Aliases for FERMT2 Gene
Aliases for FERMT2 Gene
- Fermitin Family Member 2 2 3 5
- Pleckstrin Homology Domain Containing, Family C (With FERM Domain) Member 1 2 3
- PH Domain-Containing Family C Member 1 3 4
- Kindlin-2 2 4
- PLEKHC1 3 4
- KIND2 3 4
- MIG2 3 4
- Pleckstrin Homology Domain Containing, Family C Member 1 3
- Pleckstrin Homology Domain-Containing Family C Member 1 4
- Fermitin Family Homolog 2 (Drosophila) 2
External Ids for FERMT2 Gene
- HGNC: 15767
- Entrez Gene: 10979
- Ensembl: ENSG00000073712
- OMIM: 607746
- UniProtKB: Q96AC1
Previous HGNC Symbols for FERMT2 Gene
- PLEKHC1
Previous GeneCards Identifiers for FERMT2 Gene
- GC14M052394
- GC14M053323
- GC14M033486
Summaries for FERMT2 Gene
GeneCards Summary for FERMT2 Gene
FERMT2 (Fermitin Family Member 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is FERMT1.
UniProtKB/Swiss-Prot for FERMT2 Gene
-
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
Additional gene information for FERMT2 Gene
- Monarch Initiative
- Search for FERMT2 at DataMed
- Search for FERMT2 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FERMT2 Gene
Genomics for FERMT2 Gene
GeneHancer (GH) Regulatory Elements for FERMT2 Gene
Promoters and enhancers for FERMT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FERMT2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FERMT2 gene promoter:
-
- SREBP-1b
- SREBP-1a
- SREBP-1c
- Sox9
- Egr-2
- FOXD3
- HNF-1A
- HNF-1
- SEF-1 (1)
- deltaCREB
Regulatory Element Products
Genomic Locations for FERMT2 Gene
Genomic Locations for FERMT2 Gene
- chr14:52,857,268-52,952,435
- (GRCh38/hg38)
- Size:
- 95,168 bases
- Orientation:
- Minus strand
- chr14:53,323,986-53,419,153
- (GRCh37/hg19)
- Size:
- 95,168 bases
- Orientation:
- Minus strand
Genomic View for FERMT2 Gene
Genes around FERMT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.1 by Entrez Gene
- 14q22.1 by HGNC
- 14q22.1 by Ensembl
FERMT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FERMT2 Gene
Proteins for FERMT2 Gene
-
Protein details for FERMT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96AC1-FERM2_HUMAN
- Recommended name:
- Fermitin family homolog 2
- Protein Accession:
- Q96AC1
- B5TJY2
- Q14840
- Q86TY7
Protein attributes for FERMT2 Gene
- Size:
- 680 amino acids
- Molecular mass:
- 77861 Da
- Quaternary structure:
-
- Interacts with ILK (By similarity). Interacts with FBLIM1. Interacts with ITGB1 and ITGB3. Interacts with active, unphosphorylated CTNNB1. Identified in a complex with CTNNB1 and TCF7L2/TCF4. Interacts with ITGB1; the interaction is inhibited in presence of ITGB1BP1.
- SequenceCaution:
-
- Sequence=CAA80852.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for FERMT2 Gene
Protein Expression for FERMT2 Gene
Post-translational modifications for FERMT2 Gene
Other Protein References for FERMT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FERMT2 (MIG2)
- Novus Biologicals Antibodies for FERMT2
-
Abcam antibodies for FERMT2
- Invitrogen Antibodies for FERMT2 (AFLGC-FERMT2)
- GeneTex FERMT2 Antibody for FERMT2
-
Boster Bio Antibodies for FERMT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FERMT2
Protein Products
-
OriGene Purified Proteins for FERMT2
- Search Origene for MassSpec and Protein Over-expression Lysates for FERMT2
- Origene Custom Protein Services for FERMT2
- Search GeneTex for Proteins for FERMT2
-
Abcam proteins for FERMT2
Assay Products
No data available for DME Specific Peptides for FERMT2 Gene
Domains & Families for FERMT2 Gene
Gene Families for FERMT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FERMT2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FERMT2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96AC1UniProtKB/Swiss-Prot:
FERM2_HUMAN :- The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
- Belongs to the kindlin family.
