This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] See more...

Aliases for FCGR1A Gene

Aliases for FCGR1A Gene

  • Fc Fragment Of IgG Receptor Ia 2 3 5
  • Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64) 2 3
  • Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64) 2 3
  • High Affinity Immunoglobulin Gamma Fc Receptor I 3 4
  • Fc Gamma Receptor Ia 2 3
  • IgG Fc Receptor I 3 4
  • Fc-Gamma RIA 3 4
  • Fc-Gamma RI 3 4
  • FcgammaRIa 3 4
  • CD64A 2 3
  • IGFR1 3 4
  • CD64 2 3
  • Fc-Gamma Receptor I A1 3
  • CD64 Antigen 4
  • FCGR1A 5
  • FCGR1 4
  • FCRI 3
  • FCG1 4
  • FcRI 4

External Ids for FCGR1A Gene

Previous GeneCards Identifiers for FCGR1A Gene

  • GC01P147395
  • GC01P141381
  • GC01P146529
  • GC01P146970
  • GC01P146567
  • GC01P148020

Summaries for FCGR1A Gene

Entrez Gene Summary for FCGR1A Gene

  • This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCGR1A Gene

FCGR1A (Fc Fragment Of IgG Receptor Ia) is a Protein Coding gene. Diseases associated with FCGR1A include Cervical Adenitis and Goat Milk Allergy. Among its related pathways are Phagocytosis of Microbes and Phagosome. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and IgG binding. An important paralog of this gene is FCGR1B.

UniProtKB/Swiss-Prot Summary for FCGR1A Gene

  • High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Gene Wiki entry for FCGR1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCGR1A Gene

Genomics for FCGR1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCGR1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J149782 Promoter 0.7 EPDnew Ensembl 250.7 +0.6 630 1.8 HSALNG0006966 FCGR1A lnc-PPIAL4F-2-003 HSALNG0006968 H2BC18 lnc-HIST2H3D-2
GH01J149746 Promoter/Enhancer 0.7 Ensembl ENCODE 8 -35.1 -35070 1.6 ZBTB33 EZH2 PDE4DIPP7 HG983795 lnc-HIST2H2BF-3 SV2A FCGR1A MN308985 LOC105371406 PPIAL4C
GH01J149792 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 0.4 +10.6 10562 2.3 CTCF ELF1 NONO ZIC2 REST CUX1 ZEB2 CTBP1 SIN3A SMARCA5 ENSG00000233030 HSALNG0006970 HSALNG0006971 lnc-FCGR1A-1 SV2A FCGR1A H2BC18 lnc-HIST2H3D-2
GH01J149787 Promoter/Enhancer 0.7 Ensembl ENCODE 0.4 +5.3 5330 0.8 IKZF1 KDM1A CBFA2T3 HSALNG0006968 ENSG00000233030 FCGR1A lnc-PPIAL4F-2-003 H2BC18 lnc-HIST2H3D-2
GH01J149784 Promoter 0.3 Ensembl 0.7 +2.0 2030 0.6 lnc-PPIAL4F-2-003 FCGR1A HSALNG0006968 H2BC18 lnc-HIST2H3D-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGR1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCGR1A

Top Transcription factor binding sites by QIAGEN in the FCGR1A gene promoter:
  • HNF-3beta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • p53
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for FCGR1A Gene

Latest Assembly
17,939 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
17,916 bases
Plus strand

(GRCh37/hg19 by Ensembl)
9,848 bases
Plus strand

Genomic View for FCGR1A Gene

Genes around FCGR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGR1A Gene

Proteins for FCGR1A Gene

  • Protein details for FCGR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    High affinity immunoglobulin gamma Fc receptor I
    Protein Accession:
    Secondary Accessions:
    • P12315
    • Q5QNW7
    • Q92495
    • Q92663

    Protein attributes for FCGR1A Gene

    374 amino acids
    Molecular mass:
    42632 Da
    Quaternary structure:
    • Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

    Three dimensional structures from OCA and Proteopedia for FCGR1A Gene

    Alternative splice isoforms for FCGR1A Gene


neXtProt entry for FCGR1A Gene

Post-translational modifications for FCGR1A Gene

  • Phosphorylated on serine residues.
  • Glycosylation at Asn59, Asn78, Asn152, Asn159, Asn163, Asn195, and Asn240
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for FCGR1A

Protein products for research

  • Novus Biologicals lysates for FCGR1A
  • Abcam proteins for FCGR1A

No data available for DME Specific Peptides for FCGR1A Gene

Domains & Families for FCGR1A Gene

Gene Families for FCGR1A Gene

Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for FCGR1A Gene

  • Immunoglobulin C-2 type
  • Immunoglobulin subtype

Suggested Antigen Peptide Sequences for FCGR1A Gene

GenScript: Design optimal peptide antigens:
  • Fc-gamma RIA (FCGR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. FCGR1 family.
  • Belongs to the immunoglobulin superfamily. FCGR1 family.
genes like me logo Genes that share domains with FCGR1A: view

Function for FCGR1A Gene

Molecular function for FCGR1A Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
GENATLAS Biochemistry:
immunoglobulin G,high affinity Fc receptor 1A,expressed by macrophages,monocytes,neutrophils

Phenotypes From GWAS Catalog for FCGR1A Gene

Gene Ontology (GO) - Molecular Function for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA 21873635
GO:0005515 protein binding IPI 18322202
GO:0019864 IgG binding IEA --
genes like me logo Genes that share ontologies with FCGR1A: view
genes like me logo Genes that share phenotypes with FCGR1A: view

Animal Models for FCGR1A Gene

MGI Knock Outs for FCGR1A:

Animal Models for research

miRNA for FCGR1A Gene

miRTarBase miRNAs that target FCGR1A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCGR1A Gene

