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Aliases for FCER1A Gene

Aliases for FCER1A Gene

  • Fc Fragment Of IgE Receptor Ia 2 3 5
  • Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide 2 3
  • IgE Fc Receptor Subunit Alpha 3 4
  • Fc Epsilon Receptor Ia 2 3
  • Fc-Epsilon RI-Alpha 3 4
  • FCE1A 3 4
  • FcERI 3 4
  • Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide 3
  • High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit 3
  • High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha 3
  • Fc IgE Receptor, Alpha Polypeptide 3
  • Fc Epsilon RI Alpha-Chain 3

External Ids for FCER1A Gene

Previous HGNC Symbols for FCER1A Gene

  • FCE1A

Previous GeneCards Identifiers for FCER1A Gene

  • GC01P157051
  • GC01P154991
  • GC01P156037
  • GC01P156476
  • GC01P156072
  • GC01P157526
  • GC01P130616

Summaries for FCER1A Gene

Entrez Gene Summary for FCER1A Gene

  • The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

GeneCards Summary for FCER1A Gene

FCER1A (Fc Fragment Of IgE Receptor Ia) is a Protein Coding gene. Diseases associated with FCER1A include Allergic Urticaria and Dermatographia. Among its related pathways are Akt Signaling and IL1 and megakaryocytes in obesity. Gene Ontology (GO) annotations related to this gene include IgE binding and IgE receptor activity. An important paralog of this gene is FCGR3A.

UniProtKB/Swiss-Prot for FCER1A Gene

  • Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Gene Wiki entry for FCER1A Gene

Additional gene information for FCER1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FCER1A Gene

Genomics for FCER1A Gene

GeneHancer (GH) Regulatory Elements for FCER1A Gene

Promoters and enhancers for FCER1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159282 Enhancer 0.8 Ensembl 550.8 -1.5 -1504 0.6 FOXA2 RAD21 YY1 RCOR1 FOS RXRA CEBPB REST ZEB2 SP1 FCER1A ACKR1 OR10J2P
GH01I159302 Promoter 0.5 EPDnew 550.4 +18.4 18429 0.1 FCER1A OR10J3
GH01I159141 Enhancer 0.8 FANTOM5 Ensembl 14.8 -141.9 -141899 0.8 MXI1 SP1 JUND ATF3 POLR3A ZBTB48 POLR2A FOS PRDM10 ZBTB17 GC01M159143 TRR-TCT4-1 OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5
GH01I159229 Enhancer 0.5 ENCODE 15.1 -54.0 -54008 1.1 SP1 STAT1 HNF4A RCOR1 REST FCER1A CADM3-AS1 ACKR1 OR10J2P OR10J3 MPTX1
GH01I159211 Enhancer 0.7 Ensembl 9.8 -72.5 -72487 0.4 CTCF ARNT CEBPG RAD21 CC2D1A ARID2 SCRT2 SMC3 ZNF143 SCRT1 CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FCER1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FCER1A gene promoter:

Genomic Locations for FCER1A Gene

Genomic Locations for FCER1A Gene
chr1:159,283,888-159,308,224
(GRCh38/hg38)
Size:
24,337 bases
Orientation:
Plus strand
chr1:159,259,504-159,278,014
(GRCh37/hg19)

Genomic View for FCER1A Gene

Genes around FCER1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FCER1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FCER1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FCER1A Gene

Proteins for FCER1A Gene

  • Protein details for FCER1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12319-FCERA_HUMAN
    Recommended name:
    High affinity immunoglobulin epsilon receptor subunit alpha
    Protein Accession:
    P12319

    Protein attributes for FCER1A Gene

    Size:
    257 amino acids
    Molecular mass:
    29596 Da
    Quaternary structure:
    • Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.

    Three dimensional structures from OCA and Proteopedia for FCER1A Gene

neXtProt entry for FCER1A Gene

Post-translational modifications for FCER1A Gene

  • Glycosylation at posLast=4646, Asn67, Asn75, Asn99, Asn160, Asn165, and Asn191

Other Protein References for FCER1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FCER1A Gene

Domains & Families for FCER1A Gene

Gene Families for FCER1A Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for FCER1A Gene

Suggested Antigen Peptide Sequences for FCER1A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FCER1A: view

No data available for UniProtKB/Swiss-Prot for FCER1A Gene

Function for FCER1A Gene

Molecular function for FCER1A Gene

GENATLAS Biochemistry:
immunoglobulin E,high affinity Fc receptor,alpha polypeptide,expressed in most cells complexing with a beta chain and a homodimeric gamma subunit
UniProtKB/Swiss-Prot Function:
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Phenotypes From GWAS Catalog for FCER1A Gene

