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This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014] See more...
Aliases for FDX2 Gene
Aliases for FDX2 Gene
External Ids for FDX2 Gene
- HGNC: 30546
- Entrez Gene: 112812
- Ensembl: ENSG00000267673
- OMIM: 614585
- UniProtKB: Q6P4F2
Previous HGNC Symbols for FDX2 Gene
- FDX1L
Previous GeneCards Identifiers for FDX2 Gene
- GC00U990097
Summaries for FDX2 Gene
-
This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]
GeneCards Summary for FDX2 Gene
FDX2 (Ferredoxin 2) is a Protein Coding gene. Diseases associated with FDX2 include Mitochondrial Myopathy, Episodic, With Or Without Optic Atrophy And Reversible Leukoencephalopathy and Mitochondrial Myopathy. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of steroid hormones. An important paralog of this gene is ENSG00000167807.
UniProtKB/Swiss-Prot Summary for FDX2 Gene
-
Essential for heme A and Fe/S protein biosynthesis.
Additional gene information for FDX2 Gene
- HGNC(30546)
- Entrez Gene(112812)
- Ensembl(ENSG00000267673)
- OMIM(614585)
- UniProtKB(Q6P4F2)
- Open Targets Platform(ENSG00000267673)
- Search for FDX2 at DataMed
- Search for FDX2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FDX2 Gene
Genomics for FDX2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FDX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FDX2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FDX2
Genomic Locations for FDX2 Gene
Genomic Locations for FDX2 Gene
- chr19:10,310,045-10,316,015
- (GRCh38/hg38)
- Size:
- 5,971 bases
- Orientation:
- Minus strand
- chr19:10,416,103-10,426,691
- (GRCh37/hg19)
- Size:
- 10,589 bases
- Orientation:
- Minus strand
Genomic View for FDX2 Gene
Genes around FDX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
FDX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FDX2 Gene
Proteins for FDX2 Gene
-
Protein details for FDX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P4F2-FDX2_HUMAN
- Recommended name:
- Ferredoxin-2, mitochondrial
- Protein Accession:
- Q6P4F2
- B7Z6L7
- Q8N8B8
Protein attributes for FDX2 Gene
- Size:
- 186 amino acids
- Molecular mass:
- 19888 Da
- Cofactor:
- Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH63460.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Post-translational modifications for FDX2 Gene
Other Protein References for FDX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FDX2
- Invitrogen Antibodies for FDX2 (AFLGC-FDX1L)
Protein Products
-
OriGene Purified Proteins for FDX2
- Search Origene for MassSpec and Protein Over-expression Lysates for FDX2
- Origene Custom Protein Services for FDX2
- antibodies-online: Show 4 available FDX1L Proteins ranked by validation data
- Compare Top FDX1L Proteins
-
Quality Products:
Assay Products
- antibodies-online: Show 5 available FDX1L Elisa Kits ranked by validation data
- Compare Top FDX1L Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FDX2 Gene
Domains & Families for FDX2 Gene
Gene Families for FDX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FDX2 Gene
- InterPro:
- Blocks:
-
- Ferredoxin
- Adrenodoxin
- ProtoNet:
Suggested Antigen Peptide Sequences for FDX2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ferredoxin-1-like protein (ADXL_HUMAN)
- cDNA FLJ39703 fis, clone SMINT2012195 (Q8N8B8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6P4F2- Family:
-
- Belongs to the adrenodoxin/putidaredoxin family.
Function for FDX2 Gene
Molecular function for FDX2 Gene
- UniProtKB/Swiss-Prot Function:
- Essential for heme A and Fe/S protein biosynthesis.
Phenotypes From GWAS Catalog for FDX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0009055 | electron transfer activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0051536 | iron-sulfur cluster binding | IEA | -- |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | IEA | -- |
Phenotypes for FDX2 Gene
- MGI mutant phenotypes for FDX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FDX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FDX2 - Select products 50% OFF >
- * FDX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FDX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FDX2
miRNA for FDX2 Gene
- miRTarBase miRNAs that target FDX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FDX2
- Browse OriGene Inhibitory RNA Products For FDX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FDX2
Clone Products
- Applied Biological Materials (abm): Clones for FDX2 - Select products 50% OFF >
- * FDX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FDX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FDX2
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FDX2 Gene
Localization for FDX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FDX2 Gene
- Mitochondrion. Mitochondrion matrix.
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FDX2 Gene
Pathways & Interactions for FDX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type | ||
| 2 | Diseases of metabolism | ||
| 3 | Metabolism |
.40
|
|
| 4 | Metabolism of steroid hormones | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for FDX2 Gene
Interacting Proteins for FDX2 Gene
Selected Interacting proteins:
Q6P4F2-FDX2_HUMAN
ENSP00000377311
for FDX2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FDX2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006700 | C21-steroid hormone biosynthetic process | TAS | -- |
| GO:0016125 | sterol metabolic process | TAS | -- |
| GO:0022900 | electron transport chain | IEA | -- |
| GO:0044281 | small molecule metabolic process | TAS | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for FDX2 Gene
Transcripts for FDX2 Gene
mRNA/cDNA for FDX2 Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343376 614 nts (view in UCSC)
- ENST00000393708 1012 nts (view in UCSC)
- ENST00000453681 635 nts (view in UCSC)
- ENST00000460631 777 nts (view in UCSC)
- ENST00000486454 584 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FDX2 - Select products 50% OFF >
- * FDX2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FDX2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FDX2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FDX2
- Browse OriGene Inhibitory RNA Products For FDX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FDX2
Clone Products
- Applied Biological Materials (abm): Clones for FDX2 - Select products 50% OFF >
- * FDX2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FDX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FDX2
Relevant External Links for FDX2 Gene
- GeneLoc Exon Structure for
- FDX2
Expression for FDX2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FDX2
mRNA Expression by UniProt/SwissProt for FDX2 Gene:
Q6P4F2-FDX2_HUMAN
Tissue specificity:
Widely expressed, with highest levels in testis, kidney and brain (at protein level) (PubMed:20547883). Expressed in muscle (at protein level) (PubMed:24281368, PubMed:30010796). Expressed in fibroblasts (at protein level) (PubMed:24281368).
