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This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
FCGR3A (Fc Fragment Of IgG Receptor IIIa) is a Protein Coding gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster. Among its related pathways are Role of phospholipids in phagocytosis and Phagosome. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR3B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019864 | IgG binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0009897 | external side of plasma membrane | IDA | 10706735 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Role of DAP12 receptors in NK cells | ||
2 | Regulation of actin dynamics for phagocytic cup formation | ||
3 | Role of phospholipids in phagocytosis |
.39
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4 | Innate Immune System |
.61
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5 | Fc gamma R-mediated phagocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006955 | immune response | TAS | 2138330 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Etanercept | Approved, Investigational | Pharma | Target | 436 | ||
Trastuzumab | Approved, Investigational | Pharma | Target | HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 932 | |
Cetuximab | Approved | Pharma | Target | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 846 | |
rituximab | Approved | Pharma | Therapeutic Antibodies | 2022 | ||
Abciximab | Approved | Pharma | Target | 66 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FCGR3A 32 |
|
||
-- 33 |
|
OneToMany | |||
cow (Bos Taurus) |
Mammalia | FCGR3A 33 32 |
|
OneToMany | |
dog (Canis familiaris) |
Mammalia | LOC478984 32 |
|
||
-- 33 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Fcgr4 33 32 |
|
OneToMany | |
rat (Rattus norvegicus) |
Mammalia | Fcgr3a 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10127939 | benign, uncertain-significance, not specified, Immunodeficiency 20, -, Immunodeficiency 20 (IMD20) [MIM:615707] | 161,548,543(-) | A/C/T | coding_sequence_variant, missense_variant | |
rs148181339 | not-provided, benign, not provided, not specified | 161,548,424(-) | T/C | coding_sequence_variant, missense_variant | |
rs396991 | drug-response, likely-benign, rituximab response - Efficacy, trastuzumab response - Efficacy, not specified, - | 161,544,752(-) | A/C/G/T | coding_sequence_variant, intron_variant, missense_variant | |
rs769001959 | uncertain-significance, Immunodeficiency 20 | 161,548,644(-) | A/G | coding_sequence_variant, synonymous_variant | |
rs77144485 | not-provided, benign, not provided, not specified | 161,548,546(-) | C/T | coding_sequence_variant, missense_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 20 |
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herpes zoster |
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poliomyelitis |
|
|
systemic lupus erythematosus |
|
|
cryptococcosis |
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|