Aliases for FFAR3 Gene

Aliases for FFAR3 Gene

  • Free Fatty Acid Receptor 3 2 3 4 5
  • G-Protein Coupled Receptor 41 3 4
  • FFA3R 2 3
  • GPR41 3 4
  • G Protein-Coupled Receptor 41 2
  • GPR42 3
  • FFAR3 5

External Ids for FFAR3 Gene

Previous HGNC Symbols for FFAR3 Gene

  • GPR41

Previous GeneCards Identifiers for FFAR3 Gene

  • GC19P040542
  • GC19P035850
  • GC19P035851
  • GC19P035960
  • GC19P035504
  • GC19P035514
  • GC19P037088
  • GC19P037261
  • GC19P037333
  • GC19P037805
  • GC19P035523
  • GC19P035542
  • GC19P036135
  • GC19P036272
  • GC19P036443
  • GC19P036615
  • GC19P036777
  • GC19P036926

Summaries for FFAR3 Gene

GeneCards Summary for FFAR3 Gene

FFAR3 (Free Fatty Acid Receptor 3) is a Protein Coding gene. Diseases associated with FFAR3 include Diversion Colitis. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and lipid binding. An important paralog of this gene is GPR42.

UniProtKB/Swiss-Prot Summary for FFAR3 Gene

  • G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).

Gene Wiki entry for FFAR3 Gene

Additional gene information for FFAR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FFAR3 Gene

Genomics for FFAR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FFAR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J035357 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.2 198 0.2 ATF7 CEBPB CREB1 CEBPG RAD21 ATF4 ATF3 ATF2 HLF FFAR3 GPR42
GH19J035352 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.1 -4.6 -4605 2.2 CREB1 GATAD2A CTCF PRDM10 IKZF1 ZNF692 JUND LARP7 ZNF143 PHF21A FFAR1 NONHSAG025575.2 FXYD3 ZNF302 FFAR3 ZNF181 KRTDAP DMKN LIN37 ZNF599
GH19J035374 Enhancer 1.1 Ensembl ENCODE 12.1 +18.0 17995 3.8 RNF2 ARHGAP35 SP1 PRDM10 ZNF512 JUND ZNF143 MTA2 PRDM1 RELA ZNF302 ZNF599 KMT2B ZNF181 ZNF30 LINC00665 CLIP3 HAUS5 PROSER3 ZNF146
GH19J035316 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -39.4 -39419 5 CREB1 GATAD2A TFE3 BACH1 JUND MTA2 ZIC2 PKNOX1 POLR2A REST CD22 MN297586 MAG TMEM147-AS1 HAUS5 ZNF792 KMT2B ZNF599 U2AF1L4 ZNF146
GH19J035380 Enhancer 1.3 Ensembl ENCODE dbSUPER 8 +22.6 22618 1.4 ARHGAP35 GATAD2A TFE3 RFX1 LEF1 IKZF1 RCOR2 JUND DDX20 MTA2 EEF1A1P7 lnc-GPR42-2 FFAR3 GPR42 FFAR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FFAR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FFAR3

Top Transcription factor binding sites by QIAGEN in the FFAR3 gene promoter:
  • AML1a
  • Brachyury
  • GATA-2
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for FFAR3 Gene

Genomic Locations for FFAR3 Gene
chr19:35,358,106-35,360,491
(GRCh38/hg38)
Size:
2,386 bases
Orientation:
Plus strand
chr19:35,849,362-35,851,391
(GRCh37/hg19)
Size:
2,030 bases
Orientation:
Plus strand

Genomic View for FFAR3 Gene

Genes around FFAR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FFAR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FFAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FFAR3 Gene

Proteins for FFAR3 Gene

  • Protein details for FFAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14843-FFAR3_HUMAN
    Recommended name:
    Free fatty acid receptor 3
    Protein Accession:
    O14843
    Secondary Accessions:
    • B2RWM8
    • Q14CM7

    Protein attributes for FFAR3 Gene

    Size:
    346 amino acids
    Molecular mass:
    38649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FFAR3 Gene