Evidence on tissue expression from TISSUES for FDX2 Gene
- Liver(4.2)
- Nervous system(4.2)
- Intestine(4)
Primer Products
-
OriGene qPCR primer pairs for FDX2
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FDX2 Gene
Orthologs for FDX2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FDX1L 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FDX1L 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FDX1L 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fdx1l 30 31 |
|
OneToOne | |
| Fdx2 17 |
|
||||
| Rat (Rattus norvegicus) |
Mammalia | Fdx1l 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fdx1l 30 |
|
||
| Str.7854 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | fdx1l 30 31 |
|
OneToMany | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5955 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Fdxh 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006799 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y73F8A.27 30 |
|
||
| Y73F8A.27 31 |
|
OneToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFL169C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YAH1 30 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B10307g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MFDX1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os09g0437900 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07794 30 |
|
- Species where no ortholog for FDX2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FDX2 Gene
- ENSEMBL:
- Gene Tree for FDX2 (if available)
- TreeFam:
- Gene Tree for FDX2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FDX2: view image
Paralogs for FDX2 Gene
Paralogs for FDX2 Gene
Pseudogenes.org Pseudogenes for FDX2 Gene
Variants for FDX2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FDX2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 668503 | Likely Benign: not provided | 10,315,509(-) | G/T | INTRON_VARIANT | |
| rs1048941 | Benign: not specified; not provided | 10,310,540(-) | C/A | SYNONYMOUS_VARIANT | |
| rs1064794814 | Likely Benign: not specified | 10,315,505(-) | GGAAGTGCGAA/AGAA | INTRON_VARIANT | |
| rs138346574 | Likely Benign: not specified | 10,315,914(-) | C/G | MISSENSE_VARIANT | |
| rs145549252 | Benign: not specified | 10,316,029(-) | G/GCGC |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2667969 | CNV | deletion | 23128226 |
| nsv470124 | CNV | gain | 18288195 |
Residual Variation Intolerance Score:
58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FDX2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FDX2 Gene
Disorders for FDX2 Gene
(9) MalaCards diseases for FDX2 Gene - From: UniProtKB/Swiss-Prot, OMIM, GTR, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mitochondrial myopathy, episodic, with or without optic atrophy and reversible leukoencephalopathy |
|
|
| mitochondrial myopathy |
|
|
| myopathy |
|
|
| multiple mitochondrial dysfunctions syndrome 1 |
|
|
| combined oxidative phosphorylation deficiency 19 |
|
|
Search FDX2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FDX2_HUMAN- Mitochondrial myopathy, episodic, with optic atrophy and reversible leukoencephalopathy (MEOAL) [MIM:251900]: An autosomal recessive neuromuscular disorder characterized by childhood onset of recurrent episodes of proximal weakness and myalgia often precipitated by exercise, infections or low temperature. Additional features are optic atrophy, axonal polyneuropathy, and reversible or partially reversible leukoencephalopathy. {ECO:0000269 PubMed:24281368, ECO:0000269 PubMed:30010796}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FDX2
No data available for Genatlas for FDX2 Gene
Publications for FDX2 Gene
- Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy. (PMID: 24281368) Spiegel R … Elpeleg O (European journal of human genetics : EJHG 2014) 2 3 4
- A novel complex neurological phenotype due to a homozygous mutation in FDX2. (PMID: 30010796) Gurgel-Giannetti J … Kok F (Brain : a journal of neurology 2018) 3 4
- Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. (PMID: 22101253) Shi Y … Rouault TA (Biochimica et biophysica acta 2012) 2 3
- Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. (PMID: 20547883) Sheftel AD … Lill R (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for FDX2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FDX2
- Search Origene for MassSpec and Protein Over-expression Lysates for FDX2
- Origene Custom Protein Services for FDX2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FDX2
- Browse OriGene Inhibitory RNA Products For FDX2
- OriGene qPCR primer pairs for FDX2
- OriGene CRISPR knockouts for FDX2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FDX2
- Sino Biological Human cDNA Clone for FDX2
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FDX2
- Novus Biologicals proteins and lysates for FDX2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for FDX2 (AFLGC-FDX1L)
- VectorBuilder Custom and pre-made DNA vectors for FDX2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FDX2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FDX2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FDX2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FDX2
- antibodies-online: Search results for available FDX1L related products ranked by validation data
- antibodies-online: Show 5 available FDX1L Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 4 available FDX1L Proteins ranked by validation data
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- Quality Products:
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FDX2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FDX2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FDX2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FDX2
Sources for FDX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB