Aliases for FCAR Gene
External Ids for FCAR Gene
Previous GeneCards Identifiers for FCAR Gene
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FCAR Gene
FCAR (Fc Fragment Of IgA Receptor) is a Protein Coding gene. Diseases associated with FCAR include Iga Glomerulonephritis and Hypersensitivity Vasculitis. Among its related pathways are Phagosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include IgA binding. An important paralog of this gene is LILRA2.
UniProtKB/Swiss-Prot Summary for FCAR Gene
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.