This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013] See more...

Aliases for FEM1B Gene

Aliases for FEM1B Gene

  • Fem-1 Homolog B 2 3 5
  • Fem-1-Like Death Receptor-Binding Protein Alpha 3 4
  • Fem-1-Like In Apoptotic Pathway Protein Alpha 3 4
  • Protein Fem-1 Homolog B 3 4
  • FEM1-Beta 3 4
  • F1AA 3 4
  • FEM-1-Like Death Receptor Binding Protein 3
  • FEM-1 (C. Elegans) Homolog B 2
  • Fem-1 Homolog B (C. Elegans) 2
  • F1A-ALPHA 3
  • F1A-Alpha 4
  • KIAA0396 4
  • FEM1B 5
  • FEM1b 4

External Ids for FEM1B Gene

Previous GeneCards Identifiers for FEM1B Gene

  • GC15P064410
  • GC15P061668
  • GC15P066148
  • GC15P066285
  • GC15P066357
  • GC15P068570
  • GC15P045400
  • GC15P068278
  • GC15P069504
  • GC15P069612
  • GC15P069668
  • GC15P071837
  • GC15P068410
  • GC15P068412
  • GC15P068437
  • GC15P068921
  • GC15P069395
  • GC15P072886
  • GC15P073966

Summaries for FEM1B Gene

Entrez Gene Summary for FEM1B Gene

  • This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

GeneCards Summary for FEM1B Gene

FEM1B (Fem-1 Homolog B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and death receptor binding. An important paralog of this gene is FEM1C.

UniProtKB/Swiss-Prot Summary for FEM1B Gene

  • Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FEM1B Gene

Genomics for FEM1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FEM1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FEM1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FEM1B

Top Transcription factor binding sites by QIAGEN in the FEM1B gene promoter:
  • AML1a
  • Bach1
  • GATA-2
  • MRF-2
  • Nkx2-2
  • p53
  • Pax-5
  • PPAR-alpha

Genomic Locations for FEM1B Gene

Latest Assembly
chr15:68,277,745-68,295,862
(GRCh38/hg38)
Size:
18,118 bases
Orientation:
Plus strand

Previous Assembly
chr15:68,570,083-68,588,200
(GRCh37/hg19 by Entrez Gene)
Size:
18,118 bases
Orientation:
Plus strand

chr15:68,570,141-68,588,203
(GRCh37/hg19 by Ensembl)
Size:
18,063 bases
Orientation:
Plus strand

Genomic View for FEM1B Gene

Genes around FEM1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1B Gene

Proteins for FEM1B Gene

  • Protein details for FEM1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK73-FEM1B_HUMAN
    Recommended name:
    Protein fem-1 homolog B
    Protein Accession:
    Q9UK73
    Secondary Accessions:
    • O43146

    Protein attributes for FEM1B Gene

    Size:
    627 amino acids
    Molecular mass:
    70264 Da
    Quaternary structure:
    • Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, ELOB, ELOC and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A. Interacts with CHEK1.

    Three dimensional structures from OCA and Proteopedia for FEM1B Gene

neXtProt entry for FEM1B Gene

Post-translational modifications for FEM1B Gene

  • Ubiquitination at Lys469
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1B Gene

No data available for DME Specific Peptides for FEM1B Gene

Domains & Families for FEM1B Gene

Gene Families for FEM1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FEM1B Gene

InterPro:
Blocks:
  • Ankyrin repeat signature

Suggested Antigen Peptide Sequences for FEM1B Gene

GenScript: Design optimal peptide antigens:
  • Fem-1-like in apoptotic pathway protein alpha (FEM1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK73

UniProtKB/Swiss-Prot:

FEM1B_HUMAN :
  • Belongs to the fem-1 family.
Family:
  • Belongs to the fem-1 family.
genes like me logo Genes that share domains with FEM1B: view

Function for FEM1B Gene

Molecular function for FEM1B Gene

UniProtKB/Swiss-Prot Function:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.

