Aliases for FEM1B Gene
External Ids for FEM1B Gene
Previous GeneCards Identifiers for FEM1B Gene
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
GeneCards Summary for FEM1B Gene
FEM1B (Fem-1 Homolog B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and death receptor binding. An important paralog of this gene is FEM1C.
UniProtKB/Swiss-Prot Summary for FEM1B Gene
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.