Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FEM1A Gene

Aliases for FEM1A Gene

  • Fem-1 Homolog A 2 3 5
  • Prostaglandin E Receptor 4-Associated Protein 3 4
  • FEM1-Alpha 3 4
  • EPRAP 3 4
  • Fem-1 Homolog A (C. Elegans) 2
  • Protein Fem-1 Homolog A 3
  • FEM1a 4

External Ids for FEM1A Gene

Previous GeneCards Identifiers for FEM1A Gene

  • GC19P004883
  • GC19P004732
  • GC19P004742
  • GC19P004553

Summaries for FEM1A Gene

GeneCards Summary for FEM1A Gene

FEM1A (Fem-1 Homolog A) is a Protein Coding gene. Diseases associated with FEM1A include Rhabdomyosarcoma. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and EP4 subtype prostaglandin E2 receptor binding. An important paralog of this gene is FEM1C.

UniProtKB/Swiss-Prot for FEM1A Gene

  • Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.

Additional gene information for FEM1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FEM1A Gene

Genomics for FEM1A Gene

GeneHancer (GH) Regulatory Elements for FEM1A Gene

Promoters and enhancers for FEM1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004790 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 650.7 +0.2 172 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000268536 GC19P004792 FEM1A DUS3L YJU2 ENSG00000267030 SNRPEP4 DPP9-AS1 SAFB SAFB2
GH19J004793 Enhancer 0.5 ENCODE dbSUPER 650.7 +1.8 1837 0.2 CBLL2 FEM1A GC19P004792 LOC100287614 ENSG00000269604
GH19J004828 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 +39.5 39485 4.6 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B TICAM1 GC19P004832 DPP9-AS1 DUS3L SAFB2 PLIN3 SAFB ARRDC5 ENSG00000267255 FEM1A
GH19J004744 Enhancer 1 Ensembl ENCODE 13.4 -46.6 -46584 1.1 HDAC1 FOXA2 INSM2 KLF17 EGR1 ZNF366 FOS CREM EGR2 PHF21A MIR7-3HG MIR7-3 FEM1A DPP9 PLIN3 TRV-CAC3-1 GC19M004737
GH19J004741 Enhancer 0.7 ENCODE 13.4 -49.0 -48967 1.4 MXI1 ZNF473 ZSCAN4 CEBPG ZIC2 ZNF48 ZFHX2 POLR2A ZBTB48 RCOR1 MIR7-3HG MIR7-3 FEM1A HDGFL2 PIAS4 PLIN3 TRV-CAC3-1 GC19M004737
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FEM1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FEM1A gene promoter:
  • Pax-4a
  • YY1
  • Lmo2
  • Pax-5
  • AP-4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • E2F
  • E2F-1

Genomic Locations for FEM1A Gene

Genomic Locations for FEM1A Gene
9,593 bases
Plus strand
3,844 bases
Plus strand

Genomic View for FEM1A Gene

Genes around FEM1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FEM1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FEM1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FEM1A Gene

Proteins for FEM1A Gene

  • Protein details for FEM1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein fem-1 homolog A
    Protein Accession:
    Secondary Accessions:
    • B2RDI3
    • Q711P8
    • Q9NPN7
    • Q9NPW8

    Protein attributes for FEM1A Gene

    669 amino acids
    Molecular mass:
    73639 Da
    Quaternary structure:
    • Component of some E3 ubiquitin-protein ligase complex (By similarity). Interacts with PTGER4.

neXtProt entry for FEM1A Gene

Post-translational modifications for FEM1A Gene

  • Ubiquitination at isoforms=320, isoforms=206, isoforms=182, and isoforms=21
  • Modification sites at PhosphoSitePlus

Other Protein References for FEM1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FEM1A Gene

Domains & Families for FEM1A Gene

Gene Families for FEM1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FEM1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the fem-1 family.
  • Belongs to the fem-1 family.
genes like me logo Genes that share domains with FEM1A: view

Function for FEM1A Gene

Molecular function for FEM1A Gene

UniProtKB/Swiss-Prot Function:
Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.
UniProtKB/Swiss-Prot Induction:
Frequently down-regulated in rhabdomyosarcoma.

