This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] See more...

Aliases for FCGRT Gene

Aliases for FCGRT Gene

  • Fc Fragment Of IgG Receptor And Transporter 2 3 5
  • FCRN 2 3 4
  • Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor 2 3
  • Transmembrane Alpha Chain Of The Neonatal Receptor 2 3
  • Fc Fragment Of IgG, Receptor, Transporter, Alpha 2 3
  • IgG Fc Fragment Receptor Transporter Alpha Chain 3 4
  • IgG Receptor FcRn Large Subunit P51 3 4
  • Neonatal Fc Receptor 3 4
  • Alpha-Chain 2 3
  • Major Histocompatibility Complex Class I-Like Fc Receptor 3
  • Immunoglobulin Receptor, Intestinal, Heavy Chain 3
  • Neonatal Fc-Receptor For Ig 3
  • FcRn Alpha Chain 3
  • FCGRT 5
  • FcRn 4

External Ids for FCGRT Gene

Previous GeneCards Identifiers for FCGRT Gene

  • GC19P050674
  • GC19P050384
  • GC19P054691
  • GC19P054707
  • GC19P054708
  • GC19P050015
  • GC19P046393
  • GC19P050028
  • GC19P050047

Summaries for FCGRT Gene

Entrez Gene Summary for FCGRT Gene

  • This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for FCGRT Gene

FCGRT (Fc Fragment Of IgG Receptor And Transporter) is a Protein Coding gene. Diseases associated with FCGRT include Selective Igg Deficiency Disease and Immunodeficiency 43. Gene Ontology (GO) annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot Summary for FCGRT Gene

  • Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).
  • (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

Gene Wiki entry for FCGRT Gene

Additional gene information for FCGRT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCGRT Gene

Genomics for FCGRT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCGRT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049511 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 614.7 +7.5 7540 5.7 TFE3 ZNF512 IKZF1 ZNF7 LARP7 ZIC2 RBFOX2 PKNOX1 RXRB PATZ1 FCGRT NONHSAG026245.2 PRR12 RCN3 SNORD32A SNORD33 SNORD34 SNORD35A RPL13A PRRG2
GH19J049506 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +0.0 20 0.4 CTCF PRDM10 ZNF692 ZNF143 PHF21A ZSCAN4 RXRB PATZ1 REST RAD21 FCGRT RCN3 FLT3LG NONHSAG026245.2
GH19J049507 Enhancer 0.2 Ensembl 600.7 -0.9 -915 0.2 FCGRT COX6CP7 lnc-PIH1D1-1 RPS11
GH19J049505 Enhancer 0.2 Ensembl 600.7 -1.7 -1715 0.2 FCGRT COX6CP7 lnc-PIH1D1-1 RPS11
GH19J049527 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 16.3 +21.5 21530 2.5 HNRNPL ZNF512 SIX5 JUND ZNF143 RBFOX2 PKNOX1 MTA1 NR2C1 POLR2A RCN3 FCGRT RF00005-076 PRRG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGRT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCGRT

Top Transcription factor binding sites by QIAGEN in the FCGRT gene promoter:
  • NF-1
  • NF-1/L
  • STAT3
  • STAT5A

Genomic Locations for FCGRT Gene

Genomic Locations for FCGRT Gene
chr19:49,506,816-49,526,428
(GRCh38/hg38)
Size:
19,613 bases
Orientation:
Plus strand
chr19:50,010,073-50,029,685
(GRCh37/hg19)
Size:
19,613 bases
Orientation:
Plus strand

Genomic View for FCGRT Gene

Genes around FCGRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGRT Gene

Proteins for FCGRT Gene

  • Protein details for FCGRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55899-FCGRN_HUMAN
    Recommended name:
    IgG receptor FcRn large subunit p51
    Protein Accession:
    P55899
    Secondary Accessions:
    • Q5HYM5
    • Q9HBV7
    • Q9NZ19

    Protein attributes for FCGRT Gene

    Size:
    365 amino acids
    Molecular mass:
    39743 Da
    Quaternary structure:
    • FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (PubMed:24469444, PubMed:28330995).
    • (Microbial infection) Interacts with Echovirus 6, Echovirus 11 and Echovirus 30 capsid protein VP1.

    Three dimensional structures from OCA and Proteopedia for FCGRT Gene

neXtProt entry for FCGRT Gene

Post-translational modifications for FCGRT Gene

  • Glycosylation at Asn125
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FCGRN_HUMAN (1387)

No data available for DME Specific Peptides for FCGRT Gene

Domains & Families for FCGRT Gene

Gene Families for FCGRT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCGRT Gene

Suggested Antigen Peptide Sequences for FCGRT Gene

GenScript: Design optimal peptide antigens:
  • Neonatal Fc receptor (FCGRN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55899

UniProtKB/Swiss-Prot:

FCGRN_HUMAN :
  • Belongs to the immunoglobulin superfamily.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with FCGRT: view

Function for FCGRT Gene

Molecular function for FCGRT Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
GENATLAS Biochemistry:
MHC,class I-like FC receptor,FCGRT

Phenotypes From GWAS Catalog for FCGRT Gene

Gene Ontology (GO) - Molecular Function for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019864 IgG binding IEA,IDA 7964511
GO:0030881 beta-2-microglobulin binding IBA 21873635
GO:0042605 NOT peptide antigen binding ISS --
genes like me logo Genes that share ontologies with FCGRT: view
genes like me logo Genes that share phenotypes with FCGRT: view

Animal Models for FCGRT Gene

MGI Knock Outs for FCGRT:

Animal Model Products

CRISPR Products

miRNA for FCGRT Gene

miRTarBase miRNAs that target FCGRT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGRT

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGRT Gene

Localization for FCGRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGRT Gene

Cell membrane. Single-pass type I membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGRT gene
Compartment Confidence
plasma membrane 5
extracellular 4
endosome 4
lysosome 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IEA,IBA 21873635
GO:0009897 external side of plasma membrane IBA 21873635
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with FCGRT: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCGRT Gene

Pathways & Interactions for FCGRT Gene

PathCards logo

SuperPathways for FCGRT Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCGRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IBA --
GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS 7964511
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA --
GO:0006955 immune response IBA 21873635
genes like me logo Genes that share ontologies with FCGRT: view

No data available for Pathways by source and SIGNOR curated interactions for FCGRT Gene

Drugs & Compounds for FCGRT Gene

(3) Drugs for FCGRT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FCGRT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGRT: view

Transcripts for FCGRT Gene

mRNA/cDNA for FCGRT Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGRT

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGRT Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - - - - - -
SP13: - - - - -
SP14: -
SP15: - - - - -
SP16: - - - - -
SP17:
SP18: - - - - - - - - - - - - - - - -
SP19: - - - - -

ExUns: 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b
SP1: - - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: - -
SP14:
SP15:
SP16: - - - - - - -
SP17:
SP18: - - - - - -
SP19: -

Relevant External Links for FCGRT Gene

GeneLoc Exon Structure for
FCGRT

Expression for FCGRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCGRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGRT Gene

This gene is overexpressed in Whole Blood (x6.6).

Protein differential expression in normal tissues from HIPED for FCGRT Gene

This gene is overexpressed in Spleen (10.1) and Nasopharynx (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FCGRT Gene



Protein tissue co-expression partners for FCGRT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCGRT

SOURCE GeneReport for Unigene cluster for FCGRT Gene:

Hs.111903

mRNA Expression by UniProt/SwissProt for FCGRT Gene:

P55899-FCGRN_HUMAN
Tissue specificity: Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.

Evidence on tissue expression from TISSUES for FCGRT Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.6)
  • Intestine(3.8)
  • Blood(3.6)
  • Spleen(3.5)
  • Kidney(3.4)
  • Lymph node(3.3)
  • Heart(3.1)
  • Bone marrow(3.1)
  • Skin(2.9)
  • Stomach(2.8)
  • Muscle(2.7)
  • Thyroid gland(2.5)
  • Pancreas(2.5)
  • Gall bladder(2.3)
  • Eye(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with FCGRT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGRT Gene

Orthologs for FCGRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGRT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FCGRT 30 31
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FCGRT 30 31
  • 84.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FCGRT 30 31
  • 81.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fcgrt 30 17 31
  • 70.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fcgrt 30
  • 69.88 (n)
Oppossum
(Monodelphis domestica)
Mammalia FCGRT 31
  • 45 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 25 (a)
OneToMany
Chicken
(Gallus gallus)
Aves BFIV21 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
BF1 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 29 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for FCGRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCGRT Gene

ENSEMBL:
Gene Tree for FCGRT (if available)
TreeFam:
Gene Tree for FCGRT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCGRT: view image

Paralogs for FCGRT Gene

(34) SIMAP similar genes for FCGRT Gene using alignment to 10 proteins:

  • FCGRN_HUMAN
  • M0QYM4_HUMAN
  • M0QYN1_HUMAN
  • M0QYN9_HUMAN
  • M0R0A9_HUMAN
  • M0R0H0_HUMAN
  • M0R0K7_HUMAN
  • M0R220_HUMAN
  • M0R266_HUMAN
  • M0R2T3_HUMAN
genes like me logo Genes that share paralogs with FCGRT: view

Variants for FCGRT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCGRT Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
771778 Benign: not provided 49,514,281(+) G/C MISSENSE_VARIANT
783847 Benign: not provided 49,526,041(+) C/T SYNONYMOUS_VARIANT
787141 Benign: not provided 49,513,934(+) G/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FCGRT Gene

Structural Variations from Database of Genomic Variants (DGV) for FCGRT Gene

Variant ID Type Subtype PubMed ID
esv3644626 CNV loss 21293372
nsv1160655 CNV deletion 26073780
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for FCGRT Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGRT Gene

Human Gene Mutation Database (HGMD)
FCGRT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGRT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGRT Gene

Disorders for FCGRT Gene

MalaCards: The human disease database

(15) MalaCards diseases for FCGRT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
selective igg deficiency disease
  • immunoglobin g subclass deficiency
immunodeficiency 43
  • imd43
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
epidermolysis bullosa acquisita
  • acquired epidermolysis bullosa
neonatal myasthenia gravis
  • myasthenia gravis, neonatal
- elite association - COSMIC cancer census association via MalaCards
Search FCGRT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCGRT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FCGRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGRT Gene

Publications for FCGRT Gene

  1. Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients. (PMID: 19772792) Zhou XJ … Zhang H (Clinical and experimental rheumatology 2009) 3 23 41
  2. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,). (PMID: 10933786) West AP … Bjorkman PJ (Biochemistry 2000) 3 4 23
  3. Cloning and analysis of the gene encoding the human neonatal Fc receptor. (PMID: 10998088) Mikulska JE … Simister NE (European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000) 3 4 23
  4. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. (PMID: 8646894) Kandil E … Miyosi O (Cytogenetics and cell genetics 1996) 2 3 23
  5. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. (PMID: 7964511) Story CM … Simister NE (The Journal of experimental medicine 1994) 2 3 4

Products for FCGRT Gene

Sources for FCGRT Gene