Localization for FCGR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGR1A Gene

Cell membrane. Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGR1A gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030669 clathrin-coated endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with FCGR1A: view

Pathways & Interactions for FCGR1A Gene

genes like me logo Genes that share pathways with FCGR1A: view

Pathways by source for FCGR1A Gene

4 Qiagen pathways for FCGR1A Gene
  • Fc-GammaR Pathway
  • Fc-GammaR-Mediated Phagocytosis in Macrophages
  • NFAT in Immune Response
  • Phagocytosis of Microbes

SIGNOR curated interactions for FCGR1A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FCGR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006911 phagocytosis, engulfment TAS 10879688
GO:0006955 immune response TAS 10879688
genes like me logo Genes that share ontologies with FCGR1A: view

Drugs & Compounds for FCGR1A Gene

(33) Drugs for FCGR1A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alemtuzumab Approved, Investigational Pharma Target Therapeutic Antibodies 353
Atomoxetine Approved Pharma Carrier, binder 0
Bevacizumab Approved, Investigational Pharma Target VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2478
Catumaxomab Approved, Investigational, Withdrawn Pharma Target, agonist Others 15
Cetuximab Approved Pharma Target, binder EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 894

(19) Additional Compounds for FCGR1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCGR1A: view

Transcripts for FCGR1A Gene

mRNA/cDNA for FCGR1A Gene

9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCGR1A

Alternative Splicing Database (ASD) splice patterns (SP) for FCGR1A Gene

No ASD Table

Relevant External Links for FCGR1A Gene

GeneLoc Exon Structure for

Expression for FCGR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCGR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGR1A Gene

This gene is overexpressed in Whole Blood (x25.7).

Protein differential expression in normal tissues from HIPED for FCGR1A Gene

This gene is overexpressed in Placenta (47.1), Peripheral blood mononuclear cells (13.2), and Spleen (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGR1A Gene

Protein tissue co-expression partners for FCGR1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCGR1A

SOURCE GeneReport for Unigene cluster for FCGR1A Gene:


mRNA Expression by UniProt/SwissProt for FCGR1A Gene:

Tissue specificity: Monocyte/macrophage specific.

Evidence on tissue expression from TISSUES for FCGR1A Gene

  • Blood(4.6)
  • Liver(4.5)
  • Lymph node(3.1)
  • Intestine(3)
  • Bone marrow(2.9)
  • Spleen(2.8)
  • Lung(2.6)
  • Nervous system(2.6)
  • Heart(2.3)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with FCGR1A: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGR1A Gene

Orthologs for FCGR1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCGR1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
  • 98.93 (n)
(Canis familiaris)
Mammalia FCGR1A 30 31
  • 82.77 (n)
(Bos Taurus)
Mammalia FCGR1A 30 31
  • 80.99 (n)
(Mus musculus)
Mammalia Fcgr1 30 17 31
  • 78.17 (n)
(Rattus norvegicus)
Mammalia Fcgr1a 30
  • 77.38 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 44 (a)
-- 31
  • 42 (a)
-- 31
  • 39 (a)
-- 31
  • 38 (a)
-- 31
  • 38 (a)
Species where no ortholog for FCGR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCGR1A Gene

Gene Tree for FCGR1A (if available)
Gene Tree for FCGR1A (if available)
Evolutionary constrained regions (ECRs) for FCGR1A: view image

Paralogs for FCGR1A Gene

(15) SIMAP similar genes for FCGR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FCGR1A: view

Variants for FCGR1A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCGR1A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs141598661 Likely Benign: not provided 149,782,764(+) G/A
NM_000566.3(FCGR1A):c.21G>A (p.Leu7=)
rs587645491 Benign: not provided 149,791,461(+) AAAG/A
rs637882 Uncertain Significance: Peritoneal Gliomatosis 149,790,230(+) C/T
NM_000566.3(FCGR1A):c.736C>T (p.Gln246Ter)
rs74315310 Pathogenic: IGG receptor I, phagocytic, familial deficiency of 149,784,224(+) C/T
rs80039899 Likely Benign: not provided 149,784,064(+) C/T
NM_000566.3(FCGR1A):c.114C>T (p.Thr38=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FCGR1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FCGR1A Gene

Variant ID Type Subtype PubMed ID
dgv73n67 CNV gain 20364138
nsv469694 CNV loss 16826518
nsv824564 CNV gain 20364138
nsv831503 CNV gain 17160897
nsv831525 CNV gain 17160897
nsv946376 CNV duplication 23825009
nsv952796 CNV duplication 24416366

Variation tolerance for FCGR1A Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGR1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGR1A Gene

Disorders for FCGR1A Gene

MalaCards: The human disease database

(20) MalaCards diseases for FCGR1A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cervical adenitis
  • cervical lymphadenitis
goat milk allergy
  • capra hircus milk allergy
  • post kala-azar dermal leishmaniasis
  • acute pharyngitis
tetrasomy 21
  • isochromosome 21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCGR1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FCGR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCGR1A Gene

Publications for FCGR1A Gene

  1. Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1. (PMID: 9763663) Maresco DL … Theil KS (Cytogenetics and cell genetics 1998) 2 3 23
  2. The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. (PMID: 8697799) Maresco DL … Anderson CL (Cytogenetics and cell genetics 1996) 2 3 23
  3. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. (PMID: 8064233) Wang AV … Geha RS (The Journal of experimental medicine 1994) 3 4 23
  4. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. (PMID: 1379234) Ernst LK … Anderson CL (The Journal of biological chemistry 1992) 3 4 23
  5. Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding. (PMID: 21965667) Lu J … Sun PD (The Journal of biological chemistry 2011) 3 4

Products for FCGR1A Gene

Sources for FCGR1A Gene