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Aliases for FCF1 Gene

Aliases for FCF1 Gene

  • FCF1, RRNA-Processing Protein 2 3 5
  • C14orf111 3 4
  • FCF1 Small Subunit (SSU) Processome Component Homolog (S. Cerevisiae) 2
  • RRNA-Processing Protein FCF1 Homolog 3
  • Chromosome 14 Open Reading Frame 111 2
  • FCF1 Small Subunit 3
  • CGI-35 3
  • UTP24 3
  • Bka 3

External Ids for FCF1 Gene

Previous HGNC Symbols for FCF1 Gene

  • C14orf111

Previous GeneCards Identifiers for FCF1 Gene

  • GC14P074250
  • GC14P075179

Summaries for FCF1 Gene

GeneCards Summary for FCF1 Gene

FCF1 (FCF1, RRNA-Processing Protein) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot for FCF1 Gene

  • Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Gene Wiki entry for FCF1 Gene

Additional gene information for FCF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCF1 Gene

Genomics for FCF1 Gene

GeneHancer (GH) Regulatory Elements for FCF1 Gene

Promoters and enhancers for FCF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J074712 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.0 36 2.3 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 GC14P074712 FCF1 AREL1 ENSG00000222604 RPS6KL1 DLST PIR37391
GH14J074711 Enhancer 0.3 ENCODE 650.7 -1.3 -1284 0.2 HLF GC14P074712 FCF1 AREL1 ENSG00000222604 GC14M074665
GH14J075273 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.5 +564.7 564703 9.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B FOS GC14P075279 GC14P075280 GPATCH2L ENSG00000258559 ABCD4 FCF1 NEK9 PROX2 ACYP1
GH14J074083 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 -628.2 -628206 3.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 LIN52 PIR52311 ALDH6A1 ZNF410 LOC100506476 ELMSAN1 MLH3 YLPM1 FCF1 PTGR2
GH14J074564 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -142.6 -142567 11.5 PKNOX1 SIN3A FEZF1 GLI4 ZBTB7B YY1 ZNF213 ZNF416 ZNF143 KLF7 ELMSAN1 ZNF410 YLPM1 ENSG00000258559 FCF1 PROX2 LTBP2 ENSG00000259005 RPS2P2 SUB1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCF1 gene promoter:
  • AREB6
  • C/EBPbeta
  • Bach2
  • TBP
  • Pax-5
  • FOXD1
  • AML1a
  • RP58
  • NCX

Genomic Locations for FCF1 Gene

Genomic Locations for FCF1 Gene
25,504 bases
Plus strand
23,548 bases
Plus strand

Genomic View for FCF1 Gene

Genes around FCF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCF1 Gene

Proteins for FCF1 Gene

  • Protein details for FCF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Protein Accession:
    Secondary Accessions:
    • Q86TW8
    • Q8TBL8

    Protein attributes for FCF1 Gene

    198 amino acids
    Molecular mass:
    23370 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FCF1 Gene

Post-translational modifications for FCF1 Gene

  • Ubiquitination at Lys137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FCF1 Gene

Domains & Families for FCF1 Gene

Gene Families for FCF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FCF1 Gene

Suggested Antigen Peptide Sequences for FCF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
  • Belongs to the UTP23/FCF1 family. FCF1 subfamily.
genes like me logo Genes that share domains with FCF1: view

Function for FCF1 Gene

Molecular function for FCF1 Gene

UniProtKB/Swiss-Prot Function:
Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.

Phenotypes From GWAS Catalog for FCF1 Gene

Gene Ontology (GO) - Molecular Function for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with FCF1: view
genes like me logo Genes that share phenotypes with FCF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FCF1 Gene

Localization for FCF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCF1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCF1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA --
GO:0032040 small-subunit processome IBA,IEA --
genes like me logo Genes that share ontologies with FCF1: view

Pathways & Interactions for FCF1 Gene

genes like me logo Genes that share pathways with FCF1: view

Gene Ontology (GO) - Biological Process for FCF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with FCF1: view

No data available for SIGNOR curated interactions for FCF1 Gene

Drugs & Compounds for FCF1 Gene

No Compound Related Data Available

Transcripts for FCF1 Gene

Unigene Clusters for FCF1 Gene

FCF1 small subunit (SSU) processome component homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCF1

