Aliases for FER1L4 Gene

Aliases for FER1L4 Gene

  • Fer-1 Like Family Member 4 (Pseudogene) 2 3 5
  • Fer-1 Like Family Member 4, Pseudogene (Functional) 2 3
  • C20orf124 3 4
  • Fer-1-Like 4 (C. Elegans), Pseudogene (Functional) 2
  • Fer-1-Like 4, Pseudogene (Functional) 3
  • Fer-1-Like 4 (C. Elegans) 2
  • Fer-1-Like Protein 4 4
  • BA563A22B.1 2
  • DJ309K20.1 2
  • FER1L4 5

External Ids for FER1L4 Gene

Previous HGNC Symbols for FER1L4 Gene

  • C20orf124

Previous GeneCards Identifiers for FER1L4 Gene

  • GC20M033904
  • GC20M034814
  • GC20M034861
  • GC20M034862
  • GC20M033609
  • GC20M034146
  • GC20M030924

Summaries for FER1L4 Gene

GeneCards Summary for FER1L4 Gene

FER1L4 (Fer-1 Like Family Member 4 (Pseudogene)) is a Pseudogene. Diseases associated with FER1L4 include Endometrial Cancer and Gastric Cancer.

Additional gene information for FER1L4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FER1L4 Gene

Genomics for FER1L4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FER1L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J035606 Promoter/Enhancer 1 Ensembl ENCODE 600.7 +0.1 118 1.3 HNRNPL ZHX2 HMBOX1 EGR1 CEBPB CTBP1 ESRRA ZNF217 GATAD2B NFIC FER1L4 DLGAP4 lnc-CPNE1-2 SPAG4 ERGIC3
GH20J035607 Enhancer 0.2 Ensembl 600.7 +1.5 1461 0.2 FER1L4 CPNE1 C20orf173 ENSG00000242507 CEP250-AS1 CEP250 lnc-CPNE1-2 SPAG4 ERGIC3
GH20J035301 Promoter/Enhancer 2.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 +295.7 295707 20.9 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 TFE3 LEF1 UQCC1 EIF6 GDF5 MMP24 NCOA6 FAM83C-AS1 MMP24OS EDEM2 MIR1289-1 CEP250
GH20J035324 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.7 +279.7 279678 5.8 GATAD2A CTCF ATF7 REST TFE3 SOX13 NFKBIZ NFRKB RCOR2 JUND UQCC1 CPNE1 RBM12 RBM39 RPL36P4 NCOA6 FAM83C FAM83C-AS1 EIF6 MMP24OS
GH20J035611 Enhancer 0.9 Ensembl ENCODE 0.7 -3.9 -3864 0.8 TCF12 DPF2 PKNOX1 CTBP1 RUNX3 CBFB BCL11A NBN BCOR NR2F1 FER1L4 SPAG4 ERGIC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FER1L4 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the FER1L4 gene promoter:
  • aMEF-2
  • ATF-2
  • Brachyury
  • CRE-BP1
  • HEN1
  • HNF-4alpha1
  • MEF-2
  • MEF-2A
  • Pax-5
  • YY1

Genomic Locations for FER1L4 Gene

Genomic Locations for FER1L4 Gene
chr20:35,558,737-35,607,562
(GRCh38/hg38)
Size:
48,826 bases
Orientation:
Minus strand
chr20:34,146,507-34,195,484
(GRCh37/hg19)
Size:
48,978 bases
Orientation:
Minus strand

Genomic View for FER1L4 Gene

Genes around FER1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER1L4 Gene

Proteins for FER1L4 Gene

  • Protein details for FER1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A9Z1Z3-FR1L4_HUMAN
    Recommended name:
    Fer-1-like protein 4
    Protein Accession:
    A9Z1Z3
    Secondary Accessions:
    • Q9GZQ9
    • Q9H646
    • Q9H8L7

    Protein attributes for FER1L4 Gene

    Size:
    1794 amino acids
    Molecular mass:
    200980 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14597.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FER1L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER1L4 Gene

