FGF1 Gene (Protein Coding)

Fibroblast Growth Factor 1

GC05M142555
GIFtS:
48
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell m... See more...

Aliases for FGF1 Gene

Aliases for FGF1 Gene

  • Fibroblast Growth Factor 1 2 3 4 5
  • Heparin-Binding Growth Factor 1 2 3 4
  • AFGF 2 3 4
  • ECGF 2 3 4
  • Endothelial Cell Growth Factor, Alpha 2 3
  • Endothelial Cell Growth Factor, Beta 2 3
  • Fibroblast Growth Factor 1 (Acidic) 2 3
  • ECGF-Beta 2 3
  • FGF-Alpha 2 3
  • GLIO703 2 3
  • HBGF-1 3 4
  • ECGFA 2 3
  • ECGFB 2 3
  • FGF-1 3 4
  • HBGF1 2 3
  • FGFA 3 4
  • Beta-Endothelial Cell Growth Factor 3
  • Acidic Fibroblast Growth Factor 4
  • Endothelial Cell Growth Factor 4
  • FGF1 5

External Ids for FGF1 Gene

Previous HGNC Symbols for FGF1 Gene

  • FGFA

Previous GeneCards Identifiers for FGF1 Gene

  • GC05M141873
  • GC05M142001
  • GC05M141953
  • GC05M137120

Summaries for FGF1 Gene

Entrez Gene Summary for FGF1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for FGF1 Gene

FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Common Peroneal Nerve Lesion and Overnutrition. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include growth factor activity and Hsp70 protein binding. An important paralog of this gene is FGF2.

UniProtKB/Swiss-Prot Summary for FGF1 Gene

  • Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

Gene Wiki entry for FGF1 Gene

Additional gene information for FGF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF1 Gene

Genomics for FGF1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FGF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J142695 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.4 393 3.4 CTCF PRDM10 ZNF629 ZNF692 JUND PRDM1 ZNF143 PATZ1 REST RAD21 FGF1 lnc-SPRY4-5 DELE1 FJ601684-391 SPRY4 SPRY4-AS1
GH05J142684 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 637.4 +12.5 12542 3 PRDM10 PRDM1 ZIC2 ZSCAN4 POLR2A RFX3 RFX1 FOXA2 ZFHX2 SAP130 FGF1 lnc-SPRY4-5 FJ601684-391 SPRY4-AS1 SPRY4
GH05J142620 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 615.9 +76.2 76232 2.1 FOS ZNF189 JUND FGF1 RF00017-4978 RPS12P10 lnc-ARHGAP26-7 lnc-SPRY4-5 SPRY4 SPRY4-AS1
GH05J142680 Enhancer 1.1 Ensembl ENCODE dbSUPER 31.3 +17.0 16993 1.8 CEBPG CREB1 GATAD2A JUND FOXA1 CEBPA ATF7 SCRT2 CEBPB ETS1 FGF1 lnc-SPRY4-5 FJ601684-391 SPRY4-AS1 SPRY4
GH05J142673 Enhancer 0.8 Ensembl ENCODE dbSUPER 37.5 +22.9 22900 3.4 JUND JUN SMARCA4 HLF FGF1 lnc-SPRY4-5 FJ601684-391 SPRY4 SPRY4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF1

Top Transcription factor binding sites by QIAGEN in the FGF1 gene promoter:
  • AP-1
  • PPAR-gamma1

Genomic Locations for FGF1 Gene

Genomic Locations for FGF1 Gene
chr5:142,592,178-142,698,070
(GRCh38/hg38)
Size:
105,893 bases
Orientation:
Minus strand
chr5:141,971,743-142,077,635
(GRCh37/hg19)
Size:
105,893 bases
Orientation:
Minus strand

Genomic View for FGF1 Gene

Genes around FGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGF1 Gene

Proteins for FGF1 Gene

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  • Protein details for FGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05230-FGF1_HUMAN
    Recommended name:
    Fibroblast growth factor 1
    Protein Accession:
    P05230
    Secondary Accessions:
    • B2R5T0
    • D3DQF2
    • P07502
    • Q16588

    Protein attributes for FGF1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17460 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).

