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Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]
FCGR1B (Fc Fragment Of IgG Receptor Ib) is a Pseudogene. Diseases associated with FCGR1B include Cerebral Neuroblastoma. Among its related pathways are Innate Immune System and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCGR1A.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J121089 | Promoter | 0.3 | Ensembl | 250.7 | +2.0 | 1956 | 0.2 | FCGR1B ENSG00000233029 ENSG00000234998 H3P4 SRGAP2C PPIAL4A | ||
GH01J121087 | Promoter | 0.3 | Ensembl | 250.7 | +1.0 | 956 | 1 | FCGR1B ENSG00000233029 ENSG00000234998 H3P4 SRGAP2C PPIAL4A | ||
GH01J121086 | Promoter | 0.3 | Ensembl | 250.7 | 0.0 | -44 | 0.6 | FCGR1B ENSG00000234998 HG983613-001 H3P4 SRGAP2C PPIAL4A | ||
GH01J120088 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 1.7 | -999.0 | -999040 | 0.6 | ZNF146 FOS ZNF600 | NOTCH2 ZNF697 FCGR1B MN308776-001 lnc-NOTCH2-3 lnc-NOTCH2-2 lnc-PHGDH-4 ADAM30 | |
GH01J121090 | Promoter | 0.3 | Ensembl | 0.7 | +2.4 | 2356 | 0.2 | FCGR1B ENSG00000233029 ENSG00000234998 H3P4 SRGAP2C PPIAL4A |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | 21873635 |
GO:0019763 | immunoglobulin receptor activity | NAS | 1430234 |
GO:0019864 | IgG binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030669 | clathrin-coated endocytic vesicle membrane | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
GO:0006898 | receptor-mediated endocytosis | TAS | -- |
GO:0006955 | immune response | NAS | 1430234 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Human immunoglobulin G | Approved, Investigational | Pharma | Target, antagonist | 0 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | FCGR1A 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | FCGR1A 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Fcgr1 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
cerebral neuroblastoma |
|
|