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Aliases for FEM1C Gene

Aliases for FEM1C Gene

  • Fem-1 Homolog C 2 3 5
  • FEM1-Gamma 3 4
  • Fem-1 Homolog C (C. Elegans) 2
  • Protein Fem-1 Homolog C 3
  • EUROIMAGE686608 3
  • EUROIMAGE783647 3
  • KIAA1785 4
  • FEM1a 3
  • FEM1c 4

External Ids for FEM1C Gene

Previous GeneCards Identifiers for FEM1C Gene

  • GC05M114624
  • GC05M115264
  • GC05M114887
  • GC05M114932
  • GC05M114884
  • GC05M110038

Summaries for FEM1C Gene

GeneCards Summary for FEM1C Gene

FEM1C (Fem-1 Homolog C) is a Protein Coding gene. An important paralog of this gene is FEM1A.

UniProtKB/Swiss-Prot for FEM1C Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.

Additional gene information for FEM1C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1C Gene

Genomics for FEM1C Gene

GeneHancer (GH) Regulatory Elements for FEM1C Gene

Promoters and enhancers for FEM1C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I115540 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 555.8 +1.7 1749 5.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FEM1C SEMA6A-AS1 ENSG00000250015 ATG12 LOC101927100 TICAM2 PGGT1B TMED7-TICAM2 TMED7 CCT5P1
GH05I115459 Enhancer 1.2 FANTOM5 Ensembl ENCODE 19.7 +83.8 83809 4 KLF1 JUN BACH1 BATF IRF4 FOSL1 POLR2A FOSL2 FOS IKZF2 TICAM2 FEM1C PGGT1B GC05M115471 AK3P4
GH05I115418 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.5 +125.5 125521 2.6 NFIB JUN ZNF133 MAX FOSL1 ZFHX2 ZNF143 FOSL2 FOS STAT1 TICAM2 FEM1C PGGT1B AK3P4 GC05M115471
GH05I115574 Enhancer 0.6 ENCODE 11.9 -29.9 -29875 0.1 CTCF ZNF654 ZNF362 NR2F1 ZNF384 REST ZNF2 RAD21 IKZF1 SMC3 GC05P115575 LOC101927100 FEM1C TICAM2 CCDC112 TMED7-TICAM2 TMED7
GH05I115413 Enhancer 1.2 FANTOM5 Ensembl ENCODE 5.5 +129.8 129817 2.5 SOX13 KLF1 MXI1 JUN MAX KLF17 BATF IRF4 RAD21 FOSL1 FEM1C AK3P4 GC05M115471
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FEM1C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FEM1C gene promoter:

Genomic Locations for FEM1C Gene

Genomic Locations for FEM1C Gene
23,987 bases
Minus strand

Genomic View for FEM1C Gene

Genes around FEM1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1C Gene

Proteins for FEM1C Gene

  • Protein details for FEM1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein fem-1 homolog C
    Protein Accession:
    Secondary Accessions:
    • B2RE47
    • Q8N3V8
    • Q9H704
    • Q9NPL6
    • Q9NPL9

    Protein attributes for FEM1C Gene

    617 amino acids
    Molecular mass:
    68673 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex.
    • Sequence=BAB15096.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FEM1C Gene

Post-translational modifications for FEM1C Gene

  • Ubiquitination at posLast=267267
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEM1C Gene

Domains & Families for FEM1C Gene

Gene Families for FEM1C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FEM1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fem-1 family.
  • Belongs to the fem-1 family.
genes like me logo Genes that share domains with FEM1C: view

Function for FEM1C Gene

Molecular function for FEM1C Gene

UniProtKB/Swiss-Prot Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.

Phenotypes From GWAS Catalog for FEM1C Gene

Gene Ontology (GO) - Molecular Function for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FEM1C: view
genes like me logo Genes that share phenotypes with FEM1C: view

Animal Model Products

CRISPR Products

miRNA for FEM1C Gene

miRTarBase miRNAs that target FEM1C

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FEM1C Gene

Localization for FEM1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1C Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEM1C gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FEM1C: view

Pathways & Interactions for FEM1C Gene

SuperPathways for FEM1C Gene

No Data Available

UniProtKB/Swiss-Prot Q96JP0-FEM1C_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FEM1C: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1C Gene

Drugs & Compounds for FEM1C Gene

No Compound Related Data Available

Transcripts for FEM1C Gene

mRNA/cDNA for FEM1C Gene

Unigene Clusters for FEM1C Gene

Fem-1 homolog c (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: -
SP2: -

Relevant External Links for FEM1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEM1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FEM1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FEM1C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FEM1C Gene

Protein tissue co-expression partners for FEM1C Gene

NURSA nuclear receptor signaling pathways regulating expression of FEM1C Gene:


SOURCE GeneReport for Unigene cluster for FEM1C Gene:


mRNA Expression by UniProt/SwissProt for FEM1C Gene:

Tissue specificity: Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.

Evidence on tissue expression from TISSUES for FEM1C Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FEM1C: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEM1C Gene

Orthologs for FEM1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FEM1C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FEM1C 34
  • 100 (a)
LOC541180 33
  • 95.25 (n)
(Pan troglodytes)
Mammalia FEM1C 33 34
  • 99.78 (n)
(Monodelphis domestica)
Mammalia FEM1C 34
  • 95 (a)
(Canis familiaris)
Mammalia FEM1C 33 34
  • 93.63 (n)
(Rattus norvegicus)
Mammalia Fem1c 33
  • 93.08 (n)
(Mus musculus)
Mammalia Fem1c 33 16 34
  • 92.38 (n)
(Ornithorhynchus anatinus)
Mammalia FEM1C 34
  • 86 (a)
(Gallus gallus)
Aves FEM1C 33 34
  • 82.39 (n)
(Anolis carolinensis)
Reptilia FEM1C 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fem1c 33
  • 76.77 (n)
Str.15002 33
(Danio rerio)
Actinopterygii fem1c 33 34
  • 66.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6966 33 34
  • 54.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003839 33
  • 53.31 (n)
(Caenorhabditis elegans)
Secernentea fem-1 33 34
  • 49.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAR1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for FEM1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FEM1C Gene

Gene Tree for FEM1C (if available)
Gene Tree for FEM1C (if available)

Paralogs for FEM1C Gene

Paralogs for FEM1C Gene

(2) SIMAP similar genes for FEM1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEM1C: view

Variants for FEM1C Gene

Sequence variations from dbSNP and Humsavar for FEM1C Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_039810 A breast cancer sample p.Asp434Asn
VAR_039811 A breast cancer sample p.Asp462Asn
rs1000053329 -- 115,538,032(-) C/A intron_variant
rs1000125456 -- 115,531,450(-) G/A/T intron_variant
rs1000207561 -- 115,521,124(-) A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1C Gene

Variant ID Type Subtype PubMed ID
esv3444399 CNV insertion 20981092
nsv830455 CNV gain 17160897
nsv950116 CNV duplication 24416366

Variation tolerance for FEM1C Gene

Residual Variation Intolerance Score: 9.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEM1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1C Gene

Disorders for FEM1C Gene

Additional Disease Information for FEM1C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FEM1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1C Gene

Publications for FEM1C Gene

  1. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. (PMID: 14527725) Ventura-Holman T … Maher JF (Gene 2003) 2 3 4 22 58
  2. Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene. (PMID: 11733146) Krakow D … Cohn DH (Gene 2001) 2 3 4 22 58
  3. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi MO … Azziz R (Human reproduction (Oxford, England) 2008) 3 22 44 58
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FEM1C Gene

Sources for FEM1C Gene

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