Phenotypes From GWAS Catalog for FEM1B Gene

Gene Ontology (GO) - Molecular Function for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding NAS 10623617
GO:0005515 protein binding IEA,IPI 11559703
genes like me logo Genes that share ontologies with FEM1B: view
genes like me logo Genes that share phenotypes with FEM1B: view

Animal Models for FEM1B Gene

MGI Knock Outs for FEM1B:

miRNA for FEM1B Gene

miRTarBase miRNAs that target FEM1B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEM1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEM1B Gene

Localization for FEM1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1B Gene

Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEM1B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 19330022
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 19330022
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FEM1B: view

Pathways & Interactions for FEM1B Gene

PathCards logo

SuperPathways for FEM1B Gene

No Data Available

UniProtKB/Swiss-Prot Q9UK73-FEM1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002070 epithelial cell maturation IEA --
GO:0006915 apoptotic process NAS 10623617
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
GO:0051438 regulation of ubiquitin-protein transferase activity IMP 15601820
genes like me logo Genes that share ontologies with FEM1B: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1B Gene

Drugs & Compounds for FEM1B Gene

No Compound Related Data Available

Transcripts for FEM1B Gene

mRNA/cDNA for FEM1B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FEM1B

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for FEM1B Gene

GeneLoc Exon Structure for
FEM1B

Expression for FEM1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FEM1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FEM1B Gene

This gene is overexpressed in Lung (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FEM1B Gene



Protein tissue co-expression partners for FEM1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FEM1B

SOURCE GeneReport for Unigene cluster for FEM1B Gene:

Hs.362733

mRNA Expression by UniProt/SwissProt for FEM1B Gene:

Q9UK73-FEM1B_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.

Evidence on tissue expression from TISSUES for FEM1B Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FEM1B: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FEM1B Gene

Orthologs for FEM1B Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FEM1B 29 30
  • 99.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FEM1B 29 30
  • 94.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FEM1B 29 30
  • 93.78 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FEM1B 30
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fem1b 29
  • 90.64 (n)
Mouse
(Mus musculus)
Mammalia Fem1b 29 16 30
  • 90.38 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FEM1B 30
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FEM1B 29 30
  • 78.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FEM1B 30
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fem1b 29
  • 73.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11486 29
Zebrafish
(Danio rerio)
Actinopterygii fem1b 29 30
  • 70.28 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Fem-1 29 30
  • 49.16 (n)
OneToOne
CG9025 31
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007382 29
  • 49.14 (n)
Worm
(Caenorhabditis elegans)
Secernentea C01H6.2 30
  • 11 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4940 30
  • 47 (a)
OneToOne
Species where no ortholog for FEM1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FEM1B Gene

ENSEMBL:
Gene Tree for FEM1B (if available)
TreeFam:
Gene Tree for FEM1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FEM1B: view image
Alliance of Genome Resources:
Additional Orthologs for FEM1B

Paralogs for FEM1B Gene

Paralogs for FEM1B Gene

(10) SIMAP similar genes for FEM1B Gene using alignment to 3 proteins:

  • FEM1B_HUMAN
  • H3BT12_HUMAN
  • H3BTV3_HUMAN
genes like me logo Genes that share paralogs with FEM1B: view

Variants for FEM1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FEM1B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs35606342 Benign: not provided 68,278,456(+) C/T
NM_015322.5(FEM1B):c.39C>T (p.Ser13=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FEM1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FEM1B Gene

Variant ID Type Subtype PubMed ID
esv2760036 CNV loss 17122850

Variation tolerance for FEM1B Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEM1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FEM1B
Leiden Open Variation Database (LOVD)
FEM1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1B Gene

Disorders for FEM1B Gene

Additional Disease Information for FEM1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FEM1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FEM1B Gene

Publications for FEM1B Gene

  1. Sequence, organization, and expression of the human FEM1B gene. (PMID: 10623617) Ventura-Holman T … Maher JF (Biochemical and biophysical research communications 2000) 2 3 4
  2. Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens KG … Spielman RS (The Journal of clinical endocrinology and metabolism 2010) 3 40
  3. Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. (PMID: 19330022) Sun TP … Shieh SY (Oncogene 2009) 3 4
  4. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 40
  5. FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. (PMID: 18757445) Goodarzi MO … Azziz R (Human reproduction (Oxford, England) 2008) 3 40

Products for FEM1B Gene

Sources for FEM1B Gene