FEZ1 Gene (Protein Coding)

Fasciculation And Elongation Protein Zeta 1

GC11M125445
GIFtS:
38
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alte... See more...

Aliases for FEZ1 Gene

Aliases for FEZ1 Gene

  • Fasciculation And Elongation Protein Zeta 1 2 3 5
  • Zygin I 2 3 4
  • Fasciculation And Elongation Protein Zeta-1 3 4
  • Zygin-1 3 4
  • UNC-76 2 3
  • FEZ1 5

External Ids for FEZ1 Gene

Previous GeneCards Identifiers for FEZ1 Gene

  • GC11M127316
  • GC11M126828
  • GC11M125349
  • GC11M124853
  • GC11M124820
  • GC11M121257
  • GC11M125316

Summaries for FEZ1 Gene

Entrez Gene Summary for FEZ1 Gene

  • This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEZ1 Gene

FEZ1 (Fasciculation And Elongation Protein Zeta 1) is a Protein Coding gene. Diseases associated with FEZ1 include Lissencephaly 1 and Schizophrenia. Among its related pathways are Neuroscience and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and gamma-tubulin binding. An important paralog of this gene is FEZ2.

UniProtKB/Swiss-Prot Summary for FEZ1 Gene

  • May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Gene Wiki entry for FEZ1 Gene

Additional gene information for FEZ1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FEZ1 Gene

Genomics for FEZ1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FEZ1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FEZ1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FEZ1

Top Transcription factor binding sites by QIAGEN in the FEZ1 gene promoter:
  • ATF-2
  • c-Jun
  • c-Myc
  • FAC1
  • Max1
  • MRF-2
  • MZF-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for FEZ1 Gene

Genomic Locations for FEZ1 Gene
chr11:125,442,881-125,592,568
(GRCh38/hg38)
Size:
149,688 bases
Orientation:
Minus strand
chr11:125,315,641-125,366,213
(GRCh37/hg19)
Size:
50,573 bases
Orientation:
Minus strand

Genomic View for FEZ1 Gene

Genes around FEZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEZ1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FEZ1 Gene

Proteins for FEZ1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FEZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99689-FEZ1_HUMAN
    Recommended name:
    Fasciculation and elongation protein zeta-1
    Protein Accession:
    Q99689
    Secondary Accessions:
    • O00679
    • O00728
    • Q6IBI7

    Protein attributes for FEZ1 Gene

    Size:
    392 amino acids
    Molecular mass:
    45119 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation.

    Alternative splice isoforms for FEZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FEZ1 Gene

Protein Expression for FEZ1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FEZ1 Gene

  • Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.
  • Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FEZ1
  • Boster Bio Antibodies for FEZ1

No data available for DME Specific Peptides for FEZ1 Gene

Domains & Families for FEZ1 Gene

Gene Families for FEZ1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FEZ1 Gene

InterPro:
Blocks:
  • FEZ-like
ProtoNet:

Suggested Antigen Peptide Sequences for FEZ1 Gene

GenScript: Design optimal peptide antigens:
  • Zygin-1 (FEZ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99689

UniProtKB/Swiss-Prot:

FEZ1_HUMAN :
  • Belongs to the zygin family.
Family:
  • Belongs to the zygin family.
genes like me logo Genes that share domains with FEZ1: view

Function for FEZ1 Gene

Products:

  1. Animal Model
  2. CRISPR
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  6. Cell Line

Molecular function for FEZ1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.

Phenotypes From GWAS Catalog for FEZ1 Gene

Gene Ontology (GO) - Molecular Function for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI 14690447
GO:0043015 gamma-tubulin binding IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with FEZ1: view
genes like me logo Genes that share phenotypes with FEZ1: view

Animal Models for FEZ1 Gene

MGI Knock Outs for FEZ1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEZ1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEZ1 Gene

Localization for FEZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEZ1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEZ1 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 4
golgi apparatus 4
mitochondrion 3
nucleus 3
cytosol 3
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA 25495476
GO:0005813 centrosome IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with FEZ1: view

Pathways & Interactions for FEZ1 Gene

PathCards logo

SuperPathways for FEZ1 Gene

genes like me logo Genes that share pathways with FEZ1: view

Pathways by source for FEZ1 Gene

2 Cell Signaling Technology pathways for FEZ1 Gene

Gene Ontology (GO) - Biological Process for FEZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9096408
GO:0007399 nervous system development TAS 9096408
GO:0007411 axon guidance TAS 9096408
GO:0010976 positive regulation of neuron projection development IEA --
GO:0021766 hippocampus development IEA --
genes like me logo Genes that share ontologies with FEZ1: view

