Aliases for FCRL6 Gene

Aliases for FCRL6 Gene

  • Fc Receptor Like 6 2 3 5
  • Fc Receptor-Like Protein 6 3 4
  • Fc Receptor Homolog 6 3 4
  • FcR-Like Protein 6 3 4
  • FcRH6 3 4
  • IFGP6 3 4
  • IgSF Type I Transmembrane Receptor 3
  • Fc Receptor-Like Protein 7 3
  • Leukocyte Receptor 3
  • Fc Receptor-Like 6 2
  • FCRH6 4
  • FcRL6 4

External Ids for FCRL6 Gene

Previous GeneCards Identifiers for FCRL6 Gene

  • GC01P156584
  • GC01P158036
  • GC01P159771
  • GC01P131128

Summaries for FCRL6 Gene

GeneCards Summary for FCRL6 Gene

FCRL6 (Fc Receptor Like 6) is a Protein Coding gene. Diseases associated with FCRL6 include Viral Pneumonia and Lymphocytic Leukemia. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding. An important paralog of this gene is FCRL5.

UniProtKB/Swiss-Prot Summary for FCRL6 Gene

  • Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).

Additional gene information for FCRL6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCRL6 Gene

Genomics for FCRL6 Gene

GeneHancer (GH) Regulatory Elements for FCRL6 Gene

Promoters and enhancers for FCRL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159800 Promoter/Enhancer 0.9 EPDnew ENCODE 500.7 -0.1 -84 0.8 MEF2B SPI1 IKZF1 TBX21 FOS MTA2 IKZF2 EBF1 TCF12 MLLT1 FCRL6 MF281467 LOC105371464
GH01J159798 Enhancer 0.7 ENCODE 500.7 -1.5 -1475 0.2 CTCF REST MYC RAD21 TRIM22 ZBTB26 SMC3 ARNT YY1 ZNF707 FCRL6 MF281467 LOC729867 piR-30197-001
GH01J159802 Promoter 0.3 EPDnew 500.7 +1.8 1830 0.1 FCRL6 LOC105371464
GH01J159908 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.6 +117.0 116995 18.6 RXRA HNRNPK ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 MYC POLR2G TAGLN2 lnc-IGSF9-1 CFAP45 SNHG28 NCSTN ENSG00000228606 ENSG00000272668 RAD1P2 VSIG8 CADM3
GH01J159778 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -20.0 -20040 3.5 HNRNPK ZNF217 EP300 CTCF TCF12 NRF1 USF1 SP1 PHF8 JUND DUSP23 LOC101928264 lnc-CRP-2 FCRL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCRL6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCRL6

Top Transcription factor binding sites by QIAGEN in the FCRL6 gene promoter:
  • Cart-1
  • FOXF2
  • GATA-1
  • GATA-2
  • GATA-3
  • Lhx3a
  • LHX3b
  • LyF-1
  • Pbx1a
  • POU3F2

Genomic Locations for FCRL6 Gene

Genomic Locations for FCRL6 Gene
chr1:159,800,511-159,816,257
(GRCh38/hg38)
Size:
15,747 bases
Orientation:
Plus strand
chr1:159,770,301-159,786,047
(GRCh37/hg19)
Size:
15,747 bases
Orientation:
Plus strand

Genomic View for FCRL6 Gene

Genes around FCRL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL6 Gene

Proteins for FCRL6 Gene

  • Protein details for FCRL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DN72-FCRL6_HUMAN
    Recommended name:
    Fc receptor-like protein 6
    Protein Accession:
    Q6DN72
    Secondary Accessions:
    • A1KXW6
    • A2A4D6
    • Q6DN73
    • Q6XRC3
    • Q6ZNI1

    Protein attributes for FCRL6 Gene

    Size:
    434 amino acids
    Molecular mass:
    47748 Da
    Quaternary structure:
    • Interacts (tyrosine phosphorylated) with PTPN11 (PubMed:17213291, PubMed:20933011). Interacts (tyrosine phosphorylated) with PTPN6, INPP5D, INPPL1 and GRB2 (PubMed:20933011). Interacts with class II MHC HLA-DR when the alpha chain is associated with a beta-1, beta-4 or a beta-5 but not a beta-3 chain (PubMed:20519654).

    Alternative splice isoforms for FCRL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCRL6 Gene

Post-translational modifications for FCRL6 Gene

  • Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.
  • Glycosylation at Asn65 and Asn273
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCRL6 Gene

Domains & Families for FCRL6 Gene

Gene Families for FCRL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCRL6 Gene

Blocks:
  • Immunoglobulin C-2 type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCRL6 Gene

GenScript: Design optimal peptide antigens:
  • IFGP6 (FCRL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DN72

UniProtKB/Swiss-Prot:

FCRL6_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.
genes like me logo Genes that share domains with FCRL6: view

Function for FCRL6 Gene

Molecular function for FCRL6 Gene

UniProtKB/Swiss-Prot Function:
Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).
UniProtKB/Swiss-Prot Induction:
Down-regulated upon stimulation with mitogen phytohaemagglutinin (PHA) or concavalin A in peripheral blood mononuclear cells (PBMCs).

