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FCGR3A Gene(Protein Coding)

Fc Fragment Of IgG Receptor IIIa

GCID:
GC01M161541
GIFtS:
52
Genes Participants
UDN Logo

Aliases for FCGR3A Gene

Aliases for FCGR3A Gene

  • Fc Fragment Of IgG Receptor IIIa 2 3 5
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a) 2 3
  • IgG Fc Receptor III-2 3 4
  • Fc-Gamma RIII-Alpha 3 4
  • CD16a Antigen 3 4
  • FCGR3 3 4
  • CD16A 3 4
  • IGFR3 3 4
  • FCG3 3 4
  • Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A 3
  • Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16) 2
  • Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16) 3
  • Immunoglobulin G Fc Receptor III 3
  • Fc-Gamma Receptor III-2 (CD 16) 3
  • Neutrophil-Specific Antigen NA 3
  • Fc-Gamma Receptor IIIb (CD16) 3
  • Fc Gamma Receptor III-A 3
  • Fc Gamma Receptor IIIa 2
  • Fc-Gamma RIIIa 4
  • Fc-Gamma RIII 4
  • FcgammaRIIIA 3
  • FCGRIII 3
  • FCRIIIA 3
  • FcRIIIa 4
  • FCR-10 3
  • FCRIII 3
  • FcR-10 4
  • FcRIII 4
  • IMD20 3
  • CD16 3

External Ids for FCGR3A Gene

Previous HGNC Symbols for FCGR3A Gene

  • FCGR3
  • FCG3

Previous GeneCards Identifiers for FCGR3A Gene

  • GC01M159227
  • GC01M157243
  • GC01M158288
  • GC01M158780
  • GC01M158324
  • GC01M159778
  • GC01M161511
  • GC01M132836

Summaries for FCGR3A Gene

Entrez Gene Summary for FCGR3A Gene

  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CIViC summary for FCGR3A Gene

GeneCards Summary for FCGR3A Gene

FCGR3A (Fc Fragment Of IgG Receptor IIIa) is a Protein Coding gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR3B.

UniProtKB/Swiss-Prot for FCGR3A Gene

  • Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Gene Wiki entry for FCGR3A Gene

Additional gene information for FCGR3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCGR3A Gene

Genomics for FCGR3A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FCGR3A Gene

Promoters and enhancers for FCGR3A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J161544 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +3.1 3136 6.4 SP1 MEIS2 JUND PKNOX1 FOXK2 CEBPB CEBPG HNF4A ZBTB40 FCGR3A FCGR2C FCGR2A FCRLA FCRLB HSPA7 FCGR2B RPS23P10 FCGR3B TRN-GTT1-1
GH01J161620 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8 -72.3 -72342 4.6 HDGF PKNOX1 CLOCK ARNT FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 GC01P161621 USP21 DUSP12 FCGR2B B4GALT3 PPOX DEDD LOC148430 FCGR3B ATF6
GH01J161528 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +19.6 19577 4.7 PKNOX1 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 TRG-TCC2-6 TRL-CAG1-6 USP21 DUSP12 PPOX FCGR2C DEDD FCGR2A B4GALT3 FCRLA
GH01J162002 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 7.6 -453.1 -453130 2.6 ZNF664 REST ZNF600 MAFK SPI1 FCGR3A OLFML2B FCGR2A PIR31181
GH01J161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.4 +482.1 482122 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGR3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCGR3A gene promoter:
  • Nkx3-1 v1
  • Nkx3-1 v4
  • Pax-4a
  • Nkx3-1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for FCGR3A Gene

Genomic Locations for FCGR3A Gene
chr1:161,541,759-161,550,737
(GRCh38/hg38)
Size:
8,979 bases
Orientation:
Minus strand
chr1:161,511,549-161,600,917
(GRCh37/hg19)
Size:
89,369 bases
Orientation:
Minus strand

Genomic View for FCGR3A Gene

Genes around FCGR3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR3A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FCGR3A Gene

Proteins for FCGR3A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FCGR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08637-FCG3A_HUMAN
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-A
    Protein Accession:
    P08637
    Secondary Accessions:
    • A2N6W9
    • Q53FJ0
    • Q53FL6
    • Q5EBR4
    • Q65ZM6
    • Q6PIJ0

    Protein attributes for FCGR3A Gene

    Size:
    254 amino acids
    Molecular mass:
    29089 Da
    Quaternary structure:
    • Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 (By similarity).
    Miscellaneous:
    • Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the Ser-203 in III-B determines the GPI-anchoring.
    SequenceCaution:
    • Sequence=BAD96988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FCGR3A Gene

neXtProt entry for FCGR3A Gene

Protein Expression for FCGR3A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FCGR3A Gene

  • Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
  • The soluble form is produced by a proteolytic cleavage.
  • Glycosylation at Asn187, isoforms=180, isoforms=92, Asn63, and Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FCGR3A (Fc gamma RIIIA/CD16a)

No data available for DME Specific Peptides for FCGR3A Gene

Domains & Families for FCGR3A Gene

Gene Families for FCGR3A Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCGR3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCGR3A: view

No data available for UniProtKB/Swiss-Prot for FCGR3A Gene

Function for FCGR3A Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FCGR3A Gene

UniProtKB/Swiss-Prot Function:
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
GENATLAS Biochemistry:
immunoglobulin G,low affinity receptor 3A (see IGFCR@),expressed in natural killer cells,monocytes and renal mesangial cells

Phenotypes From GWAS Catalog for FCGR3A Gene

Gene Ontology (GO) - Molecular Function for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR3A: view
genes like me logo Genes that share phenotypes with FCGR3A: view

Human Phenotype Ontology for FCGR3A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for FCGR3A (Fc gamma RIIIA/CD16a)

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FCGR3A Gene

Localization for FCGR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR3A Gene

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR3A gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytosol 2
lysosome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 10706735
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with FCGR3A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCGR3A Gene

Pathways & Interactions for FCGR3A Gene

genes like me logo Genes that share pathways with FCGR3A: view

Gene Ontology (GO) - Biological Process for FCGR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2138330
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with FCGR3A: view

No data available for SIGNOR curated interactions for FCGR3A Gene

Drugs & Compounds for FCGR3A Gene

Products:

  1. Drug

(45) Drugs for FCGR3A Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma Target 413
rituximab Approved Pharma Target Therapeutic Antibodies 1808
Trastuzumab Approved, Investigational Pharma Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 848
Adalimumab Approved Pharma Target 521
Abciximab Approved Pharma Target 65

(5) Additional Compounds for FCGR3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR3A: view

Transcripts for FCGR3A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FCGR3A Gene

(8) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(153) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCGR3A Gene

Fc fragment of IgG, low affinity IIIa, receptor (CD16a):
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for FCGR3A (Fc gamma RIIIA/CD16a)

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR3A Gene

No ASD Table

Relevant External Links for FCGR3A Gene

GeneLoc Exon Structure for
FCGR3A
ECgene alternative splicing isoforms for
FCGR3A

Expression for FCGR3A Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGR3A Gene

mRNA expression in normal human tissues for FCGR3A Gene
mRNA expression by BioGPS for FCGR3A GenemRNA expression by GTEx for FCGR3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR3A Gene

This gene is overexpressed in Whole Blood (x20.1) and Spleen (x6.7).

Protein differential expression in normal tissues from HIPED for FCGR3A Gene

This gene is overexpressed in Spleen (20.2) and NK cells (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGR3A Gene



NURSA nuclear receptor signaling pathways regulating expression of FCGR3A Gene:

FCGR3A

SOURCE GeneReport for Unigene cluster for FCGR3A Gene:

Hs.372679

mRNA Expression by UniProt/SwissProt for FCGR3A Gene:

P08637-FCG3A_HUMAN
Tissue specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

Evidence on tissue expression from TISSUES for FCGR3A Gene

  • Blood(4.9)
  • Lung(4.6)
  • Nervous system(3.7)
  • Spleen(3.5)
  • Lymph node(3.1)
  • Bone marrow(2.9)
  • Intestine(2.7)
  • Heart(2.5)
  • Liver(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR3A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • immune
  • lymphatic
  • nervous
  • respiratory
  • skeleton
Regions:
Head and neck:
  • ear
  • head
  • middle ear
  • sinus
  • skull
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with FCGR3A: view

No data available for Protein tissue co-expression partners for FCGR3A Gene

Orthologs for FCGR3A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FCGR3A 33
  • 98.95 (n)
-- 34
  • 97 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia FCGR3A 34 33
  • 76 (n)
 OneToMany
dog
(Canis familiaris)
 Mammalia LOC478984 33
  • 75.57 (n)
-- 34
  • 58 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Fcgr4 34 33
  • 72.69 (n)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Fcgr3a 33
  • 72.02 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 45 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 41 (a)
 ManyToMany
-- 34
  • 40 (a)
 ManyToMany
-- 34
  • 34 (a)
 ManyToMany
-- 34
  • 31 (a)
 ManyToMany
-- 34
  • 28 (a)
 ManyToMany
Species where no ortholog for FCGR3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCGR3A Gene

ENSEMBL:
Gene Tree for FCGR3A (if available)
TreeFam:
Gene Tree for FCGR3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCGR3A: view image

