Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially ... See more...

Aliases for FCN3 Gene

Aliases for FCN3 Gene

  • Ficolin 3 2 3 5
  • HAKA1 2 3 4
  • FCNH 2 3 4
  • Collagen/Fibrinogen Domain-Containing Lectin 3 P35 3 4
  • Collagen/Fibrinogen Domain-Containing Protein 3 3 4
  • Hakata Antigen 2 4
  • Ficolin-3 3 4
  • Ficolin (Collagen/Fibrinogen Domain-Containing) 3 (Hakata Antigen) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen) 3
  • Ficolin (Collagen/Fibrinogen Domain Containing) 3 2
  • H-Ficolin 3
  • FCN3 5

External Ids for FCN3 Gene

Previous GeneCards Identifiers for FCN3 Gene

  • GC01P027890
  • GC01M026727
  • GC01M026928
  • GC01M027300
  • GC01M027568
  • GC01M027695
  • GC01M025951

Summaries for FCN3 Gene

Entrez Gene Summary for FCN3 Gene

  • Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN3 Gene

FCN3 (Ficolin 3) is a Protein Coding gene. Diseases associated with FCN3 include Ficolin 3 Deficiency and Rheumatic Heart Disease. Among its related pathways are Creation of C4 and C2 activators and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and antigen binding. An important paralog of this gene is FCN2.

UniProtKB/Swiss-Prot Summary for FCN3 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.

Gene Wiki entry for FCN3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCN3 Gene

Genomics for FCN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J027372 Enhancer 0.6 Ensembl 250.7 +2.0 1951 0.2 MYC IKZF1 REST BHLHE40 CTCF RAD21 ZNF384 ZBTB33 NRF1 ZNF362 FCN3 lnc-CD164L2-1 CD164L2 MAP3K6
GH01J027374 Promoter 0.4 EPDnew 250.7 +0.0 8 0.1 GLIS1 FCN3 lnc-CD164L2-1 MAP3K6
GH01J027373 Promoter 0.3 Ensembl 250.7 +0.4 351 0.6 FCN3 lnc-CD164L2-1 MAP3K6
GH01J027382 Promoter 1.1 EPDnew Ensembl 0.4 -8.4 -8449 1 POLR2A KLF9 BCL11B TAF1 SP1 NRF1 KLF1 SP3 ZFX PKNOX1 CD164L2 FCN3
GH01J027377 Enhancer 0.6 Ensembl 0.7 -3.2 -3248 0.6 IKZF1 ZNF223 ZIC2 MBD2 TBP TAL1 SMARCA4 HDAC2 TCF12 HDAC1 CD164L2 FCN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCN3

Top Transcription factor binding sites by QIAGEN in the FCN3 gene promoter:
  • E2F
  • E2F-1
  • Elk-1
  • HOXA5
  • Ik-3
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • STAT5A

Genomic Locations for FCN3 Gene

Latest Assembly
chr1:27,369,110-27,374,852
(GRCh38/hg38)
Size:
5,743 bases
Orientation:
Minus strand

Previous Assembly
chr1:27,695,601-27,701,343
(GRCh37/hg19 by Entrez Gene)
Size:
5,743 bases
Orientation:
Minus strand

chr1:27,695,603-27,701,315
(GRCh37/hg19 by Ensembl)
Size:
5,713 bases
Orientation:
Minus strand

Genomic View for FCN3 Gene

Genes around FCN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN3 Gene

Proteins for FCN3 Gene

  • Protein details for FCN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75636-FCN3_HUMAN
    Recommended name:
    Ficolin-3
    Protein Accession:
    O75636
    Secondary Accessions:
    • Q6IBJ5
    • Q8WW86

    Protein attributes for FCN3 Gene

    Size:
    299 amino acids
    Molecular mass:
    32903 Da
    Quaternary structure:
    • Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.

