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Aliases for FETUB Gene

Aliases for FETUB Gene

  • Fetuin B 2 3 5
  • Fetuin-Like Protein IRL685 3 4
  • 16G2 3 4
  • Gugu 3 4
  • Fetuin-B 3
  • IRL685 3

External Ids for FETUB Gene

Previous GeneCards Identifiers for FETUB Gene

  • GC03P183129
  • GC03P187615
  • GC03P187760
  • GC03P187679
  • GC03P187840
  • GC03P186353
  • GC03P183767

Summaries for FETUB Gene

Entrez Gene Summary for FETUB Gene

  • The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FETUB Gene

FETUB (Fetuin B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. An important paralog of this gene is AHSG.

UniProtKB/Swiss-Prot for FETUB Gene

  • Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Gene Wiki entry for FETUB Gene

Additional gene information for FETUB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FETUB Gene

Genomics for FETUB Gene

GeneHancer (GH) Regulatory Elements for FETUB Gene

Promoters and enhancers for FETUB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I186640 Promoter/Enhancer 1.1 EPDnew ENCODE 567.3 +4.7 4724 1.1 RXRA MAX REST FOXA1 NR2F2 JUND ATF3 CEBPA HNF4G HNF4A FETUB HRG LOC105374258
GH03I186752 Enhancer 1.1 Ensembl ENCODE 10.6 +118.3 118306 3.9 FOXA2 ARID4B BRCA1 YY1 TCF12 ZNF121 ZNF143 ATF7 FOS REST LOC105374259 KNG1 EIF4A2 SNORA63 SNORA81 ENSG00000200418 RFC4 FETUB ENSG00000231724 AHSG
GH03I186588 Enhancer 1.1 Ensembl ENCODE 10.4 -45.9 -45918 3.2 PKNOX1 FOXA2 ARNT BRCA1 RAD21 RARA GTF3C2 SLC30A9 ZNF366 SCRT2 AHSG SNORD2 EIF4A2 ENSG00000200418 SNORA63 SNORA81 ENSG00000231724 RFC4 FETUB KNG1
GH03I186597 Enhancer 0.9 ENCODE 11 -36.2 -36182 3.4 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 FETUB KNG1 HRG ENSG00000283390 AHSG LOC105374258
GH03I186596 Enhancer 0.9 Ensembl ENCODE 10.4 -38.8 -38831 0.4 CTCF HDAC1 ATF1 JUN CEBPG ZBTB40 IRF9 CTBP1 TRIM24 ATF7 ENSG00000283390 LOC100287402 FETUB KNG1 HRG RFC4 ENSG00000231724 ENSG00000283149 AHSG LOC105374258
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FETUB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FETUB gene promoter:

Genomic Locations for FETUB Gene

Genomic Locations for FETUB Gene
17,310 bases
Plus strand

Genomic View for FETUB Gene

Genes around FETUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FETUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FETUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FETUB Gene

Proteins for FETUB Gene

  • Protein details for FETUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RCW6
    • E9PG06
    • Q1RMZ0
    • Q5J876
    • Q6DK58
    • Q6GRB6
    • Q9Y6Z0

    Protein attributes for FETUB Gene

    382 amino acids
    Molecular mass:
    42055 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FETUB Gene


neXtProt entry for FETUB Gene

Post-translational modifications for FETUB Gene

  • Glycosylation at Asn37, posLast=136136, Asn182, Thr289, and Thr292

Antibody Products

No data available for DME Specific Peptides for FETUB Gene

Domains & Families for FETUB Gene

Gene Families for FETUB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FETUB Gene

Suggested Antigen Peptide Sequences for FETUB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fetuin family.
  • Belongs to the fetuin family.
genes like me logo Genes that share domains with FETUB: view

Function for FETUB Gene

Molecular function for FETUB Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

Phenotypes From GWAS Catalog for FETUB Gene

Gene Ontology (GO) - Molecular Function for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004857 enzyme inhibitor activity IEA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity IBA,ISS --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with FETUB: view
genes like me logo Genes that share phenotypes with FETUB: view

Animal Models for FETUB Gene

MGI Knock Outs for FETUB:

Animal Model Products

CRISPR Products

miRNA for FETUB Gene

miRTarBase miRNAs that target FETUB

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FETUB Gene

Localization for FETUB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FETUB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FETUB gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with FETUB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FETUB Gene

Pathways & Interactions for FETUB Gene

SuperPathways for FETUB Gene

No Data Available

Interacting Proteins for FETUB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q9UGM5-FETUB_HUMAN ENSP00000265029 for FETUB Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for FETUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization ISS --
GO:0007339 binding of sperm to zona pellucida IBA,ISS --
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity ISS --
genes like me logo Genes that share ontologies with FETUB: view

No data available for Pathways by source and SIGNOR curated interactions for FETUB Gene

Drugs & Compounds for FETUB Gene

No Compound Related Data Available

Transcripts for FETUB Gene

Unigene Clusters for FETUB Gene

Fetuin B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FETUB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7

Relevant External Links for FETUB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FETUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FETUB Gene

mRNA differential expression in normal tissues according to GTEx for FETUB Gene

This gene is overexpressed in Liver (x42.6).

Protein differential expression in normal tissues from HIPED for FETUB Gene

This gene is overexpressed in Serum (26.9), Plasma (14.9), and Synovial fluid (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FETUB Gene

Protein tissue co-expression partners for FETUB Gene

NURSA nuclear receptor signaling pathways regulating expression of FETUB Gene:


SOURCE GeneReport for Unigene cluster for FETUB Gene:


mRNA Expression by UniProt/SwissProt for FETUB Gene:

Tissue specificity: Liver and testis.

Evidence on tissue expression from TISSUES for FETUB Gene

  • Liver(4.7)
  • Bone marrow(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FETUB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FETUB Gene

Orthologs for FETUB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FETUB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FETUB 33 34
  • 98.43 (n)
(Canis familiaris)
Mammalia FETUB 33 34
  • 79.93 (n)
(Bos Taurus)
Mammalia FETUB 33 34
  • 77.42 (n)
(Mus musculus)
Mammalia Fetub 33 16 34
  • 74.79 (n)
(Rattus norvegicus)
Mammalia Fetub 33
  • 72.8 (n)
(Ornithorhynchus anatinus)
Mammalia FETUB 34
  • 50 (a)
(Gallus gallus)
Aves FETUB 33 34
  • 53.78 (n)
(Anolis carolinensis)
Reptilia FETUB 34
  • 28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fetub 33
  • 46.77 (n)
(Danio rerio)
Actinopterygii LOC563738 33
  • 53.78 (n)
FETUB (3 of 3) 34
  • 30 (a)
FETUB (2 of 3) 34
  • 26 (a)
fetub 34
  • 23 (a)
Species where no ortholog for FETUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FETUB Gene

Gene Tree for FETUB (if available)
Gene Tree for FETUB (if available)

Paralogs for FETUB Gene

Paralogs for FETUB Gene

(1) SIMAP similar genes for FETUB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FETUB: view

Variants for FETUB Gene

Sequence variations from dbSNP and Humsavar for FETUB Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000123933 -- 186,639,445(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000456445 -- 186,638,650(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000745700 -- 186,647,708(+) A/G intron_variant
rs1000755221 -- 186,641,944(+) G/A intron_variant
rs1000927591 -- 186,644,270(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FETUB Gene

Variant ID Type Subtype PubMed ID
nsv525368 CNV loss 19592680
nsv508974 CNV insertion 20534489
nsv4153 CNV insertion 18451855
esv2759206 CNV loss 17122850

Variation tolerance for FETUB Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FETUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FETUB Gene

Disorders for FETUB Gene

Additional Disease Information for FETUB

No disorders were found for FETUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FETUB Gene

Publications for FETUB Gene

  1. Fetuin-B, a second member of the fetuin family in mammals. (PMID: 10947975) Olivier E … Salier JP (The Biochemical journal 2000) 2 3 4 58
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. (PMID: 15499407) Hsu SJ … Balmain A (Genome 2004) 3 4 58
  5. Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study. (PMID: 27628583) Zhu J … Li Y (Endocrine 2017) 3 58

Products for FETUB Gene

Sources for FETUB Gene

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