Aliases for FEZF2 Gene

Aliases for FEZF2 Gene

  • FEZ Family Zinc Finger 2 2 3 5
  • Zinc Finger Protein 312 2 3 4
  • Forebrain Embryonic Zinc Finger-Like Protein 2 3 4
  • Fez Family Zinc Finger Protein 2 3 4
  • ZNF312 3 4
  • FEZL 3 4
  • Testis Tissue Sperm-Binding Protein Li 80P 3
  • Zinc Finger Protein Fez-Like 4
  • FKSG36 3
  • ZFP312 3
  • FEZ 3
  • TOF 3

External Ids for FEZF2 Gene

Previous HGNC Symbols for FEZF2 Gene

  • ZNF312

Previous GeneCards Identifiers for FEZF2 Gene

  • GC03M062331

Summaries for FEZF2 Gene

GeneCards Summary for FEZF2 Gene

FEZF2 (FEZ Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with FEZF2 include Uterine Inversion and Thymic Dysplasia. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is FEZF1.

UniProtKB/Swiss-Prot Summary for FEZF2 Gene

  • Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).

Additional gene information for FEZF2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FEZF2 Gene

Genomics for FEZF2 Gene

GeneHancer (GH) Regulatory Elements for FEZF2 Gene

Promoters and enhancers for FEZF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J062374 Promoter/Enhancer 1.2 VISTA Ensembl ENCODE 500.7 -0.2 -176 1 EZH2 CBX8 SUZ12 MAZ RNF2 JUN CTBP2 POLR2A FEZF2 LOC105377647
GH03J062373 Promoter 0.7 EPDnew 500.7 +1.2 1229 0.1 ZBTB26 ZNF335 MAZ ZNF398 RNF2 SUZ12 EZH2 PRDM10 FEZF2 PTPRG-AS1
GH03J062375 Promoter 0.6 EPDnew 500.7 +0.8 754 0.1 EZH2 CBX8 RNF2 SUZ12 CTBP2 FEZF2 PTPRG-AS1
GH03J062435 Enhancer 0.7 FANTOM5 Ensembl 4.3 -62.4 -62377 2.6 ESRRA RAD21 SMARCE1 CTCF ZSCAN4 BMI1 ZSCAN29 CADPS FEZF2 C3orf14 lnc-FEZF2-2 RF00017-4031
GH03J062441 Enhancer 0.3 FANTOM5 3.3 -67.6 -67613 0.4 ZFX CADPS FEZF2 lnc-FEZF2-2 RF00017-4031
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FEZF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FEZF2

Top Transcription factor binding sites by QIAGEN in the FEZF2 gene promoter:
  • AML1a
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for FEZF2 Gene

Genomic Locations for FEZF2 Gene
chr3:62,369,672-62,374,324
(GRCh38/hg38)
Size:
4,653 bases
Orientation:
Minus strand
chr3:62,355,347-62,359,999
(GRCh37/hg19)
Size:
4,653 bases
Orientation:
Minus strand

Genomic View for FEZF2 Gene

Genes around FEZF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEZF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEZF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEZF2 Gene

Proteins for FEZF2 Gene

  • Protein details for FEZF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBJ5-FEZF2_HUMAN
    Recommended name:
    Fez family zinc finger protein 2
    Protein Accession:
    Q8TBJ5
    Secondary Accessions:
    • A8K349
    • Q9BZ91
    • Q9NWB9

    Protein attributes for FEZF2 Gene

    Size:
    459 amino acids
    Molecular mass:
    48811 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FEZF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FEZF2 Gene

Post-translational modifications for FEZF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEZF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEZF2 Gene

Domains & Families for FEZF2 Gene

Gene Families for FEZF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FEZF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FEZF2 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein Fez-like (FEZF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TBJ5

UniProtKB/Swiss-Prot:

FEZF2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with FEZF2: view

Function for FEZF2 Gene

Molecular function for FEZF2 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).

