factor 1 (acidic):
Representative Sequences:

Clone Products

  • Addgene plasmids for FGF1

Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16: - -

ExUns: 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGF1 Gene

GeneLoc Exon Structure for
FGF1
ECgene alternative splicing isoforms for
FGF1

Expression for FGF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for FGF1 Gene

This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FGF1 Gene



Protein tissue co-expression partners for FGF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF1 Gene:

FGF1

SOURCE GeneReport for Unigene cluster for FGF1 Gene:

Hs.483635

mRNA Expression by UniProt/SwissProt for FGF1 Gene:

P05230-FGF1_HUMAN
Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for FGF1 Gene

  • Nervous system(5)
  • Liver(4.4)
  • Heart(3.3)
  • Muscle(3.1)
  • Kidney(2.8)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with FGF1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF1 Gene

Orthologs for FGF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGF1 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia FGF1 33 34
  • 94.84 (n)
cow
(Bos Taurus)
Mammalia FGF1 33 34
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Fgf1 33 16 34
  • 90.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FGF1 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fgf1 33
  • 89.25 (n)
oppossum
(Monodelphis domestica)
Mammalia FGF1 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGF1 33 34
  • 79.78 (n)
lizard
(Anolis carolinensis)
Reptilia FGF1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf1 33
  • 69.25 (n)
zebrafish
(Danio rerio)
Actinopterygii fgf1a 34
  • 54 (a)
ManyToMany
fgf1b 34
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bnl 34
  • 6 (a)
OneToMany
Species where no ortholog for FGF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF1 Gene

ENSEMBL:
Gene Tree for FGF1 (if available)
TreeFam:
Gene Tree for FGF1 (if available)

Paralogs for FGF1 Gene

Paralogs for FGF1 Gene

genes like me logo Genes that share paralogs with FGF1: view

Variants for FGF1 Gene

Sequence variations from dbSNP and Humsavar for FGF1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000033172 -- 142,616,532(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000048145 -- 142,602,377(-) A/C intron_variant
rs1000078835 -- 142,602,685(-) G/A intron_variant
rs1000111556 -- 142,624,030(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000156285 -- 142,655,486(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FGF1 Gene

Variant ID Type Subtype PubMed ID
dgv1046e199 CNV deletion 23128226
esv2421733 CNV deletion 20811451
esv2665244 CNV deletion 23128226
esv2760957 CNV loss 21179565
esv27821 CNV loss 19812545
esv3570474 CNV loss 25503493
esv3606999 CNV gain 21293372
esv3607005 CNV gain 21293372
esv3607006 CNV loss 21293372
esv3607007 CNV loss 21293372
esv3607008 CNV loss 21293372
nsv1023306 CNV gain 25217958
nsv1031126 CNV gain 25217958
nsv1034911 CNV gain 25217958
nsv1123991 CNV deletion 24896259
nsv441966 CNV loss 18776908
nsv514325 CNV loss 21397061
nsv517346 CNV loss 19592680
nsv525272 CNV loss 19592680
nsv823281 CNV loss 20364138
nsv830510 CNV gain 17160897

Variation tolerance for FGF1 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF1 Gene

Human Gene Mutation Database (HGMD)
FGF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene

Disorders for FGF1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FGF1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
overnutrition
sclerosteosis
  • sost
8p11 myeloproliferative syndrome
  • 8p11 stem cell leukemia/lymphoma syndrome
blount's disease
  • blount disease, infantile
vitreoretinopathy, neovascular inflammatory
  • vrni
- elite association - COSMIC cancer census association via MalaCards
Search FGF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene

Publications for FGF1 Gene

  1. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. (PMID: 18400376) Di Serio C … Tarantini F (Cancer letters 2008) 3 4 22 58
  2. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. (PMID: 18441324) Mori S … Takada Y (The Journal of biological chemistry 2008) 3 4 22 58
  3. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C … Rahman P (BMC musculoskeletal disorders 2007) 3 22 44 58
  4. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 22 44 58
  5. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. (PMID: 11069186) Pellegrini L … Blundell TL (Nature 2000) 3 4 22 58

Products for FGF1 Gene