Aliases for FGD3 Gene
External Ids for FGD3 Gene
Previous GeneCards Identifiers for FGD3 Gene
GeneCards Summary for FGD3 Gene
FGD3 (FYVE, RhoGEF And PH Domain Containing 3) is a Protein Coding gene. Diseases associated with FGD3 include Aarskog-Scott Syndrome and Charcot-Marie-Tooth Disease, Type 4H. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and small GTPase binding. An important paralog of this gene is FGD1.
UniProtKB/Swiss-Prot Summary for FGD3 Gene
Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).