Gene Ontology (GO) - Molecular Function for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with FEZF2: view
genes like me logo Genes that share phenotypes with FEZF2: view

Animal Models for FEZF2 Gene

MGI Knock Outs for FEZF2:

Clone Products

  • Addgene plasmids for FEZF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEZF2 Gene

Localization for FEZF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEZF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEZF2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with FEZF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FEZF2 Gene

Pathways & Interactions for FEZF2 Gene

PathCards logo

SuperPathways for FEZF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FEZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007413 axonal fasciculation IEA --
GO:0007626 locomotory behavior IEA --
genes like me logo Genes that share ontologies with FEZF2: view

No data available for Pathways by source and SIGNOR curated interactions for FEZF2 Gene

Drugs & Compounds for FEZF2 Gene

No Compound Related Data Available

Transcripts for FEZF2 Gene

mRNA/cDNA for FEZF2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for FEZF2

Alternative Splicing Database (ASD) splice patterns (SP) for FEZF2 Gene

No ASD Table

Relevant External Links for FEZF2 Gene

GeneLoc Exon Structure for
FEZF2

Expression for FEZF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEZF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEZF2 Gene

This gene is overexpressed in Brain - Hippocampus (x14.2), Brain - Anterior cingulate cortex (BA24) (x9.3), Brain - Amygdala (x7.4), Brain - Cortex (x7.2), and Brain - Frontal Cortex (BA9) (x6.5).

Protein differential expression in normal tissues from HIPED for FEZF2 Gene

This gene is overexpressed in Brain (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FEZF2 Gene



Protein tissue co-expression partners for FEZF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FEZF2

SOURCE GeneReport for Unigene cluster for FEZF2 Gene:

Hs.241523

Evidence on tissue expression from TISSUES for FEZF2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with FEZF2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEZF2 Gene

Orthologs for FEZF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FEZF2 31 30
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FEZF2 31 30
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FEZF2 31 30
  • 93.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fezf2 30
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Fezf2 17 31 30
  • 90.75 (n)
oppossum
(Monodelphis domestica)
Mammalia FEZF2 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FEZF2 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FEZF2 31 30
  • 78.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FEZF2 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fezf2 30
  • 73.1 (n)
Str.17861 30
zebrafish
(Danio rerio)
Actinopterygii fezf2 31 30
  • 70.39 (n)
OneToOne
fezl 30
fruit fly
(Drosophila melanogaster)
Insecta erm 31
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fezf-1 31
  • 66 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 78 (a)
OneToMany
Species where no ortholog for FEZF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEZF2 Gene

ENSEMBL:
Gene Tree for FEZF2 (if available)
TreeFam:
Gene Tree for FEZF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FEZF2: view image

Paralogs for FEZF2 Gene

Variants for FEZF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FEZF2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
717184 Likely Benign: not provided 62,372,524(-) G/C SYNONYMOUS_VARIANT
791932 Benign: not provided 62,372,545(-) G/GCCGCCGCCT INFRAME_INSERTION
rs17852031 - p.Pro164Thr
rs17852032 - p.Ser250Trp
rs199850439 - p.Gly188Asp

Additional dbSNP identifiers (rs#s) for FEZF2 Gene

Variation tolerance for FEZF2 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEZF2 Gene

Human Gene Mutation Database (HGMD)
FEZF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEZF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FEZF2 Gene

Disorders for FEZF2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FEZF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uterine inversion
  • inversion of uterus during delivery
thymic dysplasia
eyelid carcinoma
  • carcinoma of the eyelid
partial fetal alcohol syndrome
anterograde amnesia
  • amnesia, anterograde
- elite association - COSMIC cancer census association via MalaCards
Search FEZF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FEZF2

genes like me logo Genes that share disorders with FEZF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FEZF2 Gene

Publications for FEZF2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. (PMID: 29228324) Li Z … Dang Y (Nucleic acids research 2018) 3 54
  3. Loss of Fezf2 promotes malignant progression of bladder cancer by regulating the NF-κB signaling pathway. (PMID: 29925938) Chen Z … Hou T (Laboratory investigation; a journal of technical methods and pathology 2018) 3 54
  4. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. (PMID: 26544942) Takaba H … Takayanagi H (Cell 2015) 3 54
  5. Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system. (PMID: 24913420) Eckler MJ … Chen B (BioEssays : news and reviews in molecular, cellular and developmental biology 2014) 3 54

Products for FEZF2 Gene

Sources for FEZF2 Gene