The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spli... See more...

Aliases for FCN2 Gene

Aliases for FCN2 Gene

  • Ficolin 2 2 3 5
  • Collagen/Fibrinogen Domain-Containing Protein 2 2 3 4
  • Serum Lectin P35 2 3 4
  • L-Ficolin 2 3 4
  • Ficolin-2 2 3 4
  • EBP-37 2 3 4
  • FCNL 2 3 4
  • 37 KDa Elastin-Binding Protein 3 4
  • Ficolin-Beta 3 4
  • Ficolin B 2 3
  • Hucolin 2 4
  • P35 2 3
  • Ficolin (Collagen/Fibrinogen Domain-Containing Lectin) 2 (Hucolin) 2
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 (Hucolin) 3
  • Ficolin (Collagen/Fibrinogen Domain Containing Lectin) 2 2
  • Ficolin-B 4
  • FCN2 5

External Ids for FCN2 Gene

Previous GeneCards Identifiers for FCN2 Gene

  • GC09P128922
  • GC09P129541
  • GC09P131295
  • GC09P133211
  • GC09P134998
  • GC09P136912
  • GC09P137772
  • GC09P107236

Summaries for FCN2 Gene

Entrez Gene Summary for FCN2 Gene

  • The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCN2 Gene

FCN2 (Ficolin 2) is a Protein Coding gene. Diseases associated with FCN2 include Adenoiditis and Necrotizing Soft Tissue Infection. Among its related pathways are Creation of C4 and C2 activators and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding. An important paralog of this gene is FCN1.

UniProtKB/Swiss-Prot Summary for FCN2 Gene

  • May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Gene Wiki entry for FCN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCN2 Gene

Genomics for FCN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J134880 Promoter 0.5 EPDnew 250.4 +16.7 16734 0.1 ZIC2 GLIS1 FCN2 FCN1 LOC101448202
GH09J134864 Enhancer 0.3 Ensembl 258.7 +0.3 309 0.9 ZIC2 FCN2 FCN1 COL5A1-AS1 COL5A1 lnc-FCN2-2 LOC101448202
GH09J134936 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +72.8 72780 1.7 EZH2 SP1 BCL11A EBF1 CBFB SMARCA5 BHLHE40 SPI1 PKNOX1 POLR2A ENSG00000236403 LOC105376314 FCN2 COL5A1 FCN1 LOC105376313 OLFM1
GH09J134805 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 -54.7 -54664 7.7 ZNF600 ATF2 ZIC2 FEZF1 ZNF639 ZNF341 RXRA PAX8 ZNF843 ZNF146 HSALNG0075101 BRD3 FCN2 FCN1 WDR5 PPP1R26-AS1 COL5A1 RXRA HSALNG0075103
GH09J134669 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.7 -193.4 -193361 3.4 JUND BRCA1 ZNF217 CEBPB DEK EP300 MBD2 CTBP1 CUX1 STAT3 COL5A1 FCN2 COL5A1-AS1 lnc-FCN2-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCN2

Top Transcription factor binding sites by QIAGEN in the FCN2 gene promoter:
  • AREB6
  • En-1
  • p53
  • USF-1
  • USF1
  • YY1

Genomic Locations for FCN2 Gene

Latest Assembly
chr9:134,864,062-134,890,506
(GRCh38/hg38)
Size:
26,445 bases
Orientation:
Plus strand

Previous Assembly
chr9:137,772,656-137,779,369
(GRCh37/hg19 by Entrez Gene)
Size:
6,714 bases
Orientation:
Plus strand

chr9:137,772,654-137,779,924
(GRCh37/hg19 by Ensembl)
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for FCN2 Gene

Genes around FCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCN2 Gene

Proteins for FCN2 Gene

  • Protein details for FCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15485-FCN2_HUMAN
    Recommended name:
    Ficolin-2
    Protein Accession:
    Q15485
    Secondary Accessions:
    • A6NFG7
    • A8K478
    • Q6IS69
    • Q7M4P4
    • Q9UC57

    Protein attributes for FCN2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34001 Da
    Quaternary structure:
    • Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2. Interacts with CR1.

    Three dimensional structures from OCA and Proteopedia for FCN2 Gene

    Alternative splice isoforms for FCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCN2 Gene

Post-translational modifications for FCN2 Gene

  • Glycosylation at Asn240 and Asn300

Other Protein References for FCN2 Gene

No data available for DME Specific Peptides for FCN2 Gene

Domains & Families for FCN2 Gene

Gene Families for FCN2 Gene

Protein Domains for FCN2 Gene

InterPro:
Blocks:
  • Collagen triple helix repeat
  • Fibrinogen, beta/gamma chain, C-terminal globular

Suggested Antigen Peptide Sequences for FCN2 Gene

GenScript: Design optimal peptide antigens:
  • Serum lectin p35 (FCN2_HUMAN)
  • FCN2 protein (Q14CE6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15485

UniProtKB/Swiss-Prot:

FCN2_HUMAN :
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
  • Belongs to the ficolin lectin family.
Domain:
  • The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
Family:
  • Belongs to the ficolin lectin family.
genes like me logo Genes that share domains with FCN2: view

Function for FCN2 Gene

Molecular function for FCN2 Gene

UniProtKB/Swiss-Prot Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
GENATLAS Biochemistry:
ficolin 2 (ficolin/opronin p35) lectin family,TGFB1 binding protein P35,expressed in liver

Phenotypes From GWAS Catalog for FCN2 Gene

Gene Ontology (GO) - Molecular Function for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IDA 8576206
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IPI 19632990
GO:0030246 carbohydrate binding IEA --
GO:0043394 proteoglycan binding IDA 8576206
genes like me logo Genes that share ontologies with FCN2: view
genes like me logo Genes that share phenotypes with FCN2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCN2 Gene