Paralogs for FCGR3A Gene

Paralogs for FCGR3A Gene

(11) SIMAP similar genes for FCGR3A Gene using alignment to 5 proteins:

  • FCG3A_HUMAN
  • C9JC71_HUMAN
  • E9PG94_HUMAN
  • H0Y755_HUMAN
  • M9MML0_HUMAN
genes like me logo Genes that share paralogs with FCGR3A: view

Variants for FCGR3A Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for FCGR3A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs10127939 benign, pathogenic, uncertain-significance, not specified, Immunodeficiency 20, Immunodeficiency 20 (IMD20) [MIM:615707] 161,548,543(-) A/C/T coding_sequence_variant, missense_variant
rs148181339 not-provided, benign, not provided, not specified 161,548,424(-) T/C coding_sequence_variant, missense_variant
rs396991 drug-response, likely-benign, rituximab response - Efficacy, cetuximab response - Efficacy, trastuzumab response - Efficacy, not specified 161,544,752(-) A/C/G coding_sequence_variant, intron_variant, missense_variant
rs77144485 not-provided, benign, not provided, not specified 161,548,546(-) C/T coding_sequence_variant, missense_variant
rs114535887 benign, not specified 161,548,524(-) C/G/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for FCGR3A Gene

Variant ID Type Subtype PubMed ID
dgv1n39 CNV gain 20164927
dgv22n16 CNV deletion 17901297
dgv23n16 CNV insertion 17901297
dgv447n100 CNV gain 25217958
dgv448n100 CNV loss 25217958
dgv449n100 CNV gain+loss 25217958
dgv450n100 CNV gain 25217958
dgv451n100 CNV loss 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv605n54 CNV loss 21841781
dgv74e199 CNV deletion 23128226
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2507888 CNV deletion 19546169
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv33393 CNV gain+loss 17666407
esv3584532 CNV gain 24956385
esv3587729 CNV loss 21293372
esv3587730 CNV gain 21293372
esv3587731 CNV loss 21293372
esv3890693 CNV loss 25118596
esv990743 CNV loss 20482838
esv997087 CNV loss 20482838
nsv1112219 CNV deletion 24896259
nsv1161730 CNV duplication 26073780
nsv1161862 CNV duplication 26073780
nsv159772 CNV deletion 16902084
nsv428257 CNV loss 18775914
nsv442209 CNV gain 18776908
nsv464173 CNV gain 19166990
nsv509546 CNV insertion 20534489
nsv514915 CNV gain 21397061
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548061 CNV loss 21841781
nsv818489 CNV gain 17921354
nsv818500 CNV gain 17921354
nsv819523 CNV loss 19587683
nsv820341 CNV duplication 20802225
nsv825176 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946464 CNV duplication 23825009
nsv952226 CNV duplication 24416366

Variation tolerance for FCGR3A Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGR3A Gene

Human Gene Mutation Database (HGMD)
FCGR3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR3A Gene

Disorders for FCGR3A Gene

MalaCards: The human disease database

(25) MalaCards diseases for FCGR3A Gene - From: HGMD, OMIM, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 20
  • imd20
herpes zoster
  • herpes zona
systemic lupus erythematosus
  • sle
cryptococcosis
  • busse-buschke's disease
chronic nk-cell lymphocytosis
  • nk-cell large granular lymphocyte lymphocytosis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FCG3A_HUMAN
  • Immunodeficiency 20 (IMD20) [MIM:615707]: A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). {ECO:0000269 PubMed:23006327, ECO:0000269 PubMed:8608639, ECO:0000269 PubMed:8609432, ECO:0000269 PubMed:8874200}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FCGR3A Gene

lupus systemic syndrome and other autoimmune diseases

Additional Disease Information for FCGR3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCGR3A: view

Publications for FCGR3A Gene

  1. Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. (PMID: 19946017) Zhou XJ … Zhang H (International immunology 2010) 3 22 44 58
  2. Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population. (PMID: 20439102) Sadki K … El Aouad R (Journal of genetics and genomics = Yi chuan xue bao 2010) 3 22 44 58
  3. Fcgamma receptor IIIA polymorphisms and efficacy of rituximab therapy on Chinese diffuse large B-cell lymphoma. (PMID: 20137370) Zhang W … Zhou DB (Chinese medical journal 2010) 3 22 44 58
  4. [Association of Fc gamma receptors IIIA gene polymorphisms with the susceptibility to periodontitis in Chinese patients]. (PMID: 19221562) An N … Hui RT (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2009) 3 22 44 58
  5. Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis. (PMID: 19019892) Thabet MM … van der Helm-van Mil AH (Annals of the rheumatic diseases 2009) 3 22 44 58

Products for FCGR3A Gene

Sources for FCGR3A Gene