Aliases for FCGR2B Gene
External Ids for FCGR2B Gene
Previous HGNC Symbols for FCGR2B Gene
Previous GeneCards Identifiers for FCGR2B Gene
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for FCGR2B Gene
FCGR2B (Fc Fragment Of IgG Receptor IIb) is a Protein Coding gene. Diseases associated with FCGR2B include Systemic Lupus Erythematosus and Malaria. Among its related pathways are Immune response Fc epsilon RI pathway and Fc-GammaR Pathway. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.
UniProtKB/Swiss-Prot for FCGR2B Gene
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.