Aliases for FCGBP Gene

Aliases for FCGBP Gene

  • Fc Fragment Of IgG Binding Protein 2 3 5
  • Fcgamma-Binding Protein Antigen 3 4
  • IgG Fc Binding Protein 2 3
  • IgGFc-Binding Protein 3 4
  • Human Fc Gamma BP 2 3
  • FcgammaBP 3 4

External Ids for FCGBP Gene

Previous GeneCards Identifiers for FCGBP Gene

  • GC19M041007
  • GC19M040745
  • GC19M045030
  • GC19M045045
  • GC19M040353

Summaries for FCGBP Gene

GeneCards Summary for FCGBP Gene

FCGBP (Fc Fragment Of IgG Binding Protein) is a Protein Coding gene. An important paralog of this gene is ZAN.

UniProtKB/Swiss-Prot Summary for FCGBP Gene

  • May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Gene Wiki entry for FCGBP Gene

Additional gene information for FCGBP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCGBP Gene

Genomics for FCGBP Gene

GeneHancer (GH) Regulatory Elements for FCGBP Gene

Promoters and enhancers for FCGBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039933 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE 763.3 -0.9 -894 4.6 ZNF785 RELA ZNF121 ZSCAN4 SP1 EGR1 RUNX3 FOXA2 ZFHX2 ZC3H11A FCGBP ZNF780A AKT2 ENSG00000269843 SNRPA PSMC4 RN7SL566P FBL TTC9B CNTD2
GH19J039969 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.6 -36.2 -36186 3.6 ZNF785 SIN3A SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 SMARCE1 RBPJ PSMC4 lnc-FCGBP-2 piR-56186-028 ZNF780A ENSG00000269843 SNRPA FBL FCGBP AKT2 RN7SL566P
GH19J039995 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.5 -62.6 -62646 2.9 ZNF785 SIN3A ZNF24 ZBTB40 SIX5 ZBTB6 RBPJ SMARCE1 POLR2A CREB1 ZNF546 lnc-ZNF780B-2 SNRPA ENSG00000269843 PAF1 EID2B EID2 FCGBP FBL PSMC4
GH19J039940 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 35.8 -8.9 -8879 6.7 SIN3A SP1 ZBTB40 NR2F6 CREB1 MIXL1 ETV6 RELA HLF ZNF652 PRR13P5 lnc-FCGBP-1 FCGBP ZNF780A PSMC4 FBL CNTD2 TTC9B ZNF546 SERTAD1
GH19J039950 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 29.2 -18.0 -17956 3.8 SP1 ETV6 RELA MLLT1 CREM IKZF1 IKZF2 LARP7 PKNOX1 CBFB FCGBP FBL ZNF780A ZNF546 lnc-FCGBP-1 piR-41245-119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCGBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCGBP gene promoter:
  • AREB6
  • Elk-1
  • Evi-1
  • ITF-2
  • NF-1
  • NRSF form 1
  • NRSF form 2
  • Tal-1beta

Genomic Locations for FCGBP Gene

Genomic Locations for FCGBP Gene
71,304 bases
Minus strand
86,571 bases
Minus strand

Genomic View for FCGBP Gene

Genes around FCGBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCGBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCGBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCGBP Gene

Proteins for FCGBP Gene

  • Protein details for FCGBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IgGFc-binding protein
    Protein Accession:
    Secondary Accessions:
    • O95784

    Protein attributes for FCGBP Gene

    5405 amino acids
    Molecular mass:
    572017 Da
    Quaternary structure:
    • Interacts with the Fc portion of IgG and with MUC2.

neXtProt entry for FCGBP Gene

Post-translational modifications for FCGBP Gene

  • Glycosylation at Asn75, Asn91, Asn1063, Asn1317, Asn1743, Asn2111, Asn2138, Asn2518, Asn3312, Asn3719, Asn4145, Asn4540, Asn5186, and Asn5242
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FCGBP_HUMAN (1386)

Other Protein References for FCGBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCGBP Gene

Domains & Families for FCGBP Gene

Gene Families for FCGBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FCGBP Gene

GenScript: Design optimal peptide antigens:
  • Fcgamma-binding protein antigen (FCGBP_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal IgGFc-binding region is primate-specific.
  • The N-terminal IgGFc-binding region is primate-specific.
genes like me logo Genes that share domains with FCGBP: view

Function for FCGBP Gene

Molecular function for FCGBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.

Phenotypes From GWAS Catalog for FCGBP Gene

Gene Ontology (GO) - Molecular Function for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19432394
genes like me logo Genes that share ontologies with FCGBP: view
genes like me logo Genes that share phenotypes with FCGBP: view

Animal Models for FCGBP Gene

MGI Knock Outs for FCGBP:
  • Fcgbp Fcgbp<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for FCGBP

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FCGBP Gene

Localization for FCGBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCGBP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCGBP gene
Compartment Confidence
plasma membrane 2
extracellular 2
mitochondrion 1
nucleus 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FCGBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with FCGBP: view

Pathways & Interactions for FCGBP Gene

PathCards logo

SuperPathways for FCGBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FCGBP Gene


No data available for Pathways by source and SIGNOR curated interactions for FCGBP Gene

Drugs & Compounds for FCGBP Gene

No Compound Related Data Available

Transcripts for FCGBP Gene

mRNA/cDNA for FCGBP Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(263) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCGBP Gene

No ASD Table

Relevant External Links for FCGBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCGBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCGBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCGBP Gene

This gene is overexpressed in Colon - Transverse (x22.4), Thyroid (x6.9), and Small Intestine - Terminal Ileum (x6.6).

