This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, F... See more...

Aliases for FFAR4 Gene

Aliases for FFAR4 Gene

  • Free Fatty Acid Receptor 4 2 3 4 5
  • Omega-3 Fatty Acid Receptor 1 2 3 4
  • PGR4 2 3 4
  • G-Protein Coupled Receptor GT01 3 4
  • G-Protein Coupled Receptor PGR4 3 4
  • G-Protein Coupled Receptor 120 3 4
  • G-Protein Coupled Receptor 129 3 4
  • GPR120 3 4
  • GPR129 3 4
  • O3FAR1 3 4
  • G Protein-Coupled Receptor 129 2
  • G Protein-Coupled Receptor 120 2
  • BMIQ10 3
  • FFAR4 5
  • GT01 3

External Ids for FFAR4 Gene

Previous HGNC Symbols for FFAR4 Gene

  • GPR129
  • GPR120
  • O3FAR1

Previous GeneCards Identifiers for FFAR4 Gene

  • GC10P095329

Summaries for FFAR4 Gene

Entrez Gene Summary for FFAR4 Gene

  • This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for FFAR4 Gene

FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Body Mass Index Quantitative Trait Locus 10 and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Incretin synthesis, secretion, and inactivation. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and taste receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot Summary for FFAR4 Gene

  • [Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:22282525, PubMed:24742677, PubMed:27852822, PubMed:24817122, PubMed:22343897). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:27852822, PubMed:22343897, PubMed:22282525, PubMed:24742677). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:22282525, PubMed:24817122). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (By similarity). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (By similarity). Induces differentiation of brown adipocytes probably via autocrine and endocrine functions of FGF21 hormone (By similarity). Activates brown adipocytes by initiating intracellular calcium signaling that leads to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (By similarity). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (By similarity). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (By similarity). In response to dietary fats regulates hormone secretion and appetite (By similarity). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (By similarity). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (By similarity). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (By similarity). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (By similarity). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (PubMed:23809162). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of proinflammatory cytokine release (PubMed:23809162). Mediates LCFAs anti-apoptotic effects (By similarity).
  • [Isoform 1]: Receptor for LCFAs decoupled from G-protein signaling. May signal through beta-arrestin pathway. After LCFAs binding, associates with beta-arrestin ARRB2 that may act as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis.

Gene Wiki entry for FFAR4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FFAR4 Gene

Genomics for FFAR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FFAR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J093566 Promoter 1.2 EPDnew Ensembl 250.7 +0.5 523 1.4 ZNF600 CEBPA ZNF10 ZIC2 ZNF341 SIN3A KLF16 GLI4 SPI1 MYC FFAR4 RBP4 NONHSAG006546.2
GH10J093555 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.4 -10.7 -10677 2.6 ZNF654 CTCF REST RAD21 SMC3 YY1 NFE2 PRDM10 SPI1 GTF2F1 HSALNG0079755 LOC105378436 FFAR4 HSALNG0079754 lnc-CEP55-1 CEP55
GH10J093567 Enhancer 0.3 FANTOM5 252.3 +1.9 1866 0.1 EZH2 FFAR4 NONHSAG006546.2 RBP4
GH10J093591 Enhancer 0.7 Ensembl ENCODE 12.2 +25.4 25423 1.6 SSRP1 RXRA RBM22 SPI1 MAX PAF1 IKZF1 POLR2A RBFOX2 NR2F2 PDE6C FFAR4 RBP4 NONHSAG006546.2
GH10J093514 Promoter/Enhancer 0.8 Ensembl ENCODE dbSUPER 10.9 -50.8 -50754 1.5 SPI1 HSALNG0079751 CEP55 FFAR4 CYP26A1 RF00001-042 RNA5SP323
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FFAR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FFAR4

Genomic Locations for FFAR4 Gene

Latest Assembly
chr10:93,566,178-93,604,480
(GRCh38/hg38)
Size:
38,303 bases
Orientation:
Plus strand

Previous Assembly
chr10:95,326,422-95,349,829
(GRCh37/hg19 by Entrez Gene)
Size:
23,408 bases
Orientation:
Plus strand

chr10:95,326,422-95,364,237
(GRCh37/hg19 by Ensembl)
Size:
37,816 bases
Orientation:
Plus strand

Genomic View for FFAR4 Gene

Genes around FFAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FFAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FFAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR4 Gene

Proteins for FFAR4 Gene

  • Protein details for FFAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5NUL3-FFAR4_HUMAN
    Recommended name:
    Free fatty acid receptor 4
    Protein Accession:
    Q5NUL3
    Secondary Accessions:
    • Q495H1
    • Q5VY25
    • Q5VY26
    • Q7Z605
    • Q86SM7

    Protein attributes for FFAR4 Gene

    Size:
    361 amino acids
    Molecular mass:
    40494 Da
    Quaternary structure:
    • [Isoform 1]: Interacts (via C-terminus) with ARRB2 following LCFAs stimulation.
    • [Isoform 2]: Interacts (via C-terminus) with ARRB2 following LCFAs stimulation.

