Subcategory (RNA class) for FENDRR Gene
Number of RNA Genes sources:
Aliases for FENDRR Gene
Previous HGNC Symbols for FENDRR Gene
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
GeneCards Summary for FENDRR Gene
FENDRR (FOXF1 Adjacent Non-Coding Developmental Regulatory RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FENDRR include Pulmonary Disease, Chronic Obstructive and Gallbladder Cancer.