Protein differential expression in normal tissues from HIPED for FCGBP Gene

This gene is overexpressed in Vitreous humor (14.6), Rectum (13.2), Fetal gut (11.8), Pancreatic juice (10.1), Colon (8.8), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCGBP Gene

NURSA nuclear receptor signaling pathways regulating expression of FCGBP Gene:


SOURCE GeneReport for Unigene cluster for FCGBP Gene:


mRNA Expression by UniProt/SwissProt for FCGBP Gene:

Tissue specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).

Evidence on tissue expression from TISSUES for FCGBP Gene

  • Intestine(4.9)
  • Saliva(4.2)
  • Bone marrow(4)
  • Gall bladder(3)
  • Thyroid gland(2.5)
  • Stomach(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FCGBP: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCGBP Gene

Orthologs for FCGBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCGBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCGBP 32
  • 98.29 (n)
(Bos Taurus)
Mammalia FCGBP 32
  • 77.48 (n)
(Canis familiaris)
Mammalia FCGBP 32
  • 77.47 (n)
(Mus musculus)
Mammalia Fcgbp 17 32
  • 73.96 (n)
(Rattus norvegicus)
Mammalia Fcgbp 32
  • 73.49 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fcgbp 32
  • 49.46 (n)
Str.15640 32
(Danio rerio)
Actinopterygii si:dkey-65b12.6 32
  • 46.6 (n)
Species where no ortholog for FCGBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FCGBP Gene

Gene Tree for FCGBP (if available)
Gene Tree for FCGBP (if available)
Evolutionary constrained regions (ECRs) for FCGBP: view image

Paralogs for FCGBP Gene

(2) SIMAP similar genes for FCGBP Gene using alignment to 2 proteins:

  • M0QXZ1_HUMAN Pseudogenes for FCGBP Gene

genes like me logo Genes that share paralogs with FCGBP: view

Variants for FCGBP Gene

Sequence variations from dbSNP and Humsavar for FCGBP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003921 -- 39,912,991(-) G/A intron_variant
rs1000020183 -- 39,916,767(-) T/A intron_variant
rs1000025526 -- 39,881,352(-) G/A/C intron_variant
rs1000077835 -- 39,881,631(-) C/G intron_variant
rs1000286362 -- 39,867,292(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCGBP Gene

Variant ID Type Subtype PubMed ID
dgv6440n54 CNV loss 21841781
dgv6441n54 CNV loss 21841781
esv1006063 CNV gain 20482838
esv1010625 CNV loss 20482838
esv2660568 CNV deletion 23128226
esv2718556 CNV deletion 23290073
esv2758760 CNV gain 17122850
esv2763204 CNV loss 21179565
nsv1060617 CNV gain 25217958
nsv1066339 CNV loss 25217958
nsv1072353 CNV deletion 25765185
nsv1076470 CNV duplication 25765185
nsv1115548 CNV duplication 24896259
nsv1118618 CNV duplication 24896259
nsv1118830 CNV deletion 24896259
nsv1126523 CNV deletion 24896259
nsv1150919 CNV duplication 26484159
nsv1160617 CNV deletion 26073780
nsv176 CNV insertion 15895083
nsv177 CNV deletion 15895083
nsv2483 CNV deletion 18451855
nsv2484 CNV insertion 18451855
nsv436744 CNV insertion 17901297
nsv442460 CNV gain+loss 18776908
nsv482218 CNV gain 20164927
nsv509742 CNV insertion 20534489
nsv510766 CNV deletion 20534489
nsv579515 CNV loss 21841781
nsv579518 CNV loss 21841781
nsv579520 CNV loss 21841781
nsv579521 CNV loss 21841781
nsv579522 CNV loss 21841781
nsv579523 CNV loss 21841781
nsv579524 CNV loss 21841781
nsv953574 CNV deletion 24416366
nsv9725 CNV gain+loss 18304495

Variation tolerance for FCGBP Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.93; 99.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCGBP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCGBP Gene

Disorders for FCGBP Gene

Additional Disease Information for FCGBP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FCGBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCGBP Gene

Publications for FCGBP Gene

  1. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (PMID: 12208673) O'Donovan N … Marti U (The Journal of endocrinology 2002) 3 4 23 56
  2. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. (PMID: 9182547) Harada N … Morikawa M (The Journal of biological chemistry 1997) 2 3 4 56
  3. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PMID: 19956635) Holmes MV … Casas JP (PloS one 2009) 3 43 56
  4. Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. (PMID: 19432394) Johansson ME … Hansson GC (Journal of proteome research 2009) 3 4 56
  5. Downregulation of IgG Fc binding protein (Fc gammaBP) in prostate cancer. (PMID: 17938577) Gazi MH … Young CY (Cancer biology & therapy 2008) 3 23 56

Products for FCGBP Gene

Sources for FCGBP Gene