The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008] See more...

Aliases for FCER1G Gene

Aliases for FCER1G Gene

  • Fc Fragment Of IgE Receptor Ig 2 3 5
  • Fc Fragment Of IgE, High Affinity I, Receptor For; Gamma Polypeptide 2 3
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Gamma 3 4
  • Fc Receptor Gamma-Chain 3 4
  • Fc Epsilon Receptor Ig 2 3
  • Fc-Epsilon RI-Gamma 3 4
  • FceRI Gamma 3 4
  • FcRgamma 3 4
  • Immunoglobulin E Receptor, High Affinity, Gamma Chain 3
  • IgE Fc Receptor Subunit Gamma 4
  • FCRG 3

External Ids for FCER1G Gene

Previous GeneCards Identifiers for FCER1G Gene

  • GC01P158896
  • GC01P156917
  • GC01P157962
  • GC01P158402
  • GC01P158403
  • GC01P157998
  • GC01P159451
  • GC01P161185
  • GC01P132542

Summaries for FCER1G Gene

Entrez Gene Summary for FCER1G Gene

  • The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for FCER1G Gene

FCER1G (Fc Fragment Of IgE Receptor Ig) is a Protein Coding gene. Diseases associated with FCER1G include Bleeding Disorder, Platelet-Type, 11 and Asthma. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and IgE binding.

UniProtKB/Swiss-Prot Summary for FCER1G Gene

  • Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.

Additional gene information for FCER1G Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FCER1G Gene

Genomics for FCER1G Gene

GeneHancer (GH) Regulatory Elements for FCER1G Gene

Promoters and enhancers for FCER1G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J161213 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 505.7 +1.9 1930 6.4 POLR2G NCOR1 POLR2A KDM6A TCF7 TGIF2 CTBP1 ZBTB7A TRIM22 TEAD1 FCER1G B4GALT3 DEDD NCSTN ATF6 DUSP12 NDUFS2 ENSG00000228606 CFAP126 USP21
GH01J161212 Promoter 0.4 EPDnew 500.7 -2.9 -2886 0.1 RBM22 FCER1G ADAMTS4 NDUFS2
GH01J160738 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 -473.1 -473090 8 EP300 CTCF RELA TOE1 RCOR1 CTBP1 TRIM22 POLR2A NFYB RBM25 SLAMF7 FCER1G CD48 CD244 ARHGAP30 COPA HSALNG0007861 lnc-SLAMF7-1
GH01J161304 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 11.9 +91.0 91034 3.3 HNRNPK ZBTB40 CTCF ZBTB11 GABPA AFF1 TARDBP SAP30 TOE1 RUNX1 lnc-CFAP126-2 FCER1G NDUFS2 NR1I3 APOA2 TOMM40L PCP4L1 SDHC HSPA7 FCGR2C
GH01J161011 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.3 -198.0 -198021 11.7 RXRA FOXK2 ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 POLR2G F11R piR-40154-015 TSTD1 ARHGAP30 KLHDC9 FCGR2A USF1 RPSAP18 ENSG00000228606 NCSTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCER1G on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FCER1G

Top Transcription factor binding sites by QIAGEN in the FCER1G gene promoter:
  • C/EBPalpha
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for FCER1G Gene

Genomic Locations for FCER1G Gene
chr1:161,215,234-161,220,699
(GRCh38/hg38)
Size:
5,466 bases
Orientation:
Plus strand
chr1:161,185,024-161,190,489
(GRCh37/hg19)
Size:
5,466 bases
Orientation:
Plus strand

Genomic View for FCER1G Gene

Genes around FCER1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1G Gene

Proteins for FCER1G Gene

  • Protein details for FCER1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30273-FCERG_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit gamma
    Protein Accession:
    P30273
    Secondary Accessions:
    • Q5VTW4

    Protein attributes for FCER1G Gene

    Size:
    86 amino acids
    Molecular mass:
    9667 Da
    Quaternary structure:
    • IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide-linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (PubMed:8611682). Associated with CLEC6A (By similarity). Interacts with CLEC4E (PubMed:18776906). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect (By similarity). Interacts with CD300LD (By similarity). Interacts with TARM1 (PubMed:26311901).

neXtProt entry for FCER1G Gene

Post-translational modifications for FCER1G Gene

  • Ubiquitination at Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for FCER1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCER1G Gene

Domains & Families for FCER1G Gene

Gene Families for FCER1G Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for FCER1G Gene

Blocks:
  • Phosphorylated immunoreceptor signaling ITAM
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FCER1G Gene

GenScript: Design optimal peptide antigens:
  • IgE Fc receptor subunit gamma (FCERG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30273

UniProtKB/Swiss-Prot:

FCERG_HUMAN :
  • Belongs to the CD3Z/FCER1G family.
Family:
  • Belongs to the CD3Z/FCER1G family.
genes like me logo Genes that share domains with FCER1G: view

Function for FCER1G Gene

Molecular function for FCER1G Gene

UniProtKB/Swiss-Prot Function:
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
GENATLAS Biochemistry:
immunoglobulin E,high affinity Fc receptor,gamma polypeptide,expressed in most cells,homodimerizing

