Aliases for FDX1 Gene
External Ids for FDX1 Gene
Previous HGNC Symbols for FDX1 Gene
Previous GeneCards Identifiers for FDX1 Gene
This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
GeneCards Summary for FDX1 Gene
FDX1 (Ferredoxin 1) is a Protein Coding gene. Diseases associated with FDX1 include Cerebrotendinous Xanthomatosis and Xanthomatosis. Among its related pathways are Diseases of metabolism and Metabolism of steroid hormones. Gene Ontology (GO) annotations related to this gene include iron ion binding and iron-sulfur cluster binding. An important paralog of this gene is FDX2.
UniProtKB/Swiss-Prot Summary for FDX1 Gene
Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).