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Aliases for FCER1A Gene

Aliases for FCER1A Gene

  • Fc Fragment Of IgE Receptor Ia 2 3 5
  • Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide 2 3
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha 3 4
  • IgE Fc Receptor Subunit Alpha 3 4
  • Fc Epsilon Receptor Ia 2 3
  • Fc-Epsilon RI-Alpha 3 4
  • FCE1A 3 4
  • FcERI 3 4
  • Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide 3
  • High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit 3
  • Fc IgE Receptor, Alpha Polypeptide 3
  • Fc Epsilon RI Alpha-Chain 3

External Ids for FCER1A Gene

Previous HGNC Symbols for FCER1A Gene

  • FCE1A

Previous GeneCards Identifiers for FCER1A Gene

  • GC01P157051
  • GC01P154991
  • GC01P156037
  • GC01P156476
  • GC01P156072
  • GC01P157526
  • GC01P130616

Summaries for FCER1A Gene

Entrez Gene Summary for FCER1A Gene

  • The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCER1A Gene

FCER1A (Fc Fragment Of IgE Receptor Ia) is a Protein Coding gene. Diseases associated with FCER1A include Allergic Urticaria and Pleomorphic Lipoma. Among its related pathways are TCR Signaling (Qiagen) and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCGR3A.

UniProtKB/Swiss-Prot for FCER1A Gene

  • Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Gene Wiki entry for FCER1A Gene

Additional gene information for FCER1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene

Genomics for FCER1A Gene

GeneHancer (GH) Regulatory Elements for FCER1A Gene

Promoters and enhancers for FCER1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J159302 Promoter 1 EPDnew Ensembl 606.2 +18.5 18513 0.4 FCER1A OR10J3
GH01J159285 Enhancer 0.2 Ensembl 600.7 +1.2 1213 0.2 FCER1A OR10J3
GH01J159141 Promoter/Enhancer 1.1 FANTOM5 Ensembl 14.8 -142.0 -141987 1.4 SP1 PRDM10 POLR2A TCF7L2 ATF3 ZBTB48 FOS ZBTB17 JUND POLR3A GC01M159143 TRR-TCT4-1 OR6K3 CADM3 OR6N1 FCER1A ACKR1 CADM3-AS1 OR6N2 OR10J5
GH01J159229 Enhancer 0.7 Ensembl ENCODE 15.1 -54.0 -53987 1.4 SP1 STAT1 RCOR1 HNF4A RXRA REST FCER1A CADM3-AS1 ACKR1 OR10J2P OR10J3 MPTX1
GH01J159204 Promoter 1.5 EPDnew Ensembl 5.8 -78.0 -77987 2.2 CBFA2T2 ZNF148 MCM2 RELA IKZF1 NFRKB NCOR1 DPF2 FOXK2 EBF1 ACKR1 FCER1A CADM3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FCER1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCER1A gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • Cart-1
  • FosB
  • Fra-1
  • NF-kappaB
  • NF-kappaB1
  • Sox9

Genomic Locations for FCER1A Gene

Genomic Locations for FCER1A Gene
chr1:159,283,888-159,308,224
(GRCh38/hg38)
Size:
24,337 bases
Orientation:
Plus strand
chr1:159,259,504-159,278,014
(GRCh37/hg19)
Size:
18,511 bases
Orientation:
Plus strand

Genomic View for FCER1A Gene

Genes around FCER1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1A Gene

Proteins for FCER1A Gene

  • Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12319-FCERA_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit alpha
    Protein Accession:
    P12319

    Protein attributes for FCER1A Gene

    Size:
    257 amino acids
    Molecular mass:
    29596 Da
    Quaternary structure:
    • Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

    Three dimensional structures from OCA and Proteopedia for FCER1A Gene

neXtProt entry for FCER1A Gene

Post-translational modifications for FCER1A Gene

  • Glycosylation at posLast=7575, isoforms=160, isoforms=191, posLast=4646, isoforms=165, posLast=6767, and isoforms=99
  • Modification sites at PhosphoSitePlus

Other Protein References for FCER1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FCER1A Gene

Domains & Families for FCER1A Gene

Gene Families for FCER1A Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for FCER1A Gene

Suggested Antigen Peptide Sequences for FCER1A Gene

GenScript: Design optimal peptide antigens:
  • IgE Fc receptor subunit alpha (FCERA_HUMAN)
  • Fc of IgE, high affinity I, receptor for (Q6GU38_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCER1A: view

No data available for UniProtKB/Swiss-Prot for FCER1A Gene

Function for FCER1A Gene

Molecular function for FCER1A Gene

UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
GENATLAS Biochemistry:
immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit

