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This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
FCGR3A (Fc Fragment Of IgG Receptor IIIa) is a Protein Coding gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster. Among its related pathways are Tuberculosis and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | 21873635 |
GO:0019864 | IgG binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0009897 | external side of plasma membrane | IDA | 10706735 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Role of DAP12 receptors in NK cells |
Immune response CD16 signaling in NK cells
.32
|
|
2 | Regulation of actin dynamics for phagocytic cup formation | ||
3 | Role of phospholipids in phagocytosis |
.39
|
|
4 | Innate Immune System |
.61
|
|
5 | Fc gamma R-mediated phagocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006955 | immune response | TAS | 2138330 |
GO:0007166 | cell surface receptor signaling pathway | IBA | 21873635 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Etanercept | Approved, Investigational | Pharma | Target, ligand | 454 | ||
Cetuximab | Approved | Pharma | Target | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 869 | |
rituximab | Approved | Pharma | Therapeutic Antibodies | 2024 | ||
Trastuzumab | Approved, Investigational | Pharma | HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 1006 | ||
Alefacept | Approved, Investigational, Withdrawn | Pharma | Target | 40 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FCGR3A 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | FCGR3A 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LOC478984 30 |
|
||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Fcgr4 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Fcgr3a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10127939 | Benign: not specified. Uncertain Significance: Immunodeficiency 20; not specified. -. Immunodeficiency 20 (IMD20) [MIM:615707] | 161,548,543(-) | A/CA/Tp.Leu66Argp.Leu66His | MISSENSE_VARIANT | |
rs114535887 | Benign: not specified | 161,548,524(-) | C/T | SYNONYMOUS_VARIANT | |
rs148181339 | Benign: not specified | 161,548,424(-) | T/C | MISSENSE_VARIANT | |
rs396991 | Drug Response: not specified; rituximab response - Efficacy; trastuzumab response - Efficacy. - | 161,544,752(-) | A/Cp.Phe176Val | MISSENSE_VARIANT,INTRON_VARIANT | |
rs769001959 | Uncertain Significance: Immunodeficiency 20 | 161,548,644(-) | A/G | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 20 |
|
|
herpes zoster |
|
|
lupus erythematosus |
|
|
systemic lupus erythematosus |
|
|
neutropenia |
|