Phenotypes From GWAS Catalog for FCER1G Gene

Gene Ontology (GO) - Molecular Function for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 8810294
GO:0019767 IgE receptor activity IBA 21873635
GO:0019863 IgE binding IBA 21873635
GO:0019864 IgG binding IBA 21873635
genes like me logo Genes that share ontologies with FCER1G: view
genes like me logo Genes that share phenotypes with FCER1G: view

Animal Models for FCER1G Gene

MGI Knock Outs for FCER1G:

Animal Model Products

miRNA for FCER1G Gene

miRTarBase miRNAs that target FCER1G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FCER1G Gene

Localization for FCER1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1G Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER1G gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 16735691
GO:0009897 external side of plasma membrane IBA,IEA 21873635
GO:0009986 cell surface IDA,IEA 1535625
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FCER1G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCER1G Gene

Pathways & Interactions for FCER1G Gene

genes like me logo Genes that share pathways with FCER1G: view

Pathways by source for FCER1G Gene

2 GeneGo (Thomson Reuters) pathways for FCER1G Gene
  • Immune response Fc epsilon RI pathway
  • Immune response NFAT in immune response
5 Qiagen pathways for FCER1G Gene
  • Fc-EpsilonRI Pathway
  • NFAT in Immune Response
  • NFAT Signaling and Lymphocyte Interactions
  • Phagocytosis of Microbes
  • Tec Kinases Signaling

Gene Ontology (GO) - Biological Process for FCER1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001798 positive regulation of type IIa hypersensitivity IEA --
GO:0001805 positive regulation of type III hypersensitivity IEA --
GO:0001812 positive regulation of type I hypersensitivity IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002283 neutrophil activation involved in immune response IBA 21873635
genes like me logo Genes that share ontologies with FCER1G: view

No data available for SIGNOR curated interactions for FCER1G Gene

Drugs & Compounds for FCER1G Gene

(4) Drugs for FCER1G Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzylpenicilloyl polylysine Approved Pharma Target, agonist, binder 0
Aspirin Approved, Vet_approved Pharma Channel blocker 1440
R112 Pharma 0
genes like me logo Genes that share compounds with FCER1G: view

Transcripts for FCER1G Gene

mRNA/cDNA for FCER1G Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1G Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for FCER1G Gene

GeneLoc Exon Structure for
FCER1G

Expression for FCER1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FCER1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1G Gene

This gene is overexpressed in Whole Blood (x35.5).

Protein differential expression in normal tissues from HIPED for FCER1G Gene

This gene is overexpressed in Nasal epithelium (22.5), Peripheral blood mononuclear cells (10.7), Platelet (10.3), and NK cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCER1G Gene



Protein tissue co-expression partners for FCER1G Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FCER1G

SOURCE GeneReport for Unigene cluster for FCER1G Gene:

Hs.433300

Evidence on tissue expression from TISSUES for FCER1G Gene

  • Blood(4.6)
  • Liver(4.3)
  • Spleen(3.2)
  • Lymph node(2.8)
  • Bone marrow(2.6)
  • Intestine(2.2)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with FCER1G: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1G Gene

Orthologs for FCER1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1G 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FCER1G 31 30
  • 92.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FCER1G 31 30
  • 91.76 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer1g 17 31 30
  • 89.05 (n)
rat
(Rattus norvegicus)
Mammalia Fcer1g 30
  • 87.98 (n)
oppossum
(Monodelphis domestica)
Mammalia FCER1G 31
  • 70 (a)
OneToOne
Species where no ortholog for FCER1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1G Gene

ENSEMBL:
Gene Tree for FCER1G (if available)
TreeFam:
Gene Tree for FCER1G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCER1G: view image

Paralogs for FCER1G Gene

(24) SIMAP similar genes for FCER1G Gene using alignment to 2 proteins:

  • FCERG_HUMAN
  • A6NCQ8_HUMAN
genes like me logo Genes that share paralogs with FCER1G: view

No data available for Paralogs for FCER1G Gene

Variants for FCER1G Gene

Additional dbSNP identifiers (rs#s) for FCER1G Gene

Structural Variations from Database of Genomic Variants (DGV) for FCER1G Gene

Variant ID Type Subtype PubMed ID
nsv482136 CNV loss 20164927

Variation tolerance for FCER1G Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCER1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FCER1G Gene

Disorders for FCER1G Gene

MalaCards: The human disease database

(2) MalaCards diseases for FCER1G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 11
  • bdplt11
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCER1G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCER1G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1G Gene

Publications for FCER1G Gene

  1. Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family. (PMID: 2138619) Küster H … Kinet JP (The Journal of biological chemistry 1990) 2 3 4 54
  2. TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils. (PMID: 26311901) Radjabova V … Barrow AD (Journal of immunology (Baltimore, Md. : 1950) 2015) 3 4 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41 54

Products for FCER1G Gene

Sources for FCER1G Gene