Phenotypes From GWAS Catalog for FCER1A Gene

Gene Ontology (GO) - Molecular Function for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019863 IgE binding IEA --
genes like me logo Genes that share ontologies with FCER1A: view
genes like me logo Genes that share phenotypes with FCER1A: view

Animal Models for FCER1A Gene

MGI Knock Outs for FCER1A:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FCER1A - Now 50% OFF >
  • * FCER1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FCER1A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FCER1A Gene

Localization for FCER1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER1A gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2964640
GO:0009986 cell surface IDA 1535625
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCER1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCER1A Gene

Pathways & Interactions for FCER1A Gene

genes like me logo Genes that share pathways with FCER1A: view

SIGNOR curated interactions for FCER1A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FCER1A: view

Drugs & Compounds for FCER1A Gene

(8) Drugs for FCER1A Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omalizumab Approved, Investigational Pharma Target, inhibitor, antibody 158
Benzylpenicilloyl Polylysine Approved Pharma Target, agonist, binder 0
Desloratadine Approved, Investigational Pharma 70
Xolair Approved June 2003 Pharma 0
TNX-901 Investigational Pharma Target 0
genes like me logo Genes that share compounds with FCER1A: view

Transcripts for FCER1A Gene

mRNA/cDNA for FCER1A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FCER1A Gene

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FCER1A - Now 50% OFF >
  • * FCER1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FCER1A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1A Gene

No ASD Table

Relevant External Links for FCER1A Gene

GeneLoc Exon Structure for
FCER1A
ECgene alternative splicing isoforms for
FCER1A

Expression for FCER1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCER1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1A Gene

This gene is overexpressed in Whole Blood (x6.0), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.8).

Protein differential expression in normal tissues from HIPED for FCER1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FCER1A Gene



Protein tissue co-expression partners for FCER1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCER1A Gene:

FCER1A

SOURCE GeneReport for Unigene cluster for FCER1A Gene:

Hs.897

Evidence on tissue expression from TISSUES for FCER1A Gene

  • Lymph node(2.6)
  • Spleen(2.6)
  • Skin(2.5)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with FCER1A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1A Gene

Orthologs for FCER1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1A 35 34
  • 99.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FCER1A 35 34
  • 74.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FCER1A 35 34
  • 71.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fcer1a 17 35 34
  • 70.87 (n)
rat
(Rattus norvegicus)
Mammalia Fcer1a 34
  • 70.69 (n)
oppossum
(Monodelphis domestica)
Mammalia FCER1A 35
  • 31 (a)
OneToOne
Species where no ortholog for FCER1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1A Gene

ENSEMBL:
Gene Tree for FCER1A (if available)
TreeFam:
Gene Tree for FCER1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FCER1A: view image

Paralogs for FCER1A Gene

(12) SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:

  • FCERA_HUMAN
  • E9PRN1_HUMAN
  • Q6GU38_HUMAN
genes like me logo Genes that share paralogs with FCER1A: view

Variants for FCER1A Gene

Sequence variations from dbSNP and Humsavar for FCER1A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000020538 -- 159,288,572(+) G/C intron_variant
rs1000093390 -- 159,300,396(+) A/C/T intron_variant
rs1000182507 -- 159,294,159(+) G/A intron_variant
rs1000199925 -- 159,289,801(+) T/G intron_variant
rs1000224371 -- 159,287,431(+) G/A intron_variant

Variation tolerance for FCER1A Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCER1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER1A
Human Gene Mutation Database (HGMD)
FCER1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FCER1A Gene

Disorders for FCER1A Gene

MalaCards: The human disease database

(7) MalaCards diseases for FCER1A Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
allergic urticaria
pleomorphic lipoma
  • lipomatosis, multiple
physical urticaria
  • symptomatic dermographism
urticaria
dermatographia
  • dermatographic urticaria
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCER1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCER1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1A Gene

Publications for FCER1A Gene

  1. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y … Nishiyama C (International journal of immunogenetics 2010) 3 23 45 58
  2. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PMID: 11531339) Garman SC … Jardetzky TS (Journal of molecular biology 2001) 3 4 23 58
  3. High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PMID: 8125119) Yagi S … Ra C (European journal of biochemistry 1994) 3 4 23 58
  4. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J … Zhou L (Journal of immunology (Baltimore, Md. : 1950) 1993) 2 3 23 58
  5. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M … O'Connor GT (The Journal of allergy and clinical immunology 2012) 3 45 58

Products for FCER1A Gene

Sources for FCER1A Gene

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