This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011] See more...

Aliases for FDX1 Gene

Aliases for FDX1 Gene

  • Ferredoxin 1 2 3 5
  • Adrenodoxin, Mitochondrial 3 4
  • Adrenal Ferredoxin 3 4
  • Hepatoredoxin 3 4
  • ADX 3 4
  • Mitochondrial Adrenodoxin 3
  • Ferredoxin-1 4
  • Adrenodoxin 2
  • LOH11CR1D 3
  • FDX 3

External Ids for FDX1 Gene

Previous HGNC Symbols for FDX1 Gene

  • FDX

Previous GeneCards Identifiers for FDX1 Gene

  • GC11P112572
  • GC11P111771
  • GC11P110334
  • GC11P109838
  • GC11P109805
  • GC11P106225

Summaries for FDX1 Gene

Entrez Gene Summary for FDX1 Gene

  • This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]

GeneCards Summary for FDX1 Gene

FDX1 (Ferredoxin 1) is a Protein Coding gene. Diseases associated with FDX1 include Cerebrotendinous Xanthomatosis and Xanthomatosis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Mitochondrial iron-sulfur cluster biogenesis. Gene Ontology (GO) annotations related to this gene include iron ion binding and iron-sulfur cluster binding. An important paralog of this gene is FDX2.

UniProtKB/Swiss-Prot Summary for FDX1 Gene

  • Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).

Gene Wiki entry for FDX1 Gene

Additional gene information for FDX1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FDX1 Gene

Genomics for FDX1 Gene

GeneHancer (GH) Regulatory Elements for FDX1 Gene

Promoters and enhancers for FDX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J110091 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 501.9 -336.1 -336051 4.6 RXRA EP300 CTCF SIN3A POLR2G PHF8 ZFX ZNF10 POLR2A ZBTB10 FDX1 ZC3H12C RDX lnc-ARHGAP20-52
GH11J110427 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 519.7 +1.7 1715 7.5 EP300 CTCF SIN3A NRF1 POLR2G ZFX ZIC2 POLR2A ZBTB11 ZBTB26 FDX1 5MWI_A-028 ENSG00000271390 lnc-RDX-5 HSALNG0087063
GH11J110354 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 512.4 -73.3 -73343 4.2 TCF12 TRIM28 EP300 CTBP1 FOXA2 NR2F2 CREB1 MBD2 BRCA1 CEBPG FDX1 LINC02732 RDX ZC3H12C piR-47675-019 lnc-RDX-4
GH11J110372 Enhancer 1.1 FANTOM5 ENCODE 23 -55.9 -55935 3.2 SP1 EP300 JUND RELA MEF2C RCOR1 BCL11A NR2F2 FOS SRF FDX1 LINC02732 ZC3H12C RDX lnc-RDX-4 piR-47675-019
GH11J110376 Enhancer 1 ENCODE CraniofacialAtlas 22.1 -52.6 -52625 2 ZNF217 CTCF REST TGIF2 RAD21 TRIM22 SMC3 SIN3A NR2F2 CREB1 lnc-RDX-4 FDX1 piR-47675-019 LINC02732
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FDX1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FDX1

Top Transcription factor binding sites by QIAGEN in the FDX1 gene promoter:
  • C/EBPalpha
  • FAC1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • GATA-1
  • Pax-4a
  • Pbx1a
  • Sp1

Genomic Locations for FDX1 Gene

Genomic Locations for FDX1 Gene
chr11:110,429,937-110,464,884
(GRCh38/hg38)
Size:
34,948 bases
Orientation:
Plus strand
chr11:110,300,594-110,335,605
(GRCh37/hg19)
Size:
35,012 bases
Orientation:
Plus strand

Genomic View for FDX1 Gene

Genes around FDX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FDX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FDX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FDX1 Gene

Proteins for FDX1 Gene

  • Protein details for FDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10109-ADX_HUMAN
    Recommended name:
    Adrenodoxin, mitochondrial
    Protein Accession:
    P10109
    Secondary Accessions:
    • B0YJ14
    • Q53YD6

    Protein attributes for FDX1 Gene

    Size:
    184 amino acids
    Molecular mass:
    19393 Da
    Cofactor:
    Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
    Quaternary structure:
    • Interacts with CYP11A1.