Phenotypes From GWAS Catalog for FCRL6 Gene

Gene Ontology (GO) - Molecular Function for FCRL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20933011
GO:0019902 phosphatase binding IPI 20933011
GO:0019903 protein phosphatase binding IPI 20933011
GO:0042289 MHC class II protein binding IDA 20519654
genes like me logo Genes that share ontologies with FCRL6: view
genes like me logo Genes that share phenotypes with FCRL6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCRL6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL6 Gene

Localization for FCRL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL6 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL6 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
lysosome 0

Gene Ontology (GO) - Cellular Components for FCRL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 18991291
GO:0009897 external side of plasma membrane IDA 17213291
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL6 Gene

Pathways & Interactions for FCRL6 Gene

PathCards logo

SuperPathways for FCRL6 Gene

No Data Available

Interacting Proteins for FCRL6 Gene

;

Gene Ontology (GO) - Biological Process for FCRL6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FCRL6 Gene

Drugs & Compounds for FCRL6 Gene

No Compound Related Data Available

Transcripts for FCRL6 Gene

mRNA/cDNA for FCRL6 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCRL6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: - -
SP4:
SP5:

Relevant External Links for FCRL6 Gene

GeneLoc Exon Structure for
FCRL6

Expression for FCRL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCRL6 Gene

mRNA differential expression in normal tissues according to GTEx for FCRL6 Gene

This gene is overexpressed in Whole Blood (x28.5) and Spleen (x6.5).

Protein differential expression in normal tissues from HIPED for FCRL6 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL6 Gene



Protein tissue co-expression partners for FCRL6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCRL6

SOURCE GeneReport for Unigene cluster for FCRL6 Gene:

Hs.196955

mRNA Expression by UniProt/SwissProt for FCRL6 Gene:

Q6DN72-FCRL6_HUMAN
Tissue specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8(+) T-cells, and a subset of NKT cells (at protein level) (PubMed:17213291, PubMed:18991291, PubMed:20933011). Also expressed in gamma delta T cells and in a rare subset of effector CD4(+) T-cells (at protein level) (PubMed:18991291). Expressed in spleen, skin, peripheral blood leukocytes, liver, lung, bone marrow, small intestine and placenta (PubMed:20933011). Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8(+) T-cells but also populations of CD4(+) T-cells (PubMed:17213291, PubMed:20933011). Expression among CD8(+) T-cells and NK cells is expanded in individuals with chronic lymphocytic leukemia (CLL) but is reduced in PBMCs from patients with acute (AML), chronic myeloid leukemia (CML) and non-Hodgkin's lymphoma (PubMed:18991291, PubMed:20933011). Expression is higher in PBMCs and/or CD3(+) cells of patients with autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia purpura (ITP) (PubMed:20933011). In contrast, expression in CD3(+) cells from patients with lupus anticoagulans (LA) is higher (PubMed:20933011).

Evidence on tissue expression from TISSUES for FCRL6 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with FCRL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL6 Gene

Orthologs for FCRL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRL6 31 30
  • 95.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FCRL6 31 30
  • 76.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fcrl6 30
  • 66.04 (n)
mouse
(Mus musculus)
Mammalia Fcrl6 17 31 30
  • 63.53 (n)
dog
(Canis familiaris)
Mammalia FCRL6 31
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FCRL6 31
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 32 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FCRL2 31
  • 18 (a)
OneToMany
Species where no ortholog for FCRL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL6 Gene

ENSEMBL:
Gene Tree for FCRL6 (if available)
TreeFam:
Gene Tree for FCRL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCRL6: view image

Paralogs for FCRL6 Gene

(4) SIMAP similar genes for FCRL6 Gene using alignment to 2 proteins:

  • FCRL6_HUMAN
  • F5GYB3_HUMAN

Pseudogenes.org Pseudogenes for FCRL6 Gene

genes like me logo Genes that share paralogs with FCRL6: view

Variants for FCRL6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCRL6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
714796 Benign: not provided 159,808,358(+) G/A MISSENSE_VARIANT
717386 Benign: not provided 159,809,115(+) C/T SYNONYMOUS_VARIANT
722613 Benign: not provided 159,815,637(+) C/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
747029 Likely Benign: not provided 159,809,145(+) G/A SYNONYMOUS_VARIANT
758778 Likely Benign: not provided 159,809,254(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for FCRL6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FCRL6 Gene

Variant ID Type Subtype PubMed ID
esv991387 CNV insertion 20482838
nsv1005195 CNV gain 25217958
nsv521503 CNV loss 19592680

Variation tolerance for FCRL6 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRL6 Gene

Human Gene Mutation Database (HGMD)
FCRL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCRL6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL6 Gene

Disorders for FCRL6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FCRL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
viral pneumonia
  • pneumonia, viral
lymphocytic leukemia
  • lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search FCRL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCRL6

genes like me logo Genes that share disorders with FCRL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCRL6 Gene

Publications for FCRL6 Gene

  1. FCRL6 receptor: expression and associated proteins. (PMID: 20933011) Kulemzin SV … Mechetina LV (Immunology letters 2011) 3 4 54
  2. Cutting edge: FcR-like 6 is an MHC class II receptor. (PMID: 20519654) Schreeder DM … Davis RS (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 4 54
  3. FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia. (PMID: 18991291) Schreeder DM … Davis RS (European journal of immunology 2008) 3 4 54
  4. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. (PMID: 17213291) Wilson TJ … Colonna M (Blood 2007) 3 4 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for FCRL6 Gene

Sources for FCRL6 Gene