Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019] See more...

Aliases for FCGR1B Gene

Aliases for FCGR1B Gene

  • Fc Fragment Of IgG Receptor Ib 2 3 5
  • Fc Fragment Of IgG, High Affinity Ib, Receptor (CD64) 2 3
  • High Affinity Immunoglobulin Gamma Fc Receptor IB 3 4
  • Fc Gamma Receptor Ib 2 3
  • IgG Fc Receptor IB 3 4
  • Fc-Gamma RIB 3 4
  • HFcgammaRIB 3 4
  • CD64b 2 3
  • IGFRB 3 4
  • FcRIB 3 4
  • Fc Fragment Of IgG, High Affinity Ib, Receptor For (CD64) 2
  • High Affinity Immunoglobulin Gamma Fc Receptor I 3
  • Fc-Gamma Receptor I B2 3
  • IgG Fc Receptor I 3
  • Fc-Gamma RIA 3
  • Fc-Gamma RI 3
  • FcgammaRIa 3
  • FCGR1A 3
  • FCGR1B 5
  • FCGR1 3
  • IGFR1 3
  • FCG1 3
  • FcRI 3

External Ids for FCGR1B Gene

Previous GeneCards Identifiers for FCGR1B Gene

  • GC01U990044
  • GC01M120729
  • GC01M120926
  • GC01M118453

Summaries for FCGR1B Gene

Entrez Gene Summary for FCGR1B Gene

  • Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]

GeneCards Summary for FCGR1B Gene

FCGR1B (Fc Fragment Of IgG Receptor Ib) is a Pseudogene. Diseases associated with FCGR1B include Cerebral Neuroblastoma. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include IgG binding and immunoglobulin receptor activity. An important paralog of this gene is FCGR1A.

UniProtKB/Swiss-Prot Summary for FCGR1B Gene

  • May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.

Additional gene information for FCGR1B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCGR1B Gene

Genomics for FCGR1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCGR1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J121086 Promoter 0.3 Ensembl 600.7 +0.7 656 1.6 FCGR1B ENSG00000233029 ENSG00000234998 H3P4 SRGAP2C PPIAL4A
GH01J120088 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 1.7 -999.0 -999040 0.6 ZNF600 ZNF146 FOS NOTCH2 ZNF697 FCGR1B MN308776-001 lnc-NOTCH2-3 lnc-PHGDH-4 ADAM30
GH01J121089 Promoter 0.3 Ensembl 0.7 +2.2 2156 0.6 FCGR1B ENSG00000233029 H3P4 ENSG00000234998 SRGAP2C PPIAL4A
GH01J121092 Promoter 0.3 Ensembl 0.7 +3.9 3856 0.4 FCGR1B ENSG00000233029 LOC100996318 H3P4 ENSG00000234998 SRGAP2C PPIAL4A
GH01J121091 Promoter 0.3 Ensembl 0.4 +5.5 5456 0.4 ENSG00000233029 FCGR1B LOC100996318 ENSG00000234998 H3P4 SRGAP2C PPIAL4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGR1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCGR1B

Top Transcription factor binding sites by QIAGEN in the FCGR1B gene promoter:
  • AP-1
  • c-Fos
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-E2
  • NF-E2 p45
  • STAT1

Genomic Locations for FCGR1B Gene

Genomic Locations for FCGR1B Gene
chr1:121,087,345-121,097,161
(GRCh38/hg38)
Size:
9,817 bases
Orientation:
Plus strand
chr1:120,926,908-120,935,944
(GRCh37/hg19)
Size:
9,037 bases
Orientation:
Minus strand

Genomic View for FCGR1B Gene

Genes around FCGR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1B Gene

Proteins for FCGR1B Gene

  • Protein details for FCGR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92637-FCGRB_HUMAN
    Recommended name:
    High affinity immunoglobulin gamma Fc receptor IB
    Protein Accession:
    Q92637
    Secondary Accessions:
    • Q7KZ13
    • Q92638

    Protein attributes for FCGR1B Gene

    Size:
    280 amino acids
    Molecular mass:
    32232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FCGR1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FCGR1B Gene

Post-translational modifications for FCGR1B Gene

  • Glycosylation at Asn59, Asn152, and Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for FCGR1B Gene