Gene Ontology (GO) - Molecular Function for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019863 IgE binding IEA --
genes like me logo Genes that share ontologies with FCER1A: view
genes like me logo Genes that share phenotypes with FCER1A: view

Animal Models for FCER1A Gene

MGI Knock Outs for FCER1A:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for FCER1A (Fc epsilon RI alpha)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FCER1A Gene

Localization for FCER1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FCER1A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FCER1A gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2964640
GO:0009986 cell surface IDA 1535625
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FCER1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FCER1A Gene

Pathways & Interactions for FCER1A Gene

genes like me logo Genes that share pathways with FCER1A: view

Gene Ontology (GO) - Biological Process for FCER1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FCER1A: view

No data available for SIGNOR curated interactions for FCER1A Gene

Drugs & Compounds for FCER1A Gene

(8) Drugs for FCER1A Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omalizumab Approved, Investigational Pharma Target, antibody 151
Benzylpenicilloyl Polylysine Approved Pharma Target, agonist, binder 0
Desloratadine Approved, Investigational Pharma 70
Xolair Approved June 2003 Pharma 0
TNX-901 Investigational Pharma Target 0
genes like me logo Genes that share compounds with FCER1A: view

Transcripts for FCER1A Gene

mRNA/cDNA for FCER1A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FCER1A Gene

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for FCER1A (Fc epsilon RI alpha)

Alternative Splicing Database (ASD) splice patterns (SP) for FCER1A Gene

No ASD Table

Relevant External Links for FCER1A Gene

GeneLoc Exon Structure for
FCER1A
ECgene alternative splicing isoforms for
FCER1A

Expression for FCER1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FCER1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FCER1A Gene

This gene is overexpressed in Whole Blood (x6.0), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.8).

Protein differential expression in normal tissues from HIPED for FCER1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FCER1A Gene



Protein tissue co-expression partners for FCER1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FCER1A Gene:

FCER1A

SOURCE GeneReport for Unigene cluster for FCER1A Gene:

Hs.897

Evidence on tissue expression from TISSUES for FCER1A Gene

  • Lymph node(2.6)
  • Spleen(2.6)
  • Skin(2.5)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with FCER1A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FCER1A Gene

Orthologs for FCER1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FCER1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FCER1A 33 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia FCER1A 33 34
  • 74.7 (n)
dog
(Canis familiaris)
Mammalia FCER1A 33 34
  • 71.35 (n)
mouse
(Mus musculus)
Mammalia Fcer1a 33 16 34
  • 70.87 (n)
rat
(Rattus norvegicus)
Mammalia Fcer1a 33
  • 70.69 (n)
oppossum
(Monodelphis domestica)
Mammalia FCER1A 34
  • 31 (a)
OneToOne
Species where no ortholog for FCER1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FCER1A Gene

ENSEMBL:
Gene Tree for FCER1A (if available)
TreeFam:
Gene Tree for FCER1A (if available)

Paralogs for FCER1A Gene

(12) SIMAP similar genes for FCER1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FCER1A: view

Variants for FCER1A Gene

Sequence variations from dbSNP and Humsavar for FCER1A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000020538 -- 159,288,572(+) G/C intron_variant
rs1000093390 -- 159,300,396(+) A/C/T intron_variant
rs1000182507 -- 159,294,159(+) G/A intron_variant
rs1000199925 -- 159,289,801(+) T/G intron_variant
rs1000224371 -- 159,287,431(+) G/A intron_variant

Variation tolerance for FCER1A Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FCER1A Gene

Human Gene Mutation Database (HGMD)
FCER1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FCER1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FCER1A Gene

Disorders for FCER1A Gene

MalaCards: The human disease database

(6) MalaCards diseases for FCER1A Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
allergic urticaria
dermatographia
  • dermatographic urticaria
pleomorphic lipoma
  • lipomatosis, multiple
physical urticaria
  • symptomatic dermographism
urticaria
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FCER1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FCER1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FCER1A Gene

Publications for FCER1A Gene

  1. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. (PMID: 20141544) Niwa Y … Nishiyama C (International journal of immunogenetics 2010) 3 22 44 58
  2. The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (PMID: 11531339) Garman SC … Jardetzky TS (Journal of molecular biology 2001) 3 4 22 58
  3. High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product. (PMID: 8125119) Yagi S … Ra C (European journal of biochemistry 1994) 3 4 22 58
  4. Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain. (PMID: 8245459) Pang J … Zhou L (Journal of immunology (Baltimore, Md. : 1950) 1993) 2 3 22 58
  5. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M … O'Connor GT (The Journal of allergy and clinical immunology 2012) 3 44 58

Products for FCER1A Gene

Sources for FCER1A Gene

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