Aliases for FCGR2A Gene
External Ids for FCGR2A Gene
Previous HGNC Symbols for FCGR2A Gene
Previous GeneCards Identifiers for FCGR2A Gene
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
GeneCards Summary for FCGR2A Gene
FCGR2A (Fc Fragment Of IgG Receptor IIa) is a Protein Coding gene. Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus. Among its related pathways are Role of phospholipids in phagocytosis and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include IgG binding. An important paralog of this gene is FCGR2C.
UniProtKB/Swiss-Prot for FCGR2A Gene
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.