No data available for SIGNOR curated interactions for FEZ1 Gene

Drugs & Compounds for FEZ1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FEZ1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FEZ1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEZ1

Alternative Splicing Database (ASD) splice patterns (SP) for FEZ1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - -
SP11: -
SP12:
SP13: - -
SP14:
SP15: -

ExUns: 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FEZ1 Gene

GeneLoc Exon Structure for
FEZ1

Expression for FEZ1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEZ1 Gene

mRNA expression in normal human tissues for FEZ1 Gene
mRNA expression by GTEx for FEZ1 GenemRNA expression by BioGPS for FEZ1 Gene

mRNA differential expression in normal tissues according to GTEx for FEZ1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.5) and Brain - Substantia nigra (x5.3).

Protein differential expression in normal tissues from HIPED for FEZ1 Gene

This gene is overexpressed in Frontal cortex (39.2), Fetal Brain (12.3), Platelet (9.2), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FEZ1 Gene



Protein tissue co-expression partners for FEZ1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FEZ1

SOURCE GeneReport for Unigene cluster for FEZ1 Gene:

Hs.224008

mRNA Expression by UniProt/SwissProt for FEZ1 Gene:

Q99689-FEZ1_HUMAN
Tissue specificity: Mainly expressed in brain.

Evidence on tissue expression from TISSUES for FEZ1 Gene

  • Nervous system(4.8)
  • Pancreas(4.2)
  • Eye(2.4)
  • Adrenal gland(2.3)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with FEZ1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FEZ1 Gene

Orthologs for FEZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FEZ1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FEZ1 30 31
  • 99.57 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FEZ1 30 31
  • 93.96 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FEZ1 30 31
  • 92.35 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FEZ1 31
  • 92 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fez1 30
  • 91.33 (n)
Mouse
(Mus musculus)
 Mammalia Fez1 30 17 31
  • 91.16 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FEZ1 31
  • 81 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FEZ1 30 31
  • 67.9 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FEZ1 31
  • 81 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fez1 30
  • 73.83 (n)
Zebrafish
(Danio rerio)
 Actinopterygii fez1 30 31
  • 70.21 (n)
 OneToOne
Dr.27157 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Unc-76 31
  • 24 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea unc-76 31
  • 28 (a)
 OneToMany
Species where no ortholog for FEZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FEZ1 Gene

ENSEMBL:
Gene Tree for FEZ1 (if available)
TreeFam:
Gene Tree for FEZ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FEZ1: view image

Paralogs for FEZ1 Gene

Paralogs for FEZ1 Gene

(2) SIMAP similar genes for FEZ1 Gene using alignment to 3 proteins:

  • FEZ1_HUMAN
  • E9PNH2_HUMAN
  • J3KTR6_HUMAN
genes like me logo Genes that share paralogs with FEZ1: view

Variants for FEZ1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FEZ1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
716326 Benign: not provided 125,454,123(-) C/T INTRON_VARIANT
717005 Benign: not provided 125,452,365(-) G/A SYNONYMOUS_VARIANT
782872 Benign: not provided 125,446,118(-) C/T INTRON_VARIANT
786218 Benign: not provided 125,452,358(-) C/G MISSENSE_VARIANT
rs597570 - p.Asp123Glu

Additional dbSNP identifiers (rs#s) for FEZ1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FEZ1 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV gain+loss 17666407
nsv1141206 CNV deletion 24896259
nsv532 CNV deletion 18451855

Variation tolerance for FEZ1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEZ1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEZ1 Gene

Disorders for FEZ1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FEZ1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FEZ1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FEZ1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FEZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FEZ1 Gene

Publications for FEZ1 Gene

  1. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. (PMID: 17374448) Koga M … Arinami T (Neuroscience letters 2007) 3 23 41
  2. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann EM … Kobarg J (The Journal of biological chemistry 2006) 3 4 23
  3. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. (PMID: 15843383) Suzuki T … Sawa H (The Journal of biological chemistry 2005) 2 3 23
  4. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. (PMID: 9096408) Bloom L … Horvitz HR (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4
  5. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. (PMID: 24098481) Behrens C … Kühnel K (PloS one 2013) 3 4

ExternalLinks

View latest publications for FEZ1 gene in Mastermind

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