Phenotypes From GWAS Catalog for FEM1A Gene

Gene Ontology (GO) - Molecular Function for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IEA --
GO:0031867 EP4 subtype prostaglandin E2 receptor binding IPI 16424369
genes like me logo Genes that share ontologies with FEM1A: view
genes like me logo Genes that share phenotypes with FEM1A: view

Animal Models for FEM1A Gene

MGI Knock Outs for FEM1A:

Animal Model Products

miRNA for FEM1A Gene

miRTarBase miRNAs that target FEM1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FEM1A Gene

Localization for FEM1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FEM1A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FEM1A gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FEM1A: view

Pathways & Interactions for FEM1A Gene

SuperPathways for FEM1A Gene

No Data Available

UniProtKB/Swiss-Prot Q9BSK4-FEM1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FEM1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
GO:0050728 negative regulation of inflammatory response IDA 16424369
GO:0051438 regulation of ubiquitin-protein transferase activity ISS --
genes like me logo Genes that share ontologies with FEM1A: view

No data available for Pathways by source and SIGNOR curated interactions for FEM1A Gene

Drugs & Compounds for FEM1A Gene

No Compound Related Data Available

Transcripts for FEM1A Gene

mRNA/cDNA for FEM1A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FEM1A Gene

Fem-1 homolog a (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FEM1A Gene

No ASD Table

Relevant External Links for FEM1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FEM1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FEM1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FEM1A Gene

This gene is overexpressed in Muscle - Skeletal (x20.8).

Protein differential expression in normal tissues from HIPED for FEM1A Gene

This gene is overexpressed in Adrenal (40.1) and Plasma (24.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FEM1A Gene

Protein tissue co-expression partners for FEM1A Gene

NURSA nuclear receptor signaling pathways regulating expression of FEM1A Gene:


SOURCE GeneReport for Unigene cluster for FEM1A Gene:


mRNA Expression by UniProt/SwissProt for FEM1A Gene:

Tissue specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).

Evidence on tissue expression from TISSUES for FEM1A Gene

  • Muscle(4.7)
  • Kidney(4.2)
  • Nervous system(4.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with FEM1A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FEM1A Gene

Orthologs for FEM1A Gene

This gene was present in the common ancestor of animals.

Orthologs for FEM1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FEM1A 34 33
  • 99.25 (n)
(Bos Taurus)
Mammalia FEM1A 34 33
  • 90.05 (n)
(Canis familiaris)
Mammalia FEM1A 33
  • 89.64 (n)
(Monodelphis domestica)
Mammalia FEM1A 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia FEM1A 34
  • 86 (a)
(Mus musculus)
Mammalia 4931440F15Rik 34
  • 86 (a)
Fem1a 16 34 33
  • 83.84 (n)
(Rattus norvegicus)
Mammalia Fem1a 33
  • 82.72 (n)
(Gallus gallus)
Aves FEM1A 34 33
  • 74.29 (n)
(Danio rerio)
Actinopterygii fem1a 34 33
  • 74.96 (n)
wufi20c04 33
fruit fly
(Drosophila melanogaster)
Insecta CG6966 34 35
  • 50 (a)
CG11896 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea fem-1 34 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for FEM1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FEM1A Gene

Gene Tree for FEM1A (if available)
Gene Tree for FEM1A (if available)
Evolutionary constrained regions (ECRs) for FEM1A: view image

Paralogs for FEM1A Gene

Paralogs for FEM1A Gene

(2) SIMAP similar genes for FEM1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FEM1A: view

Variants for FEM1A Gene

Sequence variations from dbSNP and Humsavar for FEM1A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000625232 -- 4,795,663(+) C/T downstream_transcript_variant
rs1000976145 -- 4,795,986(+) G/A downstream_transcript_variant
rs1002244460 -- 4,791,146(+) A/C upstream_transcript_variant
rs1002642024 -- 4,789,717(+) C/T upstream_transcript_variant
rs1002701738 -- 4,790,906(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FEM1A Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv962994 CNV duplication 23825009

Variation tolerance for FEM1A Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FEM1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FEM1A Gene

Disorders for FEM1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FEM1A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search FEM1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FEM1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FEM1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FEM1A Gene

Publications for FEM1A Gene

  1. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. (PMID: 16424369) Takayama K … Libby P (Circulation research 2006) 3 4 22 58
  2. The Fem1a gene is downregulated in Rhabdomyosarcoma. (PMID: 16254458) Ventura-Holman T … Maher JF (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2005) 3 4 22 58
  3. FEM1A is a candidate gene for polycystic ovary syndrome. (PMID: 16390781) Maher JF … Cowan BD (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2005) 3 4 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens KG … Spielman RS (The Journal of clinical endocrinology and metabolism 2010) 3 44 58

Products for FEM1A Gene

Sources for FEM1A Gene

Loading form....