- Domain:
-
- The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
- The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (PubMed:22030399).
- The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues.
- Family:
-
- Belongs to the kindlin family.
Function for FERMT2 Gene
Molecular function for FERMT2 Gene
- UniProtKB/Swiss-Prot Function:
- Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.
- UniProtKB/Swiss-Prot Induction:
- By serum in lung fetal fibroblast cultured cells.
Phenotypes From GWAS Catalog for FERMT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 22699938 |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 21325030 |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for FERMT2 Gene
- MGI mutant phenotypes for FERMT2:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for FERMT2:
Animal Models for FERMT2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FERMT2
-
CRISPR Products
-
OriGene CRISPR knockouts for FERMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FERMT2
- genomics-online: gRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- Applied Biological Materials CRISPR for FERMT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FERMT2
- GenScript: Design CRISPR guide RNA sequences for FERMT2
miRNA for FERMT2 Gene
- miRTarBase miRNAs that target FERMT2
-
- hsa-mir-1-3p (MIRT005281)
- hsa-mir-21-5p (MIRT031065)
- hsa-mir-30b-5p (MIRT046125)
- hsa-mir-200b-3p (MIRT054683)
- hsa-mir-218-5p (MIRT440645)
- hsa-mir-4423-3p (MIRT507260)
- hsa-mir-6131 (MIRT507261)
- hsa-mir-133a-5p (MIRT507262)
- hsa-mir-3166 (MIRT507263)
- hsa-mir-4299 (MIRT507264)
- hsa-mir-1324 (MIRT507265)
- hsa-mir-4728-3p (MIRT507266)
- hsa-mir-8062 (MIRT507267)
- hsa-mir-449c-5p (MIRT507268)
- hsa-mir-34b-5p (MIRT507269)
- hsa-mir-2682-5p (MIRT507270)
- hsa-mir-940 (MIRT507271)
- hsa-mir-6893-5p (MIRT507272)
- hsa-mir-6808-5p (MIRT507273)
- hsa-mir-6511a-5p (MIRT507274)
- hsa-mir-1910-3p (MIRT507275)
- hsa-mir-8084 (MIRT507276)
- hsa-mir-138-5p (MIRT507277)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FERMT2
- Browse OriGene Inhibitory RNA Products For FERMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FERMT2
- genomics-online: shRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
Clone Products
-
OriGene ORF clones in human for FERMT2
- RC205727
- RC205727L1
- RC205727L2
- RC205727L3
- RC205727L4
- RC226047
- RC226047L1
- RC226047L2
- RC226047L3
- RC226047L4
- RC226092
- RC226092L1
- RC226092L2
- RC226092L3
- RC226092L4
- RC505727
- RG205727
- RG226047
- RG226092
- RC205727L1V
- RC205727L2V
- RC205727L3V
- RC205727L4V
- RC226047L1V
- RC226047L2V
- RC226047L3V
- RC226047L4V
- RC226092L1V
- RC226092L2V
- RC226092L3V
- RC226092L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FERMT2
- Addgene plasmids for FERMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FERMT2
- Applied Biological Materials Clones for FERMT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FERMT2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FERMT2 Gene
Localization for FERMT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FERMT2 Gene
- Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| extracellular | 2 |
- Focal adhesion sites (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 22699938 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 22699938 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FERMT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell junction organization | ||
| 2 | MAPK-Erk Pathway |
.38
|
|
| 3 | Adhesion |
-
|
|
| 4 | Cytoskeletal Signaling | ||
| 5 | ERK Signaling |
.49
|
|
Pathways by source for FERMT2 Gene
2 Sino Biological pathways for FERMT2 Gene
3 Reactome pathways for FERMT2 Gene
1 Qiagen pathway for FERMT2 Gene
2 Cell Signaling Technology pathways for FERMT2 Gene
Interacting Proteins for FERMT2 Gene
Selected Interacting proteins:
ENSP00000342858
Q96AC1-FERM2_HUMAN
for FERMT2 Gene via
STRING
IID
MINT
UniProtKB
GPS-Prot Interaction Network for FERMT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007160 | cell-matrix adhesion | ISS,IEA | -- |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IMP | 21325030 |
| GO:0007229 | integrin-mediated signaling pathway | IMP | 21325030 |
| GO:0008360 | regulation of cell shape | IEA | -- |
No data available for SIGNOR curated interactions for FERMT2 Gene
Transcripts for FERMT2 Gene
mRNA/cDNA for FERMT2 Gene
