Aliases for FETUB Gene
External Ids for FETUB Gene
Previous GeneCards Identifiers for FETUB Gene
The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for FETUB Gene
FETUB (Fetuin B) is a Protein Coding gene. Diseases associated with FETUB include Encephalitozoonosis and Ureteral Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is HRG.
UniProtKB/Swiss-Prot Summary for FETUB Gene
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).