The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq... See more...

Aliases for FER Gene

Aliases for FER Gene

  • FER Tyrosine Kinase 2 3 5
  • TYK3 2 3 4
  • Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer 3 4
  • Protein Phosphatase 1, Regulatory Subunit 74 2 3
  • Feline Encephalitis Virus-Related Kinase FER 3 4
  • Fer (Fps/Fes Related) Tyrosine Kinase 2 3
  • Tyrosine-Protein Kinase Fer 3 4
  • Phosphoprotein NCP94 2 3
  • Proto-Oncogene C-Fer 3 4
  • Tyrosine Kinase 3 3 4
  • EC 2.7.10.2 4 50
  • PPP1R74 2 3
  • P94-Fer 3 4
  • EC 2.7.10 50
  • FER 5

External Ids for FER Gene

Previous GeneCards Identifiers for FER Gene

  • GC05P107703
  • GC05P108524
  • GC05P108114
  • GC05P108159
  • GC05P108111
  • GC05P103255

Summaries for FER Gene

Entrez Gene Summary for FER Gene

  • The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

GeneCards Summary for FER Gene

FER (FER Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FER include Ceroid Lipofuscinosis, Neuronal, 6 and Leukemia, Acute Myeloid. Among its related pathways are RET signaling and Adherens junction. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FES.

UniProtKB/Swiss-Prot Summary for FER Gene

  • Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Gene Wiki entry for FER Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FER Gene

Genomics for FER Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FER Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J108746 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 259.6 +2.7 2667 3.7 SP1 ZNF207 IKZF1 ZNF600 ZNF580 ATF2 POLR2A ZNF10 ZSCAN16 BRCA1 FER lnc-FBXL17-4 LINC01023 lnc-MAN2A1-7 MK280269-053 PJA2
GH05J108924 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 250.1 +178.7 178745 1.5 CEBPA HOMEZ CTCF KMT2B THAP11 SAP130 MIER3 DMAP1 GABPB1 ZSCAN9 FER RF00998-108 LOC100820733 MK280269-053 PJA2
GH05J108785 Promoter 0.3 EPDnew 250.3 +39.0 39010 0.1 ENSG00000249921 RACK1P1 FER HSALNG0044047 ENSG00000250383 MK280269-053 PJA2
GH05J109468 Enhancer 1.2 Ensembl ENCODE 39.6 +722.7 722737 0.8 BCLAF1 ZNF654 MYC ZNF580 ZNF10 NFIC ZIC2 MXD4 CTCF REST ENSG00000251367 HSALNG0044068 FER LINC01023 PJA2 ENSG00000248876 HSALNG0044069 lnc-MAN2A1-11 LOC105379117 MAN2A1
GH05J108530 Enhancer 1.1 Ensembl ENCODE 19.7 -214.7 -214676 1.6 MYC NCOR1 IKZF1 ZNF592 NFIC NONO REST HES1 BHLHE40 MNT piR-32325-159 LOC285638 LINC01023 FER HSALNG0044033-001 HSALNG0044033-002 piR-44110-066 ENSG00000286503 FBXL17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FER on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FER

Top Transcription factor binding sites by QIAGEN in the FER gene promoter:
  • AP-2alpha
  • AREB6
  • c-Myc
  • Egr-1
  • GATA-1
  • Max
  • NF-1
  • NF-1/L
  • p53
  • STAT3

Genomic Locations for FER Gene

Latest Assembly
chr5:108,746,085-109,196,841
(GRCh38/hg38)
Size:
450,757 bases
Orientation:
Plus strand

Previous Assembly
chr5:108,083,598-108,532,542
(GRCh37/hg19 by Entrez Gene)
Size:
448,945 bases
Orientation:
Plus strand

chr5:108,083,523-108,532,542
(GRCh37/hg19 by Ensembl)
Size:
449,020 bases
Orientation:
Plus strand

Genomic View for FER Gene

Genes around FER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FER Gene

Proteins for FER Gene

  • Protein details for FER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16591-FER_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fer
    Protein Accession:
    P16591
    Secondary Accessions:
    • B2RCR4
    • B4DSQ2
    • H2FLB8

    Protein attributes for FER Gene

    Size:
    822 amino acids
    Molecular mass:
    94638 Da
    Quaternary structure:
    • Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320' (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1.
    Miscellaneous:
    • [Isoform 3]: Produced by alternative promoter usage.