    Three dimensional structures from OCA and Proteopedia for FDX1 Gene

neXtProt entry for FDX1 Gene

Post-translational modifications for FDX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FDX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FDX1 Gene

Domains & Families for FDX1 Gene

Gene Families for FDX1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FDX1 Gene

Suggested Antigen Peptide Sequences for FDX1 Gene

GenScript: Design optimal peptide antigens:
  • Hepatoredoxin (ADX_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10109

UniProtKB/Swiss-Prot:

ADX_HUMAN :
  • Belongs to the adrenodoxin/putidaredoxin family.
Family:
  • Belongs to the adrenodoxin/putidaredoxin family.
genes like me logo Genes that share domains with FDX1: view

Function for FDX1 Gene

Molecular function for FDX1 Gene

UniProtKB/Swiss-Prot Function:
Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Redox potential: E(0) is -448 mV.;
GENATLAS Biochemistry:
ferredoxin,ion sulfur electron transport protein for mitochondrial P450s

Phenotypes From GWAS Catalog for FDX1 Gene

Gene Ontology (GO) - Molecular Function for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding TAS 2969697
GO:0009055 electron transfer activity IDA,TAS 21636783
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
GO:0051537 2 iron, 2 sulfur cluster binding IDA 21636783
genes like me logo Genes that share ontologies with FDX1: view
genes like me logo Genes that share phenotypes with FDX1: view

Animal Models for FDX1 Gene

MGI Knock Outs for FDX1:
  • Fdx1 Fdx1<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FDX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FDX1 Gene

Localization for FDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FDX1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FDX1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,TAS --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with FDX1: view

Pathways & Interactions for FDX1 Gene

genes like me logo Genes that share pathways with FDX1: view

Gene Ontology (GO) - Biological Process for FDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006700 C21-steroid hormone biosynthetic process TAS --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process IDA,IEA 21636783
genes like me logo Genes that share ontologies with FDX1: view

No data available for SIGNOR curated interactions for FDX1 Gene

Drugs & Compounds for FDX1 Gene

(17) Drugs for FDX1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitotane Approved Pharma Target, unknown 14

(21) Additional Compounds for FDX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FDX1: view

Transcripts for FDX1 Gene

mRNA/cDNA for FDX1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FDX1

Alternative Splicing Database (ASD) splice patterns (SP) for FDX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for FDX1 Gene

GeneLoc Exon Structure for
FDX1

Expression for FDX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FDX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FDX1 Gene

This gene is overexpressed in Adrenal Gland (x21.0).

Protein differential expression in normal tissues from HIPED for FDX1 Gene

This gene is overexpressed in Nasal epithelium (23.6), Adrenal (7.5), and Fetal testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FDX1 Gene



Protein tissue co-expression partners for FDX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FDX1

SOURCE GeneReport for Unigene cluster for FDX1 Gene:

Hs.744

mRNA Expression by UniProt/SwissProt for FDX1 Gene:

P10109-ADX_HUMAN
Tissue specificity: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level).

Evidence on tissue expression from TISSUES for FDX1 Gene

  • Liver(4.5)
  • Lung(4.2)
  • Adrenal gland(3.9)
  • Nervous system(3.1)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with FDX1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FDX1 Gene

Orthologs for FDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FDX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FDX1 31 30
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FDX1 31 30
  • 84.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fdx1 30
  • 77.9 (n)
cow
(Bos Taurus)
Mammalia FDX1 31 30
  • 77.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fdx1 17 31 30
  • 77.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FDX1 31
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FDX1 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FDX1 31 30
  • 76.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FDX1 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fdx1 30
  • 72.18 (n)
Str.909 30
zebrafish
(Danio rerio)
Actinopterygii fdx1 31 30
  • 69.05 (n)
OneToOne
Dr.13680 30
fruit fly
(Drosophila melanogaster)
Insecta CG1319 31 30
  • 61.01 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003212 30
  • 52.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAH1 31
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4213 31
  • 36 (a)
OneToOne
Species where no ortholog for FDX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FDX1 Gene

ENSEMBL:
Gene Tree for FDX1 (if available)
TreeFam:
Gene Tree for FDX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FDX1: view image

Paralogs for FDX1 Gene

Paralogs for FDX1 Gene

(1) SIMAP similar genes for FDX1 Gene using alignment to 1 proteins:

  • ADX_HUMAN

Pseudogenes.org Pseudogenes for FDX1 Gene

genes like me logo Genes that share paralogs with FDX1: view

Variants for FDX1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FDX1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
709108 Benign: not provided 110,457,021(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FDX1 Gene

Variation tolerance for FDX1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FDX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FDX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FDX1 Gene

Disorders for FDX1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for FDX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebrotendinous xanthomatosis
  • ctx
xanthomatosis
  • xanthomatosis, susceptibility to
maxillary sinus neoplasm
  • neoplasm of maxillary sinus
alzheimer disease 10
  • alzheimer disease, familial, 10
adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete
  • p450scc deficiency
- elite association - COSMIC cancer census association via MalaCards
Search FDX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FDX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FDX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FDX1 Gene

Publications for FDX1 Gene

  1. Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. (PMID: 12699818) Johnson D … Martin LL (Bioelectrochemistry (Amsterdam, Netherlands) 2003) 3 4 23 54
  2. Molecular cloning and sequence analysis of human placental ferredoxin. (PMID: 2969697) Mittal S … Vickery LE (Archives of biochemistry and biophysics 1988) 2 3 4 54
  3. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. (PMID: 21636783) Strushkevich N … Park HW (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54

Products for FDX1 Gene

Sources for FDX1 Gene