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Aliases for FDXACB1 Gene

Aliases for FDXACB1 Gene

  • Ferredoxin-Fold Anticodon Binding Domain Containing 1 2 3 5
  • FDX-ACDB Domain-Containing Protein 1 3 4
  • Hypothetical Protein BC006136 2 3
  • Ferredoxin-Fold Anticodon-Binding Domain-Containing Protein 1 3
  • HCG_2033039 3

External Ids for FDXACB1 Gene

Previous GeneCards Identifiers for FDXACB1 Gene

  • GC11M111252
  • GC11M111653
  • GC11M111745

Summaries for FDXACB1 Gene

Entrez Gene Summary for FDXACB1 Gene

  • This gene encodes a protein which contains a ferredoxin-fold anticodon-binding domain which is contained in a subset of phenylalanyl tRNA synthetases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDXACB1 Gene

FDXACB1 (Ferredoxin-Fold Anticodon Binding Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and phenylalanine-tRNA ligase activity. An important paralog of this gene is FARS2.

Additional gene information for FDXACB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FDXACB1 Gene

Genomics for FDXACB1 Gene

GeneHancer (GH) Regulatory Elements for FDXACB1 Gene

Promoters and enhancers for FDXACB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I111878 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.9 1896 2.4 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 C11orf1 ENSG00000258529 FDXACB1 PPP2R1B
GH11I111934 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -58.8 -58822 11.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DIXDC1 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 TIMM8B ENSG00000255292 FDXACB1 C11orf1
GH11I112023 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 -143.9 -143889 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DLAT PPP2R1B FDXACB1 ALG9 PIH1D2 NKAPD1 DIXDC1 IL18 CRYAB C11orf52
GH11I111917 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11 -37.5 -37503 2.3 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 RXRA REST ZNF518A KAT8 C11orf52 LOC105369494 PPP2R1B FDXACB1 C11orf1 ALG9 SDHD CRYAB HSPB2-C11orf52
GH11I111844 Enhancer 1 Ensembl ENCODE dbSUPER 10.7 +34.9 34878 3.1 PKNOX1 MAX CEBPB FEZF1 JUND POLR2A FOS MYC ZBTB12 SP7 PPP2R1B ALG9 SIK2 FDXACB1 C11orf1 ENSG00000254980 ALG9-IT1 GNG5P3 ENSG00000258529
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FDXACB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FDXACB1 gene promoter:

Genomic Locations for FDXACB1 Gene

Genomic Locations for FDXACB1 Gene
7,188 bases
Minus strand

Genomic View for FDXACB1 Gene

Genes around FDXACB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDXACB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDXACB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDXACB1 Gene

Proteins for FDXACB1 Gene

  • Protein details for FDXACB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferredoxin-fold anticodon-binding domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW7
    • B4DUU2

    Protein attributes for FDXACB1 Gene

    624 amino acids
    Molecular mass:
    70416 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH06136.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FDXACB1 Gene


neXtProt entry for FDXACB1 Gene

Post-translational modifications for FDXACB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDXACB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDXACB1 Gene

Domains & Families for FDXACB1 Gene

Gene Families for FDXACB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FDXACB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FDXACB1: view

No data available for UniProtKB/Swiss-Prot for FDXACB1 Gene

Function for FDXACB1 Gene

Gene Ontology (GO) - Molecular Function for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004826 phenylalanine-tRNA ligase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FDXACB1: view
genes like me logo Genes that share phenotypes with FDXACB1: view

Animal Models for FDXACB1 Gene

MGI Knock Outs for FDXACB1:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDXACB1 Gene

Localization for FDXACB1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009328 phenylalanine-tRNA ligase complex IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FDXACB1 Gene

Pathways & Interactions for FDXACB1 Gene

SuperPathways for FDXACB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FDXACB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006432 phenylalanyl-tRNA aminoacylation IBA --
genes like me logo Genes that share ontologies with FDXACB1: view

No data available for Pathways by source and SIGNOR curated interactions for FDXACB1 Gene

Drugs & Compounds for FDXACB1 Gene

No Compound Related Data Available

Transcripts for FDXACB1 Gene

mRNA/cDNA for FDXACB1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FDXACB1 Gene

Ferredoxin-fold anticodon binding domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FDXACB1 Gene

No ASD Table

Relevant External Links for FDXACB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FDXACB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FDXACB1 Gene

Protein differential expression in normal tissues from HIPED for FDXACB1 Gene

This gene is overexpressed in Plasma (30.9), Adipocyte (19.3), and Lung (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FDXACB1 Gene

Protein tissue co-expression partners for FDXACB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FDXACB1 Gene:


SOURCE GeneReport for Unigene cluster for FDXACB1 Gene:

genes like me logo Genes that share expression patterns with FDXACB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDXACB1 Gene

Orthologs for FDXACB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDXACB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FDXACB1 33
  • 99.52 (n)
-- 34
  • 99 (a)
(Canis familiaris)
Mammalia FDXACB1 33
  • 87.11 (n)
(Bos Taurus)
Mammalia FDXACB1 33
  • 85.58 (n)
-- 34
  • 81 (a)
(Mus musculus)
Mammalia Fdxacb1 34 16 33
  • 80.55 (n)
(Rattus norvegicus)
Mammalia Fdxacb1 33
  • 79.67 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
-- 34
  • 53 (a)
-- 34
  • 16 (a)
(Gallus gallus)
Aves FDXACB1 33
  • 58.14 (n)
-- 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fdxacb1 33
  • 51.83 (n)
(Danio rerio)
Actinopterygii LOC566022 33
  • 51.68 (n)
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSF1 34
  • 18 (a)
Species where no ortholog for FDXACB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDXACB1 Gene

Gene Tree for FDXACB1 (if available)
Gene Tree for FDXACB1 (if available)

Paralogs for FDXACB1 Gene

Paralogs for FDXACB1 Gene

(1) SIMAP similar genes for FDXACB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FDXACB1: view

Variants for FDXACB1 Gene

Sequence variations from dbSNP and Humsavar for FDXACB1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000043705 -- 111,875,242(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000266546 -- 111,879,973(-) G/T upstream_transcript_variant
rs1001322959 -- 111,879,458(-) G/C upstream_transcript_variant
rs1003034139 -- 111,878,610(-) C/G coding_sequence_variant, intron_variant, missense_variant
rs1003391583 -- 111,878,245(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FDXACB1 Gene

Variant ID Type Subtype PubMed ID
esv3627745 CNV gain 21293372
nsv832269 CNV loss 17160897

Variation tolerance for FDXACB1 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FDXACB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDXACB1 Gene

Disorders for FDXACB1 Gene

Additional Disease Information for FDXACB1

No disorders were found for FDXACB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FDXACB1 Gene

Publications for FDXACB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58

Products for FDXACB1 Gene

Sources for FDXACB1 Gene

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