    Three dimensional structures from OCA and Proteopedia for FER Gene

    Alternative splice isoforms for FER Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FER Gene

Selected DME Specific Peptides for FER Gene

P16591:
  • TKKSGVVL
  • RDLAARN
  • KWTAPEA
  • WYHGAIPR
  • LGELLGKGNFGEVYKG
  • ILKQYDHPNIVKLIG
  • GGDFLTFLR
  • CIHRDLAARNCLV
  • PYPGMTN
  • LKISDFGMSR
  • KFLQEAKILKQY
  • YSSESDVWSFGILLWE
  • HAEDLNSGPL
  • LHNQYVLA

Post-translational modifications for FER Gene

Domains & Families for FER Gene

Protein Domains for FER Gene

Suggested Antigen Peptide Sequences for FER Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56544, highly similar to Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (B4DDX7_HUMAN)
  • p94-Fer (FER_HUMAN)
  • FER protein (Q05DA5_HUMAN)
  • FER protein (Q6PEJ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P16591

UniProtKB/Swiss-Prot:

FER_HUMAN :
  • The coiled coil domains mediate homooligomerization and are required for location at microtubules.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
Domain:
  • The coiled coil domains mediate homooligomerization and are required for location at microtubules.
  • The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
genes like me logo Genes that share domains with FER: view

Function for FER Gene

Molecular function for FER Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:19738202};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).
GENATLAS Biochemistry:
fer (fps/fes related) oncogene homolog

Enzyme Numbers (IUBMB) for FER Gene

Phenotypes From GWAS Catalog for FER Gene

Gene Ontology (GO) - Molecular Function for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS 2725517
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA,IDA 12972546
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with FER: view
genes like me logo Genes that share phenotypes with FER: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FER

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FER Gene

Localization for FER Gene

Subcellular locations from UniProtKB/Swiss-Prot for FER Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cell projection. Cell junction. Membrane. Peripheral membrane protein. Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FER gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin IDA 1990274
GO:0005634 nucleus IEA,IDA 19147545
GO:0005737 cytoplasm IEA,IDA 1990274
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FER: view

Pathways & Interactions for FER Gene

PathCards logo

SuperPathways for FER Gene

genes like me logo Genes that share pathways with FER: view

Pathways by source for FER Gene

3 GeneGo (Thomson Reuters) pathways for FER Gene
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Immune response Fc epsilon RI pathway
  • Neurophysiological process Receptor-mediated axon growth repulsion
4 Qiagen pathways for FER Gene
  • Epithelial Adherens Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Remodeling of Adherens Junctions
  • Transendothelial Migration of Leukocytes
2 Cell Signaling Technology pathways for FER Gene

SIGNOR curated interactions for FER Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for FER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 12972546
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006468 protein phosphorylation IEA,TAS 2725517
GO:0006935 chemotaxis IBA 21873635
GO:0007155 cell adhesion IBA 21873635
genes like me logo Genes that share ontologies with FER: view

Drugs & Compounds for FER Gene

(5) Drugs for FER Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra 0
Dovitinib (TKI-258, CHIR-258) Pharma Multitargeted RTK inhibitor 0

(2) Additional Compounds for FER Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0

(1) ApexBio Compounds for FER Gene

Compound Action Cas Number
Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor 405169-16-6
genes like me logo Genes that share compounds with FER: view

Drug products for research

Transcripts for FER Gene

mRNA/cDNA for FER Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FER

Alternative Splicing Database (ASD) splice patterns (SP) for FER Gene

No ASD Table

Relevant External Links for FER Gene

GeneLoc Exon Structure for
FER

Expression for FER Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FER Gene

Protein differential expression in normal tissues from HIPED for FER Gene

This gene is overexpressed in Lung (46.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FER Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FER