Post-translational modifications for FFAR3 Gene

  • Glycosylation at Asn166

Other Protein References for FFAR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FFAR3 Gene

Domains & Families for FFAR3 Gene

Gene Families for FFAR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for FFAR3 Gene

Suggested Antigen Peptide Sequences for FFAR3 Gene

GenScript: Design optimal peptide antigens:
  • Free fatty acid receptor 3 (B0M0K0_HUMAN)
  • G-protein coupled receptor 41 (FFAR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14843

UniProtKB/Swiss-Prot:

FFAR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FFAR3: view

Function for FFAR3 Gene

Molecular function for FFAR3 Gene

UniProtKB/Swiss-Prot Function:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604).

Phenotypes From GWAS Catalog for FFAR3 Gene

Gene Ontology (GO) - Molecular Function for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IDA 12496283
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FFAR3: view
genes like me logo Genes that share phenotypes with FFAR3: view

Animal Models for FFAR3 Gene

MGI Knock Outs for FFAR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FFAR3

CRISPR Products

miRNA for FFAR3 Gene

miRTarBase miRNAs that target FFAR3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FFAR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FFAR3 Gene

Localization for FFAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FFAR3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FFAR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9344866
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FFAR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FFAR3 Gene

Pathways & Interactions for FFAR3 Gene

genes like me logo Genes that share pathways with FFAR3: view

SIGNOR curated interactions for FFAR3 Gene

Activates:

Gene Ontology (GO) - Biological Process for FFAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002385 mucosal immune response ISS --
GO:0002720 positive regulation of cytokine production involved in immune response ISS --
GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus ISS --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with FFAR3: view

Drugs & Compounds for FFAR3 Gene

(10) Drugs for FFAR3 Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Pharma Agonist, Full agonist 139
propanoic acid Approved, Vet_approved Pharma Agonist, Full agonist 0
Butyric Acid Experimental, Investigational Pharma Agonist, Full agonist 25
Isobutyric acid Experimental Pharma Agonist, Full agonist 0
pentanoic acid Pharma Agonist, Full agonist 0

(3) ApexBio Compounds for FFAR3 Gene

Compound Action Cas Number
4-CMTB 300851-67-6
MEDICA 16 87272-20-6
TUG 424 1082058-99-8
genes like me logo Genes that share compounds with FFAR3: view

Drug Products

Transcripts for FFAR3 Gene

mRNA/cDNA for FFAR3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FFAR3

Alternative Splicing Database (ASD) splice patterns (SP) for FFAR3 Gene

No ASD Table

Relevant External Links for FFAR3 Gene

GeneLoc Exon Structure for
FFAR3

Expression for FFAR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FFAR3 Gene

mRNA differential expression in normal tissues according to GTEx for FFAR3 Gene

This gene is overexpressed in Whole Blood (x29.0) and Adipose - Visceral (Omentum) (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FFAR3

SOURCE GeneReport for Unigene cluster for FFAR3 Gene:

Hs.248055

mRNA Expression by UniProt/SwissProt for FFAR3 Gene:

O14843-FFAR3_HUMAN
Tissue specificity: Highest level in adipose tissue, and lower expression across all tissues tested. Expressed in sympathetic ganglia.

Evidence on tissue expression from TISSUES for FFAR3 Gene

  • Nervous system(4.4)
  • Intestine(3.2)
  • Stomach(2.6)
  • Pancreas(2.4)
  • Liver(2.4)
  • Blood(2.3)
  • Kidney(2.3)
  • Lung(2.3)
  • Spleen(2.2)
  • Gall bladder(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with FFAR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FFAR3 Gene

Orthologs for FFAR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FFAR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FFAR3 30
  • 98.94 (n)
-- 31
  • 98 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia FFAR3 30
  • 83.23 (n)
GPR41 31
  • 78 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia FFAR3 30
  • 82.3 (n)
-- 31
  • 73 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ffar3 30 17 31
  • 76.58 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Ffar3 30
  • 75.58 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 60 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489751 30
  • 54.32 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100333904 30
  • 55.1 (n)
si:ch73-90p23.1 31
  • 47 (a)
ManyToMany
CU855821.1 31
  • 43 (a)
ManyToMany
CU855821.2 31
  • 41 (a)
ManyToMany
si:dkey-211g8.6 31
  • 39 (a)
ManyToMany
si:dkey-211g8.7 31
  • 34 (a)
ManyToMany
Species where no ortholog for FFAR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FFAR3 Gene

