Aliases for FDXR Gene
External Ids for FDXR Gene
Previous HGNC Symbols for FDXR Gene
Previous GeneCards Identifiers for FDXR Gene
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for FDXR Gene
FDXR (Ferredoxin Reductase) is a Protein Coding gene. Diseases associated with FDXR include Auditory Neuropathy And Optic Atrophy and Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and ferredoxin-NADP+ reductase activity. An important paralog of this gene is DPYD.
UniProtKB/Swiss-Prot Summary for FDXR Gene
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.