SOURCE GeneReport for Unigene cluster for FER Gene:

Hs.221472

mRNA Expression by UniProt/SwissProt for FER Gene:

P16591-FER_HUMAN
Tissue specificity: Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for FER Gene

  • Nervous system(4.5)
  • Spleen(2.4)
  • Liver(2.2)
  • Blood(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with FER: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FER Gene

Orthologs for FER Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FER Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FER 29 30
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FER 29 30
  • 93.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fer 16 30
  • 93 (a)
OneToOne
Fert2 29
  • 88.44 (n)
Cow
(Bos Taurus)
Mammalia FER 29 30
  • 91.16 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FER 30
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FER 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fert2 29
  • 86.26 (n)
Chicken
(Gallus gallus)
Aves FER 29 30
  • 81.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FER 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fer 29
  • 73.99 (n)
Zebrafish
(Danio rerio)
Actinopterygii fer 29 30
  • 71.1 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Fps85D 29 30 31
  • 48.14 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003651 29
  • 48.06 (n)
Worm
(Caenorhabditis elegans)
Secernentea kin-14 29 30 31
  • 49.42 (n)
ManyToMany
C35E7.10b 31
  • 38 (a)
W04G5.10 31
  • 37 (a)
C35E7.10a 31
  • 37 (a)
F01D4.3 31
  • 36 (a)
T14E8.1a 31
  • 35 (a)
T14E8.1b 31
  • 35 (a)
F46F5.2 31
  • 35 (a)
ZK622.1 30 31
  • 33 (a)
ManyToMany
F09A5.2 31
  • 33 (a)
kin-23 31
  • 33 (a)
C18H7.4 30 31
  • 32 (a)
ManyToMany
C25A8.5 30 31
  • 32 (a)
ManyToMany
F23C8.7 30 31
  • 32 (a)
ManyToMany
R11E3.1 31
  • 32 (a)
frk-1 30 31
  • 31 (a)
ManyToMany
C35E7.10 30
  • 31 (a)
ManyToMany
C55C3.4 30 31
  • 31 (a)
ManyToMany
R05H5.4 30 31
  • 30 (a)
ManyToMany
ZC581.7 30 31
  • 30 (a)
ManyToMany
F26E4.5 30 31
  • 30 (a)
ManyToMany
K09B11.5 31
  • 30 (a)
T25B9.5 31
  • 30 (a)
Y69E1A.3 31
  • 30 (a)
F57B9.8 30 31
  • 29 (a)
ManyToMany
kin-26 30 31
  • 29 (a)
ManyToMany
Y43C5B.2 30
  • 28 (a)
ManyToMany
kin-6 30
  • 28 (a)
ManyToMany
kin-31 30
  • 28 (a)
ManyToMany
W02A2.4 31
  • 28 (a)
Y52D5A.2 31
  • 28 (a)
T06C10.3 30 31
  • 26 (a)
ManyToMany
Y4C6A.1 30 31
  • 25 (a)
ManyToMany
kin-5 30
  • 24 (a)
ManyToMany
spe-8 30 31
  • 24 (a)
ManyToMany
F22B3.8 30
  • 23 (a)
ManyToMany
T21G5.1 30 31
  • 23 (a)
ManyToMany
W01B6.5 30 31
  • 22 (a)
ManyToMany
F59A3.8 30 31
  • 22 (a)
ManyToMany
W03F8.2 30 31
  • 22 (a)
ManyToMany
kin-24 30 31
  • 21 (a)
ManyToMany
T25B9.4 30 31
  • 21 (a)
ManyToMany
ZK593.9 30 31
  • 20 (a)
ManyToMany
Y116A8C.38 30 31
  • 20 (a)
ManyToMany
Y106G6A.1 30
  • 20 (a)
ManyToMany
Y116A8C.24 30 31
  • 20 (a)
ManyToMany
B0252.1 30
  • 18 (a)
ManyToMany
W03A5.1 30
  • 15 (a)
ManyToMany
C34F11.5 30
  • 13 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 30
  • 9 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 39 (a)
OneToMany
Species where no ortholog for FER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FER Gene