    Three dimensional structures from OCA and Proteopedia for FCN3 Gene

    Alternative splice isoforms for FCN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN3 Gene

Post-translational modifications for FCN3 Gene

  • The N-terminus is blocked.
  • Glycosylation at Asn189
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for FCN3 Gene

No data available for DME Specific Peptides for FCN3 Gene

Domains & Families for FCN3 Gene

Gene Families for FCN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for FCN3 Gene

InterPro:
Blocks:
  • Collagen triple helix repeat
  • Fibrinogen, beta/gamma chain, C-terminal globular

Suggested Antigen Peptide Sequences for FCN3 Gene

GenScript: Design optimal peptide antigens:
  • Hakata antigen (FCN3_HUMAN)
  • NL3 (Q6UXM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75636

UniProtKB/Swiss-Prot:

FCN3_HUMAN :
  • Belongs to the ficolin lectin family.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN3: view

Function for FCN3 Gene

Molecular function for FCN3 Gene

UniProtKB/Swiss-Prot Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
GENATLAS Biochemistry:
ficolin 3 (collagen/fibrinogen domain-containing),TGF1 binding protein,Hakata antigen,present in the serum as homopolymers,reactin with the serum from patients with systemic lupus erythromatous,expressed in the lung,produced by both ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was secreted into the bronchus and alveolus,also expressed in liver,Hakata antigen is produced by bile duct epithelial cells and hepatocytes and secreted into the bile duct

Phenotypes From GWAS Catalog for FCN3 Gene

Gene Ontology (GO) - Molecular Function for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 22851708
GO:0005515 protein binding IPI 11907111
GO:0030246 carbohydrate binding TAS,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FCN3: view
genes like me logo Genes that share phenotypes with FCN3: view

Human Phenotype Ontology for FCN3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCN3

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCN3 Gene

Localization for FCN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN3 Gene

Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCN3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IBA 21873635
GO:0062023 collagen-containing extracellular matrix IBA 21873635
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with FCN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCN3 Gene

Pathways & Interactions for FCN3 Gene

genes like me logo Genes that share pathways with FCN3: view

Pathways by source for FCN3 Gene

1 GeneGo (Thomson Reuters) pathway for FCN3 Gene
  • Immune response Lectin induced complement pathway

SIGNOR curated interactions for FCN3 Gene

Activates:

Gene Ontology (GO) - Biological Process for FCN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0002376 immune system process IEA --
GO:0006956 complement activation IDA,TAS --
GO:0043654 recognition of apoptotic cell IDA 15804047
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with FCN3: view

Drugs & Compounds for FCN3 Gene

(3) Drugs for FCN3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 1706
zinc acetate Approved, Investigational Pharma Target 0

(2) Additional Compounds for FCN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCN3: view

Transcripts for FCN3 Gene

mRNA/cDNA for FCN3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCN3

Alternative Splicing Database (ASD) splice patterns (SP) for FCN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for FCN3 Gene

GeneLoc Exon Structure for
FCN3

Expression for FCN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)
  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for FCN3 Gene

This gene is overexpressed in Lung (x26.4) and Liver (x6.5).

Protein differential expression in normal tissues from HIPED for FCN3 Gene

This gene is overexpressed in Serum (35.7), Plasma (20.6), and Synovial fluid (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCN3 Gene



Protein tissue co-expression partners for FCN3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCN3

SOURCE GeneReport for Unigene cluster for FCN3 Gene:

Hs.333383

mRNA Expression by UniProt/SwissProt for FCN3 Gene:

O75636-FCN3_HUMAN
Tissue specificity: Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.

