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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Common Peroneal Nerve Lesion and Overnutrition. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005104 | fibroblast growth factor receptor binding | IPI | 10830168 |
GO:0005178 | integrin binding | IDA | 18441324 |
GO:0005515 | protein binding | IPI | 10618369 |
GO:0008083 | growth factor activity | TAS,IDA | 20145243 |
GO:0008201 | heparin binding | IMP | 18441324 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA | 18400376 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Downstream signaling of activated FGFR2 | ||
3 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
4 | Negative regulation of FGFR3 signaling | ||
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0000187 | activation of MAPK activity | IMP | 18441324 |
GO:0001525 | angiogenesis | IEA | -- |
GO:0001759 | organ induction | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Pentosan Polysulfate | Approved | Pharma | Target, antagonist, inhibitor | 0 | ||
Amlexanox | Approved, Investigational, Withdrawn | Pharma | Target, inhibitor | Inhibitor of TBK1 and IKKepsilon; antiallergic agent | 3 | |
Heparin | Approved, Investigational | Pharma | Antagonist, Target | 1058 | ||
Foreskin fibroblast (neonatal) | Approved | Pharma | Target, agonist | 0 | ||
Foreskin keratinocyte (neonatal) | Approved | Pharma | Target, agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | · | 10g | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - |
ExUns: | 10h | · | 10i | · | 10j |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | |||||
SP13: | |||||
SP14: | |||||
SP15: | |||||
SP16: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGF1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fgf1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FGF1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgf1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FGF1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FGF1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FGF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgf1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fgf1a 31 |
|
ManyToMany | |
fgf1b 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | bnl 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
786817 | Benign: not provided | 142,614,066(-) | C/T | MISSENSE_VARIANT | |
rs17223632 | - | p.Gly21Glu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1046e199 | CNV | deletion | 23128226 |
esv2421733 | CNV | deletion | 20811451 |
esv2665244 | CNV | deletion | 23128226 |
esv2760957 | CNV | loss | 21179565 |
esv27821 | CNV | loss | 19812545 |
esv3570474 | CNV | loss | 25503493 |
esv3606999 | CNV | gain | 21293372 |
esv3607005 | CNV | gain | 21293372 |
esv3607006 | CNV | loss | 21293372 |
esv3607007 | CNV | loss | 21293372 |
esv3607008 | CNV | loss | 21293372 |
nsv1023306 | CNV | gain | 25217958 |
nsv1031126 | CNV | gain | 25217958 |
nsv1034911 | CNV | gain | 25217958 |
nsv1123991 | CNV | deletion | 24896259 |
nsv441966 | CNV | loss | 18776908 |
nsv514325 | CNV | loss | 21397061 |
nsv517346 | CNV | loss | 19592680 |
nsv525272 | CNV | loss | 19592680 |
nsv823281 | CNV | loss | 20364138 |
nsv830510 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
common peroneal nerve lesion |
|
|
overnutrition |
|
|
pleomorphic adenoma |
|
|
pancreatic adenocarcinoma |
|
|
8p11 myeloproliferative syndrome |
|
|