ENSEMBL:
Gene Tree for FER (if available)
TreeFam:
Gene Tree for FER (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FER: view image
Alliance of Genome Resources:
Additional Orthologs for FER

Paralogs for FER Gene

(33) SIMAP similar genes for FER Gene using alignment to 5 proteins:

  • FER_HUMAN
  • B4DDX7_HUMAN
  • D6RAF9_HUMAN
  • Q05DA5_HUMAN
  • Q6PEJ9_HUMAN
genes like me logo Genes that share paralogs with FER: view

Variants for FER Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FER Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs115520719 Benign: not provided 108,897,661(+) T/C
NM_005246.4(FER):c.1049T>C (p.Ile350Thr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1582454977 Uncertain Significance: not provided 109,187,450(+) C/G
NM_005246.4(FER):c.2344C>G (p.Pro782Ala)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs34320303 Benign: not provided 108,959,248(+) T/C
NM_005246.4(FER):c.1557T>C (p.Thr519=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs55876507 Benign: not provided 109,186,231(+) C/T
NM_005246.4(FER):c.2235C>T (p.Ser745=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs56199104 Benign: not provided 108,798,371(+) T/C
NM_005246.4(FER):c.189T>C (p.Tyr63=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FER Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FER Gene

Variant ID Type Subtype PubMed ID
esv2450464 CNV deletion 19546169
esv2502982 CNV insertion 19546169
esv2668245 CNV deletion 23128226
esv2677654 CNV deletion 23128226
esv2730582 CNV deletion 23290073
esv3566428 CNV deletion 23714750
esv3566430 CNV deletion 23714750
esv3570334 CNV loss 25503493
esv3606212 CNV loss 21293372
esv3606214 CNV loss 21293372
esv3890706 CNV gain 25118596
nsv1016343 CNV gain 25217958
nsv1074323 CNV deletion 25765185
nsv1129748 CNV tandem duplication 24896259
nsv327356 CNV insertion 16902084
nsv471039 CNV gain 18288195
nsv475926 CNV novel sequence insertion 20440878
nsv4952 CNV deletion 18451855
nsv4953 CNV deletion 18451855
nsv509988 OTHER sequence alteration 20534489
nsv512857 CNV insertion 21212237
nsv525993 CNV loss 19592680
nsv830443 CNV gain 17160897
nsv968974 CNV duplication 23825009
nsv969258 CNV deletion 23825009

Variation tolerance for FER Gene

Residual Variation Intolerance Score: 5.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FER Gene

Human Gene Mutation Database (HGMD)
FER
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FER
Leiden Open Variation Database (LOVD)
FER

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FER Gene

Disorders for FER Gene

MalaCards: The human disease database

(2) MalaCards diseases for FER Gene - From: COP

Disorder Aliases PubMed IDs
ceroid lipofuscinosis, neuronal, 6
  • cln6
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards
Search FER in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FER

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FER: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FER Gene

Publications for FER Gene

  1. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. (PMID: 19147545) Zoubeidi A … Chevalier S (Molecular cancer research : MCR 2009) 3 4 22
  2. Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. (PMID: 19339212) Oh MA … Lee JW (Biochimica et biophysica acta 2009) 3 4 22
  3. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. (PMID: 19738202) Itoh T … Takenawa T (Science signaling 2009) 3 4 22
  4. Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. (PMID: 14517306) Miravet S … García de Herreros A (Molecular and cellular biology 2003) 3 4 22
  5. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. (PMID: 12972546) Kogata N … Mochizuki N (Molecular biology of the cell 2003) 3 4 22

Products for FER Gene

Sources for FER Gene