    Alternative splice isoforms for FFAR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FFAR4 Gene

Post-translational modifications for FFAR4 Gene

  • Phosphorylated at two clusters of Ser and Thr residues located in the intracellular C-terminus, a prerequisite for FFAR4 internalization via an ARRB2-dependent pathway.
  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for FFAR4 Gene

No data available for DME Specific Peptides for FFAR4 Gene

Domains & Families for FFAR4 Gene

Gene Families for FFAR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for FFAR4 Gene

InterPro:

Suggested Antigen Peptide Sequences for FFAR4 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor PGR4 (O3FA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5NUL3

UniProtKB/Swiss-Prot:

FFAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FFAR4: view

Function for FFAR4 Gene

Molecular function for FFAR4 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways (PubMed:22282525, PubMed:24742677, PubMed:27852822, PubMed:24817122, PubMed:22343897). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:27852822, PubMed:22343897, PubMed:22282525, PubMed:24742677). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed:22282525, PubMed:24817122). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (By similarity). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (By similarity). Induces differentiation of brown adipocytes probably via autocrine and endocrine functions of FGF21 hormone (By similarity). Activates brown adipocytes by initiating intracellular calcium signaling that leads to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (By similarity). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (By similarity). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (By similarity). In response to dietary fats regulates hormone secretion and appetite (By similarity). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (By similarity). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (By similarity). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (By similarity). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (By similarity). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (PubMed:23809162). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of proinflammatory cytokine release (PubMed:23809162). Mediates LCFAs anti-apoptotic effects (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Receptor for LCFAs decoupled from G-protein signaling. May signal through beta-arrestin pathway. After LCFAs binding, associates with beta-arrestin ARRB2 that may act as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis.

Phenotypes From GWAS Catalog for FFAR4 Gene

Gene Ontology (GO) - Molecular Function for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0005504 fatty acid binding IEA,ISS --
GO:0005515 protein binding IPI --
GO:0008289 lipid binding IEA --
GO:0008527 taste receptor activity IBA 21873635
genes like me logo Genes that share ontologies with FFAR4: view
genes like me logo Genes that share phenotypes with FFAR4: view

Animal Models for FFAR4 Gene

MGI Knock Outs for FFAR4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FFAR4

Clone products for research

  • Addgene plasmids for FFAR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FFAR4 Gene

Localization for FFAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR4 Gene

[Isoform 1]: Cell membrane. Multi-pass membrane protein. Endosome membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein. Note=Sorted to late endosome/lysosome compartments upon internalization. {ECO:0000269 PubMed:22282525}.
[Isoform 2]: Cell membrane. Multi-pass membrane protein. Endosome membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein. Cell projection, cilium membrane. Multi-pass membrane protein. Note=Sorted to late endosome/lysosome compartments upon internalization (PubMed:22282525). Specifically localizes to the primary cilium of undifferentiated adipocytes. Ciliary trafficking is TULP3-dependent. As the cilium is lost during adipogenesis, moves to the plasma membrane (Probable). {ECO:0000269 PubMed:22282525, ECO:0000305 PubMed:31761534}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FFAR4 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 5
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with FFAR4: view

Pathways & Interactions for FFAR4 Gene

genes like me logo Genes that share pathways with FFAR4: view

SIGNOR curated interactions for FFAR4 Gene

Gene Ontology (GO) - Biological Process for FFAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA,ISS --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FFAR4: view

Drugs & Compounds for FFAR4 Gene

(22) Drugs for FFAR4 Gene - From: DrugBank, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fish oil Approved Nutra Target, agonist, inhibits downstream inflammation cascades 0
linoleic acid Approved, Experimental Pharma 0
oleic acid Approved, Investigational, Vet_approved Pharma 0
Myristic acid Experimental Pharma 0
BMS-488043 Investigational Pharma Target 0

(1) Additional Compounds for FFAR4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TC-G 1008
1621175-65-2

(5) Tocris Compounds for FFAR4 Gene

Compound Action Cas Number
Diphenyleneiodonium chloride GPR3 agonist; also inhibits NOS and NADPH oxidases 4673-26-1
PF9 tetrasodium salt Potent GPR17 agonist 851265-78-6
Prosaptide TX14(A) Potent GPR37 and GPR37L1 agonist 196391-82-9
TC-G 1008 Potent and selective GPR39 agonist 1621175-65-2
TC-O 9311 Potent and selective GPR139 agonist 444932-31-4

(7) ApexBio Compounds for FFAR4 Gene

Compound Action Cas Number
4-CMTB 300851-67-6
AH 7614 FFA4/GPR120 antagonist 6326-06-3
GPR120 modulator 1 GPR120 modulator 1050506-75-6
GPR120 modulator 2 GPR120 modulator 1050506-87-0
GSK 137647 FFA4/GPR120 antagonist,potent and selective 349085-82-1
MEDICA 16 87272-20-6
TUG 424 1082058-99-8
genes like me logo Genes that share compounds with FFAR4: view

