Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FCRL5 Gene

Aliases for FCRL5 Gene

  • Fc Receptor Like 5 2 3 5
  • Immune Receptor Translocation-Associated Protein 2 3 4
  • Fc Receptor Homolog 5 3 4
  • FcR-Like Protein 5 3 4
  • BXMAS1 3 4
  • FCRH5 3 4
  • IRTA2 3 4
  • Immunoglobulin Superfamily Receptor Translocation Associated 2 (IRTA2) 3
  • Fc Receptor-Like Protein 5 3
  • Fc Receptor-Like 5 2
  • CD307e Antigen 4
  • CD307e 3
  • PRO820 3
  • CD307 3
  • FcRH5 4
  • FcRL5 4

External Ids for FCRL5 Gene

Previous GeneCards Identifiers for FCRL5 Gene

  • GC01M154297
  • GC01M155752
  • GC01M128841

Summaries for FCRL5 Gene

Entrez Gene Summary for FCRL5 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for FCRL5 Gene

FCRL5 (Fc Receptor Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include Hairy Cell Leukemia and Burkitt Lymphoma. An important paralog of this gene is FCRL3.

UniProtKB/Swiss-Prot for FCRL5 Gene

  • May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Gene Wiki entry for FCRL5 Gene

Additional gene information for FCRL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL5 Gene

Genomics for FCRL5 Gene

GeneHancer (GH) Regulatory Elements for FCRL5 Gene

Promoters and enhancers for FCRL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J157552 Promoter/Enhancer 1.2 EPDnew ENCODE 685.4 0.0 -45 1 PKNOX1 SMAD1 IRF4 RELA POLR2A NFATC1 ATF7 BCLAF1 IKZF2 RUNX3 FCRL5 FCRL4 GC01P157412
GH01J157562 Enhancer 0.7 FANTOM5 40 -10.2 -10155 0.3 SRF PKNOX1 MEF2B DPF2 ATF2 ZNF217 IKZF1 NFATC1 NBN ATF7 FCRL5 FCRL4
GH01J157566 Enhancer 0.6 ENCODE 36.2 -14.4 -14436 1.7 MAFG MEF2B ELF1 RELA ZNF217 IKZF1 VEZF1 NFATC1 ATF7 NFE2 FCRL5 ENSG00000227217 FCRL3 FCRL4
GH01J157510 Enhancer 1 ENCODE dbSUPER 17.2 +40.5 40499 2.5 HDGF PKNOX1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 FCRL5 PRCC FCRL1 PIR33564 GC01P157412
GH01J157595 Enhancer 0.8 ENCODE 11.2 -43.0 -43016 0.1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM CBFB FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCRL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCRL5 gene promoter:
  • POU2F1a
  • POU2F1
  • AML1a
  • LUN-1
  • FOXJ2 (long isoform)
  • FOXJ2
  • GCNF-2
  • GCNF-1
  • GCNF
  • RORalpha1

Genomic Locations for FCRL5 Gene

Genomic Locations for FCRL5 Gene
39,144 bases
Minus strand
39,144 bases
Minus strand

Genomic View for FCRL5 Gene

Genes around FCRL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL5 Gene

Proteins for FCRL5 Gene

  • Protein details for FCRL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fc receptor-like protein 5
    Protein Accession:
    Secondary Accessions:
    • A0N0M2
    • B7WNT9
    • B7WP94
    • Q495Q2
    • Q495Q4
    • Q5VYK9
    • Q6UY46

    Protein attributes for FCRL5 Gene

    977 amino acids
    Molecular mass:
    106437 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL5 Gene


neXtProt entry for FCRL5 Gene

Post-translational modifications for FCRL5 Gene

  • Glycosylation at Asn383
  • Modification sites at PhosphoSitePlus

Other Protein References for FCRL5 Gene

Antibody Products

  • Abcam antibodies for FCRL5
  • Boster Bio Antibodies for FCRL5

No data available for DME Specific Peptides for FCRL5 Gene

Domains & Families for FCRL5 Gene

Gene Families for FCRL5 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCRL5 Gene

Suggested Antigen Peptide Sequences for FCRL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).
genes like me logo Genes that share domains with FCRL5: view