No data available for DME Specific Peptides for FCGR1B Gene

Domains & Families for FCGR1B Gene

Gene Families for FCGR1B Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FCGR1B Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for FCGR1B Gene

GenScript: Design optimal peptide antigens:
  • Fc-gamma RIB (FCGRB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92637

UniProtKB/Swiss-Prot:

FCGRB_HUMAN :
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
Family:
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
genes like me logo Genes that share domains with FCGR1B: view

Function for FCGR1B Gene

Molecular function for FCGR1B Gene

UniProtKB/Swiss-Prot Function:
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma.
GENATLAS Biochemistry:
immunoglobulin G,high affinity Fc receptor 1B,expressed in most cells,complexing with homodimeric gamma subunit,with the immunoreceptor based inhibition motif (ITIM)

Gene Ontology (GO) - Molecular Function for FCGR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0019763 immunoglobulin receptor activity NAS 1430234
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR1B: view
genes like me logo Genes that share phenotypes with FCGR1B: view

Animal Model Products

CRISPR Products

miRNA for FCGR1B Gene

miRTarBase miRNAs that target FCGR1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR1B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCGR1B Gene

Localization for FCGR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1B Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR1B gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCGR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030669 clathrin-coated endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with FCGR1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCGR1B Gene

Pathways & Interactions for FCGR1B Gene

genes like me logo Genes that share pathways with FCGR1B: view

Gene Ontology (GO) - Biological Process for FCGR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 1430234
genes like me logo Genes that share ontologies with FCGR1B: view

No data available for SIGNOR curated interactions for FCGR1B Gene

Drugs & Compounds for FCGR1B Gene

(1) Drugs for FCGR1B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Human immunoglobulin G Approved, Investigational Pharma Target, antagonist 0
genes like me logo Genes that share compounds with FCGR1B: view

Transcripts for FCGR1B Gene

mRNA/cDNA for FCGR1B Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR1B

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1B Gene

No ASD Table

Relevant External Links for FCGR1B Gene

GeneLoc Exon Structure for
FCGR1B

Expression for FCGR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCGR1B Gene

mRNA differential expression in normal tissues according to GTEx for FCGR1B Gene

This gene is overexpressed in Whole Blood (x26.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCGR1B

SOURCE GeneReport for Unigene cluster for FCGR1B Gene:

Hs.534956

Evidence on tissue expression from TISSUES for FCGR1B Gene

  • Blood(4.5)
  • Intestine(2.5)
  • Nervous system(2.2)
  • Lymph node(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with FCGR1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR1B Gene

Orthologs for FCGR1B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 73 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia FCGR1A 31
  • 47 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia FCGR1A 31
  • 45 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fcgr1 31
  • 44 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 38 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
Species where no ortholog for FCGR1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCGR1B Gene

ENSEMBL:
Gene Tree for FCGR1B (if available)
TreeFam:
Gene Tree for FCGR1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCGR1B: view image

Paralogs for FCGR1B Gene

(10) SIMAP similar genes for FCGR1B Gene using alignment to 1 proteins:

  • FCGRB_HUMAN

Pseudogenes.org Pseudogenes for FCGR1B Gene

genes like me logo Genes that share paralogs with FCGR1B: view

Variants for FCGR1B Gene

Structural Variations from Database of Genomic Variants (DGV) for FCGR1B Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV gain 19592680

Variation tolerance for FCGR1B Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGR1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCGR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for FCGR1B Gene

Disorders for FCGR1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FCGR1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral neuroblastoma
  • neuroblastoma of brain
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCGR1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FCGR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR1B Gene

Publications for FCGR1B Gene

  1. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco DL … Anderson CL (Cytogenetics and cell genetics 1996) 2 3 4
  2. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (PMID: 19330030) Thomas G … Hunter DJ (Nature genetics 2009) 3 41
  3. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. (PMID: 11802953) Tang Y … Li Y (Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 2001) 3 41
  4. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco DL … Theil KS (Cytogenetics and cell genetics 1998) 2 3
  5. Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. (PMID: 9881690) Ernst LK … Anderson CL (Molecular immunology 1998) 3 4

Products for FCGR1B Gene

Sources for FCGR1B Gene