ENSEMBL:
Gene Tree for FFAR3 (if available)
TreeFam:
Gene Tree for FFAR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FFAR3: view image

Paralogs for FFAR3 Gene

(8) SIMAP similar genes for FFAR3 Gene using alignment to 2 proteins:

  • FFAR3_HUMAN
  • B0M0K0_HUMAN
genes like me logo Genes that share paralogs with FFAR3: view

Variants for FFAR3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FFAR3 Gene

FFAR3_HUMAN-O14843
The 6 amino acid differences at positions 44, 45, 174, 227, 256 and 346 between GPR42 and FFAR3, are polymorphic in the human population. The frequency of the probable inactive allele of FFAR3, with a Trp at position 174 was estimated to 1%.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FFAR3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
768984 Benign: not provided 35,359,024(+) G/A MISSENSE_VARIANT
769969 Likely Benign: not provided 35,359,658(+) G/A SYNONYMOUS_VARIANT
771218 Benign: not provided 35,359,809(+) A/G MISSENSE_VARIANT
774735 Likely Benign: not provided 35,359,493(+) C/T SYNONYMOUS_VARIANT
rs1170582382 - p.Ala256Val

Additional dbSNP identifiers (rs#s) for FFAR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FFAR3 Gene

Variant ID Type Subtype PubMed ID
dgv141n111 CNV deletion 26073780
dgv3518n100 CNV gain+loss 25217958
dgv3519n100 CNV loss 25217958
dgv3520n100 CNV gain 25217958
dgv3521n100 CNV loss 25217958
dgv637e199 CNV deletion 23128226
dgv6420n54 CNV gain 21841781
esv2421571 CNV deletion 20811451
esv25268 CNV loss 19812545
esv2718493 CNV deletion 23290073
esv2758758 CNV loss 17122850
esv2760519 CNV loss 21179565
esv2762943 CNV gain+loss 21179565
esv32683 CNV gain+loss 17666407
esv3574419 CNV gain 25503493
nsv1160606 CNV deletion 26073780
nsv173 CNV deletion 15895083
nsv2471 CNV deletion 18451855
nsv442764 CNV gain+loss 18776908
nsv498899 CNV loss 21111241
nsv510765 CNV deletion 20534489
nsv514897 CNV loss 21397061
nsv820224 CNV gain 19587683
nsv828536 CNV loss 20364138
nsv828537 CNV loss 20364138
nsv833810 CNV gain 17160897
nsv833811 CNV gain 17160897
nsv953284 CNV deletion 24416366
nsv9712 CNV loss 18304495
nsv978808 CNV duplication 23825009

Variation tolerance for FFAR3 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FFAR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FFAR3

SNP Genotyping and Copy Number Assay Products

Disorders for FFAR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FFAR3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diversion colitis
- elite association - COSMIC cancer census association via MalaCards
Search FFAR3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FFAR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FFAR3 Gene

Publications for FFAR3 Gene

  1. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. (PMID: 12711604) Le Poul E … Detheux M (The Journal of biological chemistry 2003) 3 4 23
  2. A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. (PMID: 9344866) Sawzdargo M … O'Dowd BF (Biochemical and biophysical research communications 1997) 2 3 4
  3. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. (PMID: 23066016) Hudson BD … Milligan G (The Journal of biological chemistry 2012) 3 4
  4. GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins. (PMID: 22493486) Bahar Halpern K … Walker MD (The Journal of biological chemistry 2012) 2 3
  5. Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42. (PMID: 19630535) Liaw CW … Connolly DT (DNA and cell biology 2009) 3 4

Products for FFAR3 Gene

Sources for FFAR3 Gene