Function for FCRL5 Gene

Molecular function for FCRL5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Phenotypes From GWAS Catalog for FCRL5 Gene

genes like me logo Genes that share phenotypes with FCRL5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FCRL5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCRL5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL5 Gene

Localization for FCRL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FCRL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 16849395
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with FCRL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL5 Gene

Pathways & Interactions for FCRL5 Gene

SuperPathways for FCRL5 Gene

No Data Available

Interacting Proteins for FCRL5 Gene

Gene Ontology (GO) - Biological Process for FCRL5 Gene


No data available for Pathways by source and SIGNOR curated interactions for FCRL5 Gene

Drugs & Compounds for FCRL5 Gene

No Compound Related Data Available

Transcripts for FCRL5 Gene

Unigene Clusters for FCRL5 Gene

Fc receptor-like 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCRL5

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP9: - -

Relevant External Links for FCRL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCRL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL5 Gene

This gene is overexpressed in Spleen (x12.2) and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for FCRL5 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL5 Gene

Protein tissue co-expression partners for FCRL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCRL5 Gene:


SOURCE GeneReport for Unigene cluster for FCRL5 Gene:


mRNA Expression by UniProt/SwissProt for FCRL5 Gene:

Tissue specificity: Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).

Evidence on tissue expression from TISSUES for FCRL5 Gene

  • Lymph node(4.3)
genes like me logo Genes that share expression patterns with FCRL5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL5 Gene

Orthologs for FCRL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCRL5 34 33
  • 98.5 (n)
(Canis familiaris)
Mammalia FCRL5 34 33
  • 72.58 (n)
(Bos Taurus)
Mammalia FCRL5 34 33
  • 66.81 (n)
(Mus musculus)
Mammalia Fcrl5 16 34 33
  • 62.82 (n)
(Rattus norvegicus)
Mammalia Fcrl3 33
  • 60.48 (n)
(Gallus gallus)
Aves FCRL2 34
  • 30 (a)
Species where no ortholog for FCRL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL5 Gene

Gene Tree for FCRL5 (if available)
Gene Tree for FCRL5 (if available)
Evolutionary constrained regions (ECRs) for FCRL5: view image

Paralogs for FCRL5 Gene

(10) SIMAP similar genes for FCRL5 Gene using alignment to 3 proteins:

  • F5GXJ2_HUMAN Pseudogenes for FCRL5 Gene

genes like me logo Genes that share paralogs with FCRL5: view

Variants for FCRL5 Gene

Sequence variations from dbSNP and Humsavar for FCRL5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035514 A breast cancer sample p.Ser687Cys
rs1000047883 -- 157,531,420(-) A/G intron_variant
rs1000436157 -- 157,548,355(-) A/C intron_variant
rs1000577338 -- 157,548,094(-) G/T intron_variant
rs1000620773 -- 157,553,134(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL5 Gene

Variant ID Type Subtype PubMed ID
esv2718507 CNV deletion 23290073
esv275399 CNV loss 21479260
nsv3143 CNV insertion 18451855
nsv831681 CNV gain+loss 17160897
nsv946430 CNV duplication 23825009
nsv946431 CNV duplication 23825009

Variation tolerance for FCRL5 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL5 Gene

Disorders for FCRL5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FCRL5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hairy cell leukemia
  • hcl-v
burkitt lymphoma
  • bl
- elite association - COSMIC cancer census association via MalaCards
Search FCRL5 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269 PubMed:11290337}.

Additional Disease Information for FCRL5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCRL5: view

No data available for Genatlas for FCRL5 Gene

Publications for FCRL5 Gene

  1. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PMID: 11929751) Miller I … Dalla-Favera R (Blood 2002) 3 4 22 58
  2. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. (PMID: 11290337) Hatzivassiliou G … Dalla-Favera R (Immunity 2001) 2 3 4 58
  3. Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. (PMID: 20626413) Simmonds MJ … Gough SC (Clinical endocrinology 2010) 3 44 58
  4. A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients. (PMID: 19775371) Tang X … Xu J (Tissue antigens 2009) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for FCRL5 Gene

Sources for FCRL5 Gene

Loading form....