    Three dimensional structures from OCA and Proteopedia for FGF1 Gene

    Alternative splice isoforms for FGF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF1 Gene

Protein Expression for FGF1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FGF1 Gene

Other Protein References for FGF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

No data available for DME Specific Peptides for FGF1 Gene

Domains & Families for FGF1 Gene

Gene Families for FGF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FGF1 Gene

InterPro:
Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature
ProtoNet:

Suggested Antigen Peptide Sequences for FGF1 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor 1 (Acidic), isoform CRA_a (D3DQF1_HUMAN)
  • ECGF-beta (FGF1_HUMAN)
  • Acidic fibroblast growth factor (Q9UBK1_HUMAN)
  • Acid fibroblast growth factor-like protein (Q9UH63_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05230

UniProtKB/Swiss-Prot:

FGF1_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF1: view

Function for FGF1 Gene

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Molecular function for FGF1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
GENATLAS Biochemistry:
fibroblast growth factor 1,acidic (endothelial cell),associated with S100A13 and p40 extracellular domain of synaptotagmin 1 (SYT1) for the release of signal peptide-less FGF1 in a temperature stress-induced pathway,mainly expressed in brain,and delinating a retrocaudal boundary in the granule cell layer of the (murine) cerebellar cortex,also expressed in the retina (accessible to pharmacologic regulation)

Phenotypes From GWAS Catalog for FGF1 Gene

Gene Ontology (GO) - Molecular Function for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IPI 10830168
GO:0005178 integrin binding IDA 18441324
GO:0005515 protein binding IPI 10618369
GO:0008083 growth factor activity TAS,IDA 20145243
GO:0008201 heparin binding IMP 18441324
genes like me logo Genes that share ontologies with FGF1: view
genes like me logo Genes that share phenotypes with FGF1: view

Animal Models for FGF1 Gene

MGI Knock Outs for FGF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF1

Clone Products

  • Addgene plasmids for FGF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF1 Gene

Localization for FGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF1 Gene

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18400376
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with FGF1: view

Pathways & Interactions for FGF1 Gene

PathCards logo

SuperPathways for FGF1 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
.88
Signaling by FGFR3 in disease
.88
Signaling by FGFR3 point mutants in cancer
.88
FRS-mediated FGFR2 signaling
.85
SHC-mediated cascade-FGFR2
.85
Downstream signaling of activated FGFR2
.83
FRS-mediated FGFR1 signaling
.83
SHC-mediated cascade-FGFR1
.83
Downstream signaling of activated FGFR4
.81
FRS-mediated FGFR4 signaling
.81
PI-3K cascade-FGFR2
.77
PI-3K cascade-FGFR1
.76
Downstream signaling of activated FGFR1
.74
Activated point mutants of FGFR2
.01
FGFR1b ligand binding and activation
.01
FGFR2c ligand binding and activation
.01
FGFR4 ligand binding and activation
.01
FRS-mediated FGFR3 signaling
.01
Phospholipase C-mediated cascade- FGFR1
.01
Phospholipase C-mediated cascade; FGFR2
.01
Phospholipase C-mediated cascade; FGFR3
.01
Phospholipase C-mediated cascade; FGFR4
.01
PI-3K cascade-FGFR3
.01
PI-3K cascade-FGFR4
.01
SHC-mediated cascade-FGFR3
.01
SHC-mediated cascade-FGFR4
.01
3 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
4 Negative regulation of FGFR3 signaling
Signaling by FGFR3
.84
Signaling by FGFR4
.84
Negative regulation of FGFR3 signaling
.82
Negative regulation of FGFR4 signaling
.82
Negative regulation of FGFR1 signaling
.81
Negative regulation of FGFR2 signaling
.81
Signaling by FGFR1
.70
FGFR1 ligand binding and activation
.01
FGFR1c ligand binding and activation
.01
Signaling by activated point mutants of FGFR1
.01
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
genes like me logo Genes that share pathways with FGF1: view

Pathways by source for FGF1 Gene

1 PharmGKB pathway for FGF1 Gene
1 GeneGo (Thomson Reuters) pathway for FGF1 Gene
  • Development FGF-family signaling
59 Qiagen pathways for FGF1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
2 Cell Signaling Technology pathways for FGF1 Gene

SIGNOR curated interactions for FGF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for FGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity IMP 18441324
GO:0001525 angiogenesis IEA --
GO:0001759 organ induction IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with FGF1: view

Drugs & Compounds for FGF1 Gene

Products:

  1. Drug

(54) Drugs for FGF1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma Target, antagonist, inhibitor 0
Amlexanox Approved, Investigational, Withdrawn Pharma Target, inhibitor Inhibitor of TBK1 and IKKepsilon; antiallergic agent 3
Heparin Approved, Investigational Pharma Antagonist, Target 1058
Foreskin fibroblast (neonatal) Approved Pharma Target, agonist 0
Foreskin keratinocyte (neonatal) Approved Pharma Target, agonist 0

(48) Additional Compounds for FGF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF1: view

Transcripts for FGF1 Gene

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mRNA/cDNA for FGF1 Gene

27 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF1

Clone Products

  • Addgene plasmids for FGF1

Alternative Splicing Database (ASD) splice patterns (SP) for FGF1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - -
SP16: - -

ExUns: 10h · 10i · 10j
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FGF1 Gene

