The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have... See more...

Aliases for FCER2 Gene

Aliases for FCER2 Gene

  • Fc Fragment Of IgE Receptor II 2 3 5
  • CLEC4J 2 3 4
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23) 2 3
  • Low Affinity Immunoglobulin Epsilon Fc Receptor 3 4
  • Immunoglobulin E-Binding Factor 3 4
  • Lymphocyte IgE Receptor 3 4
  • Fc Epsilon Receptor II 2 3
  • Fc-Epsilon-RII 3 4
  • CD23 Antigen 3 4
  • BLAST-2 3 4
  • CD23A 3 4
  • IGEBF 3 4
  • CD23 2 3
  • FCE2 3 4
  • Fc Fragment Of IgE, Low Affinity II, Receptor For (CD23A) 2
  • C-Type Lectin Domain Family 4, Member J 3
  • C-Type Lectin Domain Family 4 Member J 4
  • Immunoglobulin Epsilon-Chain 3
  • FCER2 5

External Ids for FCER2 Gene

Previous HGNC Symbols for FCER2 Gene

  • CD23A
  • FCE2

Previous GeneCards Identifiers for FCER2 Gene

  • GC19M007712
  • GC19M007858
  • GC19M007648
  • GC19M007659
  • GC19M007423
  • GC19M007754

Summaries for FCER2 Gene

Entrez Gene Summary for FCER2 Gene

  • The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for FCER2 Gene

FCER2 (Fc Fragment Of IgE Receptor II) is a Protein Coding gene. Diseases associated with FCER2 include Chronic Conjunctivitis and Extrinsic Allergic Alveolitis. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is ASGR2.

UniProtKB/Swiss-Prot Summary for FCER2 Gene

  • Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Gene Wiki entry for FCER2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCER2 Gene

Genomics for FCER2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FCER2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCER2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCER2

Top Transcription factor binding sites by QIAGEN in the FCER2 gene promoter:
  • AML1a
  • ARP-1
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • RP58
  • STAT3
  • XBP-1

Genomic Locations for FCER2 Gene

Latest Assembly
chr19:7,688,758-7,702,755
(GRCh38/hg38)
Size:
13,998 bases
Orientation:
Minus strand

Previous Assembly
chr19:7,753,662-7,767,017
(GRCh37/hg19 by Entrez Gene)
Size:
13,356 bases
Orientation:
Minus strand

chr19:7,753,644-7,767,032
(GRCh37/hg19 by Ensembl)
Size:
13,389 bases
Orientation:
Minus strand

Genomic View for FCER2 Gene

Genes around FCER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER2 Gene

Proteins for FCER2 Gene

  • Protein details for FCER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06734-FCER2_HUMAN
    Recommended name:
    Low affinity immunoglobulin epsilon Fc receptor
    Protein Accession:
    P06734

    Protein attributes for FCER2 Gene

    Size:
    321 amino acids
    Molecular mass:
    36469 Da
    Quaternary structure:
    • Homotrimer.
    SequenceCaution:
    • Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

    Three dimensional structures from OCA and Proteopedia for FCER2 Gene

neXtProt entry for FCER2 Gene

Post-translational modifications for FCER2 Gene

Other Protein References for FCER2 Gene

Antibodies for research

  • Abcam antibodies for FCER2

No data available for DME Specific Peptides for FCER2 Gene

Domains & Families for FCER2 Gene

Gene Families for FCER2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FCER2 Gene

InterPro:
Blocks:
  • Type II antifreeze protein signature

Suggested Antigen Peptide Sequences for FCER2 Gene

GenScript: Design optimal peptide antigens:
  • Lymphocyte IgE receptor (FCER2_HUMAN)
  • CD23 antigen (Q30218_HUMAN)
  • FCER2 protein (Q30219_HUMAN)
genes like me logo Genes that share domains with FCER2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FCER2 Gene

Function for FCER2 Gene

Molecular function for FCER2 Gene

UniProtKB/Swiss-Prot Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
GENATLAS Biochemistry:
immunoglobulin E,low affinity Fc receptor

Phenotypes From GWAS Catalog for FCER2 Gene

Gene Ontology (GO) - Molecular Function for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 2529542
GO:0005515 protein binding IPI 25416956
GO:0019863 IgE binding IEA --
GO:0030246 carbohydrate binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FCER2: view
genes like me logo Genes that share phenotypes with FCER2: view

Animal Models for FCER2 Gene

MGI Knock Outs for FCER2:

miRNA for FCER2 Gene

miRTarBase miRNAs that target FCER2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCER2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER2 Gene

Localization for FCER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER2 Gene

Cell membrane. Single-pass type II membrane protein. Cell membrane. Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2529542
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FCER2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCER2 Gene