Localization for FCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCN2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCN2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IBA 21873635
GO:0062023 collagen-containing extracellular matrix IBA 21873635
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with FCN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCN2 Gene

Pathways & Interactions for FCN2 Gene

genes like me logo Genes that share pathways with FCN2: view

Pathways by source for FCN2 Gene

1 GeneGo (Thomson Reuters) pathway for FCN2 Gene
  • Immune response Lectin induced complement pathway

SIGNOR curated interactions for FCN2 Gene

Activates:

Gene Ontology (GO) - Biological Process for FCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001867 complement activation, lectin pathway TAS --
GO:0002376 immune system process IEA --
GO:0006956 complement activation TAS --
GO:0008228 opsonization IDA 8576206
GO:0043654 recognition of apoptotic cell IDA 15804047
genes like me logo Genes that share ontologies with FCN2: view

Drugs & Compounds for FCN2 Gene

(4) Drugs for FCN2 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
duloxetine Approved Pharma 0
Calcium Nutra 6959

(5) Additional Compounds for FCN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCN2: view

Transcripts for FCN2 Gene

mRNA/cDNA for FCN2 Gene

4 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCN2

Alternative Splicing Database (ASD) splice patterns (SP) for FCN2 Gene

No ASD Table

Relevant External Links for FCN2 Gene

GeneLoc Exon Structure for
FCN2

Expression for FCN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for FCN2 Gene

This gene is overexpressed in Liver (x28.5) and Adrenal Gland (x9.1).

Protein differential expression in normal tissues from HIPED for FCN2 Gene

This gene is overexpressed in Serum (52.3) and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCN2 Gene



Protein tissue co-expression partners for FCN2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCN2

SOURCE GeneReport for Unigene cluster for FCN2 Gene:

Hs.54517

mRNA Expression by UniProt/SwissProt for FCN2 Gene:

Q15485-FCN2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for FCN2 Gene

  • Liver(4.6)
  • Bone marrow(4.3)
  • Blood(2.4)
  • Kidney(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with FCN2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCN2 Gene

Orthologs for FCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FCN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FCN2 29 30
  • 98.4 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 71 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fcnb 30
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 64 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia FCNB 30
  • 60 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 53 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 57 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 41 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG30280 31
  • 44 (a)
CG30281 31
  • 44 (a)
CG5550 31
  • 44 (a)
CG9500 31
  • 42 (a)
sca 31
  • 42 (a)
CG1791 31
  • 42 (a)
CG8642 31
  • 42 (a)
CG10359 31
  • 37 (a)
CG41520 30
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 49 (a)
ManyToMany
-- 30
  • 46 (a)
ManyToMany
-- 30
  • 44 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
Species where no ortholog for FCN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCN2 Gene

ENSEMBL:
Gene Tree for FCN2 (if available)
TreeFam:
Gene Tree for FCN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCN2: view image
Alliance of Genome Resources:
Additional Orthologs for FCN2

Paralogs for FCN2 Gene

Pseudogenes.org Pseudogenes for FCN2 Gene

genes like me logo Genes that share paralogs with FCN2: view

Variants for FCN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCN2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs139943705 Benign: not provided 134,885,372(+) T/C
NM_004108.3(FCN2):c.429+6T>C
INTRON
rs55797213 Benign: not provided 134,880,854(+) C/T
NM_004108.3(FCN2):c.33C>T (p.Gly11=)
SYNONYMOUS
rs55895215 Benign: not provided 134,885,244(+) C/T
NM_004108.3(FCN2):c.307C>T (p.Arg103Cys)
MISSENSE
rs61736807 Benign: not provided 134,880,832(+) A/T
NM_004108.3(FCN2):c.11A>T (p.Asp4Val)
MISSENSE
VAR_036342 A colorectal cancer sample p.Pro80Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FCN2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FCN2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1043726 CNV gain 25217958
nsv1125319 OTHER inversion 24896259
nsv831753 CNV loss 17160897
nsv951815 CNV deletion 24416366

Variation tolerance for FCN2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCN2 Gene

Human Gene Mutation Database (HGMD)
FCN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCN2
Leiden Open Variation Database (LOVD)
FCN2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCN2 Gene

Disorders for FCN2 Gene

MalaCards: The human disease database

(14) MalaCards diseases for FCN2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
adenoiditis
  • chronic adenoiditis
necrotizing soft tissue infection
  • nsti
rheumatic fever
  • acute rheumatic fever
rheumatic heart disease
  • rheumatic carditis
progressive relapsing multiple sclerosis
  • prms
- elite association - COSMIC cancer census association via MalaCards
Search FCN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCN2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FCN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCN2 Gene

Publications for FCN2 Gene

  1. Cloning and characterization of the human lectin P35 gene and its related gene. (PMID: 8884275) Endo Y … Fujita T (Genomics 1996) 2 3 4 22
  2. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. (PMID: 19220833) Ruskamp JM … Sanders EA (Clinical and experimental immunology 2009) 3 22 40
  3. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. (PMID: 19434912) de Messias-Reason I … Kun JF (The Journal of infectious diseases 2009) 3 22 40
  4. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. (PMID: 19664148) Messias-Reason IJ … Kun JF (Clinical and experimental immunology 2009) 3 22 40
  5. Structural insights into the innate immune recognition specificities of L- and H-ficolins. (PMID: 17215869) Garlatti V … Gaboriaud C (The EMBO journal 2007) 3 4 22

Products for FCN2 Gene

  • Boster Bio Antibodies for FCN2
  • Boster Bio ELISA Kits for FCN2

Sources for FCN2 Gene