Aliases for FFAR1 Gene
External Ids for FFAR1 Gene
Previous HGNC Symbols for FFAR1 Gene
Previous GeneCards Identifiers for FFAR1 Gene
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
GeneCards Summary for FFAR1 Gene
FFAR1 (Free Fatty Acid Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is FFAR3.
UniProtKB/Swiss-Prot Summary for FFAR1 Gene
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Free Fatty Acid (FFA) receptors are a group of Gq/11 protein-coupled receptors currently classified into FFA1, FFA2, FFA3 and FFA4 subtypes. FFA receptors are concentrated in pancreatic islet cells, immune cells and in the brain and are important in immunity and metabolism.