Aliases for FCGRT Gene
- Fc Fragment Of IgG Receptor And Transporter 2 3 5
- Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor 2 3
- Transmembrane Alpha Chain Of The Neonatal Receptor 2 3
- Fc Fragment Of IgG, Receptor, Transporter, Alpha 2 3
- IgG Fc Fragment Receptor Transporter Alpha Chain 3 4
- IgG Receptor FcRn Large Subunit P51 3 4
- Neonatal Fc Receptor 3 4
External Ids for FCGRT Gene
Previous GeneCards Identifiers for FCGRT Gene
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
GeneCards Summary for FCGRT Gene
FCGRT (Fc Fragment Of IgG Receptor And Transporter) is a Protein Coding gene. Diseases associated with FCGRT include Selective Igg Deficiency Disease and Immunodeficiency 43. Gene Ontology (GO) annotations related to this gene include antigen binding and beta-2-microglobulin binding. An important paralog of this gene is HLA-C.
UniProtKB/Swiss-Prot Summary for FCGRT Gene
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).
(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.