- (7) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (174) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000395631 3369 bps (uc001xad.4)
- ENST00000341590 3338 bps (uc001xae.4)
- ENST00000557255 6001 bps (uc059bpj.1)
- ENST00000554152 3029 bps (uc059bpk.1)
- ENST00000555546 2384 bps (uc059bpl.1)
Unigene Clusters for FERMT2 Gene
- Fermitin family member 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FERMT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FERMT2
- genomics-online: gRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- Applied Biological Materials CRISPR for FERMT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FERMT2
- GenScript: Design CRISPR guide RNA sequences for FERMT2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FERMT2
- Browse OriGene Inhibitory RNA Products For FERMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FERMT2
- genomics-online: shRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
Clone Products
-
OriGene ORF clones in human for FERMT2
- RC205727
- RC205727L1
- RC205727L2
- RC205727L3
- RC205727L4
- RC226047
- RC226047L1
- RC226047L2
- RC226047L3
- RC226047L4
- RC226092
- RC226092L1
- RC226092L2
- RC226092L3
- RC226092L4
- RC505727
- RG205727
- RG226047
- RG226092
- RC205727L1V
- RC205727L2V
- RC205727L3V
- RC205727L4V
- RC226047L1V
- RC226047L2V
- RC226047L3V
- RC226047L4V
- RC226092L1V
- RC226092L2V
- RC226092L3V
- RC226092L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FERMT2
- Addgene plasmids for FERMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FERMT2
- Applied Biological Materials Clones for FERMT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FERMT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Uterus (9.1), Prostate (8.4), and Urinary Bladder (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FERMT2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FERMT2 Gene:
FERMT2SOURCE GeneReport for Unigene cluster for FERMT2 Gene:
Hs.509343mRNA Expression by UniProt/SwissProt for FERMT2 Gene:
Q96AC1-FERM2_HUMAN
Tissue specificity:
Ubiquitous. Found in numerous tumor tissues.
Evidence on tissue expression from TISSUES for FERMT2 Gene
- Liver(4.4)
- Lung(4.3)
- Nervous system(2.8)
- Heart(2.3)
- Muscle(2.3)
Primer Products
-
OriGene qPCR primer pairs for FERMT2
-
OriGene qPCR primer pairs and template standards for FERMT2
- genomics-online: primer clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FERMT2 Gene
Orthologs for FERMT2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FERMT2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FERMT2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FERMT2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FERMT2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FERMT2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fermt2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fermt2 33 |
|
||
| chicken (Gallus gallus) |
Aves | FERMT2 34 |
|
OneToOne | |
| PLEKHC1 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | FERMT2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fermt2 33 |
|
||
| Str.10934 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3392 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fermt2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Fit1 34 33 |
|
ManyToMany | |
| Fit2 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002054 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-112 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for FERMT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FERMT2 Gene
- ENSEMBL:
- Gene Tree for FERMT2 (if available)
- TreeFam:
- Gene Tree for FERMT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FERMT2: view image
Paralogs for FERMT2 Gene
Variants for FERMT2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000027489 | -- | 52,952,328(-) | T/G | upstream_transcript_variant | |
| rs1000050095 | -- | 52,895,003(-) | T/C | intron_variant | |
| rs1000133968 | -- | 52,858,096(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000148769 | -- | 52,949,809(-) | C/T | intron_variant | |
| rs1000184276 | -- | 52,949,482(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3551569 | CNV | deletion | 23714750 |
| esv3892546 | CNV | gain | 25118596 |
| nsv1050582 | CNV | gain | 25217958 |
| nsv820177 | CNV | loss | 19587683 |
| nsv832796 | CNV | loss | 17160897 |
