Aliases for FECH Gene
External Ids for FECH Gene
Previous GeneCards Identifiers for FECH Gene
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
GeneCards Summary for FECH Gene
FECH (Ferrochelatase) is a Protein Coding gene. Diseases associated with FECH include Protoporphyria, Erythropoietic, 1 and Erythropoietic Protoporphyria, Autosomal Recessive. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and 2 iron, 2 sulfur cluster binding.
UniProtKB/Swiss-Prot Summary for FECH Gene
Catalyzes the ferrous insertion into protoporphyrin IX.