Alternative Splicing Database (ASD) splice patterns (SP) for FCF1 Gene

No ASD Table

Relevant External Links for FCF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FCF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCF1 Gene

Protein differential expression in normal tissues from HIPED for FCF1 Gene

This gene is overexpressed in Lung (51.5) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FCF1 Gene

Protein tissue co-expression partners for FCF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FCF1 Gene:


SOURCE GeneReport for Unigene cluster for FCF1 Gene:

genes like me logo Genes that share expression patterns with FCF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCF1 Gene

Orthologs for FCF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FCF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FCF1 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
-- 34
  • 98 (a)
-- 34
  • 98 (a)
-- 34
  • 96 (a)
-- 34
  • 95 (a)
FCF1 33
  • 94.11 (n)
(Bos Taurus)
Mammalia FCF1 34 33
  • 94.61 (n)
(Monodelphis domestica)
Mammalia FCF1 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Fcf1 33
  • 90.07 (n)
(Mus musculus)
Mammalia Fcf1 16 34 33
  • 89.39 (n)
(Ornithorhynchus anatinus)
Mammalia FCF1 34
  • 68 (a)
(Gallus gallus)
Aves FCF1 34 33
  • 78.45 (n)
(Anolis carolinensis)
Reptilia FCF1 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fcf1 33
  • 76.99 (n)
Str.1834 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20881 33
(Danio rerio)
Actinopterygii fcf1 33
  • 76.43 (n)
FCF1 34
  • 76 (a)
wufc51c12 33
fruit fly
(Drosophila melanogaster)
Insecta Bka 34 33
  • 65.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009504 33
  • 60.91 (n)
(Caenorhabditis elegans)
Secernentea F30A10.9 34 33
  • 61.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF1 36 34 33
  • 60.82 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL102W 33
  • 59.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A07018g 33
  • 59.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46230 33
  • 65.81 (n)
(Glycine max)
eudicotyledons Gma.13234 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2007 33
(Oryza sativa)
Liliopsida Os06g0158600 33
  • 64.29 (n)
Os.33206 33
(Zea mays)
Liliopsida Zm.10381 33
(Triticum aestivum)
Liliopsida Ta.9069 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6957 34
  • 76 (a)
Cin.4808 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC32H8.04c 33
  • 61.38 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04159 33
  • 55.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4808 33
Species where no ortholog for FCF1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FCF1 Gene

Gene Tree for FCF1 (if available)
Gene Tree for FCF1 (if available)
Evolutionary constrained regions (ECRs) for FCF1: view image

Paralogs for FCF1 Gene

(2) SIMAP similar genes for FCF1 Gene using alignment to 8 proteins:

  • G3V1S4_HUMAN
  • G3V2M5_HUMAN
  • G3V3N8_HUMAN
  • G3V5D2_HUMAN
  • G3V5L8_HUMAN
  • G3V5S9_HUMAN
  • Q66K47_HUMAN
genes like me logo Genes that share paralogs with FCF1: view

No data available for Paralogs for FCF1 Gene

Variants for FCF1 Gene

Sequence variations from dbSNP and Humsavar for FCF1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000124777 -- 74,712,467(+) A/G upstream_transcript_variant
rs1000189115 -- 74,718,623(+) G/A intron_variant
rs1000231869 -- 74,718,909(+) T/C intron_variant
rs1000337272 -- 74,724,604(+) T/G intron_variant
rs1000727506 -- 74,718,270(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FCF1 Gene

Variant ID Type Subtype PubMed ID
nsv477903 CNV novel sequence insertion 20440878
nsv832831 CNV loss 17160897
nsv832832 CNV gain+loss 17160897

Variation tolerance for FCF1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCF1 Gene

Disorders for FCF1 Gene

Additional Disease Information for FCF1

No disorders were found for FCF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FCF1 Gene

Publications for FCF1 Gene

  1. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. (PMID: 16762320) Rempola B … Rytka J (Biochemical and biophysical research communications 2006) 2 3 58
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for FCF1 Gene

Sources for FCF1 Gene

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