The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. ... See more...

Aliases for FETUB Gene

Aliases for FETUB Gene

  • Fetuin B 2 3 5
  • Fetuin-Like Protein IRL685 3 4
  • Fetuin-B 3 4
  • 16G2 3 4
  • Gugu 3 4
  • IRL685 3

External Ids for FETUB Gene

Previous GeneCards Identifiers for FETUB Gene

  • GC03P183129
  • GC03P187615
  • GC03P187760
  • GC03P187679
  • GC03P187840
  • GC03P186353
  • GC03P183767

Summaries for FETUB Gene

Entrez Gene Summary for FETUB Gene

  • The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FETUB Gene

FETUB (Fetuin B) is a Protein Coding gene. Diseases associated with FETUB include Encephalitozoonosis and Ureteral Benign Neoplasm. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is HRG.

UniProtKB/Swiss-Prot Summary for FETUB Gene

  • Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Wiki entry for FETUB Gene

Additional gene information for FETUB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FETUB Gene

Genomics for FETUB Gene

GeneHancer (GH) Regulatory Elements for FETUB Gene

Promoters and enhancers for FETUB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J186640 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 517.2 +4.8 4769 1.6 NR2F2 FOS JUND STAT3 FOSL2 REST RXRA MAX HNF4A FOXA1 FETUB AHSG KNG1 RFC4 ENSG00000231724 ADIPOQ piR-32285-068 LOC105374258 ENSG00000197099
GH03J186635 Promoter 0.6 EPDnew 500.7 +0.1 118 0.1 HNF4A RXRA ATF3 FETUB piR-32285-068 ENSG00000197099
GH03J186752 Promoter/Enhancer 1.2 Ensembl ENCODE 10.6 +118.3 118306 3.9 ZNF217 CTCF ZSCAN5C FOS TRIM28 TARDBP REST CUX1 CTBP1 EP300 LOC105374259 EIF4A2 KNG1 SNORA63 SNORA63B SNORA81 RFC4 FETUB ENSG00000231724 AHSG
GH03J186663 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 10.1 +28.9 28909 2.9 FOXK2 EP300 NCOR1 TEAD4 TEAD1 FOXA2 POLR2A NR2F2 ZBTB33 JUND HRG KNG1 FETUB AHSG piR-37567-129 LOC100533663 lnc-HRG-2 LOC105374258 ENSG00000197099
GH03J186597 Enhancer 1.1 Ensembl ENCODE 11 -36.2 -36182 3.4 POLR2G NCOR1 KDM6A TCF7 ZBTB25 ZBTB7A SKI TEAD1 ZKSCAN8 ZSCAN9 FETUB KNG1 HRG ENSG00000283390 piR-50444-330 ENSG00000197099
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FETUB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FETUB

Top Transcription factor binding sites by QIAGEN in the FETUB gene promoter:
  • AML1a
  • Chx10
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXO4
  • Sox9

Genomic Locations for FETUB Gene

Genomic Locations for FETUB Gene
chr3:186,635,832-186,653,141
(GRCh38/hg38)
Size:
17,310 bases
Orientation:
Plus strand
chr3:186,353,758-186,370,930
(GRCh37/hg19)
Size:
17,173 bases
Orientation:
Plus strand

Genomic View for FETUB Gene

Genes around FETUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FETUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FETUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FETUB Gene

Proteins for FETUB Gene

  • Protein details for FETUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGM5-FETUB_HUMAN
    Recommended name:
    Fetuin-B
    Protein Accession:
    Q9UGM5
    Secondary Accessions:
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58
    • Q6GRB6
    • Q9Y6Z0

    Protein attributes for FETUB Gene

    Size:
    382 amino acids
    Molecular mass:
    42055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FETUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FETUB Gene

Post-translational modifications for FETUB Gene

  • Glycosylation at Asn37, Asn136, Asn182, Thr289, and Thr292
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FETUB_HUMAN (1234)

No data available for DME Specific Peptides for FETUB Gene

Domains & Families for FETUB Gene

Gene Families for FETUB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FETUB Gene

Blocks:
  • Cysteine protease inhibitor
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FETUB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50352, highly similar to Fetuin-B (B7Z8T3_HUMAN)
  • Gugu (FETUB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UGM5

UniProtKB/Swiss-Prot:

FETUB_HUMAN :
  • Belongs to the fetuin family.
Family:
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with FETUB: view

Function for FETUB Gene

Molecular function for FETUB Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Phenotypes From GWAS Catalog for FETUB Gene

Gene Ontology (GO) - Molecular Function for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004857 enzyme inhibitor activity IEA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity ISS,IBA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with FETUB: view
genes like me logo Genes that share phenotypes with FETUB: view

