Aliases for FCER2 Gene
External Ids for FCER2 Gene
Previous HGNC Symbols for FCER2 Gene
Previous GeneCards Identifiers for FCER2 Gene
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for FCER2 Gene
FCER2 (Fc Fragment Of IgE Receptor II) is a Protein Coding gene. Diseases associated with FCER2 include Chronic Conjunctivitis and Extrinsic Allergic Alveolitis. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is ASGR2.
UniProtKB/Swiss-Prot Summary for FCER2 Gene
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).