Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010] See more...

Aliases for FCMR Gene

Aliases for FCMR Gene

  • Fc Fragment Of IgM Receptor 2 3 5
  • Fas Apoptotic Inhibitory Molecule 3 2 3 4
  • Regulator Of Fas-Induced Apoptosis Toso 3 4
  • IgM Fc Fragment Receptor 3 4
  • FAIM3 3 4
  • TOSO 3 4
  • Immunoglobulin Mu Fc Receptor 3
  • IgM Fc Receptor 3
  • Fc Mu Receptor 3

External Ids for FCMR Gene

Previous HGNC Symbols for FCMR Gene

  • FAIM3

Summaries for FCMR Gene

Entrez Gene Summary for FCMR Gene

  • Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

GeneCards Summary for FCMR Gene

FCMR (Fc Fragment Of IgM Receptor) is a Protein Coding gene. An important paralog of this gene is PIGR.

UniProtKB/Swiss-Prot Summary for FCMR Gene

  • May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Additional gene information for FCMR Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCMR Gene

Genomics for FCMR Gene

GeneHancer (GH) Regulatory Elements for FCMR Gene

Promoters and enhancers for FCMR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206917 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 758.2 +0.2 176 12 ZNF785 SP1 POLR2A ETV6 RELA L3MBTL2 MAX MTA3 RAD21 NFIB FCMR lnc-FCMR-1 lnc-PIGR-3 CDCA4P4 EIF2D MAPKAPK2 ENSG00000271680 CD46 PIGR FCAMR
GH01J207017 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -103.4 -103421 18.4 SIN3A ZBTB40 ZBTB6 FOXA1 RBPJ SMARCE1 POLR2A TCF7L2 NR2F6 CREB1 C1orf116 EIF2D CDCA4P4 C4BPA CD46 CD34 C4BPB FCAMR PIGR FCMR
GH01J206734 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +185.3 185346 7.4 ZNF24 SP1 CTCF SMARCE1 NR2F6 RUNX1 CC2D1A ETV6 ELF1 MAX IL24 MAPKAPK2 FCMR IL19 IL10 PIGR IL20 C1orf116 DYRK3 CD55
GH01J206966 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -47.6 -47611 7.9 USF2 ETV6 RELA HLF SP1 MAFK ZNF687 ZBTB33 IKZF1 RXRA FCAMR lnc-PIGR-4 PIGR FCMR IL20 IL24 IL10 MAPKAPK2 IL19 ENSG00000271680
GH01J207001 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.3 -83.0 -83039 10.2 CTCF RBPJ SMARCE1 POLR2A MIXL1 CC2D1A HLF L3MBTL2 ZNF652 ZC3H8 HG984003 TRP-TGG5-1 PIGR FCMR FCAMR IL24 IL20 PFKFB2 MAPKAPK2 IL19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCMR on UCSC Golden Path with GeneCards custom track

Genomic Locations for FCMR Gene

Genomic Locations for FCMR Gene
chr1:206,903,285-206,923,247
(GRCh38/hg38)
Size:
19,963 bases
Orientation:
Minus strand
chr1:207,076,630-207,096,592
(GRCh37/hg19)
Size:
19,963 bases
Orientation:
Minus strand

Genomic View for FCMR Gene

Genes around FCMR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCMR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCMR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCMR Gene

Proteins for FCMR Gene

  • Protein details for FCMR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60667-FAIM3_HUMAN
    Recommended name:
    Fas apoptotic inhibitory molecule 3
    Protein Accession:
    O60667
    Secondary Accessions:
    • A8K7J2
    • B7Z6Z0
    • D9MWM3

    Protein attributes for FCMR Gene

    Size:
    390 amino acids
    Molecular mass:
    43146 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.

    Alternative splice isoforms for FCMR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCMR Gene

Post-translational modifications for FCMR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for FCMR
  • Santa Cruz Biotechnology (SCBT) Antibodies for FCMR

No data available for DME Specific Peptides for FCMR Gene

Domains & Families for FCMR Gene

Gene Families for FCMR Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCMR Gene

Suggested Antigen Peptide Sequences for FCMR Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79235, highly similar to Homo sapiens Fas apoptotic inhibitory molecule 3 (FAIM3), mRNA (B7Z6Z0_HUMAN)
  • Soluble Fc mu receptor (D9MWM3_HUMAN)
  • Regulator of Fas-induced apoptosis Toso (FAIM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60667

UniProtKB/Swiss-Prot:

FAIM3_HUMAN :
  • The Ig-like domain is required for the anti-apoptotic ability.
Domain:
  • The Ig-like domain is required for the anti-apoptotic ability.
genes like me logo Genes that share domains with FCMR: view

Function for FCMR Gene

Molecular function for FCMR Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
UniProtKB/Swiss-Prot Induction:
By T-cell activation.