Animal Models for FETUB Gene

MGI Knock Outs for FETUB:

Animal Model Products

  • Taconic Biosciences Mouse Models for FETUB

CRISPR Products

miRNA for FETUB Gene

miRTarBase miRNAs that target FETUB

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FETUB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FETUB Gene

Localization for FETUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FETUB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FETUB gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA 21873635
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with FETUB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FETUB Gene

Pathways & Interactions for FETUB Gene

PathCards logo

SuperPathways for FETUB Gene

No Data Available

Interacting Proteins for FETUB Gene

;

Gene Ontology (GO) - Biological Process for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization ISS --
GO:0007339 binding of sperm to zona pellucida IBA,ISS --
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

No data available for Pathways by source and SIGNOR curated interactions for FETUB Gene

Drugs & Compounds for FETUB Gene

No Compound Related Data Available

Transcripts for FETUB Gene

mRNA/cDNA for FETUB Gene

9 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FETUB

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FETUB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for FETUB Gene

GeneLoc Exon Structure for
FETUB

Expression for FETUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FETUB Gene

mRNA differential expression in normal tissues according to GTEx for FETUB Gene

This gene is overexpressed in Liver (x42.6).

Protein differential expression in normal tissues from HIPED for FETUB Gene

This gene is overexpressed in Serum (26.9), Plasma (14.9), and Synovial fluid (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FETUB Gene



Protein tissue co-expression partners for FETUB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FETUB

SOURCE GeneReport for Unigene cluster for FETUB Gene:

Hs.81073

mRNA Expression by UniProt/SwissProt for FETUB Gene:

Q9UGM5-FETUB_HUMAN
Tissue specificity: Liver and testis.

Evidence on tissue expression from TISSUES for FETUB Gene

  • Liver(4.7)
  • Bone marrow(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FETUB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FETUB Gene

Orthologs for FETUB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FETUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FETUB 31 30
  • 98.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FETUB 31 30
  • 79.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FETUB 31 30
  • 77.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fetub 17 31 30
  • 74.79 (n)
rat
(Rattus norvegicus)
Mammalia Fetub 30
  • 72.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FETUB 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FETUB 31 30
  • 53.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FETUB 31
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fetub 30
  • 46.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563738 30
  • 53.78 (n)
FETUB (3 of 3) 31
  • 30 (a)
OneToMany
FETUB (2 of 3) 31
  • 26 (a)
OneToMany
fetub 31
  • 23 (a)
OneToMany
Species where no ortholog for FETUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FETUB Gene

ENSEMBL:
Gene Tree for FETUB (if available)
TreeFam:
Gene Tree for FETUB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FETUB: view image

Paralogs for FETUB Gene

Paralogs for FETUB Gene

(1) SIMAP similar genes for FETUB Gene using alignment to 6 proteins:

  • FETUB_HUMAN
  • B7Z8T3_HUMAN
  • C9JC68_HUMAN
  • E9PG08_HUMAN
  • F8WAW1_HUMAN
  • F8WEP7_HUMAN
genes like me logo Genes that share paralogs with FETUB: view

Variants for FETUB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FETUB Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs34522046 - p.Ser33Pro
rs6785067 - p.Gly202Ser
rs7999 - p.Lys360Arg

Additional dbSNP identifiers (rs#s) for FETUB Gene

Structural Variations from Database of Genomic Variants (DGV) for FETUB Gene

Variant ID Type Subtype PubMed ID
esv2759206 CNV loss 17122850
nsv4153 CNV insertion 18451855
nsv508974 CNV insertion 20534489
nsv525368 CNV loss 19592680

Variation tolerance for FETUB Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FETUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FETUB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FETUB Gene

Disorders for FETUB Gene

MalaCards: The human disease database

(2) MalaCards diseases for FETUB Gene - From: DISEASES

Disorder Aliases PubMed IDs
encephalitozoonosis
  • infection by encephalitozoon
ureteral benign neoplasm
  • neoplasm of ureter
- elite association - COSMIC cancer census association via MalaCards
Search FETUB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FETUB

genes like me logo Genes that share disorders with FETUB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FETUB Gene

Publications for FETUB Gene

  1. Fetuin-B, a second member of the fetuin family in mammals. (PMID: 10947975) Olivier E … Salier JP (The Biochemical journal 2000) 2 3 4 54
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PMID: 15499407) Hsu SJ … Balmain A (Genome 2004) 3 4 54
  5. Serum and follicular fluid fetuin-B levels are correlated with fertilization rates in conventional IVF cycles. (PMID: 31073723) Fang L … Ye Y (Journal of assisted reproduction and genetics 2019) 3 54

Products for FETUB Gene

Sources for FETUB Gene