GeneLoc Exon Structure for
FGF1

Expression for FGF1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF1 Gene

mRNA expression in normal human tissues for FGF1 Gene
mRNA expression by BioGPS for FGF1 GenemRNA expression by GTEx for FGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x5.0), Brain - Amygdala (x4.9), Brain - Putamen (basal ganglia) (x4.6), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for FGF1 Gene

This gene is overexpressed in Spinal cord (24.3), Frontal cortex (11.4), Retina (10.3), and Brain (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGF1 Gene



Protein tissue co-expression partners for FGF1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF1

SOURCE GeneReport for Unigene cluster for FGF1 Gene:

Hs.483635

mRNA Expression by UniProt/SwissProt for FGF1 Gene:

P05230-FGF1_HUMAN
Tissue specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for FGF1 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Heart(3.5)
  • Muscle(3.4)
  • Kidney(3.2)
  • Eye(3)
  • Blood(2.6)
  • Skin(2.5)
  • Intestine(2.3)
  • Bone(2.3)
  • Lung(2.3)
  • Bone marrow(2.2)
  • Spleen(2.2)
  • Pancreas(2.2)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with FGF1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF1 Gene

Orthologs for FGF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGF1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FGF1 30 31
  • 99.35 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FGF1 30 31
  • 94.84 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FGF1 30 31
  • 91.4 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fgf1 30 17 31
  • 90.54 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FGF1 31
  • 90 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fgf1 30
  • 89.25 (n)
Oppossum
(Monodelphis domestica)
 Mammalia FGF1 31
  • 89 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FGF1 30 31
  • 79.78 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FGF1 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fgf1 30
  • 69.25 (n)
Zebrafish
(Danio rerio)
 Actinopterygii fgf1a 31
  • 54 (a)
 ManyToMany
fgf1b 31
  • 51 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta bnl 31
  • 6 (a)
 OneToMany
Species where no ortholog for FGF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF1 Gene

ENSEMBL:
Gene Tree for FGF1 (if available)
TreeFam:
Gene Tree for FGF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF1: view image

Paralogs for FGF1 Gene

Paralogs for FGF1 Gene

(19) SIMAP similar genes for FGF1 Gene using alignment to 6 proteins:

  • FGF1_HUMAN
  • B5MCF4_HUMAN
  • C9JDC5_HUMAN
  • C9JUP6_HUMAN
  • D3DQF1_HUMAN
  • L8ECL8_HUMAN
genes like me logo Genes that share paralogs with FGF1: view

Variants for FGF1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
786817 Benign: not provided 142,614,066(-) C/T MISSENSE_VARIANT
rs17223632 - p.Gly21Glu

Additional dbSNP identifiers (rs#s) for FGF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGF1 Gene

Variant ID Type Subtype PubMed ID
dgv1046e199 CNV deletion 23128226
esv2421733 CNV deletion 20811451
esv2665244 CNV deletion 23128226
esv2760957 CNV loss 21179565
esv27821 CNV loss 19812545
esv3570474 CNV loss 25503493
esv3606999 CNV gain 21293372
esv3607005 CNV gain 21293372
esv3607006 CNV loss 21293372
esv3607007 CNV loss 21293372
esv3607008 CNV loss 21293372
nsv1023306 CNV gain 25217958
nsv1031126 CNV gain 25217958
nsv1034911 CNV gain 25217958
nsv1123991 CNV deletion 24896259
nsv441966 CNV loss 18776908
nsv514325 CNV loss 21397061
nsv517346 CNV loss 19592680
nsv525272 CNV loss 19592680
nsv823281 CNV loss 20364138
nsv830510 CNV gain 17160897

Variation tolerance for FGF1 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF1 Gene

Human Gene Mutation Database (HGMD)
FGF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF1 Gene

Disorders for FGF1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for FGF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
common peroneal nerve lesion
overnutrition
pleomorphic adenoma
  • mixed tumor of the salivary gland
pancreatic adenocarcinoma
  • adenocarcinoma of the pancreas
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FGF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF1 Gene

Publications for FGF1 Gene

  1. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. (PMID: 18441324) Mori S … Takada Y (The Journal of biological chemistry 2008) 3 4 23
  2. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. (PMID: 18400376) Di Serio C … Tarantini F (Cancer letters 2008) 3 4 23
  3. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. (PMID: 17204151) Butt C … Rahman P (BMC musculoskeletal disorders 2007) 3 23 41
  4. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PMID: 16886895) Hwang Y … Chen DS (Pharmacogenomics 2006) 3 23 41
  5. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. (PMID: 10830168) Plotnikov AN … Mohammadi M (Cell 2000) 3 4 23

ExternalLinks

View latest publications for FGF1 gene in Mastermind

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