This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, t... See more...

Aliases for FENDRR Gene

Subcategory (RNA class) for FENDRR Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for FENDRR Gene

  • FOXF1 Adjacent Non-Coding Developmental Regulatory RNA 2 3 5
  • FOXF1 Antisense RNA 1 (Head To Head) 2 3
  • FENDRR 2 170
  • FOXF1 Antisense RNA 1 (Non-Protein Coding) 3
  • TCONS_00024240 3
  • Onco-LncRNA-21 3
  • HSALNG0113305 169
  • HSALNG0113304 169
  • NONHSAG020218 94
  • Lnc-MTHFSD-3 170
  • LincFOXF1 3
  • FOXF1-AS1 3
  • FOXF1AS1 3

External Ids for FENDRR Gene

Previous HGNC Symbols for FENDRR Gene

  • FOXF1-AS1

Summaries for FENDRR Gene

Entrez Gene Summary for FENDRR Gene

  • This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

GeneCards Summary for FENDRR Gene

FENDRR (FOXF1 Adjacent Non-Coding Developmental Regulatory RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FENDRR include Pulmonary Disease, Chronic Obstructive and Gallbladder Cancer.

Additional gene information for FENDRR Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FENDRR Gene

Genomics for FENDRR Gene

GeneHancer (GH) Regulatory Elements for FENDRR Gene

Promoters and enhancers for FENDRR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FENDRR on UCSC Golden Path with GeneCards custom track

Genomic Locations for FENDRR Gene

Genomic Locations for FENDRR Gene
chr16:86,473,638-86,509,099
(GRCh38/hg38)
Size:
35,462 bases
Orientation:
Minus strand
chr16:86,508,131-86,542,705
(GRCh37/hg19)
Size:
34,575 bases
Orientation:
Minus strand

Genomic View for FENDRR Gene

Genes around FENDRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FENDRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FENDRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FENDRR Gene

Proteins for FENDRR Gene

Post-translational modifications for FENDRR Gene

No Post-translational modifications

No data available for DME Specific Peptides for FENDRR Gene

Domains & Families for FENDRR Gene

Gene Families for FENDRR Gene

genes like me logo Genes that share domains with FENDRR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FENDRR Gene

Function for FENDRR Gene

Phenotypes From GWAS Catalog for FENDRR Gene

Phenotypes for FENDRR Gene

genes like me logo Genes that share phenotypes with FENDRR: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FENDRR Gene

Localization for FENDRR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FENDRR gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FENDRR Gene

Pathways & Interactions for FENDRR Gene

PathCards logo

SuperPathways for FENDRR Gene

No Data Available

Gene Ontology (GO) - Biological Process for FENDRR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FENDRR Gene

Drugs & Compounds for FENDRR Gene

No Compound Related Data Available

Transcripts for FENDRR Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FENDRR Gene

No ASD Table

Relevant External Links for FENDRR Gene

GeneLoc Exon Structure for
FENDRR
ECgene alternative splicing isoforms for
FENDRR

Expression for FENDRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FENDRR Gene

mRNA differential expression in normal tissues according to GTEx for FENDRR Gene

This gene is overexpressed in Colon - Sigmoid (x9.1), Esophagus - Gastroesophageal Junction (x7.5), Esophagus - Muscularis (x6.8), Bladder (x6.1), and Lung (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of FENDRR Gene:

FENDRR

SOURCE GeneReport for Unigene cluster for FENDRR Gene:

Hs.448825
genes like me logo Genes that share expression patterns with FENDRR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FENDRR Gene

Orthologs for FENDRR Gene

Evolution for FENDRR Gene

ENSEMBL:
Gene Tree for FENDRR (if available)
TreeFam:
Gene Tree for FENDRR (if available)

No data available for Orthologs for FENDRR Gene

Paralogs for FENDRR Gene

No data available for Paralogs for FENDRR Gene

Variants for FENDRR Gene

Sequence variations from dbSNP and Humsavar for FENDRR Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1057518868 likely-pathogenic, Fetal megacystis, Urethral atresia, Ventricular septal defect 86,510,849(-) A/T upstream_transcript_variant
rs121909336 pathogenic, Persistent fetal circulation 86,510,794(-) C/A upstream_transcript_variant
rs370422274 benign, Persistent fetal circulation 86,510,773(-) C/G/T upstream_transcript_variant
rs373503439 likely-benign, Persistent fetal circulation 86,510,654(-) G/T upstream_transcript_variant
rs574179816 likely-benign, Persistent fetal circulation 86,510,605(-) CGGCGGCGGCGGCGGCGGCGGCGG/CGGCGGCGG/CGGCGGCGGCGG/CGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGG/CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FENDRR Gene

Variant ID Type Subtype PubMed ID
dgv498n67 CNV gain 20364138
esv2758666 CNV gain+loss 17122850
esv29890 CNV loss 19812545
esv3639482 CNV loss 21293372
esv4262 OTHER complex 18987735
nsv1065605 CNV gain 25217958
nsv1070778 CNV deletion 25765185
nsv1143828 CNV deletion 24896259
nsv483044 CNV gain 15286789
nsv510430 OTHER sequence alteration 20534489
nsv525024 CNV loss 19592680
nsv527579 CNV loss 19592680
nsv9468 CNV gain 18304495

Additional Variant Information for FENDRR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FENDRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FENDRR Gene

Disorders for FENDRR Gene

MalaCards: The human disease database

(7) MalaCards diseases for FENDRR Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary disease, chronic obstructive
  • copd
gallbladder cancer
  • gallbladder ca
lung cancer susceptibility 3
  • lncr3
gastric cancer
  • gastric cancer, somatic
osteogenic sarcoma
  • osteosarcoma; osrc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FENDRR

genes like me logo Genes that share disorders with FENDRR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FENDRR Gene

Publications for FENDRR Gene

  1. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. (PMID: 23369715) Grote P … Herrmann BG (Developmental cell 2013) 2 3 56
  2. Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. (PMID: 23034409) Szafranski P … Stankiewicz P (Genome research 2013) 2 3 56
  3. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M … Rinn JL (eLife 2013) 2 3 56
  4. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. (PMID: 19571010) Khalil AM … Rinn JL (Proceedings of the National Academy of Sciences of the United States of America 2009) 2 3 56
  5. Long non-coding RNA FENDRR reduces prostate cancer malignancy by competitively binding miR-18a-5p with RUNX1. (PMID: 29465000) Zhang G … Li J (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2018) 3 56

Products for FENDRR Gene

Sources for FENDRR Gene