Phenotypes From GWAS Catalog for FCMR Gene

genes like me logo Genes that share phenotypes with FCMR: view

Animal Models for FCMR Gene

MGI Knock Outs for FCMR:
  • Fcmr Fcmr<tm1.2Khl>
  • Fcmr Fcmr<tm1b(KOMP)Wtsi>
  • Fcmr Fcmr<tm1Mak>
  • Fcmr Fcmr<tm1Ohno>

Animal Model Products

  • Taconic Biosciences Mouse Models for FCMR

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCMR Gene

Localization for FCMR Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCMR Gene

Isoform 1: Membrane; Single-pass membrane protein.
Isoform 3: Secreted. Note=Detected in the serum. {ECO:0000269 PubMed:21908424}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCMR gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Focal adhesion sites (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FCMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCMR: view

Pathways & Interactions for FCMR Gene

PathCards logo

SuperPathways for FCMR Gene

No Data Available

Interacting Proteins for FCMR Gene

Gene Ontology (GO) - Biological Process for FCMR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 9586636
GO:0043066 negative regulation of apoptotic process TAS 9586636
genes like me logo Genes that share ontologies with FCMR: view

No data available for Pathways by source and SIGNOR curated interactions for FCMR Gene

Drugs & Compounds for FCMR Gene

No Compound Related Data Available

Transcripts for FCMR Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCMR Gene

No ASD Table

Relevant External Links for FCMR Gene

GeneLoc Exon Structure for
FCMR
ECgene alternative splicing isoforms for
FCMR

Expression for FCMR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FCMR Gene:

FCMR

mRNA Expression by UniProt/SwissProt for FCMR Gene:

O60667-FAIM3_HUMAN
Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.

Evidence on tissue expression from TISSUES for FCMR Gene

  • Spleen(4.8)
  • Blood(3.3)
  • Intestine(2.5)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with FCMR: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCMR Gene

Orthologs for FCMR Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCMR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAIM3 33 32
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAIM3 33 32
  • 79.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAIM3 33 32
  • 77.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Faim3 33 32
  • 72.95 (n)
OneToOne
Fcmr 17
rat
(Rattus norvegicus)
Mammalia Faim3 32
  • 72.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAIM3 33
  • 46 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAIM3 33
  • 39 (a)
OneToOne
Species where no ortholog for FCMR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCMR Gene

ENSEMBL:
Gene Tree for FCMR (if available)
TreeFam:
Gene Tree for FCMR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCMR: view image

Paralogs for FCMR Gene

genes like me logo Genes that share paralogs with FCMR: view

Variants for FCMR Gene

Sequence variations from dbSNP and Humsavar for FCMR Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000038588 -- 206,905,112(-) C/T 3_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000337753 -- 206,904,843(-) A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000594936 -- 206,917,337(-) A/T intron_variant
rs1000615249 -- 206,910,678(-) C/T intron_variant
rs1000668506 -- 206,917,098(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCMR Gene

Variant ID Type Subtype PubMed ID
nsv1010486 CNV gain 25217958
nsv468049 CNV loss 19166990
nsv549071 CNV loss 21841781
nsv946617 CNV duplication 23825009
nsv952662 CNV deletion 24416366

Variation tolerance for FCMR Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCMR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCMR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCMR Gene

Disorders for FCMR Gene

Additional Disease Information for FCMR

No disorders were found for FCMR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCMR Gene

Publications for FCMR Gene

  1. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. (PMID: 9586636) Hitoshi Y … Nolan GP (Immunity 1998) 2 3 4 56
  2. Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. (PMID: 25888699) Kubagawa H … Coligan JE (Journal of immunology (Baltimore, Md. : 1950) 2015) 2 3 56
  3. Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia. (PMID: 21908424) Li FJ … Kubagawa H (Blood 2011) 3 4 56
  4. Effects of misoprostol on the pharmacokinetics of indomethacin in human volunteers. (PMID: 1563211) Rainsford KD … Hantsbarger G (Clinical pharmacology and therapeutics 1992) 2 3 56
  5. Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. (PMID: 21264533) Hancer VS … Aktan M (Medical oncology (Northwood, London, England) 2012) 3 56

Products for FCMR Gene

Sources for FCMR Gene