Drug products for research

Transcripts for FFAR4 Gene

mRNA/cDNA for FFAR4 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FFAR4

Clone products for research

  • Addgene plasmids for FFAR4

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR4 Gene

No ASD Table

Relevant External Links for FFAR4 Gene

GeneLoc Exon Structure for
FFAR4

Expression for FFAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FFAR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FFAR4 Gene

This gene is overexpressed in Pituitary (x12.8) and Colon - Transverse (x9.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FFAR4

SOURCE GeneReport for Unigene cluster for FFAR4 Gene:

Hs.661022

mRNA Expression by UniProt/SwissProt for FFAR4 Gene:

Q5NUL3-FFAR4_HUMAN
Tissue specificity: [Isoform 2]: The predominant isoform in human tissues. Expressed in adipose tissue, pancreatic islets, lung and brain. Expressed in alpha cells of pancreatic islets (PubMed:24742677). Expressed in primary cilia of perivascular preadipocytes of white adipose tissue (at protein level) (PubMed:31761534).

Evidence on tissue expression from TISSUES for FFAR4 Gene

  • Pancreas(2.7)
  • Intestine(2.7)
  • Liver(2.5)
  • Stomach(2.4)
  • Kidney(2.2)
  • Gall bladder(2.2)
  • Nervous system(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FFAR4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FFAR4 Gene

Orthologs for FFAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FFAR4 30
  • 100 (a)
OneToOne
O3FAR1 29
  • 99.82 (n)
Dog
(Canis familiaris)
Mammalia O3FAR1 29
  • 88.58 (n)
FFAR4 30
  • 85 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC533266 29
  • 86.43 (n)
FFAR4 30
  • 83 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ffar4 29
  • 85.19 (n)
Mouse
(Mus musculus)
Mammalia Ffar4 29 16 30
  • 84.95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FFAR4 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves O3FAR1 29
  • 64.34 (n)
FFAR4 30
  • 53 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FFAR4 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ffar4 29
  • 57.7 (n)
Species where no ortholog for FFAR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FFAR4 Gene

ENSEMBL:
Gene Tree for FFAR4 (if available)
TreeFam:
Gene Tree for FFAR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FFAR4: view image
Alliance of Genome Resources:
Additional Orthologs for FFAR4

Paralogs for FFAR4 Gene

(1) SIMAP similar genes for FFAR4 Gene using alignment to 2 proteins:

  • FFAR4_HUMAN
  • S4R3L2_HUMAN
genes like me logo Genes that share paralogs with FFAR4: view

Variants for FFAR4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR4 Gene

FFAR4_HUMAN-Q5NUL3
Genetic variations in FFAR4 define the body mass index quantitative trait locus 10 (BMIQ10) [MIM:607514]. Variance in body mass index is a susceptibility factor for obesity.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FFAR4 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs115724324 Benign: not provided 93,587,293(+) A/G
NM_001195755.2(FFAR4):c.770A>G (p.Gln257Arg)
MISSENSE
rs116454156 Risk Factor: Body mass index quantitative trait locus 10 93,587,284(+) G/Ap.Arg254His
NM_181745.4(FFAR4):c.809G>A (p.Arg270His)
MISSENSE
rs142295722 Benign: not provided 93,587,522(+) T/A
NM_001195755.2(FFAR4):c.999T>A (p.Ile333=)
SYNONYMOUS
rs61866610 -- p.Arg67Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FFAR4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FFAR4 Gene

Variant ID Type Subtype PubMed ID
esv3579075 CNV loss 25503493

Variation tolerance for FFAR4 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FFAR4 Gene

Human Gene Mutation Database (HGMD)
FFAR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FFAR4
Leiden Open Variation Database (LOVD)
FFAR4

SNP Genotyping and Copy Number Assays for research

Disorders for FFAR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FFAR4 Gene - From: OMI, CVR, GTR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search FFAR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FFAR4

genes like me logo Genes that share disorders with FFAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FFAR4 Gene

Publications for FFAR4 Gene

  1. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. (PMID: 15619630) Hirasawa A … Tsujimoto G (Nature medicine 2005) 2 3 4 22
  2. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. (PMID: 22343897) Ichimura A … Froguel P (Nature 2012) 3 4 72
  3. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. (PMID: 20471368) Burns RN … Moniri NH (Biochemical and biophysical research communications 2010) 2 3 4
  4. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. (PMID: 31761534) Hilgendorf KI … Jackson PK (Cell 2019) 3 4
  5. Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population. (PMID: 27068006) Vestmar MA … Hansen T (Journal of medical genetics 2016) 3 72

Products for FFAR4 Gene

  • Addgene plasmids for FFAR4

Sources for FFAR4 Gene