Aliases for FCN3 Gene
External Ids for FCN3 Gene
Previous GeneCards Identifiers for FCN3 Gene
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCN3 Gene
FCN3 (Ficolin 3) is a Protein Coding gene. Diseases associated with FCN3 include Ficolin 3 Deficiency and Rheumatic Heart Disease. Among its related pathways are Creation of C4 and C2 activators and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and antigen binding. An important paralog of this gene is FCN2.
UniProtKB/Swiss-Prot Summary for FCN3 Gene
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.