Aliases for FEZ1 Gene
External Ids for FEZ1 Gene
Previous GeneCards Identifiers for FEZ1 Gene
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for FEZ1 Gene
FEZ1 (Fasciculation And Elongation Protein Zeta 1) is a Protein Coding gene. Diseases associated with FEZ1 include Lissencephaly 1 and Schizophrenia. Among its related pathways are Neuroscience and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and gamma-tubulin binding. An important paralog of this gene is FEZ2.
UniProtKB/Swiss-Prot Summary for FEZ1 Gene
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.