This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathog... See more...

Aliases for FEV Gene

Aliases for FEV Gene

  • FEV Transcription Factor, ETS Family Member 2 3 5
  • PC12 ETS Domain-Containing Transcription Factor 1 3 4
  • FEV, ETS Transcription Factor 2 3
  • Fifth Ewing Variant Protein 3 4
  • FEV (ETS Oncogene Family) 2 3
  • Protein FEV 3 4
  • Pet-1 2 4
  • FEV (Fifth Ewing Variant) 2
  • PC12 ETS Factor 1 4
  • HSRNAFEV 3
  • PET-1 3
  • PET1 4
  • FEV 5

External Ids for FEV Gene

Previous GeneCards Identifiers for FEV Gene

  • GC02M220050
  • GC02M219671
  • GC02M219554
  • GC02M219845
  • GC02M211699

Summaries for FEV Gene

Entrez Gene Summary for FEV Gene

  • This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

GeneCards Summary for FEV Gene

FEV (FEV Transcription Factor, ETS Family Member) is a Protein Coding gene. Diseases associated with FEV include Sudden Infant Death Syndrome and Ewing Sarcoma. Among its related pathways are Transcriptional misregulation in cancer and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is FLI1.

UniProtKB/Swiss-Prot Summary for FEV Gene

  • Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FEV Gene

Genomics for FEV Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FEV Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218986 Promoter 1 EPDnew Ensembl 250.7 -0.1 -104 0.2 GLIS1 ATF1 ZNF692 PATZ1 CHD2 EZH2 ZNF335 ZBTB26 FEV lnc-CDK5R2-4 CRYBA2 LINC00608
GH02J218985 Promoter 0.9 EPDnew 250.7 -0.7 -687 0.1 IKZF1 ZNF223 ETS1 ZNF341 YY1 FOXM1 HDAC2 EGR1 SP1 GATA2 FEV lnc-CDK5R2-4 CRYBA2 HSALNG0022321 LINC00608
GH02J218987 Promoter 0.9 EPDnew 250.7 -0.4 -397 0.1 IKZF1 ETS1 HES1 YY1 FOXM1 HDAC2 GLIS1 POU5F1 ZNF366 SMARCE1 FEV lnc-CDK5R2-4 CRYBA2 LINC00608
GH02J218983 Promoter 0.6 Ensembl 250.7 +1.7 1683 0.6 EZH2 CBX8 POLR2A FEV LINC00608 CDK5R2
GH02J218908 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.8 +75.5 75548 2.3 BCLAF1 SP1 MYC ZNF600 ZNF580 ZNF592 ZMYM3 KLF9 POLR2A ZNF10 HSALNG0022314-001 HSALNG0022314-002 lnc-WNT10A-4 STK36 ZNF142 CNOT9 AAMP OBSL1 CDK5R2 ENSG00000235024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FEV on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FEV

Top Transcription factor binding sites by QIAGEN in the FEV gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • NRSF form 1
  • NRSF form 2
  • Spz1

Genomic Locations for FEV Gene

Latest Assembly
chr2:218,981,087-218,985,184
(GRCh38/hg38)
Size:
4,098 bases
Orientation:
Minus strand

Previous Assembly
chr2:219,845,809-219,849,906
(GRCh37/hg19 by Entrez Gene)
Size:
4,098 bases
Orientation:
Minus strand

chr2:219,845,809-219,850,379
(GRCh37/hg19 by Ensembl)
Size:
4,571 bases
Orientation:
Minus strand

Genomic View for FEV Gene

Genes around FEV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEV Gene

Proteins for FEV Gene

  • Protein details for FEV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99581-FEV_HUMAN
    Recommended name:
    Protein FEV
    Protein Accession:
    Q99581

    Protein attributes for FEV Gene

    Size:
    238 amino acids
    Molecular mass:
    25030 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FEV Gene

neXtProt entry for FEV Gene

Post-translational modifications for FEV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FEV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEV Gene

Domains & Families for FEV Gene

Gene Families for FEV Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FEV Gene

Suggested Antigen Peptide Sequences for FEV Gene

GenScript: Design optimal peptide antigens:
  • PC12 ETS domain-containing transcription factor 1 (FEV_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99581

UniProtKB/Swiss-Prot:

FEV_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FEV: view

Function for FEV Gene

Molecular function for FEV Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
GENATLAS Biochemistry:
fused with EWS in complex translocation t(2;21;22),only detected in adult prostate and small intestine

Phenotypes From GWAS Catalog for FEV Gene

Gene Ontology (GO) - Molecular Function for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:1990837 sequence-specific double-stranded DNA binding IDA 28473536
genes like me logo Genes that share ontologies with FEV: view
genes like me logo Genes that share phenotypes with FEV: view

Animal Models for FEV Gene

MGI Knock Outs for FEV:
  • Fev Fev<tm1Esd>
  • Fev Fev<tm2.1Esd>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEV

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FEV Gene

Localization for FEV Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEV Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEV gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FEV: view

Pathways & Interactions for FEV Gene

genes like me logo Genes that share pathways with FEV: view

Pathways by source for FEV Gene

SIGNOR curated interactions for FEV Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FEV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with FEV: view

Drugs & Compounds for FEV Gene

No Compound Related Data Available

Transcripts for FEV Gene

mRNA/cDNA for FEV Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEV

Alternative Splicing Database (ASD) splice patterns (SP) for FEV Gene

No ASD Table

Relevant External Links for FEV Gene

GeneLoc Exon Structure for
FEV

Expression for FEV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEV Gene

This gene is overexpressed in Pituitary (x9.3), Prostate (x6.8), Brain - Putamen (basal ganglia) (x5.1), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FEV

SOURCE GeneReport for Unigene cluster for FEV Gene:

Hs.234759

mRNA Expression by UniProt/SwissProt for FEV Gene:

Q99581-FEV_HUMAN
Tissue specificity: In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine.

Evidence on tissue expression from TISSUES for FEV Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FEV: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEV Gene

Orthologs for FEV Gene

This gene was present in the common ancestor of animals.

Orthologs for FEV Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FEV 29
  • 99.12 (n)
Cow
(Bos Taurus)
Mammalia FEV 29 30
  • 91.56 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FEV 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fev 29 16 30
  • 90.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fev 29
  • 89.17 (n)
Chicken
(Gallus gallus)
Aves LOC100857480 29
  • 77.62 (n)
FEV 30
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 24 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fev 29
  • 73.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii fev 29 30
  • 72.14 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ets65A 30
  • 24 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ets-5 30
  • 39 (a)
ManyToMany
ast-1 30
  • 24 (a)
ManyToMany
Species where no ortholog for FEV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FEV Gene

ENSEMBL:
Gene Tree for FEV (if available)
TreeFam:
Gene Tree for FEV (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FEV: view image
Alliance of Genome Resources:
Additional Orthologs for FEV

Paralogs for FEV Gene

(15) SIMAP similar genes for FEV Gene using alignment to 1 proteins:

  • FEV_HUMAN
genes like me logo Genes that share paralogs with FEV: view

Variants for FEV Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FEV Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs145426408 Benign: not provided 218,981,970(-) C/A
NM_017521.3(FEV):c.414G>T (p.Pro138=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FEV Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FEV Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Variation tolerance for FEV Gene

Gene Damage Index Score: 0.25; 5.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEV Gene

Human Gene Mutation Database (HGMD)
FEV
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEV
Leiden Open Variation Database (LOVD)
FEV

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEV Gene

Disorders for FEV Gene

MalaCards: The human disease database

(8) MalaCards diseases for FEV Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sudden infant death syndrome
  • sids
ewing sarcoma
  • es
febrile seizures, familial, 7
  • feb7
anxiety
  • anxiety disorder
large intestine lipoma
  • lipoma of large intestine
- elite association - COSMIC cancer census association via MalaCards
Search FEV in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FEV_HUMAN
  • Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. {ECO:0000269 PubMed:17597646}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. {ECO:0000269 PubMed:9121764}.

Additional Disease Information for FEV

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FEV: view

No data available for Genatlas for FEV Gene

Publications for FEV Gene

  1. A new member of the ETS family fused to EWS in Ewing tumors. (PMID: 9121764) Peter M … Delattre O (Oncogene 1997) 2 3 4 22
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 40
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 40
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 40
  5. Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population. (PMID: 19707175) Broadbelt KG … Beggs AH (Pediatric research 2009) 3 40

Products for FEV Gene

Sources for FEV Gene