Post-translational modifications for FER1L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FER1L4 Gene

Domains & Families for FER1L4 Gene

Gene Families for FER1L4 Gene

Suggested Antigen Peptide Sequences for FER1L4 Gene

GenScript: Design optimal peptide antigens:
  • Fer-1-like protein 4 (FR1L4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A9Z1Z3

UniProtKB/Swiss-Prot:

FR1L4_HUMAN :
  • Belongs to the ferlin family.
Family:
  • Belongs to the ferlin family.
genes like me logo Genes that share domains with FER1L4: view

Function for FER1L4 Gene

Phenotypes From GWAS Catalog for FER1L4 Gene

Gene Ontology (GO) - Molecular Function for FER1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FER1L4: view

Phenotypes for FER1L4 Gene

genes like me logo Genes that share phenotypes with FER1L4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FER1L4 Gene

Localization for FER1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER1L4 Gene

Membrane. Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for FER1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FER1L4: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FER1L4 Gene

Pathways & Interactions for FER1L4 Gene

PathCards logo

SuperPathways for FER1L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FER1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IBA 21873635
genes like me logo Genes that share ontologies with FER1L4: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for FER1L4 Gene

Drugs & Compounds for FER1L4 Gene

No Compound Related Data Available

Transcripts for FER1L4 Gene

mRNA/cDNA for FER1L4 Gene

15 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FER1L4 Gene

No ASD Table

Relevant External Links for FER1L4 Gene

GeneLoc Exon Structure for
FER1L4

Expression for FER1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FER1L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FER1L4 Gene

This gene is overexpressed in Bladder (x12.0) and Stomach (x9.2).

Protein differential expression in normal tissues from HIPED for FER1L4 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FER1L4 Gene



Protein tissue co-expression partners for FER1L4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FER1L4

SOURCE GeneReport for Unigene cluster for FER1L4 Gene:

Hs.72222
genes like me logo Genes that share expression patterns with FER1L4: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER1L4 Gene

Orthologs for FER1L4 Gene

Evolution for FER1L4 Gene

ENSEMBL:
Gene Tree for FER1L4 (if available)
TreeFam:
Gene Tree for FER1L4 (if available)

No data available for Orthologs for FER1L4 Gene

Paralogs for FER1L4 Gene

(3) SIMAP similar genes for FER1L4 Gene using alignment to 2 proteins:

  • FR1L4_HUMAN
  • Q2NNQ8_HUMAN
genes like me logo Genes that share paralogs with FER1L4: view

No data available for Paralogs for FER1L4 Gene

Variants for FER1L4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FER1L4 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs11698021 - p.Asn1183Ser
rs1557202 - p.Lys1179Glu
rs2277862 - p.Val1318Ile

Structural Variations from Database of Genomic Variants (DGV) for FER1L4 Gene

Variant ID Type Subtype PubMed ID
dgv698n67 CNV loss 20364138
esv2664066 CNV deletion 23128226
esv2722366 CNV deletion 23290073
esv3645716 CNV loss 21293372
nsv178794 CNV deletion 16902084
nsv517785 CNV loss 19592680
nsv526188 CNV gain 19592680
nsv526796 CNV loss 19592680

Additional Variant Information for FER1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FER1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for FER1L4 Gene

Disorders for FER1L4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FER1L4 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
gastric cancer
  • gastric cancer, somatic
colorectal cancer
  • crc
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FER1L4

genes like me logo Genes that share disorders with FER1L4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FER1L4 Gene

Publications for FER1L4 Gene

  1. Clinical significance of the low expression of FER1L4 in gastric cancer patients. (PMID: 24961353) Liu Z … Guo J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3
  2. Long non-coding RNA expression profile in human gastric cancer and its clinical significances. (PMID: 24063685) Song H … Guo J (Journal of translational medicine 2013) 2 3
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells. (PMID: 31000382) Ma L … Wang D (Pathology, research and practice 2019) 3

Products for FER1L4 Gene

Sources for FER1L4 Gene