Aliases for FES Gene
- FES Proto-Oncogene, Tyrosine Kinase 2 3 5
- FPS 2 3 4
- Feline Sarcoma (Snyder-Theilen) Viral (V-Fes)/Fujinami Avian Sarcoma (PRCII) Viral (V-Fps) Oncogene Homolog 2 3
- Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog 3 4
- Oncogene FES, Feline Sarcoma Virus 2 3
- Tyrosine-Protein Kinase Fes/Fps 3 4
- Feline Sarcoma Oncogene 2 3
External Ids for FES Gene
Previous GeneCards Identifiers for FES Gene
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
GeneCards Summary for FES Gene
FES (FES Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FES include Sarcoma and Myeloid Leukemia. Among its related pathways are RET signaling and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FER.
UniProtKB/Swiss-Prot Summary for FES Gene
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.