| nsv832797 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.42;
27.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FERMT2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FERMT2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FERMT2 Gene
Disorders for FERMT2 Gene
Additional Disease Information for FERMT2
No disorders were found for FERMT2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FERMT2 Gene
Publications for FERMT2 Gene
- Kindlin-2 (Mig-2): a co-activator of beta3 integrins. (PMID: 18458155) Ma YQ … Plow EF (The Journal of cell biology 2008) 3 4 22 58
- URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. (PMID: 12697302) Weinstein EJ … Mazzarella R (Biochimica et biophysica acta 2003) 2 3 4 58
- Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. (PMID: 12679033) Tu Y … Wu C (Cell 2003) 3 4 22 58
- Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression. (PMID: 8175911) Wick M … Müller R (Journal of cell science 1994) 2 3 4 58
- Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling. (PMID: 22699938) Yu Y … Zhang H (EMBO reports 2012) 3 4 58
Products for FERMT2 Gene
- R&D Systems Antibodies for FERMT2 (MIG2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for FERMT2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FERMT2
- Search Origene for MassSpec and Protein Over-expression Lysates for FERMT2
- Origene Custom Protein Services for FERMT2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FERMT2
- Browse OriGene Inhibitory RNA Products For FERMT2
- OriGene qPCR primer pairs for FERMT2
- OriGene qPCR primer pairs and template standards for FERMT2
- OriGene CRISPR knockouts for FERMT2
- OriGene ORF clones in human for FERMT2
- RC205727
- RC205727L1
- RC205727L2
- RC205727L3
- RC205727L4
- RC226047
- RC226047L1
- RC226047L2
- RC226047L3
- RC226047L4
- RC226092
- RC226092L1
- RC226092L2
- RC226092L3
- RC226092L4
- RC505727
- RG205727
- RG226047
- RG226092
- RC205727L1V
- RC205727L2V
- RC205727L3V
- RC205727L4V
- RC226047L1V
- RC226047L2V
- RC226047L3V
- RC226047L4V
- RC226092L1V
- RC226092L2V
- RC226092L3V
- RC226092L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FERMT2
- GenScript: Next-day shipping of latest version cDNA ORF clones for FERMT2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FERMT2
- GenScript Custom Assay Services for FERMT2
- GenScript Custom overexpressing Cell Line Services for FERMT2
- GenScript: Design CRISPR guide RNA sequences for FERMT2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FERMT2
- Sino Biological Human cDNA Clone for FERMT2
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FERMT2
- Novus Biologicals proteins and lysates for FERMT2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for FERMT2
- Abcam proteins for FERMT2
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Invitrogen Antibodies for FERMT2 (AFLGC-FERMT2)
- Cyagen custom Knockout/knockin (KOKI) mouse models for FERMT2
- Addgene plasmids for FERMT2
- antibodies-online: Search results for 66 available FERMT2 Antibodies ranked by validation data
- Compare Top FERMT2 Antibodies
- antibodies-online: Search results for 3 available FERMT2 Elisa Kits ranked by validation data
- Compare Top FERMT2 Elisa Kits
- Recommended
- antibodies-online: Search results for 4 available FERMT2 Proteins ranked by validation data
- Compare Top FERMT2 Proteins
- GeneTex FERMT2 Antibody for FERMT2
- Search GeneTex for Proteins for FERMT2
- Santa Cruz Biotechnology (SCBT) Antibodies for FERMT2
- Search Santa Cruz Biotechnology (SCBT) for FERMT2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FERMT2
- Horizon Cell Lines for FERMT2
- genomics-online: cdna clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- orf clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- genomics-online: gRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- genomics-online: primer clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- genomics-online: shRNA clones - Search results for 130 available FERMT2 gene related products
- Overview of 130 available FERMT2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FERMT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FERMT2
- GeneCopoeia miRNA 3'UTR Target clone products for FERMT2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FERMT2
- Boster Bio Antibodies for FERMT2
- Browse Boster Bio ELISA Kits
Sources for FERMT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt