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Aliases for FCRL1 Gene

Aliases for FCRL1 Gene

  • Fc Receptor Like 1 2 3 5
  • Immune Receptor Translocation-Associated Protein 5 3 4
  • Fc Receptor Homolog 1 3 4
  • IFGP Family Protein 1 3 4
  • FcR-Like Protein 1 3 4
  • HIFGP1 3 4
  • FCRH1 3 4
  • IFGP1 3 4
  • IRTA5 3 4
  • Immunoglobulin Superfamily Fc Receptor, Gp42 3
  • Fc Receptor-Like Protein 1 3
  • Fc Receptor-Like 1 2
  • CD307a Antigen 4
  • CD307a 3
  • FcRH1 4
  • FcRL1 4

External Ids for FCRL1 Gene

Previous GeneCards Identifiers for FCRL1 Gene

  • GC01M154579
  • GC01M156030
  • GC01M129122

Summaries for FCRL1 Gene

Entrez Gene Summary for FCRL1 Gene

  • This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCRL1 Gene

FCRL1 (Fc Receptor Like 1) is a Protein Coding gene. An important paralog of this gene is FCRL2.

UniProtKB/Swiss-Prot for FCRL1 Gene

  • May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.

Gene Wiki entry for FCRL1 Gene

Additional gene information for FCRL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCRL1 Gene

Genomics for FCRL1 Gene

GeneHancer (GH) Regulatory Elements for FCRL1 Gene

Promoters and enhancers for FCRL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J157820 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.0 10 0.1 FCRL1 FCRL2
GH01J157721 Enhancer 1 Ensembl ENCODE dbSUPER 10 +95.7 95716 6.4 NR2F1 ZBTB7B ATF2 RELA GABPA ZNF585B POLR2A IKZF1 NBN ZNF143 VDAC1P9 FCRL3 ENSG00000227217 FCRL2 FCRL1 SONP1
GH01J157510 Enhancer 1 ENCODE dbSUPER 9.3 +308.1 308129 2.5 HDGF PKNOX1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 FCRL5 PRCC FCRL1 PIR33564 GC01P157412
GH01J157773 Enhancer 0.5 ENCODE 15.5 +46.0 45959 1.5 CTCF TARDBP TRIM22 NBN RAD21 SPI1 PIR43091 FCRL3 FCRL1 FCRL5 FCRL2
GH01J157595 Enhancer 0.8 ENCODE 9.5 +224.6 224614 0.1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM CBFB FCRL5 ENSG00000227217 FCRL3 FCRL2 FCRL1 FCRL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCRL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCRL1 gene promoter:
  • RORalpha1
  • Evi-1
  • AML1a
  • Max
  • c-Myc
  • AP-4
  • AP-1
  • USF-1
  • USF1
  • RP58

Genomic Locations for FCRL1 Gene

Genomic Locations for FCRL1 Gene
chr1:157,792,249-157,820,150
(GRCh38/hg38)
Size:
27,902 bases
Orientation:
Minus strand
chr1:157,764,193-157,789,940
(GRCh37/hg19)
Size:
25,748 bases
Orientation:
Minus strand

Genomic View for FCRL1 Gene

Genes around FCRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCRL1 Gene

Proteins for FCRL1 Gene

  • Protein details for FCRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA6-FCRL1_HUMAN
    Recommended name:
    Fc receptor-like protein 1
    Protein Accession:
    Q96LA6
    Secondary Accessions:
    • B2RE05
    • Q8N759
    • Q8NDI0
    • Q96PJ6

    Protein attributes for FCRL1 Gene

    Size:
    429 amino acids
    Molecular mass:
    46936 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCRL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCRL1 Gene

Post-translational modifications for FCRL1 Gene

No data available for DME Specific Peptides for FCRL1 Gene

Domains & Families for FCRL1 Gene

Gene Families for FCRL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCRL1 Gene

Suggested Antigen Peptide Sequences for FCRL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCRL1: view

No data available for UniProtKB/Swiss-Prot for FCRL1 Gene

Function for FCRL1 Gene

Molecular function for FCRL1 Gene

UniProtKB/Swiss-Prot Function:
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in activated B-cells.

Phenotypes From GWAS Catalog for FCRL1 Gene

Gene Ontology (GO) - Molecular Function for FCRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015026 coreceptor activity IDA 15479727
genes like me logo Genes that share ontologies with FCRL1: view
genes like me logo Genes that share phenotypes with FCRL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FCRL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCRL1 Gene

Localization for FCRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCRL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCRL1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 16849395
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCRL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCRL1 Gene

Pathways & Interactions for FCRL1 Gene

SuperPathways for FCRL1 Gene

No Data Available

Interacting Proteins for FCRL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357158%0d%0a9606.ENSP00000358262%0d%0a
Selected Interacting proteins: ENSP00000357158 Q96LA6-FCRL1_HUMAN for FCRL1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FCRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0042113 B cell activation IDA 15479727
genes like me logo Genes that share ontologies with FCRL1: view

No data available for Pathways by source and SIGNOR curated interactions for FCRL1 Gene

Drugs & Compounds for FCRL1 Gene

No Compound Related Data Available

Transcripts for FCRL1 Gene

Unigene Clusters for FCRL1 Gene

Fc receptor-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for FCRL1 Gene

GeneLoc Exon Structure for
FCRL1
ECgene alternative splicing isoforms for
FCRL1

Expression for FCRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCRL1 Gene

This gene is overexpressed in Spleen (x22.5), Small Intestine - Terminal Ileum (x13.5), and Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for FCRL1 Gene

This gene is overexpressed in Testis (32.2), Heart (28.6), and Blymphocyte (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCRL1 Gene



Protein tissue co-expression partners for FCRL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCRL1 Gene:

FCRL1

SOURCE GeneReport for Unigene cluster for FCRL1 Gene:

Hs.656112

mRNA Expression by UniProt/SwissProt for FCRL1 Gene:

Q96LA6-FCRL1_HUMAN
Tissue specificity: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).

Evidence on tissue expression from TISSUES for FCRL1 Gene

  • Lymph node(4.5)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with FCRL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCRL1 Gene

Orthologs for FCRL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCRL1 34 33
  • 99.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FCRL1 34 33
  • 76.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fcrl1 16 34 33
  • 75.16 (n)
dog
(Canis familiaris)
Mammalia FCRL1 34 33
  • 72.82 (n)
OneToOne
chicken
(Gallus gallus)
Aves FCRL2 34
  • 21 (a)
OneToMany
Species where no ortholog for FCRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCRL1 Gene

ENSEMBL:
Gene Tree for FCRL1 (if available)
TreeFam:
Gene Tree for FCRL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCRL1: view image

Paralogs for FCRL1 Gene

(4) SIMAP similar genes for FCRL1 Gene using alignment to 1 proteins:

  • FCRL1_HUMAN
genes like me logo Genes that share paralogs with FCRL1: view

Variants for FCRL1 Gene

Sequence variations from dbSNP and Humsavar for FCRL1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000044448 -- 157,793,340(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000133381 -- 157,816,348(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000143651 -- 157,808,106(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000202142 -- 157,794,231(-) TGT/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000522244 -- 157,811,776(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCRL1 Gene

Variant ID Type Subtype PubMed ID
esv3371841 CNV duplication 20981092
esv3587657 CNV loss 21293372

Variation tolerance for FCRL1 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCRL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCRL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCRL1 Gene

Disorders for FCRL1 Gene

Additional Disease Information for FCRL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FCRL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCRL1 Gene

Publications for FCRL1 Gene

  1. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. (PMID: 11929751) Miller I … Dalla-Favera R (Blood 2002) 2 3 4 58
  2. Identification of a family of Fc receptor homologs with preferential B cell expression. (PMID: 11493702) Davis RS … Cooper MD (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. (PMID: 17895404) Du X … Pastan I (Blood 2008) 3 22 58
  5. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. (PMID: 16849395) Polson AG … Ebens A (International immunology 2006) 3 4 58

Products for FCRL1 Gene

Sources for FCRL1 Gene

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