Evidence on tissue expression from TISSUES for FCN3 Gene

  • Liver(4.6)
  • Lung(4.6)
  • Bone marrow(4.2)
  • Blood(2.5)
  • Kidney(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FCN3 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • lymphatic
  • respiratory
Regions:
Thorax:
  • bronchus
  • lung
Limb:
  • digit
  • foot
  • lower limb
  • toe
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with FCN3: view

Primer products for research

Orthologs for FCN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FCN3 29 30
  • 96.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FCN3 29
  • 77.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 44 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Fcna 30
  • 44 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 42 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG30280 31
  • 44 (a)
CG30281 31
  • 44 (a)
CG5550 31
  • 41 (a)
sca 31
  • 38 (a)
CG41520 30
  • 13 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T15B7.1 29
  • 44.91 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 51 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 47 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
-- 30
  • 41 (a)
ManyToMany
-- 30
  • 40 (a)
ManyToMany
-- 30
  • 40 (a)
ManyToMany
-- 30
  • 39 (a)
ManyToMany
-- 30
  • 36 (a)
ManyToMany
-- 30
  • 36 (a)
ManyToMany
Species where no ortholog for FCN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for FCN3 Gene

ENSEMBL:
Gene Tree for FCN3 (if available)
TreeFam:
Gene Tree for FCN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCN3: view image
Alliance of Genome Resources:
Additional Orthologs for FCN3

Paralogs for FCN3 Gene

(27) SIMAP similar genes for FCN3 Gene using alignment to 3 proteins:

  • FCN3_HUMAN
  • Q5SSB9_HUMAN
  • Q6UXM4_HUMAN
genes like me logo Genes that share paralogs with FCN3: view

Variants for FCN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCN3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
1030693 Uncertain Significance: Immunodeficiency due to ficolin 3 deficiency 27,370,634(-) T/C
NM_003665.4(FCN3):c.620A>G (p.Tyr207Cys)
MISSENSE
1032147 Pathogenic: Immunodeficiency due to ficolin 3 deficiency 27,373,135(-) C/T
NM_003665.4(FCN3):c.393+1G>A
SPLICE_DONOR
1032148 Pathogenic: Immunodeficiency due to ficolin 3 deficiency 27,369,241(-) G/A
NM_003665.4(FCN3):c.895C>T (p.Arg299Ter)
NONSENSE
813624 Uncertain Significance: Microcephaly 27,373,143(-) C/T
NM_173452.2(FCN3):c.353G>A (p.Gly118Asp)
MISSENSE
984510 Conflicting Interpretations: Immunodeficiency due to ficolin 3 deficiency; not specified 27,373,964(-) C/T
NM_003665.4(FCN3):c.232+1G>A
SPLICE_DONOR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FCN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FCN3 Gene

Variant ID Type Subtype PubMed ID
esv1006916 CNV deletion 20482838
nsv1147132 CNV insertion 26484159
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for FCN3 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCN3 Gene

Human Gene Mutation Database (HGMD)
FCN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCN3
Leiden Open Variation Database (LOVD)
FCN3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN3 Gene

Disorders for FCN3 Gene

MalaCards: The human disease database

(13) MalaCards diseases for FCN3 Gene - From: OMI, CVR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
ficolin 3 deficiency
  • fcn3 deficiency
rheumatic heart disease
  • rheumatic carditis
rheumatic fever
  • acute rheumatic fever
progressive relapsing multiple sclerosis
  • prms
pulmonary aspergilloma
- elite association - COSMIC cancer census association via MalaCards
Search FCN3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FCN3_HUMAN
  • Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269 PubMed:19535802}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for FCN3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FCN3: view

No data available for Genatlas for FCN3 Gene

Publications for FCN3 Gene

  1. Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency. (PMID: 19535802) Munthe-Fog L … Garred P (The New England journal of medicine 2009) 4 22 72
  2. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp JM … Sanders EA (Clinical and experimental immunology 2009) 3 22 40
  3. Structural insights into the innate immune recognition specificities of L- and H-ficolins. (PMID: 17215869) Garlatti V … Gaboriaud C (The EMBO journal 2007) 3 4 22
  4. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. (PMID: 18032536) Vander Cruyssen B … De Keyser F (Rheumatology (Oxford, England) 2007) 3 22 40
  5. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). (PMID: 11907111) Matsushita M … Fujita T (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 22

Products for FCN3 Gene

Sources for FCN3 Gene