Pathways & Interactions for FCER2 Gene

genes like me logo Genes that share pathways with FCER2: view

Pathways by source for FCER2 Gene

2 GeneGo (Thomson Reuters) pathways for FCER2 Gene
  • Apoptosis and survival APRIL and BAFF signaling
  • Immune response IL-4 signaling pathway
4 Qiagen pathways for FCER2 Gene
  • IL-4 Pathway
  • NFAT in Immune Response
  • NFAT Signaling and Lymphocyte Interactions
  • Phagocytosis of Microbes

SIGNOR curated interactions for FCER2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FCER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0007219 Notch signaling pathway TAS --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0051000 positive regulation of nitric-oxide synthase activity IDA 7544003
GO:0051712 positive regulation of killing of cells of other organism IDA 7544003
genes like me logo Genes that share ontologies with FCER2: view

Drugs & Compounds for FCER2 Gene

(33) Drugs for FCER2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lumiliximab Investigational Pharma Target 0

(15) Additional Compounds for FCER2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FCER2: view

Transcripts for FCER2 Gene

mRNA/cDNA for FCER2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FCER2

Alternative Splicing Database (ASD) splice patterns (SP) for FCER2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for FCER2 Gene

GeneLoc Exon Structure for
FCER2

Expression for FCER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER2 Gene

This gene is overexpressed in Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for FCER2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCER2 Gene



Protein tissue co-expression partners for FCER2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCER2

SOURCE GeneReport for Unigene cluster for FCER2 Gene:

Hs.465778

Evidence on tissue expression from TISSUES for FCER2 Gene

  • Blood(4.6)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Bone marrow(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with FCER2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER2 Gene

Orthologs for FCER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FCER2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FCER2 29 30
  • 85.76 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FCER2 29 30
  • 78.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FCER2 29 30
  • 75.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fcer2a 29 16 30
  • 70.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fcer2 29
  • 70.13 (n)
Oppossum
(Monodelphis domestica)
Mammalia FCER2 30
  • 37 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100858751 29
  • 50.53 (n)
FCER2 30
  • 28 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 30 (a)
OneToMany
Species where no ortholog for FCER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FCER2 Gene

ENSEMBL:
Gene Tree for FCER2 (if available)
TreeFam:
Gene Tree for FCER2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCER2: view image
Alliance of Genome Resources:
Additional Orthologs for FCER2

Paralogs for FCER2 Gene

(26) SIMAP similar genes for FCER2 Gene using alignment to 5 proteins:

  • FCER2_HUMAN
  • K3W4U1_HUMAN
  • M0R1R5_HUMAN
  • Q30218_HUMAN
  • Q30219_HUMAN
genes like me logo Genes that share paralogs with FCER2: view

Variants for FCER2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCER2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs376822599 Likely Benign: not provided 7,689,204(-) GA/G
NM_001220500.2(FCER2):c.954del (p.Leu319fs)
FRAMESHIFT
rs2228137 -- p.Arg62Trp
rs8102872 -- p.Arg284Gln
VAR_069800 -- p.Ser316Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FCER2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FCER2 Gene

Variant ID Type Subtype PubMed ID
dgv501e201 CNV deletion 23290073
dgv502e201 CNV deletion 23290073
dgv6248n54 CNV loss 21841781
dgv6249n54 CNV loss 21841781
dgv6250n54 CNV loss 21841781
dgv6251n54 CNV loss 21841781
esv2405737 CNV deletion 18987734
esv26340 CNV gain 19812545
esv2718099 CNV deletion 23290073
esv2718104 CNV deletion 23290073
esv2751809 CNV gain 17911159
esv3388356 CNV duplication 20981092
esv8263 CNV loss 19470904
esv8285 CNV gain 19470904
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv1120353 CNV tandem duplication 24896259
nsv1125205 CNV insertion 24896259
nsv578518 CNV loss 21841781
nsv578522 CNV loss 21841781
nsv578535 CNV loss 21841781
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for FCER2 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCER2 Gene

Human Gene Mutation Database (HGMD)
FCER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER2
Leiden Open Variation Database (LOVD)
FCER2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FCER2 Gene

Disorders for FCER2 Gene

MalaCards: The human disease database

(37) MalaCards diseases for FCER2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
chronic conjunctivitis
extrinsic allergic alveolitis
  • alveolitis
allergic disease
  • allergic hypersensitivity disease
intrinsic asthma
  • non-atopic asthma
follicular dendritic cell sarcoma
  • follicular dendritic cell tumour
- elite association - COSMIC cancer census association via MalaCards
Search FCER2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FCER2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FCER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER2 Gene

Publications for FCER2 Gene

  1. Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding. (PMID: 16765898) Wurzburg BA … Jardetzky TS (Structure (London, England : 1993) 2006) 3 4 22
  2. The structure of human CD23 and its interactions with IgE and CD21. (PMID: 16172256) Hibbert RG … McDonnell JM (The Journal of experimental medicine 2005) 3 4 22
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 40

Products for FCER2 Gene

  • Addgene plasmids for FCER2

Sources for FCER2 Gene